Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UDQ

Human IMPDH2 treated with ATP, IMP, and 20 mM GTP. Fully compressed filament end reconstruction.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003677	molecular_function	DNA binding
A	0003723	molecular_function	RNA binding
A	0003824	molecular_function	catalytic activity
A	0003938	molecular_function	IMP dehydrogenase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005778	cellular_component	peroxisomal membrane
A	0005829	cellular_component	cytosol
A	0006164	biological_process	purine nucleotide biosynthetic process
A	0006177	biological_process	GMP biosynthetic process
A	0006183	biological_process	GTP biosynthetic process
A	0007623	biological_process	circadian rhythm
A	0016020	cellular_component	membrane
A	0016491	molecular_function	oxidoreductase activity
A	0034774	cellular_component	secretory granule lumen
A	0046651	biological_process	lymphocyte proliferation
A	0046872	molecular_function	metal ion binding
A	0070062	cellular_component	extracellular exosome
A	0071353	biological_process	cellular response to interleukin-4
A	0097294	biological_process	'de novo' XMP biosynthetic process
A	1904813	cellular_component	ficolin-1-rich granule lumen
B	0000166	molecular_function	nucleotide binding
B	0003677	molecular_function	DNA binding
B	0003723	molecular_function	RNA binding
B	0003824	molecular_function	catalytic activity
B	0003938	molecular_function	IMP dehydrogenase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005778	cellular_component	peroxisomal membrane
B	0005829	cellular_component	cytosol
B	0006164	biological_process	purine nucleotide biosynthetic process
B	0006177	biological_process	GMP biosynthetic process
B	0006183	biological_process	GTP biosynthetic process
B	0007623	biological_process	circadian rhythm
B	0016020	cellular_component	membrane
B	0016491	molecular_function	oxidoreductase activity
B	0034774	cellular_component	secretory granule lumen
B	0046651	biological_process	lymphocyte proliferation
B	0046872	molecular_function	metal ion binding
B	0070062	cellular_component	extracellular exosome
B	0071353	biological_process	cellular response to interleukin-4
B	0097294	biological_process	'de novo' XMP biosynthetic process
B	1904813	cellular_component	ficolin-1-rich granule lumen
C	0000166	molecular_function	nucleotide binding
C	0003677	molecular_function	DNA binding
C	0003723	molecular_function	RNA binding
C	0003824	molecular_function	catalytic activity
C	0003938	molecular_function	IMP dehydrogenase activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005778	cellular_component	peroxisomal membrane
C	0005829	cellular_component	cytosol
C	0006164	biological_process	purine nucleotide biosynthetic process
C	0006177	biological_process	GMP biosynthetic process
C	0006183	biological_process	GTP biosynthetic process
C	0007623	biological_process	circadian rhythm
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0034774	cellular_component	secretory granule lumen
C	0046651	biological_process	lymphocyte proliferation
C	0046872	molecular_function	metal ion binding
C	0070062	cellular_component	extracellular exosome
C	0071353	biological_process	cellular response to interleukin-4
C	0097294	biological_process	'de novo' XMP biosynthetic process
C	1904813	cellular_component	ficolin-1-rich granule lumen
D	0000166	molecular_function	nucleotide binding
D	0003677	molecular_function	DNA binding
D	0003723	molecular_function	RNA binding
D	0003824	molecular_function	catalytic activity
D	0003938	molecular_function	IMP dehydrogenase activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005778	cellular_component	peroxisomal membrane
D	0005829	cellular_component	cytosol
D	0006164	biological_process	purine nucleotide biosynthetic process
D	0006177	biological_process	GMP biosynthetic process
D	0006183	biological_process	GTP biosynthetic process
D	0007623	biological_process	circadian rhythm
D	0016020	cellular_component	membrane
D	0016491	molecular_function	oxidoreductase activity
D	0034774	cellular_component	secretory granule lumen
D	0046651	biological_process	lymphocyte proliferation
D	0046872	molecular_function	metal ion binding
D	0070062	cellular_component	extracellular exosome
D	0071353	biological_process	cellular response to interleukin-4
D	0097294	biological_process	'de novo' XMP biosynthetic process
D	1904813	cellular_component	ficolin-1-rich granule lumen
E	0000166	molecular_function	nucleotide binding
E	0003677	molecular_function	DNA binding
E	0003723	molecular_function	RNA binding
