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6TM1

Crystal structure of the DHR2 domain of DOCK10 in complex with RAC3

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0003925molecular_functionG protein activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005737cellular_componentcytoplasm
A0005789cellular_componentendoplasmic reticulum membrane
A0005829cellular_componentcytosol
A0005856cellular_componentcytoskeleton
A0005886cellular_componentplasma membrane
A0007015biological_processactin filament organization
A0007163biological_processestablishment or maintenance of cell polarity
A0007264biological_processsmall GTPase-mediated signal transduction
A0008045biological_processmotor neuron axon guidance
A0008360biological_processregulation of cell shape
A0010810biological_processregulation of cell-substrate adhesion
A0012505cellular_componentendomembrane system
A0014041biological_processregulation of neuron maturation
A0016020cellular_componentmembrane
A0016055biological_processWnt signaling pathway
A0016601biological_processRac protein signal transduction
A0016787molecular_functionhydrolase activity
A0019901molecular_functionprotein kinase binding
A0021894biological_processcerebral cortex GABAergic interneuron development
A0022604biological_processregulation of cell morphogenesis
A0030027cellular_componentlamellipodium
A0030031biological_processcell projection assembly
A0030036biological_processactin cytoskeleton organization
A0030426cellular_componentgrowth cone
A0030865biological_processcortical cytoskeleton organization
A0031175biological_processneuron projection development
A0031410cellular_componentcytoplasmic vesicle
A0031941cellular_componentfilamentous actin
A0032956biological_processregulation of actin cytoskeleton organization
A0033630biological_processpositive regulation of cell adhesion mediated by integrin
A0035556biological_processintracellular signal transduction
A0042995cellular_componentcell projection
A0043005cellular_componentneuron projection
A0043020cellular_componentNADPH oxidase complex
A0043025cellular_componentneuronal cell body
A0045730biological_processrespiratory burst
A0048306molecular_functioncalcium-dependent protein binding
A0048471cellular_componentperinuclear region of cytoplasm
A0048873biological_processhomeostasis of number of cells within a tissue
A0050885biological_processneuromuscular process controlling balance
A0050905biological_processneuromuscular process
A0051932biological_processsynaptic transmission, GABAergic
A0060326biological_processcell chemotaxis
A0070062cellular_componentextracellular exosome
A0071944cellular_componentcell periphery
A0098794cellular_componentpostsynapse
A0098974biological_processpostsynaptic actin cytoskeleton organization
A0098978cellular_componentglutamatergic synapse
A0150052biological_processregulation of postsynapse assembly
A1900026biological_processpositive regulation of substrate adhesion-dependent cell spreading
A1902622biological_processregulation of neutrophil migration
B0005085molecular_functionguanyl-nucleotide exchange factor activity
B0007264biological_processsmall GTPase-mediated signal transduction
C0005085molecular_functionguanyl-nucleotide exchange factor activity
C0007264biological_processsmall GTPase-mediated signal transduction
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues3
DetailsBINDING: BINDING => ECO:0000250
ChainResidueDetails
AGLY10
AASP57
ATHR115

site_idSWS_FT_FI2
Number of Residues1
DetailsMOD_RES: Cysteine methyl ester => ECO:0000250
ChainResidueDetails
ACYS189

site_idSWS_FT_FI3
Number of Residues1
DetailsLIPID: S-geranylgeranyl cysteine => ECO:0000250
ChainResidueDetails
ACYS189

site_idSWS_FT_FI4
Number of Residues1
DetailsCARBOHYD: O-linked (GlcNAc) tyrosine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704
ChainResidueDetails
ATYR32

site_idSWS_FT_FI5
Number of Residues2
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:24684802
ChainResidueDetails
ALYS166

237735

PDB entries from 2025-06-18

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