6TPG

Crystal structure of the Orexin-2 receptor in complex with EMPA at 2.74 A resolution

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004930	molecular_function	G protein-coupled receptor activity
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007631	biological_process	feeding behavior
A	0016020	cellular_component	membrane
A	0016499	molecular_function	orexin receptor activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue 7MA A 1201

Chain	Residue
A	GLN134
A	HOH1323
A	VAL138
A	PHE227
A	ILE320
A	SER321
A	ASN324
A	HIS350
A	TYR354
A	HOH1312

---

site_id	AC2
Number of Residues	3
Details	binding site for residue PG4 A 1202

Chain	Residue
A	LYS327
A	PHE346
A	HOH1313

---

site_id	AC3
Number of Residues	1
Details	binding site for residue OLA A 1203

Chain	Residue
A	ILE175

---

Functional Information from PROSITE/UniProt

site_id	PS00237
Number of Residues	17
Details	G_PROTEIN_RECEP_F1_1 G-protein coupled receptors family 1 signature. VSAlTLSCIALDRWYaI

Chain	Residue	Details
A	VAL140-ILE156

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	53
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25533960, ECO:0000305|PubMed:26950369

Chain	Residue	Details
A	MET1-ALA54

---

site_id	SWS_FT_FI2
Number of Residues	20
Details	TRANSMEM: Helical; Name=1 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TRP55-VAL75

---

site_id	SWS_FT_FI3
Number of Residues	31
Details	TOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	CYS76-VAL88
A	ASP151-LEU170

---

site_id	SWS_FT_FI4
Number of Residues	21
Details	TRANSMEM: Helical; Name=2 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	THR89-ALA110

---

site_id	SWS_FT_FI5
Number of Residues	61
Details	TOPO_DOM: Extracellular => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	GLU192-MET222
A	LYS327-VAL342
A	THR111-CYS127

---

site_id	SWS_FT_FI6
Number of Residues	22
Details	TRANSMEM: Helical; Name=3 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	LYS128-LEU150

---

site_id	SWS_FT_FI7
Number of Residues	20
Details	TRANSMEM: Helical; Name=4 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	ASN171-MET191

---

site_id	SWS_FT_FI8
Number of Residues	20
Details	TRANSMEM: Helical; Name=5 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TYR223-TYR243

---

site_id	SWS_FT_FI9
Number of Residues	21
Details	TRANSMEM: Helical; Name=6 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	MET305-LEU326

---

site_id	SWS_FT_FI10
Number of Residues	23
Details	TRANSMEM: Helical; Name=7 => ECO:0000269|PubMed:25533960

Chain	Residue	Details
A	TYR343-PHE366

---

site_id	SWS_FT_FI11
Number of Residues	1
Details	BINDING: BINDING => ECO:0000269|PubMed:25533960, ECO:0007744|PDB:4S0V

Chain	Residue	Details
A	ASN324

---

site_id	SWS_FT_FI12
Number of Residues	1
Details	SITE: Important for responses to orexin => ECO:0000269|PubMed:26950369

Chain	Residue	Details
A	TRP44

---

site_id	SWS_FT_FI13
Number of Residues	3
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
A	ASP14
A	ASP22
A	ASP202

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