Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TIY

DROSOPHILA GMPCPP-TUBULIN

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0000226	biological_process	microtubule cytoskeleton organization
A	0000235	cellular_component	astral microtubule
A	0000278	biological_process	mitotic cell cycle
A	0005200	molecular_function	structural constituent of cytoskeleton
A	0005525	molecular_function	GTP binding
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005813	cellular_component	centrosome
A	0005819	cellular_component	spindle
A	0005856	cellular_component	cytoskeleton
A	0005874	cellular_component	microtubule
A	0007017	biological_process	microtubule-based process
A	0016787	molecular_function	hydrolase activity
A	0032418	biological_process	lysosome localization
A	0046872	molecular_function	metal ion binding
A	0048471	cellular_component	perinuclear region of cytoplasm
B	0000166	molecular_function	nucleotide binding
B	0000226	biological_process	microtubule cytoskeleton organization
B	0000278	biological_process	mitotic cell cycle
B	0003924	molecular_function	GTPase activity
B	0005200	molecular_function	structural constituent of cytoskeleton
B	0005525	molecular_function	GTP binding
B	0005737	cellular_component	cytoplasm
B	0005856	cellular_component	cytoskeleton
B	0005874	cellular_component	microtubule
B	0007017	biological_process	microtubule-based process
B	0046872	molecular_function	metal ion binding
C	0000166	molecular_function	nucleotide binding
C	0000226	biological_process	microtubule cytoskeleton organization
C	0000235	cellular_component	astral microtubule
C	0000278	biological_process	mitotic cell cycle
C	0005200	molecular_function	structural constituent of cytoskeleton
C	0005525	molecular_function	GTP binding
C	0005634	cellular_component	nucleus
C	0005737	cellular_component	cytoplasm
C	0005813	cellular_component	centrosome
C	0005819	cellular_component	spindle
C	0005856	cellular_component	cytoskeleton
C	0005874	cellular_component	microtubule
C	0007017	biological_process	microtubule-based process
C	0016787	molecular_function	hydrolase activity
C	0032418	biological_process	lysosome localization
C	0046872	molecular_function	metal ion binding
C	0048471	cellular_component	perinuclear region of cytoplasm
D	0000166	molecular_function	nucleotide binding
D	0000226	biological_process	microtubule cytoskeleton organization
D	0000278	biological_process	mitotic cell cycle
D	0003924	molecular_function	GTPase activity
D	0005200	molecular_function	structural constituent of cytoskeleton
D	0005525	molecular_function	GTP binding
D	0005737	cellular_component	cytoplasm
D	0005856	cellular_component	cytoskeleton
D	0005874	cellular_component	microtubule
D	0007017	biological_process	microtubule-based process
D	0046872	molecular_function	metal ion binding
E	0031110	biological_process	regulation of microtubule polymerization or depolymerization

Functional Information from PDB Data

site_id	AC1
Number of Residues	28
Details	binding site for residue GTP A 501

Chain	Residue
A	GLY10
A	GLY144
A	THR145
A	GLY146
A	VAL177
A	THR179
A	GLU183
A	ASN206
A	TYR224
A	ASN228
A	ILE231
A	GLN11
A	MG502
A	HOH616
A	HOH620
A	HOH656
A	HOH657
A	HOH662
A	HOH675
A	HOH698
B	LYS252
A	ALA12
A	GLN15
A	ASP98
A	ALA99
A	ASN101
A	SER140
A	GLY143

site_id	AC2
Number of Residues	5
Details	binding site for residue MG A 502

Chain	Residue
A	GTP501
A	HOH616
A	HOH656
A	HOH662
A	HOH698

site_id	AC3
Number of Residues	5
Details	binding site for residue SO4 A 503

Chain	Residue
A	PRO175
A	LYS394
A	HOH696
A	HOH701
B	ASN347

site_id	AC4
Number of Residues	4
Details	binding site for residue SO4 A 504

Chain	Residue
A	ASN216
A	ALA294
A	HOH652
D	LYS122

site_id	AC5
Number of Residues	5
Details	binding site for residue SO4 A 505

Chain	Residue
A	ARG308
A	ARG339
A	THR340
A	HOH660
A	HOH677

site_id	AC6
Number of Residues	5
Details	binding site for residue GOL A 506

Chain	Residue
A	GLY410
A	GLU411
E	ARG61
E	GLN64
E	GLU65

site_id	AC7
Number of Residues	25
Details	binding site for residue G2P B 501

Chain	Residue
B	GLY10
B	GLN11
B	CYS12
B	GLN15
B	ALA97
B	ASN99
B	SER138
B	GLY141
B	GLY142
B	THR143
B	GLY144
B	PRO171
B	VAL175
B	ASP177
B	GLU181
B	ASN204
B	TYR222
B	ASN226
B	MG502
B	HOH609
B	HOH631
B	HOH633
B	HOH649
B	HOH668
B	HOH675

