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6U23

EM structure of MPEG-1(w.t.) soluble pre-pore

Functional Information from GO Data
ChainGOidnamespacecontents
A0002250biological_processadaptive immune response
A0002468biological_processdendritic cell antigen processing and presentation
A0002478biological_processantigen processing and presentation of exogenous peptide antigen
A0005576cellular_componentextracellular region
A0016020cellular_componentmembrane
A0022829molecular_functionwide pore channel activity
A0030670cellular_componentphagocytic vesicle membrane
A0031410cellular_componentcytoplasmic vesicle
A0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
A0042742biological_processdefense response to bacterium
A0045087biological_processinnate immune response
A0045335cellular_componentphagocytic vesicle
A0050829biological_processdefense response to Gram-negative bacterium
A0050830biological_processdefense response to Gram-positive bacterium
A0055085biological_processtransmembrane transport
A0061474cellular_componentphagolysosome membrane
A0140367biological_processantibacterial innate immune response
B0002250biological_processadaptive immune response
B0002468biological_processdendritic cell antigen processing and presentation
B0002478biological_processantigen processing and presentation of exogenous peptide antigen
B0005576cellular_componentextracellular region
B0016020cellular_componentmembrane
B0022829molecular_functionwide pore channel activity
B0030670cellular_componentphagocytic vesicle membrane
B0031410cellular_componentcytoplasmic vesicle
B0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
B0042742biological_processdefense response to bacterium
B0045087biological_processinnate immune response
B0045335cellular_componentphagocytic vesicle
B0050829biological_processdefense response to Gram-negative bacterium
B0050830biological_processdefense response to Gram-positive bacterium
B0055085biological_processtransmembrane transport
B0061474cellular_componentphagolysosome membrane
B0140367biological_processantibacterial innate immune response
C0002250biological_processadaptive immune response
C0002468biological_processdendritic cell antigen processing and presentation
C0002478biological_processantigen processing and presentation of exogenous peptide antigen
C0005576cellular_componentextracellular region
C0016020cellular_componentmembrane
C0022829molecular_functionwide pore channel activity
C0030670cellular_componentphagocytic vesicle membrane
C0031410cellular_componentcytoplasmic vesicle
C0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
C0042742biological_processdefense response to bacterium
C0045087biological_processinnate immune response
C0045335cellular_componentphagocytic vesicle
C0050829biological_processdefense response to Gram-negative bacterium
C0050830biological_processdefense response to Gram-positive bacterium
C0055085biological_processtransmembrane transport
C0061474cellular_componentphagolysosome membrane
C0140367biological_processantibacterial innate immune response
D0002250biological_processadaptive immune response
D0002468biological_processdendritic cell antigen processing and presentation
D0002478biological_processantigen processing and presentation of exogenous peptide antigen
D0005576cellular_componentextracellular region
D0016020cellular_componentmembrane
D0022829molecular_functionwide pore channel activity
D0030670cellular_componentphagocytic vesicle membrane
D0031410cellular_componentcytoplasmic vesicle
D0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
D0042742biological_processdefense response to bacterium
D0045087biological_processinnate immune response
D0045335cellular_componentphagocytic vesicle
D0050829biological_processdefense response to Gram-negative bacterium
D0050830biological_processdefense response to Gram-positive bacterium
D0055085biological_processtransmembrane transport
D0061474cellular_componentphagolysosome membrane
D0140367biological_processantibacterial innate immune response
E0002250biological_processadaptive immune response
E0002468biological_processdendritic cell antigen processing and presentation
E0002478biological_processantigen processing and presentation of exogenous peptide antigen
E0005576cellular_componentextracellular region
E0016020cellular_componentmembrane
E0022829molecular_functionwide pore channel activity
E0030670cellular_componentphagocytic vesicle membrane
E0031410cellular_componentcytoplasmic vesicle
E0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
E0042742biological_processdefense response to bacterium
E0045087biological_processinnate immune response
E0045335cellular_componentphagocytic vesicle
E0050829biological_processdefense response to Gram-negative bacterium
E0050830biological_processdefense response to Gram-positive bacterium
E0055085biological_processtransmembrane transport
E0061474cellular_componentphagolysosome membrane
E0140367biological_processantibacterial innate immune response
F0002250biological_processadaptive immune response
F0002468biological_processdendritic cell antigen processing and presentation
F0002478biological_processantigen processing and presentation of exogenous peptide antigen
F0005576cellular_componentextracellular region
F0016020cellular_componentmembrane
F0022829molecular_functionwide pore channel activity
F0030670cellular_componentphagocytic vesicle membrane
F0031410cellular_componentcytoplasmic vesicle
F0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
F0042742biological_processdefense response to bacterium
