6UEL

CPS1 bound to allosteric inhibitor H3B-193

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000050	biological_process	urea cycle
A	0000166	molecular_function	nucleotide binding
A	0001889	biological_process	liver development
A	0003824	molecular_function	catalytic activity
A	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
A	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A	0004175	molecular_function	endopeptidase activity
A	0005509	molecular_function	calcium ion binding
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005543	molecular_function	phospholipid binding
A	0005634	cellular_component	nucleus
A	0005730	cellular_component	nucleolus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0005759	cellular_component	mitochondrial matrix
A	0005829	cellular_component	cytosol
A	0005886	cellular_component	plasma membrane
A	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
A	0006541	biological_process	glutamine metabolic process
A	0007494	biological_process	midgut development
A	0009410	biological_process	response to xenobiotic stimulus
A	0009636	biological_process	response to toxic substance
A	0010043	biological_process	response to zinc ion
A	0014075	biological_process	response to amine
A	0016020	cellular_component	membrane
A	0016595	molecular_function	glutamate binding
A	0016874	molecular_function	ligase activity
A	0019240	biological_process	citrulline biosynthetic process
A	0019433	biological_process	triglyceride catabolic process
A	0030955	molecular_function	potassium ion binding
A	0032094	biological_process	response to food
A	0032496	biological_process	response to lipopolysaccharide
A	0032991	cellular_component	protein-containing complex
A	0033762	biological_process	response to glucagon
A	0034201	biological_process	response to oleic acid
A	0036094	molecular_function	small molecule binding
A	0042311	biological_process	vasodilation
A	0042594	biological_process	response to starvation
A	0042645	cellular_component	mitochondrial nucleoid
A	0043200	biological_process	response to amino acid
A	0044344	biological_process	cellular response to fibroblast growth factor stimulus
A	0044877	molecular_function	protein-containing complex binding
A	0046209	biological_process	nitric oxide metabolic process
A	0046872	molecular_function	metal ion binding
A	0048545	biological_process	response to steroid hormone
A	0050667	biological_process	homocysteine metabolic process
A	0051384	biological_process	response to glucocorticoid
A	0051591	biological_process	response to cAMP
A	0055081	biological_process	monoatomic anion homeostasis
A	0060416	biological_process	response to growth hormone
A	0070365	biological_process	hepatocyte differentiation
A	0070409	biological_process	carbamoyl phosphate biosynthetic process
A	0071242	biological_process	cellular response to ammonium ion
A	0071320	biological_process	cellular response to cAMP
A	0071377	biological_process	cellular response to glucagon stimulus
A	0071400	biological_process	cellular response to oleic acid
A	0071548	biological_process	response to dexamethasone
A	0072341	molecular_function	modified amino acid binding
A	0097305	biological_process	response to alcohol
B	0000050	biological_process	urea cycle
B	0000166	molecular_function	nucleotide binding
B	0001889	biological_process	liver development
B	0003824	molecular_function	catalytic activity
B	0004087	molecular_function	carbamoyl-phosphate synthase (ammonia) activity
B	0004088	molecular_function	carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B	0004175	molecular_function	endopeptidase activity
B	0005509	molecular_function	calcium ion binding
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005543	molecular_function	phospholipid binding
B	0005634	cellular_component	nucleus
B	0005730	cellular_component	nucleolus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0005759	cellular_component	mitochondrial matrix
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0006207	biological_process	'de novo' pyrimidine nucleobase biosynthetic process
B	0006541	biological_process	glutamine metabolic process
B	0007494	biological_process	midgut development
B	0009410	biological_process	response to xenobiotic stimulus
B	0009636	biological_process	response to toxic substance
B	0010043	biological_process	response to zinc ion
B	0014075	biological_process	response to amine
B	0016020	cellular_component	membrane
B	0016595	molecular_function	glutamate binding
B	0016874	molecular_function	ligase activity
B	0019240	biological_process	citrulline biosynthetic process
B	0019433	biological_process	triglyceride catabolic process
B	0030955	molecular_function	potassium ion binding
B	0032094	biological_process	response to food
B	0032496	biological_process	response to lipopolysaccharide
B	0032991	cellular_component	protein-containing complex
B	0033762	biological_process	response to glucagon
B	0034201	biological_process	response to oleic acid
B	0036094	molecular_function	small molecule binding
B	0042311	biological_process	vasodilation
B	0042594	biological_process	response to starvation
B	0042645	cellular_component	mitochondrial nucleoid
B	0043200	biological_process	response to amino acid
B	0044344	biological_process	cellular response to fibroblast growth factor stimulus
B	0044877	molecular_function	protein-containing complex binding
B	0046209	biological_process	nitric oxide metabolic process
B	0046872	molecular_function	metal ion binding
B	0048545	biological_process	response to steroid hormone
B	0050667	biological_process	homocysteine metabolic process
B	0051384	biological_process	response to glucocorticoid
B	0051591	biological_process	response to cAMP
B	0055081	biological_process	monoatomic anion homeostasis
B	0060416	biological_process	response to growth hormone
B	0070365	biological_process	hepatocyte differentiation
B	0070409	biological_process	carbamoyl phosphate biosynthetic process
B	0071242	biological_process	cellular response to ammonium ion
B	0071320	biological_process	cellular response to cAMP
B	0071377	biological_process	cellular response to glucagon stimulus
B	0071400	biological_process	cellular response to oleic acid
B	0071548	biological_process	response to dexamethasone
B	0072341	molecular_function	modified amino acid binding
B	0097305	biological_process	response to alcohol

