6TPG

Crystal structure of the Orexin-2 receptor in complex with EMPA at 2.74 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007631	biological_process	feeding behavior
A	0016020	cellular_component	membrane
A	0016499	molecular_function	orexin receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 7MA A 1201

Chain	Residue
A	GLN134
A	HOH1323
A	VAL138
A	PHE227
A	ILE320
A	SER321
A	ASN324
A	HIS350
A	TYR354
A	HOH1312

---

site_id	AC2
Number of Residues	3
Details	binding site for residue PG4 A 1202

Chain	Residue
A	LYS327
A	PHE346
A	HOH1313

---

site_id	AC3
Number of Residues	1
Details	binding site for residue OLA A 1203

Chain	Residue
A	ILE175

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSAlTLSCIALDRWYaI

Chain	Residue	Details
A	VAL140-ILE156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=1","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	31
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=2","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	31
Details	Topological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	22
Details	Transmembrane: {"description":"Helical; Name=3","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	21
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	23
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI10
Number of Residues	1
Details	Binding site: {"evidences":[{"source":"PubMed","id":"25533960","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"4S0V","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	Site: {"description":"Important for responses to orexin","evidences":[{"source":"PubMed","id":"26950369","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---