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6UEL

CPS1 bound to allosteric inhibitor H3B-193

Functional Information from GO Data
ChainGOidnamespacecontents
A0000050biological_processurea cycle
A0001889biological_processliver development
A0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
A0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
A0004175molecular_functionendopeptidase activity
A0005509molecular_functioncalcium ion binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005543molecular_functionphospholipid binding
A0005634cellular_componentnucleus
A0005730cellular_componentnucleolus
A0005737cellular_componentcytoplasm
A0005739cellular_componentmitochondrion
A0005743cellular_componentmitochondrial inner membrane
A0005759cellular_componentmitochondrial matrix
A0005886cellular_componentplasma membrane
A0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
A0006541biological_processglutamine metabolic process
A0006807biological_processobsolete nitrogen compound metabolic process
A0007494biological_processmidgut development
A0009410biological_processresponse to xenobiotic stimulus
A0009636biological_processresponse to toxic substance
A0010043biological_processresponse to zinc ion
A0014075biological_processresponse to amine
A0016595molecular_functionglutamate binding
A0016874molecular_functionligase activity
A0019240biological_processcitrulline biosynthetic process
A0019433biological_processtriglyceride catabolic process
A0030955molecular_functionpotassium ion binding
A0032094biological_processresponse to food
A0032496biological_processresponse to lipopolysaccharide
A0032991cellular_componentprotein-containing complex
A0033762biological_processresponse to glucagon
A0034201biological_processresponse to oleic acid
A0036094molecular_functionsmall molecule binding
A0042311biological_processvasodilation
A0042594biological_processresponse to starvation
A0042645cellular_componentmitochondrial nucleoid
A0043200biological_processresponse to amino acid
A0044344biological_processcellular response to fibroblast growth factor stimulus
A0044877molecular_functionprotein-containing complex binding
A0046209biological_processnitric oxide metabolic process
A0046872molecular_functionmetal ion binding
A0048545biological_processresponse to steroid hormone
A0050667biological_processhomocysteine metabolic process
A0051384biological_processresponse to glucocorticoid
A0051591biological_processresponse to cAMP
A0055081biological_processmonoatomic anion homeostasis
A0060416biological_processresponse to growth hormone
A0070365biological_processhepatocyte differentiation
A0070409biological_processcarbamoyl phosphate biosynthetic process
A0071242biological_processcellular response to ammonium ion
A0071320biological_processcellular response to cAMP
A0071377biological_processcellular response to glucagon stimulus
A0071400biological_processcellular response to oleic acid
A0071548biological_processresponse to dexamethasone
A0072341molecular_functionmodified amino acid binding
B0000050biological_processurea cycle
B0001889biological_processliver development
B0004087molecular_functioncarbamoyl-phosphate synthase (ammonia) activity
B0004088molecular_functioncarbamoyl-phosphate synthase (glutamine-hydrolyzing) activity
B0004175molecular_functionendopeptidase activity
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005543molecular_functionphospholipid binding
B0005634cellular_componentnucleus
B0005730cellular_componentnucleolus
B0005737cellular_componentcytoplasm
B0005739cellular_componentmitochondrion
B0005743cellular_componentmitochondrial inner membrane
B0005759cellular_componentmitochondrial matrix
B0005886cellular_componentplasma membrane
B0006207biological_process'de novo' pyrimidine nucleobase biosynthetic process
B0006541biological_processglutamine metabolic process
B0006807biological_processobsolete nitrogen compound metabolic process
B0007494biological_processmidgut development
B0009410biological_processresponse to xenobiotic stimulus
B0009636biological_processresponse to toxic substance
B0010043biological_processresponse to zinc ion
B0014075biological_processresponse to amine
B0016595molecular_functionglutamate binding
B0016874molecular_functionligase activity
B0019240biological_processcitrulline biosynthetic process
B0019433biological_processtriglyceride catabolic process
B0030955molecular_functionpotassium ion binding
B0032094biological_processresponse to food
B0032496biological_processresponse to lipopolysaccharide
B0032991cellular_componentprotein-containing complex
B0033762biological_processresponse to glucagon
B0034201biological_processresponse to oleic acid
B0036094molecular_functionsmall molecule binding
B0042311biological_processvasodilation
B0042594biological_processresponse to starvation
B0042645cellular_componentmitochondrial nucleoid
B0043200biological_processresponse to amino acid
B0044344biological_processcellular response to fibroblast growth factor stimulus
B0044877molecular_functionprotein-containing complex binding
B0046209biological_processnitric oxide metabolic process
B0046872molecular_functionmetal ion binding
B0048545biological_processresponse to steroid hormone
B0050667biological_processhomocysteine metabolic process
B0051384biological_processresponse to glucocorticoid
B0051591biological_processresponse to cAMP
B0055081biological_processmonoatomic anion homeostasis
B0060416biological_processresponse to growth hormone
B0070365biological_processhepatocyte differentiation
B0070409biological_processcarbamoyl phosphate biosynthetic process
B0071242biological_processcellular response to ammonium ion
B0071320biological_processcellular response to cAMP
B0071377biological_processcellular response to glucagon stimulus
B0071400biological_processcellular response to oleic acid
B0071548biological_processresponse to dexamethasone
B0072341molecular_functionmodified amino acid binding
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue ZN A 1601
ChainResidue
AASN315
AGLN335
AHIS337
AGLU362
AHOH1752

site_idAC2
Number of Residues16
Detailsbinding site for residue Q5A A 1602
ChainResidue
ATRP776
AASP779
APHE809
ACYS816
AHIS817
AILE820
ASER848
AARG850
AILE851
AHOH1821
AHOH1873
AHOH2093
AASP654
AVAL664
AILE773
AARG775

site_idAC3
Number of Residues5
Detailsbinding site for residue ZN B 1601
ChainResidue
BASN315
BGLN335
BHIS337
BGLU362
BHOH1789

site_idAC4
Number of Residues16
Detailsbinding site for residue Q5A B 1602
ChainResidue
BVAL653
BASP654
BVAL664
BARG775
BTRP776
BLEU778
BPHE809
BCYS816
BHIS817
BILE820
BSER848
BARG850
BILE851
BHOH1748
BHOH1873
BHOH1954

