6TLF

human 14-3-3 sigma isoform in complex with IMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000122	biological_process	negative regulation of transcription by RNA polymerase II
A	0001836	biological_process	release of cytochrome c from mitochondria
A	0003334	biological_process	keratinocyte development
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005829	cellular_component	cytosol
A	0006469	biological_process	negative regulation of protein kinase activity
A	0006611	biological_process	protein export from nucleus
A	0007165	biological_process	signal transduction
A	0008104	biological_process	intracellular protein localization
A	0008426	molecular_function	protein kinase C inhibitor activity
A	0008630	biological_process	intrinsic apoptotic signaling pathway in response to DNA damage
A	0010482	biological_process	regulation of epidermal cell division
A	0010839	biological_process	negative regulation of keratinocyte proliferation
A	0019901	molecular_function	protein kinase binding
A	0022407	biological_process	regulation of cell-cell adhesion
A	0030216	biological_process	keratinocyte differentiation
A	0030307	biological_process	positive regulation of cell growth
A	0031424	biological_process	keratinization
A	0032880	biological_process	regulation of protein localization
A	0042802	molecular_function	identical protein binding
A	0043588	biological_process	skin development
A	0043616	biological_process	keratinocyte proliferation
A	0045296	molecular_function	cadherin binding
A	0045606	biological_process	positive regulation of epidermal cell differentiation
A	0045785	biological_process	positive regulation of cell adhesion
A	0045824	biological_process	negative regulation of innate immune response
A	0046827	biological_process	positive regulation of protein export from nucleus
A	0050815	molecular_function	phosphoserine residue binding
A	0051219	molecular_function	phosphoprotein binding
A	0051726	biological_process	regulation of cell cycle
A	0061436	biological_process	establishment of skin barrier
A	0070062	cellular_component	extracellular exosome
A	0072089	biological_process	stem cell proliferation
A	0097225	cellular_component	sperm midpiece
A	0140311	molecular_function	protein sequestering activity
A	0141156	biological_process	cAMP/PKA signal transduction
A	1903077	biological_process	negative regulation of protein localization to plasma membrane
A	1903829	biological_process	positive regulation of protein localization
A	2000647	biological_process	negative regulation of stem cell proliferation

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue IMP A 301

Chain	Residue
A	ARG56
A	ARG129
A	TYR130
A	ASN175

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site_id	AC2
Number of Residues	3
Details	binding site for residue SO4 A 302

Chain	Residue
A	GLY-4
A	PRO79
A	ARG82

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Functional Information from PROSITE/UniProt

site_id	PS00796
Number of Residues	11
Details	1433_1 14-3-3 proteins signature 1. RNLLSVAYKNV

Chain	Residue	Details
A	ARG41-VAL51

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site_id	PS00797
Number of Residues	20
Details	1433_2 14-3-3 proteins signature 2. YKDSTLIMQLLRDNLTLWTA

Chain	Residue	Details
A	TYR213-ALA232

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Site: {"description":"Interaction with phosphoserine on interacting protein"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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