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ZN A 1601

Chain	Residue
A	ASN315
A	GLN335
A	HIS337
A	GLU362
A	HOH1752

---

site_id	AC2
Number of Residues	16
Details	binding site for residue Q5A A 1602

Chain	Residue
A	TRP776
A	ASP779
A	PHE809
A	CYS816
A	HIS817
A	ILE820
A	SER848
A	ARG850
A	ILE851
A	HOH1821
A	HOH1873
A	HOH2093
A	ASP654
A	VAL664
A	ILE773
A	ARG775

---

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN B 1601

Chain	Residue
B	ASN315
B	GLN335
B	HIS337
B	GLU362
B	HOH1789

---

site_id	AC4
Number of Residues	16
Details	binding site for residue Q5A B 1602

Chain	Residue
B	VAL653
B	ASP654
B	VAL664
B	ARG775
B	TRP776
B	LEU778
B	PHE809
B	CYS816
B	HIS817
B	ILE820
B	SER848
B	ARG850
B	ILE851
B	HOH1748
B	HOH1873
B	HOH1954

---

Functional Information from PROSITE/UniProt

site_id	PS00866
Number of Residues	15
Details	CPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIRSAyalGGlG

Chain	Residue	Details
A	TYR582-GLY596
A	TYR1124-ALA1138

---

site_id	PS00867
Number of Residues	8
Details	CPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. IIEVNARL

Chain	Residue	Details
A	ILE712-LEU719
A	VAL1253-ALA1260

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	370
Details	Domain: {"description":"Glutamine amidotransferase type-1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	73
Details	Modified residue: {"description":"N6-succinyllysine; alternate","evidences":[{"source":"UniProtKB","id":"Q8C196","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	26
Details	Modified residue: {"description":"N6-glutaryllysine; alternate","evidences":[{"source":"PubMed","id":"24703693","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	12
Details	Modified residue: {"description":"N6-glutaryllysine","evidences":[{"source":"PubMed","id":"24703693","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	10
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q8C196","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"Q8C196","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine; alternate","evidences":[{"source":"UniProtKB","id":"Q8C196","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	10
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P07756","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI12
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI13
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine; alternate","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI14
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) serine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI15
Number of Residues	2
Details	Glycosylation: {"description":"O-linked (GlcNAc) threonine","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---