E	0003824	molecular_function	catalytic activity
E	0003938	molecular_function	IMP dehydrogenase activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005778	cellular_component	peroxisomal membrane
E	0005829	cellular_component	cytosol
E	0006164	biological_process	purine nucleotide biosynthetic process
E	0006177	biological_process	GMP biosynthetic process
E	0006183	biological_process	GTP biosynthetic process
E	0007623	biological_process	circadian rhythm
E	0016020	cellular_component	membrane
E	0016491	molecular_function	oxidoreductase activity
E	0034774	cellular_component	secretory granule lumen
E	0046651	biological_process	lymphocyte proliferation
E	0046872	molecular_function	metal ion binding
E	0070062	cellular_component	extracellular exosome
E	0071353	biological_process	cellular response to interleukin-4
E	0097294	biological_process	'de novo' XMP biosynthetic process
E	1904813	cellular_component	ficolin-1-rich granule lumen
F	0000166	molecular_function	nucleotide binding
F	0003677	molecular_function	DNA binding
F	0003723	molecular_function	RNA binding
F	0003824	molecular_function	catalytic activity
F	0003938	molecular_function	IMP dehydrogenase activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005634	cellular_component	nucleus
F	0005737	cellular_component	cytoplasm
F	0005778	cellular_component	peroxisomal membrane
F	0005829	cellular_component	cytosol
F	0006164	biological_process	purine nucleotide biosynthetic process
F	0006177	biological_process	GMP biosynthetic process
F	0006183	biological_process	GTP biosynthetic process
F	0007623	biological_process	circadian rhythm
F	0016020	cellular_component	membrane
F	0016491	molecular_function	oxidoreductase activity
F	0034774	cellular_component	secretory granule lumen
F	0046651	biological_process	lymphocyte proliferation
F	0046872	molecular_function	metal ion binding
F	0070062	cellular_component	extracellular exosome
F	0071353	biological_process	cellular response to interleukin-4
F	0097294	biological_process	'de novo' XMP biosynthetic process
F	1904813	cellular_component	ficolin-1-rich granule lumen
G	0000166	molecular_function	nucleotide binding
G	0003677	molecular_function	DNA binding
G	0003723	molecular_function	RNA binding
G	0003824	molecular_function	catalytic activity
G	0003938	molecular_function	IMP dehydrogenase activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005634	cellular_component	nucleus
G	0005737	cellular_component	cytoplasm
G	0005778	cellular_component	peroxisomal membrane
G	0005829	cellular_component	cytosol
G	0006164	biological_process	purine nucleotide biosynthetic process
G	0006177	biological_process	GMP biosynthetic process
G	0006183	biological_process	GTP biosynthetic process
G	0007623	biological_process	circadian rhythm
G	0016020	cellular_component	membrane
G	0016491	molecular_function	oxidoreductase activity
G	0034774	cellular_component	secretory granule lumen
G	0046651	biological_process	lymphocyte proliferation
G	0046872	molecular_function	metal ion binding
G	0070062	cellular_component	extracellular exosome
G	0071353	biological_process	cellular response to interleukin-4
G	0097294	biological_process	'de novo' XMP biosynthetic process
G	1904813	cellular_component	ficolin-1-rich granule lumen
H	0000166	molecular_function	nucleotide binding
H	0003677	molecular_function	DNA binding
H	0003723	molecular_function	RNA binding
H	0003824	molecular_function	catalytic activity
H	0003938	molecular_function	IMP dehydrogenase activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005634	cellular_component	nucleus
H	0005737	cellular_component	cytoplasm
H	0005778	cellular_component	peroxisomal membrane
H	0005829	cellular_component	cytosol
H	0006164	biological_process	purine nucleotide biosynthetic process
H	0006177	biological_process	GMP biosynthetic process
H	0006183	biological_process	GTP biosynthetic process
H	0007623	biological_process	circadian rhythm
H	0016020	cellular_component	membrane
H	0016491	molecular_function	oxidoreductase activity
H	0034774	cellular_component	secretory granule lumen
H	0046651	biological_process	lymphocyte proliferation
H	0046872	molecular_function	metal ion binding
H	0070062	cellular_component	extracellular exosome
H	0071353	biological_process	cellular response to interleukin-4
H	0097294	biological_process	'de novo' XMP biosynthetic process
H	1904813	cellular_component	ficolin-1-rich granule lumen
I	0000166	molecular_function	nucleotide binding
I	0003677	molecular_function	DNA binding
I	0003723	molecular_function	RNA binding