Functional Information from PROSITE/UniProt
site_idPS00866
Number of Residues15
DetailsCPSASE_1 Carbamoyl-phosphate synthase subdomain signature 1. YPVMIRSAyalGGlG
ChainResidueDetails
ATYR582-GLY596
ATYR1124-ALA1138

site_idPS00867
Number of Residues8
DetailsCPSASE_2 Carbamoyl-phosphate synthase subdomain signature 2. IIEVNARL
ChainResidueDetails
AILE712-LEU719
AVAL1253-ALA1260

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues12
DetailsBINDING: BINDING => ECO:0000305
ChainResidueDetails
ATHR1391
BASN1437
BASN1440
BASN1449
ATHR1394
ATRP1410
AASN1437
AASN1440
AASN1449
BTHR1391
BTHR1394
BTRP1410

site_idSWS_FT_FI2
Number of Residues78
DetailsMOD_RES: N6-succinyllysine; alternate => ECO:0000250|UniProtKB:Q8C196
ChainResidueDetails
ALYS55
ALYS412
ALYS458
ALYS522
ALYS527
ALYS553
ALYS560
ALYS575
ALYS612
ALYS751
ALYS757
ALYS57
ALYS793
ALYS831
ALYS875
ALYS889
ALYS892
ALYS915
ALYS919
ALYS1074
ALYS1100
ALYS1168
ALYS119
ALYS1183
ALYS1232
ALYS1269
ALYS1291
ALYS1356
ALYS1360
ALYS1444
ALYS1471
ALYS1479
ALYS1486
ALYS157
BLYS55
BLYS57
BLYS119
BLYS157
BLYS207
BLYS214
BLYS287
BLYS307
BLYS402
BLYS412
ALYS207
BLYS458
BLYS522
BLYS527
BLYS553
BLYS560
BLYS575
BLYS612
BLYS751
BLYS757
BLYS793
ALYS214
BLYS831
BLYS875
BLYS889
BLYS892
BLYS915
BLYS919
BLYS1074
BLYS1100
BLYS1168
BLYS1183
ALYS287
BLYS1232
BLYS1269
BLYS1291
BLYS1356
BLYS1360
BLYS1444
BLYS1471
BLYS1479
BLYS1486
ALYS307
ALYS402

site_idSWS_FT_FI3
Number of Residues12
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER148
BSER1203
BSER1419
BSER1431
ASER569
ASER835
ASER1203
ASER1419
ASER1431
BSER148
BSER569
BSER835

site_idSWS_FT_FI4
Number of Residues26
DetailsMOD_RES: N6-glutaryllysine; alternate => ECO:0000269|PubMed:24703693
ChainResidueDetails
ALYS171
ALYS811
ALYS841
ALYS856
ALYS908
BLYS171
BLYS210
BLYS219
BLYS228
BLYS280
BLYS310
ALYS210
BLYS453
BLYS532
BLYS772
BLYS811
BLYS841
BLYS856
BLYS908
ALYS219
ALYS228
ALYS280
ALYS310
ALYS453
ALYS532
ALYS772

site_idSWS_FT_FI5
Number of Residues14
DetailsMOD_RES: N6-glutaryllysine => ECO:0000269|PubMed:24703693
ChainResidueDetails
ALYS176
BLYS728
BLYS869
BLYS905
BLYS1150
BLYS1224
ALYS237
ALYS728
ALYS869
ALYS905
ALYS1150
ALYS1224
BLYS176
BLYS237

site_idSWS_FT_FI6
Number of Residues10
DetailsMOD_RES: N6-acetyllysine => ECO:0000250|UniProtKB:Q8C196
ChainResidueDetails
ALYS182
BLYS1222
ALYS197
ALYS630
ALYS935
ALYS1222
BLYS182
BLYS197
BLYS630
BLYS935

site_idSWS_FT_FI7
Number of Residues4
DetailsMOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:Q8C196
ChainResidueDetails
ALYS400
ALYS1149
BLYS400
BLYS1149

site_idSWS_FT_FI8
Number of Residues2
DetailsMOD_RES: Phosphoserine; alternate => ECO:0000250|UniProtKB:Q8C196
ChainResidueDetails
ASER537
BSER537

site_idSWS_FT_FI9
Number of Residues10
DetailsMOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07756
ChainResidueDetails
ASER540
BSER1093
ASER896
ASER898
ASER1090
ASER1093
BSER540
BSER896
BSER898
BSER1090

site_idSWS_FT_FI10
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER1036
BSER1036

site_idSWS_FT_FI11
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163, ECO:0007744|PubMed:24275569
ChainResidueDetails
ASER1079
BSER1079

site_idSWS_FT_FI12
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine; alternate => ECO:0000250
ChainResidueDetails
ASER537
BSER537

site_idSWS_FT_FI13
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) serine => ECO:0000250
ChainResidueDetails
ASER1331
BSER1331

site_idSWS_FT_FI14
Number of Residues2
DetailsCARBOHYD: O-linked (GlcNAc) threonine => ECO:0000250
ChainResidueDetails
ATHR1332
BTHR1332

222036

PDB entries from 2024-07-03

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