F0045087biological_processinnate immune response
F0045335cellular_componentphagocytic vesicle
F0050829biological_processdefense response to Gram-negative bacterium
F0050830biological_processdefense response to Gram-positive bacterium
F0055085biological_processtransmembrane transport
F0061474cellular_componentphagolysosome membrane
F0140367biological_processantibacterial innate immune response
G0002250biological_processadaptive immune response
G0002468biological_processdendritic cell antigen processing and presentation
G0002478biological_processantigen processing and presentation of exogenous peptide antigen
G0005576cellular_componentextracellular region
G0016020cellular_componentmembrane
G0022829molecular_functionwide pore channel activity
G0030670cellular_componentphagocytic vesicle membrane
G0031410cellular_componentcytoplasmic vesicle
G0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
G0042742biological_processdefense response to bacterium
G0045087biological_processinnate immune response
G0045335cellular_componentphagocytic vesicle
G0050829biological_processdefense response to Gram-negative bacterium
G0050830biological_processdefense response to Gram-positive bacterium
G0055085biological_processtransmembrane transport
G0061474cellular_componentphagolysosome membrane
G0140367biological_processantibacterial innate immune response
H0002250biological_processadaptive immune response
H0002468biological_processdendritic cell antigen processing and presentation
H0002478biological_processantigen processing and presentation of exogenous peptide antigen
H0005576cellular_componentextracellular region
H0016020cellular_componentmembrane
H0022829molecular_functionwide pore channel activity
H0030670cellular_componentphagocytic vesicle membrane
H0031410cellular_componentcytoplasmic vesicle
H0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
H0042742biological_processdefense response to bacterium
H0045087biological_processinnate immune response
H0045335cellular_componentphagocytic vesicle
H0050829biological_processdefense response to Gram-negative bacterium
H0050830biological_processdefense response to Gram-positive bacterium
H0055085biological_processtransmembrane transport
H0061474cellular_componentphagolysosome membrane
H0140367biological_processantibacterial innate immune response
I0002250biological_processadaptive immune response
I0002468biological_processdendritic cell antigen processing and presentation
I0002478biological_processantigen processing and presentation of exogenous peptide antigen
I0005576cellular_componentextracellular region
I0016020cellular_componentmembrane
I0022829molecular_functionwide pore channel activity
I0030670cellular_componentphagocytic vesicle membrane
I0031410cellular_componentcytoplasmic vesicle
I0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
I0042742biological_processdefense response to bacterium
I0045087biological_processinnate immune response
I0045335cellular_componentphagocytic vesicle
I0050829biological_processdefense response to Gram-negative bacterium
I0050830biological_processdefense response to Gram-positive bacterium
I0055085biological_processtransmembrane transport
I0061474cellular_componentphagolysosome membrane
I0140367biological_processantibacterial innate immune response
J0002250biological_processadaptive immune response
J0002468biological_processdendritic cell antigen processing and presentation
J0002478biological_processantigen processing and presentation of exogenous peptide antigen
J0005576cellular_componentextracellular region
J0016020cellular_componentmembrane
J0022829molecular_functionwide pore channel activity
J0030670cellular_componentphagocytic vesicle membrane
J0031410cellular_componentcytoplasmic vesicle
J0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
J0042742biological_processdefense response to bacterium
J0045087biological_processinnate immune response
J0045335cellular_componentphagocytic vesicle
J0050829biological_processdefense response to Gram-negative bacterium
J0050830biological_processdefense response to Gram-positive bacterium
J0055085biological_processtransmembrane transport
J0061474cellular_componentphagolysosome membrane
J0140367biological_processantibacterial innate immune response
K0002250biological_processadaptive immune response
K0002468biological_processdendritic cell antigen processing and presentation
K0002478biological_processantigen processing and presentation of exogenous peptide antigen
K0005576cellular_componentextracellular region
K0016020cellular_componentmembrane
K0022829molecular_functionwide pore channel activity
K0030670cellular_componentphagocytic vesicle membrane
K0031410cellular_componentcytoplasmic vesicle
K0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
K0042742biological_processdefense response to bacterium
K0045087biological_processinnate immune response
K0045335cellular_componentphagocytic vesicle
K0050829biological_processdefense response to Gram-negative bacterium
K0050830biological_processdefense response to Gram-positive bacterium
K0055085biological_processtransmembrane transport
K0061474cellular_componentphagolysosome membrane
K0140367biological_processantibacterial innate immune response
L0002250biological_processadaptive immune response
L0002468biological_processdendritic cell antigen processing and presentation
L0002478biological_processantigen processing and presentation of exogenous peptide antigen
L0005576cellular_componentextracellular region
L0016020cellular_componentmembrane
L0022829molecular_functionwide pore channel activity
L0030670cellular_componentphagocytic vesicle membrane
