Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TMH

Cryo-EM structure of Toxoplasma gondii mitochondrial ATP synthase dimer, OSCP/F1/c-ring model

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0006754	biological_process	ATP biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0015986	biological_process	proton motive force-driven ATP synthesis
A	0016020	cellular_component	membrane
A	0016787	molecular_function	hydrolase activity
A	0032559	molecular_function	adenyl ribonucleotide binding
A	0043531	molecular_function	ADP binding
A	0045259	cellular_component	proton-transporting ATP synthase complex
A	0046034	biological_process	ATP metabolic process
A	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
A	1902600	biological_process	proton transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005743	cellular_component	mitochondrial inner membrane
B	0006754	biological_process	ATP biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0015986	biological_process	proton motive force-driven ATP synthesis
B	0016787	molecular_function	hydrolase activity
B	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
B	0045259	cellular_component	proton-transporting ATP synthase complex
B	0046034	biological_process	ATP metabolic process
B	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
B	1902600	biological_process	proton transmembrane transport
C	0000166	molecular_function	nucleotide binding
C	0005524	molecular_function	ATP binding
C	0006754	biological_process	ATP biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0015986	biological_process	proton motive force-driven ATP synthesis
C	0016020	cellular_component	membrane
C	0016787	molecular_function	hydrolase activity
C	0032559	molecular_function	adenyl ribonucleotide binding
C	0043531	molecular_function	ADP binding
C	0045259	cellular_component	proton-transporting ATP synthase complex
C	0046034	biological_process	ATP metabolic process
C	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
C	1902600	biological_process	proton transmembrane transport
d	0005739	cellular_component	mitochondrion
d	0005743	cellular_component	mitochondrial inner membrane
d	0006811	biological_process	monoatomic ion transport
d	0015986	biological_process	proton motive force-driven ATP synthesis
d	0016020	cellular_component	membrane
d	0045259	cellular_component	proton-transporting ATP synthase complex
d	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
d	1902600	biological_process	proton transmembrane transport
D	0000166	molecular_function	nucleotide binding
D	0005524	molecular_function	ATP binding
D	0005743	cellular_component	mitochondrial inner membrane
D	0006754	biological_process	ATP biosynthetic process
D	0006811	biological_process	monoatomic ion transport
D	0015986	biological_process	proton motive force-driven ATP synthesis
D	0016787	molecular_function	hydrolase activity
D	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
D	0045259	cellular_component	proton-transporting ATP synthase complex
D	0046034	biological_process	ATP metabolic process
D	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
D	1902600	biological_process	proton transmembrane transport
e	0005743	cellular_component	mitochondrial inner membrane
e	0015986	biological_process	proton motive force-driven ATP synthesis
e	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
e	0045259	cellular_component	proton-transporting ATP synthase complex
e	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	0000166	molecular_function	nucleotide binding
E	0005524	molecular_function	ATP binding
E	0006754	biological_process	ATP biosynthetic process
E	0006811	biological_process	monoatomic ion transport
E	0015986	biological_process	proton motive force-driven ATP synthesis
E	0016020	cellular_component	membrane
E	0016787	molecular_function	hydrolase activity
E	0032559	molecular_function	adenyl ribonucleotide binding
E	0043531	molecular_function	ADP binding
E	0045259	cellular_component	proton-transporting ATP synthase complex
E	0046034	biological_process	ATP metabolic process
E	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
E	1902600	biological_process	proton transmembrane transport
F	0000166	molecular_function	nucleotide binding
F	0005524	molecular_function	ATP binding
F	0005743	cellular_component	mitochondrial inner membrane
F	0006754	biological_process	ATP biosynthetic process
F	0006811	biological_process	monoatomic ion transport
F	0015986	biological_process	proton motive force-driven ATP synthesis
F	0016787	molecular_function	hydrolase activity
F	0042776	biological_process	proton motive force-driven mitochondrial ATP synthesis
F	0045259	cellular_component	proton-transporting ATP synthase complex
F	0046034	biological_process	ATP metabolic process
F	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
F	1902600	biological_process	proton transmembrane transport
g	0005739	cellular_component	mitochondrion
g	0006754	biological_process	ATP biosynthetic process
g	0006811	biological_process	monoatomic ion transport
g	0015986	biological_process	proton motive force-driven ATP synthesis
g	0016020	cellular_component	membrane
g	0045259	cellular_component	proton-transporting ATP synthase complex