I	0003824	molecular_function	catalytic activity
I	0003938	molecular_function	IMP dehydrogenase activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005634	cellular_component	nucleus
I	0005737	cellular_component	cytoplasm
I	0005778	cellular_component	peroxisomal membrane
I	0005829	cellular_component	cytosol
I	0006164	biological_process	purine nucleotide biosynthetic process
I	0006177	biological_process	GMP biosynthetic process
I	0006183	biological_process	GTP biosynthetic process
I	0007623	biological_process	circadian rhythm
I	0016020	cellular_component	membrane
I	0016491	molecular_function	oxidoreductase activity
I	0034774	cellular_component	secretory granule lumen
I	0046651	biological_process	lymphocyte proliferation
I	0046872	molecular_function	metal ion binding
I	0070062	cellular_component	extracellular exosome
I	0071353	biological_process	cellular response to interleukin-4
I	0097294	biological_process	'de novo' XMP biosynthetic process
I	1904813	cellular_component	ficolin-1-rich granule lumen
J	0000166	molecular_function	nucleotide binding
J	0003677	molecular_function	DNA binding
J	0003723	molecular_function	RNA binding
J	0003824	molecular_function	catalytic activity
J	0003938	molecular_function	IMP dehydrogenase activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005634	cellular_component	nucleus
J	0005737	cellular_component	cytoplasm
J	0005778	cellular_component	peroxisomal membrane
J	0005829	cellular_component	cytosol
J	0006164	biological_process	purine nucleotide biosynthetic process
J	0006177	biological_process	GMP biosynthetic process
J	0006183	biological_process	GTP biosynthetic process
J	0007623	biological_process	circadian rhythm
J	0016020	cellular_component	membrane
J	0016491	molecular_function	oxidoreductase activity
J	0034774	cellular_component	secretory granule lumen
J	0046651	biological_process	lymphocyte proliferation
J	0046872	molecular_function	metal ion binding
J	0070062	cellular_component	extracellular exosome
J	0071353	biological_process	cellular response to interleukin-4
J	0097294	biological_process	'de novo' XMP biosynthetic process
J	1904813	cellular_component	ficolin-1-rich granule lumen
K	0000166	molecular_function	nucleotide binding
K	0003677	molecular_function	DNA binding
K	0003723	molecular_function	RNA binding
K	0003824	molecular_function	catalytic activity
K	0003938	molecular_function	IMP dehydrogenase activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005634	cellular_component	nucleus
K	0005737	cellular_component	cytoplasm
K	0005778	cellular_component	peroxisomal membrane
K	0005829	cellular_component	cytosol
K	0006164	biological_process	purine nucleotide biosynthetic process
K	0006177	biological_process	GMP biosynthetic process
K	0006183	biological_process	GTP biosynthetic process
K	0007623	biological_process	circadian rhythm
K	0016020	cellular_component	membrane
K	0016491	molecular_function	oxidoreductase activity
K	0034774	cellular_component	secretory granule lumen
K	0046651	biological_process	lymphocyte proliferation
K	0046872	molecular_function	metal ion binding
K	0070062	cellular_component	extracellular exosome
K	0071353	biological_process	cellular response to interleukin-4
K	0097294	biological_process	'de novo' XMP biosynthetic process
K	1904813	cellular_component	ficolin-1-rich granule lumen
L	0000166	molecular_function	nucleotide binding
L	0003677	molecular_function	DNA binding
L	0003723	molecular_function	RNA binding
L	0003824	molecular_function	catalytic activity
L	0003938	molecular_function	IMP dehydrogenase activity
L	0005515	molecular_function	protein binding
L	0005576	cellular_component	extracellular region
L	0005634	cellular_component	nucleus
L	0005737	cellular_component	cytoplasm
L	0005778	cellular_component	peroxisomal membrane
L	0005829	cellular_component	cytosol
L	0006164	biological_process	purine nucleotide biosynthetic process
L	0006177	biological_process	GMP biosynthetic process
L	0006183	biological_process	GTP biosynthetic process
L	0007623	biological_process	circadian rhythm
L	0016020	cellular_component	membrane
L	0016491	molecular_function	oxidoreductase activity
L	0034774	cellular_component	secretory granule lumen
L	0046651	biological_process	lymphocyte proliferation
L	0046872	molecular_function	metal ion binding
L	0070062	cellular_component	extracellular exosome
L	0071353	biological_process	cellular response to interleukin-4
L	0097294	biological_process	'de novo' XMP biosynthetic process
L	1904813	cellular_component	ficolin-1-rich granule lumen