L0031410cellular_componentcytoplasmic vesicle
L0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
L0042742biological_processdefense response to bacterium
L0045087biological_processinnate immune response
L0045335cellular_componentphagocytic vesicle
L0050829biological_processdefense response to Gram-negative bacterium
L0050830biological_processdefense response to Gram-positive bacterium
L0055085biological_processtransmembrane transport
L0061474cellular_componentphagolysosome membrane
L0140367biological_processantibacterial innate immune response
M0002250biological_processadaptive immune response
M0002468biological_processdendritic cell antigen processing and presentation
M0002478biological_processantigen processing and presentation of exogenous peptide antigen
M0005576cellular_componentextracellular region
M0016020cellular_componentmembrane
M0022829molecular_functionwide pore channel activity
M0030670cellular_componentphagocytic vesicle membrane
M0031410cellular_componentcytoplasmic vesicle
M0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
M0042742biological_processdefense response to bacterium
M0045087biological_processinnate immune response
M0045335cellular_componentphagocytic vesicle
M0050829biological_processdefense response to Gram-negative bacterium
M0050830biological_processdefense response to Gram-positive bacterium
M0055085biological_processtransmembrane transport
M0061474cellular_componentphagolysosome membrane
M0140367biological_processantibacterial innate immune response
N0002250biological_processadaptive immune response
N0002468biological_processdendritic cell antigen processing and presentation
N0002478biological_processantigen processing and presentation of exogenous peptide antigen
N0005576cellular_componentextracellular region
N0016020cellular_componentmembrane
N0022829molecular_functionwide pore channel activity
N0030670cellular_componentphagocytic vesicle membrane
N0031410cellular_componentcytoplasmic vesicle
N0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
N0042742biological_processdefense response to bacterium
N0045087biological_processinnate immune response
N0045335cellular_componentphagocytic vesicle
N0050829biological_processdefense response to Gram-negative bacterium
N0050830biological_processdefense response to Gram-positive bacterium
N0055085biological_processtransmembrane transport
N0061474cellular_componentphagolysosome membrane
N0140367biological_processantibacterial innate immune response
O0002250biological_processadaptive immune response
O0002468biological_processdendritic cell antigen processing and presentation
O0002478biological_processantigen processing and presentation of exogenous peptide antigen
O0005576cellular_componentextracellular region
O0016020cellular_componentmembrane
O0022829molecular_functionwide pore channel activity
O0030670cellular_componentphagocytic vesicle membrane
O0031410cellular_componentcytoplasmic vesicle
O0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
O0042742biological_processdefense response to bacterium
O0045087biological_processinnate immune response
O0045335cellular_componentphagocytic vesicle
O0050829biological_processdefense response to Gram-negative bacterium
O0050830biological_processdefense response to Gram-positive bacterium
O0055085biological_processtransmembrane transport
O0061474cellular_componentphagolysosome membrane
O0140367biological_processantibacterial innate immune response
P0002250biological_processadaptive immune response
P0002468biological_processdendritic cell antigen processing and presentation
P0002478biological_processantigen processing and presentation of exogenous peptide antigen
P0005576cellular_componentextracellular region
P0016020cellular_componentmembrane
P0022829molecular_functionwide pore channel activity
P0030670cellular_componentphagocytic vesicle membrane
P0031410cellular_componentcytoplasmic vesicle
P0042590biological_processantigen processing and presentation of exogenous peptide antigen via MHC class I
P0042742biological_processdefense response to bacterium
P0045087biological_processinnate immune response
P0045335cellular_componentphagocytic vesicle
P0050829biological_processdefense response to Gram-negative bacterium
P0050830biological_processdefense response to Gram-positive bacterium
P0055085biological_processtransmembrane transport
P0061474cellular_componentphagolysosome membrane
P0140367biological_processantibacterial innate immune response
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues464
DetailsTRANSMEM: Beta stranded => ECO:0000250|UniProtKB:A1L314
ChainResidueDetails
ATYR96-SER103
CGLY110-GLU115
CALA218-PHE227
CVAL231-TYR239
DTYR96-SER103
DGLY110-GLU115
DALA218-PHE227
DVAL231-TYR239
ETYR96-SER103
EGLY110-GLU115
EALA218-PHE227
AGLY110-GLU115
EVAL231-TYR239
FTYR96-SER103
FGLY110-GLU115
FALA218-PHE227
FVAL231-TYR239
GTYR96-SER103
GGLY110-GLU115
GALA218-PHE227
GVAL231-TYR239
HTYR96-SER103
AALA218-PHE227
HGLY110-GLU115
HALA218-PHE227
HVAL231-TYR239
ITYR96-SER103
IGLY110-GLU115
IALA218-PHE227
IVAL231-TYR239
JTYR96-SER103
JGLY110-GLU115
JALA218-PHE227
AVAL231-TYR239
JVAL231-TYR239
KTYR96-SER103
KGLY110-GLU115
KALA218-PHE227
KVAL231-TYR239
LTYR96-SER103
LGLY110-GLU115
LALA218-PHE227
LVAL231-TYR239
MTYR96-SER103
BTYR96-SER103
MGLY110-GLU115
MALA218-PHE227
MVAL231-TYR239
NTYR96-SER103
NGLY110-GLU115
NALA218-PHE227
NVAL231-TYR239
OTYR96-SER103
OGLY110-GLU115
OALA218-PHE227
BGLY110-GLU115
OVAL231-TYR239
PTYR96-SER103
PGLY110-GLU115
PALA218-PHE227
PVAL231-TYR239
BALA218-PHE227
BVAL231-TYR239
CTYR96-SER103