g	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
g	1902600	biological_process	proton transmembrane transport
G	0006754	biological_process	ATP biosynthetic process
G	0006811	biological_process	monoatomic ion transport
G	0015986	biological_process	proton motive force-driven ATP synthesis
G	0016020	cellular_component	membrane
G	0046933	molecular_function	proton-transporting ATP synthase activity, rotational mechanism
G	1902600	biological_process	proton transmembrane transport
H	0006811	biological_process	monoatomic ion transport
H	0008289	molecular_function	lipid binding
H	0015078	molecular_function	proton transmembrane transporter activity
H	0015986	biological_process	proton motive force-driven ATP synthesis
H	0016020	cellular_component	membrane
H	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
H	0045259	cellular_component	proton-transporting ATP synthase complex
H	1902600	biological_process	proton transmembrane transport
I	0006811	biological_process	monoatomic ion transport
I	0008289	molecular_function	lipid binding
I	0015078	molecular_function	proton transmembrane transporter activity
I	0015986	biological_process	proton motive force-driven ATP synthesis
I	0016020	cellular_component	membrane
I	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
I	0045259	cellular_component	proton-transporting ATP synthase complex
I	1902600	biological_process	proton transmembrane transport
J	0006811	biological_process	monoatomic ion transport
J	0008289	molecular_function	lipid binding
J	0015078	molecular_function	proton transmembrane transporter activity
J	0015986	biological_process	proton motive force-driven ATP synthesis
J	0016020	cellular_component	membrane
J	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
J	0045259	cellular_component	proton-transporting ATP synthase complex
J	1902600	biological_process	proton transmembrane transport
K	0006811	biological_process	monoatomic ion transport
K	0008289	molecular_function	lipid binding
K	0015078	molecular_function	proton transmembrane transporter activity
K	0015986	biological_process	proton motive force-driven ATP synthesis
K	0016020	cellular_component	membrane
K	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
K	0045259	cellular_component	proton-transporting ATP synthase complex
K	1902600	biological_process	proton transmembrane transport
L	0006811	biological_process	monoatomic ion transport
L	0008289	molecular_function	lipid binding
L	0015078	molecular_function	proton transmembrane transporter activity
L	0015986	biological_process	proton motive force-driven ATP synthesis
L	0016020	cellular_component	membrane
L	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
L	0045259	cellular_component	proton-transporting ATP synthase complex
L	1902600	biological_process	proton transmembrane transport
M	0006811	biological_process	monoatomic ion transport
M	0008289	molecular_function	lipid binding
M	0015078	molecular_function	proton transmembrane transporter activity
M	0015986	biological_process	proton motive force-driven ATP synthesis
M	0016020	cellular_component	membrane
M	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
M	0045259	cellular_component	proton-transporting ATP synthase complex
M	1902600	biological_process	proton transmembrane transport
N	0006811	biological_process	monoatomic ion transport
N	0008289	molecular_function	lipid binding
N	0015078	molecular_function	proton transmembrane transporter activity
N	0015986	biological_process	proton motive force-driven ATP synthesis
N	0016020	cellular_component	membrane
N	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
N	0045259	cellular_component	proton-transporting ATP synthase complex
N	1902600	biological_process	proton transmembrane transport
O	0006811	biological_process	monoatomic ion transport
O	0008289	molecular_function	lipid binding
O	0015078	molecular_function	proton transmembrane transporter activity
O	0015986	biological_process	proton motive force-driven ATP synthesis
O	0016020	cellular_component	membrane
O	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
O	0045259	cellular_component	proton-transporting ATP synthase complex
O	1902600	biological_process	proton transmembrane transport
P	0006811	biological_process	monoatomic ion transport
P	0008289	molecular_function	lipid binding
P	0015078	molecular_function	proton transmembrane transporter activity
P	0015986	biological_process	proton motive force-driven ATP synthesis
P	0016020	cellular_component	membrane
P	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
P	0045259	cellular_component	proton-transporting ATP synthase complex
P	1902600	biological_process	proton transmembrane transport
Q	0006811	biological_process	monoatomic ion transport
Q	0008289	molecular_function	lipid binding
Q	0015078	molecular_function	proton transmembrane transporter activity
Q	0015986	biological_process	proton motive force-driven ATP synthesis
Q	0016020	cellular_component	membrane
Q	0033177	cellular_component	proton-transporting two-sector ATPase complex, proton-transporting domain
Q	0045259	cellular_component	proton-transporting ATP synthase complex
Q	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	14
Details	binding site for residue ATP A 601

