Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6UCA

Crystal structure of human ZCCHC4 in complex with SAH

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003676	molecular_function	nucleic acid binding
A	0008168	molecular_function	methyltransferase activity
A	0008270	molecular_function	zinc ion binding
A	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
A	0031167	biological_process	rRNA methylation
A	0032259	biological_process	methylation
B	0003676	molecular_function	nucleic acid binding
B	0008168	molecular_function	methyltransferase activity
B	0008270	molecular_function	zinc ion binding
B	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
B	0031167	biological_process	rRNA methylation
B	0032259	biological_process	methylation
C	0003676	molecular_function	nucleic acid binding
C	0008168	molecular_function	methyltransferase activity
C	0008270	molecular_function	zinc ion binding
C	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
C	0031167	biological_process	rRNA methylation
C	0032259	biological_process	methylation
D	0003676	molecular_function	nucleic acid binding
D	0008168	molecular_function	methyltransferase activity
D	0008270	molecular_function	zinc ion binding
D	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
D	0031167	biological_process	rRNA methylation
D	0032259	biological_process	methylation
E	0003676	molecular_function	nucleic acid binding
E	0008168	molecular_function	methyltransferase activity
E	0008270	molecular_function	zinc ion binding
E	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
E	0031167	biological_process	rRNA methylation
E	0032259	biological_process	methylation
F	0003676	molecular_function	nucleic acid binding
F	0008168	molecular_function	methyltransferase activity
F	0008270	molecular_function	zinc ion binding
F	0008988	molecular_function	rRNA (adenine-N6-)-methyltransferase activity
F	0031167	biological_process	rRNA methylation
F	0032259	biological_process	methylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	19
Details	binding site for residue SAH A 1001

Chain	Residue
A	ALA66
A	PRO201
A	ARG202
A	ASP225
A	ILE226
A	TYR242
A	ASN243
A	MET244
A	PHE245
A	ASP276
A	PRO278
A	ASN170
A	ALA171
A	GLN172
A	TYR173
A	LEU174
A	PHE175
A	GLY199
A	THR200

site_id	AC2
Number of Residues	4
Details	binding site for residue ZN A 1002

Chain	Residue
A	CYS40
A	HIS42
A	CYS64
A	CYS73

site_id	AC3
Number of Residues	5
Details	binding site for residue ZN A 1003

Chain	Residue
A	CYS125
A	THR127
A	CYS128
A	HIS140
A	HIS143

site_id	AC4
Number of Residues	4
Details	binding site for residue ZN A 1004

Chain	Residue
A	CYS380
A	CYS383
A	HIS393
A	CYS400

site_id	AC5
Number of Residues	4
Details	binding site for residue ZN A 1005

Chain	Residue
A	CYS394
A	CYS397
A	HIS410
A	CYS417

site_id	AC6
Number of Residues	4
Details	binding site for residue ZN A 1006

Chain	Residue
A	CYS411
A	CYS414
A	HIS424
A	CYS431

site_id	AC7
Number of Residues	4
Details	binding site for residue ZN A 1007

Chain	Residue
A	CYS425
A	CYS428
A	HIS436
A	CYS438

site_id	AC8
Number of Residues	18
Details	binding site for residue SAH B 1001

Chain	Residue
B	ALA66
B	THR169
B	ASN170
B	ALA171
B	GLN172
B	TYR173
B	LEU174
B	PHE175
B	GLY199
B	PRO201
B	ARG202
B	ASP225
B	ILE226
B	TYR242
B	ASN243
B	MET244
B	PHE245
B	ASP276

site_id	AC9
Number of Residues	4
Details	binding site for residue ZN B 1002

Chain	Residue
B	CYS40
B	HIS42
B	CYS64
B	CYS73

site_id	AD1
Number of Residues	4
Details	binding site for residue ZN B 1003

Chain	Residue
B	CYS125
B	CYS128
B	HIS140
B	HIS143

site_id	AD2
Number of Residues	4
Details	binding site for residue ZN B 1004

Chain	Residue
B	CYS380
B	CYS383
B	HIS393
B	CYS400

site_id	AD3
Number of Residues	4
Details	binding site for residue ZN B 1005

Chain	Residue
B	CYS394
B	CYS397
B	HIS410
B	CYS417

site_id	AD4
Number of Residues	4
Details	binding site for residue ZN B 1006

Chain	Residue
B	CYS411
B	CYS414
B	HIS424
B	CYS431

site_id	AD5
Number of Residues	4
Details	binding site for residue ZN B 1007

Chain	Residue
B	CYS425
B	CYS428
B	HIS436
B	CYS438

site_id	AD6
Number of Residues	18
Details	binding site for residue SAH C 1001

Chain	Residue
C	ILE226
C	TYR242
C	ASN243
C	MET244
C	ASP276
C	ALA66
C	THR169
C	ASN170
C	ALA171
C	GLN172
C	TYR173
C	LEU174
C	PHE175
C	GLY199
C	THR200
C	PRO201
C	ARG202
C	ASP225