site_idSWS_FT_FI2
Number of Residues48
DetailsSITE: Cleavage; by LGMN => ECO:0000250|UniProtKB:A1L314
ChainResidueDetails
AASP335
DASP335
DASN340
DASN342
EASP335
EASN340
EASN342
FASP335
FASN340
FASN342
GASP335
AASN340
GASN340
GASN342
HASP335
HASN340
HASN342
IASP335
IASN340
IASN342
JASP335
JASN340
AASN342
JASN342
KASP335
KASN340
KASN342
LASP335
LASN340
LASN342
MASP335
MASN340
MASN342
BASP335
NASP335
NASN340
NASN342
OASP335
OASN340
OASN342
PASP335
PASN340
PASN342
BASN340
BASN342
CASP335
CASN340
CASN342

site_idSWS_FT_FI3
Number of Residues16
DetailsSITE: Cleavage; by trypsin => ECO:0000250|UniProtKB:A1L314
ChainResidueDetails
AARG614
JARG614
KARG614
LARG614
MARG614
NARG614
OARG614
PARG614
BARG614
CARG614
DARG614
EARG614
FARG614
GARG614
HARG614
IARG614

site_idSWS_FT_FI4
Number of Residues32
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:31537793, ECO:0007744|PDB:6U23, ECO:0007744|PDB:6U2J, ECO:0007744|PDB:6U2K, ECO:0007744|PDB:6U2L, ECO:0007744|PDB:6U2W
ChainResidueDetails
AASN168
EASN252
FASN168
FASN252
GASN168
GASN252
HASN168
HASN252
IASN168
IASN252
JASN168
AASN252
JASN252
KASN168
KASN252
LASN168
LASN252
MASN168
MASN252
NASN168
NASN252
OASN168
BASN168
OASN252
PASN168
PASN252
BASN252
CASN168
CASN252
DASN168
DASN252
EASN168

site_idSWS_FT_FI5
Number of Residues16
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
AASN358
JASN358
KASN358
LASN358
MASN358
NASN358
OASN358
PASN358
BASN358
CASN358
DASN358
EASN358
FASN358
GASN358
HASN358
IASN358

226707

PDB entries from 2024-10-30

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