6TM1
Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0003925 | molecular_function | G protein activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005525 | molecular_function | GTP binding |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0005829 | cellular_component | cytosol |
| A | 0005856 | cellular_component | cytoskeleton |
| A | 0005886 | cellular_component | plasma membrane |
| A | 0007015 | biological_process | actin filament organization |
| A | 0007163 | biological_process | establishment or maintenance of cell polarity |
| A | 0008045 | biological_process | motor neuron axon guidance |
| A | 0008360 | biological_process | regulation of cell shape |
| A | 0010810 | biological_process | regulation of cell-substrate adhesion |
| A | 0012505 | cellular_component | endomembrane system |
| A | 0016055 | biological_process | Wnt signaling pathway |
| A | 0016601 | biological_process | Rac protein signal transduction |
| A | 0019901 | molecular_function | protein kinase binding |
| A | 0030027 | cellular_component | lamellipodium |
| A | 0030031 | biological_process | cell projection assembly |
| A | 0030036 | biological_process | actin cytoskeleton organization |
| A | 0030334 | biological_process | regulation of cell migration |
| A | 0030426 | cellular_component | growth cone |
| A | 0030865 | biological_process | cortical cytoskeleton organization |
| A | 0031410 | cellular_component | cytoplasmic vesicle |
| A | 0031941 | cellular_component | filamentous actin |
| A | 0032956 | biological_process | regulation of actin cytoskeleton organization |
| A | 0033630 | biological_process | positive regulation of cell adhesion mediated by integrin |
| A | 0035556 | biological_process | intracellular signal transduction |
| A | 0043005 | cellular_component | neuron projection |
| A | 0043020 | cellular_component | NADPH oxidase complex |
| A | 0043025 | cellular_component | neuronal cell body |
| A | 0045730 | biological_process | respiratory burst |
| A | 0048306 | molecular_function | calcium-dependent protein binding |
| A | 0048471 | cellular_component | perinuclear region of cytoplasm |
| A | 0060326 | biological_process | cell chemotaxis |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0071944 | cellular_component | cell periphery |
| A | 0098974 | biological_process | postsynaptic actin cytoskeleton organization |
| A | 0098978 | cellular_component | glutamatergic synapse |
| A | 1900026 | biological_process | positive regulation of substrate adhesion-dependent cell spreading |
| B | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| B | 0007264 | biological_process | small GTPase-mediated signal transduction |
| C | 0005085 | molecular_function | guanyl-nucleotide exchange factor activity |
| C | 0007264 | biological_process | small GTPase-mediated signal transduction |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2005","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Human Rac3 in Complex with Gdp.","authors":["Debreczeni J.E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","von Delft F.","Doyle D.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2006","submissionDatabase":"PDB data bank","title":"The Crystal Structure of the Human RAC3 in complex with GDP and Chloride.","authors":["Ugochukwu E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A.","von Delft F.","Doyle D."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.","authors":["Yang X.","Ugochukwu E.","Elkins J.","Doyle D."]}},{"source":"PDB","id":"2C2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IC5","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 8 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"FEB-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Knapp S.","Doyle D.A."]}},{"source":"Reference","evidenceCode":"ECO:0000305","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Bunkoczi G.","Knapp S.","Doyle D."]}},{"source":"PDB","id":"2OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QME","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2005","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Human Rac3 in Complex with Gdp.","authors":["Debreczeni J.E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","von Delft F.","Doyle D.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2006","submissionDatabase":"PDB data bank","title":"The Crystal Structure of the Human RAC3 in complex with GDP and Chloride.","authors":["Ugochukwu E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A.","von Delft F.","Doyle D."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2006","submissionDatabase":"PDB data bank","title":"Crystal structure of human RAC3 grown in the presence of Gpp(NH)p.","authors":["Yang X.","Ugochukwu E.","Elkins J.","Doyle D."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Knapp S.","Doyle D.A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Bunkoczi G.","Knapp S.","Doyle D."]}},{"source":"PDB","id":"2C2H","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2G0N","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2IC5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QME","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"FEB-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 4 (PAK4).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Knapp S.","Doyle D.A."]}},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUL-2007","submissionDatabase":"PDB data bank","title":"The crystal structure of the human RAC3 in complex with the CRIB domain of human p21-activated kinase 1 (PAK1).","authors":["Ugochukwu E.","Yang X.","Elkins J.M.","Burgess-Brown N.","Bunkoczi G.","Knapp S.","Doyle D."]}},{"source":"PDB","id":"2OV2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2QME","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"SEP-2005","submissionDatabase":"PDB data bank","title":"Crystal Structure of the Human Rac3 in Complex with Gdp.","authors":["Debreczeni J.E.","Yang X.","Zao Y.","Elkins J.","Gileadi C.","Burgess N.","Colebrook S.","Gileadi O.","Fedorov O.","Bunkoczi G.","von Delft F.","Doyle D.","Sundstrom M.","Arrowsmith C.","Weigelt J.","Edwards A."]}},{"source":"PDB","id":"2C2H","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24684802","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
