6U3J
Structure of the 2-oxoadipate dehydrogenase DHTKD1
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| A | 0004591 | molecular_function | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0160166 | molecular_function | 2-oxoadipate dehydrogenase activity |
| A | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| B | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| B | 0004591 | molecular_function | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0160166 | molecular_function | 2-oxoadipate dehydrogenase activity |
| B | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 24 |
| Details | binding site for residue TPP A 1001 |
| Chain | Residue |
| A | HIS223 |
| A | GLN339 |
| A | ASN366 |
| A | LEU368 |
| A | GLY369 |
| A | HIS435 |
| A | MG1003 |
| A | HOH1131 |
| A | HOH1181 |
| A | HOH1419 |
| A | HOH1430 |
| A | ARG224 |
| B | GLN594 |
| B | LEU638 |
| B | GLU640 |
| B | GLN664 |
| B | PHE668 |
| A | SER288 |
| A | HIS289 |
| A | LEU290 |
| A | GLY332 |
| A | ASP333 |
| A | ALA334 |
| A | SER335 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1002 |
| Chain | Residue |
| A | GLU641 |
| A | HOH1133 |
| A | HOH1291 |
| A | HOH1327 |
| B | GLU641 |
| B | HOH1139 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1003 |
| Chain | Residue |
| A | ASP333 |
| A | ASN366 |
| A | LEU368 |
| A | TPP1001 |
| A | HOH1181 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for residue TPP B 1001 |
| Chain | Residue |
| A | GLN594 |
| A | LEU638 |
| A | GLU640 |
| A | GLN664 |
| A | PHE668 |
| B | HIS223 |
| B | ARG224 |
| B | SER288 |
| B | HIS289 |
| B | LEU290 |
| B | GLY332 |
| B | ASP333 |
| B | ALA334 |
| B | SER335 |
| B | GLN339 |
| B | ASN366 |
| B | LEU368 |
| B | GLY369 |
| B | HIS435 |
| B | MG1002 |
| B | HOH1117 |
| B | HOH1190 |
| B | HOH1422 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 1002 |
| Chain | Residue |
| B | ASP333 |
| B | ASN366 |
| B | LEU368 |
| B | TPP1001 |
| B | HOH1190 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:A2ATU0 |
| Chain | Residue | Details |
| A | LYS183 | |
| A | LYS188 | |
| A | LYS800 | |
| A | LYS818 | |
| B | LYS183 | |
| B | LYS188 | |
| B | LYS800 | |
| B | LYS818 |