Functional Information from PDB Data

site_id	AC1
Number of Residues	17
Details	binding site for residue IMP A 601

Chain	Residue
A	SER68
A	GLY366
A	GLY387
A	SER388
A	TYR411
A	GLY413
A	MET414
A	GLY415
A	GLN441
A	MET70
A	ARG322
A	GLY328
A	SER329
A	ILE330
A	CYS331
A	ASP364
A	GLY365

site_id	AC2
Number of Residues	12
Details	binding site for residue GTP A 602

Chain	Residue
A	LYS109
A	TYR110
A	PRO118
A	PHE139
A	CYS140
A	GLY141
A	SER160
A	LYS208
A	THR225
A	ASP226
A	LYS229
A	ATP604

site_id	AC3
Number of Residues	9
Details	binding site for residue GTP A 603

Chain	Residue
A	GLN112
A	GLY113
A	LEU194
A	LYS195
A	ASN198
A	ILE222
A	ASN230
A	LYS238
A	LYS242

site_id	AC4
Number of Residues	12
Details	binding site for residue ATP A 604

Chain	Residue
A	SER159
A	SER160
A	ARG161
A	ASP162
A	THR180
A	LEU185
A	VAL186
A	LYS206
A	GLY207
A	LYS208
A	GTP602
E	LYS205

site_id	AC5
Number of Residues	18
Details	binding site for residue IMP E 601

Chain	Residue
E	SER68
E	MET70
E	ARG322
E	GLY328
E	SER329
E	ILE330
E	CYS331
E	THR333
E	ASP364
E	GLY365
E	GLY366
E	GLY387
E	SER388
E	TYR411
E	GLY413
E	MET414
E	GLY415
E	GLN441

site_id	AC6
Number of Residues	9
Details	binding site for residue GTP E 603

Chain	Residue
E	GLU111
E	GLN112
E	LEU194
E	ASN198
E	ASP226
E	LEU227
E	ASN230
E	LYS238
E	LYS242

site_id	AC7
Number of Residues	17
Details	binding site for residue IMP B 601

Chain	Residue
B	SER68
B	MET70
B	GLY328
B	SER329
B	ILE330
B	CYS331
B	ASP364
B	GLY365
B	GLY366
B	GLY387
B	SER388
B	TYR411
B	GLY413
B	MET414
B	GLY415
B	GLN441
B	GLY442

