6U5U
Electron cryomicroscopy Structure of S. cerevisiae FAS in the KS-stalled state
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000287 | molecular_function | magnesium ion binding |
| A | 0004312 | molecular_function | fatty acid synthase activity |
| A | 0004315 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] synthase activity |
| A | 0004316 | molecular_function | 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity |
| A | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| A | 0005835 | cellular_component | fatty acid synthase complex |
| A | 0006633 | biological_process | fatty acid biosynthetic process |
| A | 0008897 | molecular_function | holo-[acyl-carrier-protein] synthase activity |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016740 | molecular_function | transferase activity |
| A | 0016746 | molecular_function | acyltransferase activity |
| A | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| A | 0046872 | molecular_function | metal ion binding |
| G | 0004312 | molecular_function | fatty acid synthase activity |
| G | 0004313 | molecular_function | [acyl-carrier-protein] S-acetyltransferase activity |
| G | 0004314 | molecular_function | [acyl-carrier-protein] S-malonyltransferase activity |
| G | 0004318 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADH) activity |
| G | 0004321 | molecular_function | fatty-acyl-CoA synthase activity |
| G | 0005515 | molecular_function | protein binding |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0005739 | cellular_component | mitochondrion |
| G | 0005811 | cellular_component | lipid droplet |
| G | 0005829 | cellular_component | cytosol |
| G | 0005835 | cellular_component | fatty acid synthase complex |
| G | 0006633 | biological_process | fatty acid biosynthetic process |
| G | 0016297 | molecular_function | fatty acyl-[ACP] hydrolase activity |
| G | 0016409 | molecular_function | palmitoyltransferase activity |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0016740 | molecular_function | transferase activity |
| G | 0016787 | molecular_function | hydrolase activity |
| G | 0016829 | molecular_function | lyase activity |
| G | 0019171 | molecular_function | (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity |
| G | 0042759 | biological_process | long-chain fatty acid biosynthetic process |
| G | 0141148 | molecular_function | enoyl-[acyl-carrier-protein] reductase (NADPH) activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 20 |
| Details | binding site for residue NAP A 1901 |
| Chain | Residue |
| A | GLY684 |
| A | ALA772 |
| A | ALA773 |
| A | ILE774 |
| A | ILE794 |
| A | MET826 |
| A | SER827 |
| A | TYR839 |
| A | LYS843 |
| A | ILE869 |
| A | THR872 |
| A | SER687 |
| A | THR875 |
| A | ILE688 |
| A | THR707 |
| A | SER708 |
| A | ARG709 |
| A | ASN738 |
| A | GLN739 |
| A | PHE771 |
| site_id | AC2 |
| Number of Residues | 1 |
| Details | binding site for residue PNS A 1902 |
| Chain | Residue |
| A | SER180 |
| site_id | AC3 |
| Number of Residues | 21 |
| Details | binding site for residue FMN G 2101 |
| Chain | Residue |
| G | PRO595 |
| G | GLY596 |
| G | MET597 |
| G | THR598 |
| G | PRO599 |
| G | ASN650 |
| G | ILE652 |
| G | GLY682 |
| G | ALA683 |
| G | LYS706 |
| G | THR733 |
| G | GLY737 |
| G | GLY738 |
| G | SER769 |
| G | GLY770 |
| G | GLY802 |
| G | SER803 |
| G | MET806 |
| G | LEU1054 |
| G | ALA1059 |
| G | NAP2102 |
| site_id | AC4 |
| Number of Residues | 12 |
| Details | binding site for residue NAP G 2102 |
| Chain | Residue |
| G | THR598 |
| G | PHE625 |
| G | PHE657 |
| G | GLY739 |
| G | HIS740 |
| G | GLU849 |
| G | MET1011 |
| G | GLN1012 |
| G | LYS1031 |
| G | ASP1032 |
| G | LEU1034 |
| G | FMN2101 |
Functional Information from PROSITE/UniProt
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: For acetyltransferase activity => ECO:0000250 |
| Chain | Residue | Details |
| G | SER274 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: For malonyltransferase activity => ECO:0000250 |
| Chain | Residue | Details |
| G | SER1808 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylmethionine => ECO:0007744|PubMed:22814378 |
| Chain | Residue | Details |
| G | MET1 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| G | THR733 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:18407956, ECO:0007744|PubMed:19779198 |
| Chain | Residue | Details |
| G | SER1121 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0007744|PubMed:22106047 |
| Chain | Residue | Details |
| G | LYS1364 |