Chain	Residue
A	ARG222
A	ARG414
A	GLN482
A	GLN484
A	MG602
B	TYR447
A	GLN223
A	THR224
A	GLY225
A	LYS226
A	THR227
A	ALA228
A	GLU380
A	PHE409

site_id	AC2
Number of Residues	2
Details	binding site for residue MG A 602

Chain	Residue
A	THR227
A	ATP601

site_id	AC3
Number of Residues	13
Details	binding site for residue ATP E 601

Chain	Residue
E	ARG222
E	GLN223
E	THR224
E	GLY225
E	LYS226
E	THR227
E	ALA228
E	PHE409
E	ARG414
E	GLN482
E	GLN484
E	MG602
F	ARG435

site_id	AC4
Number of Residues	3
Details	binding site for residue MG E 602

Chain	Residue
E	THR227
E	GLN260
E	ATP601

site_id	AC5
Number of Residues	13
Details	binding site for residue ATP C 601

Chain	Residue
C	GLN223
C	THR224
C	GLY225
C	LYS226
C	THR227
C	ALA228
C	GLU380
C	PHE409
C	ARG414
C	GLN482
C	GLN484
C	MG602
D	TYR447

site_id	AC6
Number of Residues	2
Details	binding site for residue MG C 602

Chain	Residue
C	THR227
C	ATP601

site_id	AC7
Number of Residues	9
Details	binding site for residue ADP B 601

Chain	Residue
B	GLY228
B	GLY230
B	GLY232
B	LYS233
B	THR234
B	VAL235
B	TYR424
B	MG602
C	ARG425

site_id	AC8
Number of Residues	3
Details	binding site for residue MG B 602

Chain	Residue
B	THR234
B	GLU263
B	ADP601

site_id	AC9
Number of Residues	10
Details	binding site for residue ADP D 601

Chain	Residue
D	GLY230
D	GLY232
D	LYS233
D	THR234
D	VAL235
D	ARG260
D	TYR424
D	PHE503
D	THR504
D	MG602

site_id	AD1
Number of Residues	2
Details	binding site for residue MG D 602

Chain	Residue
D	THR234
D	ADP601

Functional Information from PROSITE/UniProt

site_id	PS00605
Number of Residues	22
Details	ATPASE_C ATP synthase c subunit signature. ARNPsikedLfTytLIgmgFlE

Chain	Residue	Details
H	ALA129-GLU150

site_id	PS00153
Number of Residues	14
Details	ATPASE_GAMMA ATP synthase gamma subunit signature. ITtElvEiisGAnA

Chain	Residue	Details
g	ILE299-ALA312

site_id	PS00152
Number of Residues	10
Details	ATPASE_ALPHA_BETA ATP synthase alpha and beta subunits signature. PAVDPLDSTS

Chain	Residue	Details
B	PRO425-SER434
A	PRO415-SER424

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)