site_id	AC8
Number of Residues	12
Details	binding site for residue GTP B 602

Chain	Residue
B	GLY141
B	SER160
B	LYS208
B	THR225
B	ASP226
B	LYS229
B	ATP604
B	LYS109
B	TYR110
B	PRO118
B	PHE139
B	CYS140

site_id	AC9
Number of Residues	10
Details	binding site for residue GTP B 603

Chain	Residue
B	GLU111
B	GLN112
B	GLY113
B	LEU194
B	LYS195
B	ASN198
B	ILE222
B	ASP226
B	ASN230
B	LYS242

site_id	AD1
Number of Residues	14
Details	binding site for residue ATP B 604

Chain	Residue
B	ILE157
B	SER159
B	SER160
B	ARG161
B	ASP162
B	THR180
B	LEU185
B	VAL186
B	LYS206
B	GLY207
B	LYS208
B	GTP602
F	LYS205
F	ATP604

site_id	AD2
Number of Residues	16
Details	binding site for residue IMP F 601

Chain	Residue
F	MET70
F	GLY328
F	SER329
F	ILE330
F	CYS331
F	THR333
F	ASP364
F	GLY365
F	GLY387
F	SER388
F	TYR411
F	GLY413
F	MET414
F	GLY415
F	GLN441
F	GLY442

site_id	AD3
Number of Residues	9
Details	binding site for residue GTP F 603

Chain	Residue
F	GLU111
F	GLN112
F	LEU194
F	ASN198
F	ASP226
F	LEU227
F	ASN230
F	LYS238
F	LYS242

site_id	AD4
Number of Residues	18
Details	binding site for residue ATP F 604

Chain	Residue
B	ARG161
B	LYS205
B	ARG224
B	ATP604
F	ILE157
F	SER159
F	SER160
F	ARG161
F	ASP162
F	THR180
F	ASP184
F	LEU185
F	VAL186
F	LYS206
F	GLY207
F	LYS208
F	PRO210
F	GTP602

site_id	AD5
Number of Residues	17
Details	binding site for residue IMP C 601

Chain	Residue
C	SER68
C	MET70
C	ARG322
C	GLY328
C	SER329
C	ILE330
C	CYS331
C	ASP364
C	GLY365
C	GLY366
C	GLY387
C	SER388
C	TYR411
C	GLY413
C	MET414
C	GLY415
C	GLN441

site_id	AD6
Number of Residues	12
Details	binding site for residue GTP C 602

Chain	Residue
C	LYS109
C	TYR110
C	PRO118
C	PHE139
C	CYS140
C	GLY141
C	SER160
C	LYS208
C	THR225
C	ASP226
C	LYS229
C	ATP604

site_id	AD7
Number of Residues	9
Details	binding site for residue GTP C 603

Chain	Residue
C	GLU111
C	GLN112
C	GLY113
C	LEU194
C	ASN198
C	ILE222
C	ASP226
C	ASN230
C	LYS242

site_id	AD8
Number of Residues	12
Details	binding site for residue ATP C 604

Chain	Residue
C	SER159
C	SER160
C	ARG161
C	ASP162
C	THR180
C	LEU185
C	VAL186
C	LYS206
C	GLY207
C	LYS208
C	GTP602
G	LYS205

site_id	AD9
Number of Residues	13
Details	binding site for residue IMP G 601

Chain	Residue
G	SER68
G	ARG322
G	GLY328
G	SER329
G	ILE330
G	CYS331
G	ASP364
G	GLY387
G	SER388
G	TYR411
G	GLY415
G	GLN441
G	GLY442

site_id	AE1
Number of Residues	9
Details	binding site for residue GTP G 603

Chain	Residue
G	GLU111
G	GLN112
G	LEU194
G	ASN198
G	ASP226
G	LEU227
G	ASN230
G	LYS238
G	LYS242

