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6UEK

Structure of Urocanate Hydratase from Trypanosoma cruzi in complex with NAD+

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0006547biological_processL-histidine metabolic process
A0006548biological_processL-histidine catabolic process
A0016153molecular_functionurocanate hydratase activity
A0016829molecular_functionlyase activity
A0019556biological_processL-histidine catabolic process to glutamate and formamide
A0019557biological_processL-histidine catabolic process to glutamate and formate
B0000166molecular_functionnucleotide binding
B0006547biological_processL-histidine metabolic process
B0006548biological_processL-histidine catabolic process
B0016153molecular_functionurocanate hydratase activity
B0016829molecular_functionlyase activity
B0019556biological_processL-histidine catabolic process to glutamate and formamide
B0019557biological_processL-histidine catabolic process to glutamate and formate
C0000166molecular_functionnucleotide binding
C0006547biological_processL-histidine metabolic process
C0006548biological_processL-histidine catabolic process
C0016153molecular_functionurocanate hydratase activity
C0016829molecular_functionlyase activity
C0019556biological_processL-histidine catabolic process to glutamate and formamide
C0019557biological_processL-histidine catabolic process to glutamate and formate
D0000166molecular_functionnucleotide binding
D0006547biological_processL-histidine metabolic process
D0006548biological_processL-histidine catabolic process
D0016153molecular_functionurocanate hydratase activity
D0016829molecular_functionlyase activity
D0019556biological_processL-histidine catabolic process to glutamate and formamide
D0019557biological_processL-histidine catabolic process to glutamate and formate
Functional Information from PDB Data
site_idAC1
Number of Residues19
Detailsbinding site for residue NAD A 701
ChainResidue
AGLY253
AVAL323
AGLN344
ATHR345
ASER346
AHIS348
AGLY354
ATYR355
ATYR356
AASN406
AHOH846
AGLY255
AGLY256
AMET257
ASER258
AALA275
AGLU276
AVAL277
AASN322

site_idAC2
Number of Residues21
Detailsbinding site for residue NAD B 701
ChainResidue
BGLY253
BGLY255
BGLY256
BMET257
BSER258
BALA275
BGLU276
BVAL277
BASN322
BVAL323
BGLN344
BTHR345
BSER346
BHIS348
BGLY354
BTYR356
BTYR404
BGLY405
BASN406
BTYR437
BHOH849

site_idAC3
Number of Residues25
Detailsbinding site for residue NAD C 701
ChainResidue
CTYR130
CGLY131
CGLY132
CGLN209
CILE223
CGLY253
CGLY255
CGLY256
CMET257
CSER258
CALA275
CGLU276
CVAL277
CASP278
CVAL323
CGLN344
CTHR345
CSER346
CHIS348
CGLY354
CTYR355
CTYR356
CASN406
CASP547
CGLY597

site_idAC4
Number of Residues17
Detailsbinding site for residue NAD D 701
ChainResidue
DGLY253
DGLY255
DGLY256
DMET257
DSER258
DALA275
DGLU276
DVAL277
DASN322
DVAL323
DGLN344
DTHR345
DSER346
DHIS348
DGLY354
DTYR356
DASN406

Functional Information from PROSITE/UniProt
site_idPS01233
Number of Residues16
DetailsUROCANASE Urocanase signature. RDHhDvSGtdSPfRET
ChainResidueDetails
AARG546-THR561

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PDB entries from 2024-11-06

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