6TM1

Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0003924	molecular_function	GTPase activity
A	0003925	molecular_function	G protein activity
A	0005515	molecular_function	protein binding
A	0005525	molecular_function	GTP binding
A	0005737	cellular_component	cytoplasm
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0005829	cellular_component	cytosol
A	0005856	cellular_component	cytoskeleton
A	0005886	cellular_component	plasma membrane
A	0007015	biological_process	actin filament organization
A	0007163	biological_process	establishment or maintenance of cell polarity
A	0007264	biological_process	small GTPase-mediated signal transduction
A	0008045	biological_process	motor neuron axon guidance
A	0008360	biological_process	regulation of cell shape
A	0010810	biological_process	regulation of cell-substrate adhesion
A	0012505	cellular_component	endomembrane system
A	0016055	biological_process	Wnt signaling pathway
A	0016601	biological_process	Rac protein signal transduction
A	0016787	molecular_function	hydrolase activity
A	0019901	molecular_function	protein kinase binding
A	0030027	cellular_component	lamellipodium
A	0030031	biological_process	cell projection assembly
A	0030036	biological_process	actin cytoskeleton organization
A	0030426	cellular_component	growth cone
A	0030865	biological_process	cortical cytoskeleton organization
A	0031410	cellular_component	cytoplasmic vesicle
A	0031941	cellular_component	filamentous actin
A	0032956	biological_process	regulation of actin cytoskeleton organization
A	0033630	biological_process	positive regulation of cell adhesion mediated by integrin
A	0035556	biological_process	intracellular signal transduction
A	0043005	cellular_component	neuron projection
A	0043020	cellular_component	NADPH oxidase complex
A	0043025	cellular_component	neuronal cell body
A	0045730	biological_process	respiratory burst
A	0048306	molecular_function	calcium-dependent protein binding
A	0048471	cellular_component	perinuclear region of cytoplasm
A	0060326	biological_process	cell chemotaxis
A	0070062	cellular_component	extracellular exosome
A	0071944	cellular_component	cell periphery
A	0098794	cellular_component	postsynapse
A	0098974	biological_process	postsynaptic actin cytoskeleton organization
A	0098978	cellular_component	glutamatergic synapse
A	0150052	biological_process	regulation of postsynapse assembly
A	1900026	biological_process	positive regulation of substrate adhesion-dependent cell spreading
A	1902622	biological_process	regulation of neutrophil migration
B	0005085	molecular_function	guanyl-nucleotide exchange factor activity
B	0007264	biological_process	small GTPase-mediated signal transduction
C	0005085	molecular_function	guanyl-nucleotide exchange factor activity
C	0007264	biological_process	small GTPase-mediated signal transduction

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	Motif: {"description":"Effector region","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	1
Details	Glycosylation: {"description":"O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230","evidences":[{"source":"PubMed","id":"24141704","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"24684802","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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