site_id	AE2
Number of Residues	17
Details	binding site for residue IMP D 601

Chain	Residue
D	SER68
D	MET70
D	GLY328
D	SER329
D	ILE330
D	CYS331
D	THR333
D	ASP364
D	GLY365
D	GLY366
D	GLY387
D	SER388
D	TYR411
D	GLY413
D	MET414
D	GLY415
D	GLN441

site_id	AE3
Number of Residues	12
Details	binding site for residue GTP D 602

Chain	Residue
D	LYS109
D	TYR110
D	PRO118
D	PHE139
D	CYS140
D	GLY141
D	SER160
D	LYS208
D	THR225
D	ASP226
D	LYS229
D	ATP604

site_id	AE4
Number of Residues	10
Details	binding site for residue GTP D 603

Chain	Residue
D	GLN112
D	GLY113
D	LEU194
D	LYS195
D	ASN198
D	ILE222
D	ASP226
D	ASN230
D	LYS238
D	LYS242

site_id	AE5
Number of Residues	13
Details	binding site for residue ATP D 604

Chain	Residue
D	ILE157
D	SER159
D	SER160
D	ARG161
D	ASP162
D	THR180
D	LEU185
D	VAL186
D	LYS206
D	GLY207
D	LYS208
D	GTP602
H	LYS205

site_id	AE6
Number of Residues	19
Details	binding site for residue IMP H 601

Chain	Residue
H	SER68
H	MET70
H	ARG322
H	GLY328
H	SER329
H	ILE330
H	CYS331
H	THR333
H	ASP364
H	GLY365
H	GLY366
H	GLY387
H	SER388
H	TYR411
H	GLY413
H	MET414
H	GLY415
H	GLN441
H	GLY442

site_id	AE7
Number of Residues	9
Details	binding site for residue GTP H 603

Chain	Residue
H	GLU111
H	GLN112
H	LEU194
H	ASN198
H	ASP226
H	LEU227
H	ASN230
H	LYS238
H	LYS242

site_id	AE8
Number of Residues	13
Details	binding site for residue ATP H 604

Chain	Residue
D	ARG161
H	SER159
H	SER160
H	ARG161
H	ASP162
H	THR180
H	LEU185
H	VAL186
H	LYS206
H	GLY207
H	LYS208
H	PRO210
H	GTP602

site_id	AE9
Number of Residues	21
Details	binding site for Di-peptide ATP A 605 and ARG A 161

Chain	Residue
A	SER159
A	SER160
A	ASP162
A	ILE163
A	ARG224
A	ATP604
E	ILE157
E	SER159
E	SER160
E	ARG161
E	ASP162
E	THR180
E	LEU185
E	VAL186
E	LYS205
E	LYS206
E	GLY207
E	LYS208
E	PRO210
E	ARG224
E	GTP602

site_id	AF1
Number of Residues	22
Details	binding site for Di-peptide ATP C 605 and ARG C 161

Chain	Residue
C	SER159
C	SER160
C	ASP162
C	ILE163
C	ARG224
C	ATP604
G	ILE157
G	SER159
G	SER160
G	ARG161
G	ASP162
G	THR180
G	ASP184
G	LEU185
G	VAL186
G	LYS205
G	LYS206
G	GLY207
G	LYS208
G	PRO210
G	ARG224
G	GTP602

site_id	AF2
Number of Residues	17
Details	binding site for Di-peptide GTP E 602 and LYS E 208

Chain	Residue
A	ATP605
E	LYS109
E	ILE115
E	PRO118
E	PHE139
E	CYS140
E	GLY141
E	ILE157
E	SER159
E	SER160
E	LYS206
E	GLY207
E	LEU209
E	ILE222
E	ALA223
E	THR225
E	ASP226

site_id	AF3
Number of Residues	15
Details	binding site for Di-peptide GTP F 602 and LYS F 208