site_id	AC8
Number of Residues	5
Details	binding site for residue MG B 502

Chain	Residue
B	G2P501
B	HOH614
B	HOH631
B	HOH668
B	HOH679

site_id	AC9
Number of Residues	3
Details	binding site for residue SO4 B 503

Chain	Residue
B	THR221
B	GLY223
B	ARG276

site_id	AD1
Number of Residues	5
Details	binding site for residue SO4 B 504

Chain	Residue
B	LYS216
B	LEU217
B	THR218
B	THR219
C	LYS326

site_id	AD2
Number of Residues	29
Details	binding site for residue GTP C 501

Chain	Residue
C	GLY143
C	GLY144
C	THR145
C	GLY146
C	VAL177
C	THR179
C	GLU183
C	ASN206
C	TYR224
C	ASN228
C	ILE231
C	MG502
C	HOH606
C	HOH620
C	HOH624
C	HOH627
C	HOH634
C	HOH640
C	HOH668
D	LYS252
C	GLY10
C	GLN11
C	ALA12
C	GLN15
C	ASP98
C	ALA99
C	ALA100
C	ASN101
C	SER140

site_id	AD3
Number of Residues	5
Details	binding site for residue MG C 502

Chain	Residue
C	GTP501
C	HOH624
C	HOH627
C	HOH634
C	HOH668

site_id	AD4
Number of Residues	1
Details	binding site for residue SO4 C 503

Chain	Residue
C	TYR262

site_id	AD5
Number of Residues	4
Details	binding site for residue SO4 C 504

Chain	Residue
C	PRO175
C	LYS394
C	HOH612
D	ASN347

site_id	AD6
Number of Residues	29
Details	binding site for residue G2P D 501

Chain	Residue
D	GLY10
D	GLN11
D	CYS12
D	GLN15
D	ALA97
D	GLY98
D	ASN99
D	SER138
D	GLY141
D	GLY142
D	THR143
D	GLY144
D	PRO171
D	VAL175
D	SER176
D	GLU181
D	ASN204
D	TYR222
D	ASN226
D	MG502
D	HOH603
D	HOH604
D	HOH611
D	HOH619
D	HOH624
D	HOH647
D	HOH655
D	HOH665
D	HOH672

site_id	AD7
Number of Residues	5
Details	binding site for residue MG D 502

Chain	Residue
D	G2P501
D	HOH603
D	HOH655
D	HOH665
D	HOH677

site_id	AD8
Number of Residues	8
Details	binding site for residue SO4 D 503

Chain	Residue
D	THR221
D	ARG276
D	ALA393
D	PHE394
D	HOH620
D	HOH636
D	HOH649
D	HOH667

site_id	AD9
Number of Residues	5
Details	binding site for residue SO4 D 504

Chain	Residue
D	LYS19
D	HIS227
D	SER230
D	ARG276
D	ARG359

site_id	AE1
Number of Residues	7
Details	binding site for residue SO4 D 505

Chain	Residue
D	ALA271
D	PRO272
D	LEU273
D	LEU284
D	GLN292
D	ASN298
D	HOH663

site_id	AE2
Number of Residues	4
Details	binding site for residue SO4 E 201

Chain	Residue
E	HIS115
E	ALA118
E	ARG122
E	HOH301

Functional Information from PROSITE/UniProt

site_id	PS00227
Number of Residues	7
Details	TUBULIN Tubulin subunits alpha, beta, and gamma signature. GGGTGSG

Chain	Residue	Details
A	GLY142-GLY148
B	GLY140-GLY146

site_id	PS00228
Number of Residues	4
Details	TUBULIN_B_AUTOREG Tubulin-beta mRNA autoregulation signal. MREI

Chain	Residue	Details
B	MET1-ILE4

site_id	PS00563
Number of Residues	10
Details	STATHMIN_1 Stathmin family signature 1. PRRRDpSLEE

Chain	Residue	Details
E	PRO40-GLU49

site_id	PS01041
Number of Residues	10
Details	STATHMIN_2 Stathmin family signature 2. AEKREHEREV

Chain	Residue	Details
E	ALA73-VAL82

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	18
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P68363","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"Q13509","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18327897","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	21
Details	Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	99
Details	Coiled coil: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"22673903","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)