site_id	AD7
Number of Residues	4
Details	binding site for residue ZN C 1002

Chain	Residue
C	CYS40
C	HIS42
C	CYS64
C	CYS73

site_id	AD8
Number of Residues	4
Details	binding site for residue ZN C 1003

Chain	Residue
C	CYS125
C	CYS128
C	HIS140
C	HIS143

site_id	AD9
Number of Residues	4
Details	binding site for residue ZN C 1004

Chain	Residue
C	CYS380
C	CYS383
C	HIS393
C	CYS400

site_id	AE1
Number of Residues	4
Details	binding site for residue ZN C 1005

Chain	Residue
C	CYS394
C	CYS397
C	HIS410
C	CYS417

site_id	AE2
Number of Residues	4
Details	binding site for residue ZN C 1006

Chain	Residue
C	CYS411
C	CYS414
C	HIS424
C	CYS431

site_id	AE3
Number of Residues	4
Details	binding site for residue ZN C 1007

Chain	Residue
C	CYS425
C	CYS428
C	HIS436
C	CYS438

site_id	AE4
Number of Residues	19
Details	binding site for residue SAH D 1001

Chain	Residue
D	ALA66
D	ASN170
D	ALA171
D	GLN172
D	TYR173
D	LEU174
D	PHE175
D	GLY199
D	THR200
D	PRO201
D	ARG202
D	ASP225
D	ILE226
D	TYR242
D	ASN243
D	MET244
D	PHE245
D	ASP276
D	PRO278

site_id	AE5
Number of Residues	4
Details	binding site for residue ZN D 1002

Chain	Residue
D	CYS40
D	HIS42
D	CYS64
D	CYS73

site_id	AE6
Number of Residues	5
Details	binding site for residue ZN D 1003

Chain	Residue
D	CYS125
D	THR127
D	CYS128
D	HIS140
D	HIS143

site_id	AE7
Number of Residues	4
Details	binding site for residue ZN D 1004

Chain	Residue
D	CYS380
D	CYS383
D	HIS393
D	CYS400

site_id	AE8
Number of Residues	4
Details	binding site for residue ZN D 1005

Chain	Residue
D	CYS394
D	CYS397
D	HIS410
D	CYS417

site_id	AE9
Number of Residues	4
Details	binding site for residue ZN D 1006

Chain	Residue
D	CYS411
D	CYS414
D	HIS424
D	CYS431

site_id	AF1
Number of Residues	4
Details	binding site for residue ZN D 1007

Chain	Residue
D	CYS425
D	CYS428
D	HIS436
D	CYS438

site_id	AF2
Number of Residues	21
Details	binding site for residue SAH E 1001

Chain	Residue
E	ALA66
E	THR169
E	ASN170
E	ALA171
E	GLN172
E	TYR173
E	LEU174
E	PHE175
E	GLY199
E	THR200
E	PRO201
E	ARG202
E	LEU203
E	ASP225
E	ILE226
E	TYR242
E	ASN243
E	MET244
E	PHE245
E	ASP276
E	PRO278

site_id	AF3
Number of Residues	4
Details	binding site for residue ZN E 1002

Chain	Residue
E	CYS40
E	HIS42
E	CYS64
E	CYS73

site_id	AF4
Number of Residues	4
Details	binding site for residue ZN E 1003

Chain	Residue
E	CYS125
E	CYS128
E	HIS140
E	HIS143

site_id	AF5
Number of Residues	4
Details	binding site for residue ZN E 1004

Chain	Residue
E	CYS380
E	CYS383
E	HIS393
E	CYS400

site_id	AF6
Number of Residues	4
Details	binding site for residue ZN E 1005

Chain	Residue
E	CYS394
E	CYS397
E	HIS410
E	CYS417

site_id	AF7
Number of Residues	4
Details	binding site for residue ZN E 1006

Chain	Residue
E	CYS411
E	CYS414
E	HIS424
E	CYS431

site_id	AF8
Number of Residues	4
Details	binding site for residue ZN E 1007

Chain	Residue
E	CYS425
E	CYS428
E	HIS436
E	CYS438

site_id	AF9
Number of Residues	22
Details	binding site for residue SAH F 1001

Chain	Residue
F	ALA66
F	THR169
F	ASN170
F	ALA171
F	GLN172
F	TYR173
F	LEU174
F	PHE175
F	GLY199
F	THR200
F	PRO201
F	ARG202
F	LEU203
F	ASP225
F	ILE226
F	ASP227
F	TYR242
F	ASN243
F	MET244
F	PHE245
F	ASP276
F	PRO278