Chain	Residue
F	LYS109
F	GLN112
F	ILE115
F	PRO118
F	GLY138
F	PHE139
F	CYS140
F	GLY141
F	SER160
F	LYS206
F	GLY207
F	LEU209
F	ILE222
F	THR225
F	ATP604

site_id	AF4
Number of Residues	17
Details	binding site for Di-peptide GTP G 602 and LYS G 208

Chain	Residue
C	ATP605
G	LYS109
G	GLN112
G	ILE115
G	PRO118
G	PHE139
G	CYS140
G	GLY141
G	ILE157
G	SER159
G	SER160
G	LYS206
G	GLY207
G	LEU209
G	ILE221
G	ILE222
G	THR225

site_id	AF5
Number of Residues	17
Details	binding site for Di-peptide GTP H 602 and LYS H 208

Chain	Residue
H	LYS109
H	TYR110
H	GLN112
H	ILE115
H	PRO118
H	PHE139
H	CYS140
H	GLY141
H	LYS206
H	GLY207
H	LEU209
H	ILE221
H	ILE222
H	THR225
H	ASP226
H	LYS229
H	ATP604

Functional Information from PROSITE/UniProt

site_id	PS00487
Number of Residues	13
Details	IMP_DH_GMP_RED IMP dehydrogenase / GMP reductase signature. LRVGMGsGSICiT

Chain	Residue	Details
I	LEU321-THR333

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	12
Details	ACT_SITE: Thioimidate intermediate => ECO:0000255\|HAMAP-Rule:MF_03156, ECO:0000269\|PubMed:10097070

Chain	Residue	Details
I	CYS331
L	CYS331
D	CYS331
H	CYS331
A	CYS331
E	CYS331
J	CYS331
B	CYS331
F	CYS331
K	CYS331
C	CYS331
G	CYS331

site_id	SWS_FT_FI2
Number of Residues	12
Details	ACT_SITE: Proton acceptor => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
I	ARG429
L	ARG429
D	ARG429
H	ARG429
A	ARG429
E	ARG429
J	ARG429
B	ARG429
F	ARG429
K	ARG429
C	ARG429
G	ARG429

site_id	SWS_FT_FI3
Number of Residues	36
Details	BINDING:

Chain	Residue	Details
I	ASP274
J	ASP274
J	ASP364
J	GLY387
B	ASP274
B	ASP364
B	GLY387
F	ASP274
F	ASP364
F	GLY387
K	ASP274
I	ASP364
K	ASP364
K	GLY387
C	ASP274
C	ASP364
C	GLY387
G	ASP274
G	ASP364
G	GLY387
L	ASP274
L	ASP364
I	GLY387
L	GLY387
D	ASP274
D	ASP364
D	GLY387
H	ASP274
H	ASP364
H	GLY387
A	ASP274
A	ASP364
A	GLY387
E	ASP274
E	ASP364
E	GLY387

site_id	SWS_FT_FI4
Number of Residues	84
Details	BINDING: BINDING => ECO:0000255\|HAMAP-Rule:MF_03156

Chain	Residue	Details
I	GLY324
A	TYR411
A	GLN441
A	GLU500
A	GLY501
A	GLY502
E	GLY324
E	SER329
E	TYR411
E	GLN441
E	GLU500
I	SER329
E	GLY501
E	GLY502
J	GLY324
J	SER329
J	TYR411
J	GLN441
J	GLU500
J	GLY501
J	GLY502
B	GLY324
I	TYR411
B	SER329
B	TYR411
B	GLN441
B	GLU500
B	GLY501
B	GLY502
F	GLY324
F	SER329
F	TYR411
F	GLN441
I	GLN441
F	GLU500
F	GLY501
F	GLY502
K	GLY324
K	SER329
K	TYR411
K	GLN441
K	GLU500
K	GLY501
K	GLY502
I	GLU500
C	GLY324
C	SER329
C	TYR411
C	GLN441
C	GLU500
C	GLY501
C	GLY502
G	GLY324
G	SER329
G	TYR411
I	GLY501
G	GLN441
G	GLU500
G	GLY501
G	GLY502
L	GLY324
L	SER329
L	TYR411
L	GLN441
L	GLU500
L	GLY501
I	GLY502
L	GLY502
D	GLY324
D	SER329
D	TYR411
D	GLN441
D	GLU500
D	GLY501
D	GLY502
H	GLY324
H	SER329
A	GLY324
H	TYR411
H	GLN441
H	GLU500
H	GLY501
H	GLY502
A	SER329

site_id	SWS_FT_FI5
Number of Residues	36
Details	BINDING: in other chain => ECO:0000255\|HAMAP-Rule:MF_03156, ECO:0000269\|Ref.28

Chain	Residue	Details
I	GLY326
J	GLY326
J	GLY328
J	CYS331
B	GLY326
B	GLY328
B	CYS331
F	GLY326
F	GLY328
F	CYS331
K	GLY326
I	GLY328
K	GLY328
K	CYS331
C	GLY326
C	GLY328
C	CYS331
G	GLY326
G	GLY328
G	CYS331
L	GLY326
L	GLY328
I	CYS331
L	CYS331
D	GLY326
D	GLY328
D	CYS331
H	GLY326
H	GLY328
H	CYS331
A	GLY326
A	GLY328
A	CYS331
E	GLY326
E	GLY328
E	CYS331

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:18669648, ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163

Chain	Residue	Details
I	SER122
L	SER122
D	SER122
H	SER122
A	SER122
E	SER122
J	SER122
B	SER122
F	SER122
K	SER122
C	SER122
G	SER122

site_id	SWS_FT_FI7
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:23186163

Chain	Residue	Details
I	SER160
L	SER160
D	SER160
H	SER160
A	SER160
E	SER160
J	SER160
B	SER160
F	SER160
K	SER160
C	SER160
G	SER160

site_id	SWS_FT_FI8
Number of Residues	12
Details	MOD_RES: Phosphotyrosine => ECO:0007744\|PubMed:15592455

Chain	Residue	Details
I	TYR400
L	TYR400
D	TYR400
H	TYR400
A	TYR400
E	TYR400
J	TYR400
B	TYR400
F	TYR400
K	TYR400
C	TYR400
G	TYR400

site_id	SWS_FT_FI9
Number of Residues	12
Details	MOD_RES: Phosphoserine => ECO:0007744\|PubMed:20068231, ECO:0007744\|PubMed:23186163, ECO:0007744\|PubMed:24275569

Chain	Residue	Details
I	SER416
L	SER416
D	SER416
H	SER416
A	SER416
E	SER416
J	SER416
B	SER416
F	SER416
K	SER416
C	SER416
G	SER416

site_id	SWS_FT_FI10
Number of Residues	12
Details	MOD_RES: N6-acetyllysine => ECO:0007744\|PubMed:19608861

Chain	Residue	Details
I	LYS511
L	LYS511
D	LYS511
H	LYS511
A	LYS511
E	LYS511
J	LYS511
B	LYS511
F	LYS511
K	LYS511
C	LYS511
G	LYS511

site_id	SWS_FT_FI11
Number of Residues	48
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744\|PubMed:28112733

Chain	Residue	Details
I	LYS195
E	LYS208
E	LYS438
J	LYS195
J	LYS208
J	LYS438
B	LYS195
B	LYS208
B	LYS438
F	LYS195
F	LYS208
F	LYS438
K	LYS195
K	LYS208
K	LYS438
C	LYS195
I	LYS208
C	LYS208
C	LYS438
G	LYS195
G	LYS208
G	LYS438
L	LYS195
L	LYS208
I	LYS438
L	LYS438
D	LYS195
D	LYS208
D	LYS438
H	LYS195
H	LYS208
H	LYS438
A	LYS195
A	LYS208
A	LYS438
E	LYS195

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)