site_id	AG1
Number of Residues	4
Details	binding site for residue ZN F 1002

Chain	Residue
F	CYS40
F	HIS42
F	CYS64
F	CYS73

site_id	AG2
Number of Residues	4
Details	binding site for residue ZN F 1003

Chain	Residue
F	CYS125
F	CYS128
F	HIS140
F	HIS143

site_id	AG3
Number of Residues	4
Details	binding site for residue ZN F 1004

Chain	Residue
F	CYS380
F	CYS383
F	HIS393
F	CYS400

site_id	AG4
Number of Residues	4
Details	binding site for residue ZN F 1005

Chain	Residue
F	CYS394
F	CYS397
F	HIS410
F	CYS417

site_id	AG5
Number of Residues	4
Details	binding site for residue ZN F 1006

Chain	Residue
F	CYS411
F	CYS414
F	HIS424
F	CYS431

site_id	AG6
Number of Residues	4
Details	binding site for residue ZN F 1007

Chain	Residue
F	CYS425
F	CYS428
F	HIS436
F	CYS438

Functional Information from PROSITE/UniProt

site_id	PS00092
Number of Residues	7
Details	N6_MTASE N-6 Adenine-specific DNA methylases signature. MVTDPPF

Chain	Residue	Details
A	MET273-PHE279

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	252
Details	ZN_FING: GRF-type => ECO:0000255\|PROSITE-ProRule:PRU01343

Chain	Residue	Details
A	CYS40-LYS82
B	CYS40-LYS82
C	CYS40-LYS82
D	CYS40-LYS82
E	CYS40-LYS82
F	CYS40-LYS82

site_id	SWS_FT_FI2
Number of Residues	102
Details	ZN_FING: CCHC-type

Chain	Residue	Details
A	HIS443-ASN460
B	HIS443-ASN460
C	HIS443-ASN460
D	HIS443-ASN460
E	HIS443-ASN460
F	HIS443-ASN460

site_id	SWS_FT_FI3
Number of Residues	24
Details	BINDING: BINDING => ECO:0000255\|PROSITE-ProRule:PRU01343, ECO:0000269\|PubMed:31695039, ECO:0007744\|PDB:6UCA

Chain	Residue	Details
A	CYS40
C	HIS42
C	CYS64
C	CYS73
D	CYS40
D	HIS42
D	CYS64
D	CYS73
E	CYS40
E	HIS42
E	CYS64
A	HIS42
E	CYS73
F	CYS40
F	HIS42
F	CYS64
F	CYS73
A	CYS64
A	CYS73
B	CYS40
B	HIS42
B	CYS64
B	CYS73
C	CYS40

site_id	SWS_FT_FI4
Number of Residues	150
Details	BINDING: BINDING => ECO:0000269\|PubMed:31695039, ECO:0007744\|PDB:6UCA

Chain	Residue	Details
A	CYS125
A	CYS380
D	CYS438
E	CYS125
E	CYS128
E	HIS140
E	HIS143
E	GLN172
E	ARG202
E	ASP225
E	ASN243
E	ASP276
A	CYS383
E	CYS380
E	CYS383
E	HIS393
E	CYS394
E	CYS397
E	CYS400
E	HIS410
E	CYS411
E	CYS414
E	CYS417
A	HIS393
E	HIS424
E	CYS425
E	CYS428
E	CYS431
E	HIS436
E	CYS438
F	CYS125
F	CYS128
F	HIS140
F	HIS143
A	CYS394
F	GLN172
F	ARG202
F	ASP225
F	ASN243
F	ASP276
F	CYS380
F	CYS383
F	HIS393
F	CYS394
F	CYS397
A	CYS397
F	CYS400
F	HIS410
F	CYS411
F	CYS414
F	CYS417
F	HIS424
F	CYS425
F	CYS428
F	CYS431
F	HIS436
A	CYS400
F	CYS438
A	HIS410
A	CYS411
A	CYS414
A	CYS417
A	CYS128
A	HIS424
A	CYS425
A	CYS428
A	CYS431
A	HIS436
A	CYS438
B	CYS125
B	CYS128
B	HIS140
B	HIS143
A	HIS140
B	GLN172
B	ARG202
B	ASP225
B	ASN243
B	ASP276
B	CYS380
B	CYS383
B	HIS393
B	CYS394
B	CYS397
A	HIS143
B	CYS400
B	HIS410
B	CYS411
B	CYS414
B	CYS417
B	HIS424
B	CYS425
B	CYS428
B	CYS431
B	HIS436
A	GLN172
B	CYS438
C	CYS125
C	CYS128
C	HIS140
C	HIS143
C	GLN172
C	ARG202
C	ASP225
C	ASN243
C	ASP276
A	ARG202
C	CYS380
C	CYS383
C	HIS393
C	CYS394
C	CYS397
C	CYS400
C	HIS410
C	CYS411
C	CYS414
C	CYS417
A	ASP225
C	HIS424
C	CYS425
C	CYS428
C	CYS431
C	HIS436
C	CYS438
D	CYS125
D	CYS128
D	HIS140
D	HIS143
A	ASN243
D	GLN172
D	ARG202
D	ASP225
D	ASN243
D	ASP276
D	CYS380
D	CYS383
D	HIS393
D	CYS394
D	CYS397
A	ASP276
D	CYS400
D	HIS410
D	CYS411
D	CYS414
D	CYS417
D	HIS424
D	CYS425
D	CYS428
D	CYS431
D	HIS436

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)