6TI4
SHMT from Streptococcus thermophilus Tyr55Ser variant in complex with PLP/D-Serine/Lys230 gem diamine complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005829 | cellular_component | cytosol |
| A | 0006544 | biological_process | glycine metabolic process |
| A | 0006545 | biological_process | glycine biosynthetic process |
| A | 0006563 | biological_process | L-serine metabolic process |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008652 | biological_process | amino acid biosynthetic process |
| A | 0016740 | molecular_function | transferase activity |
| A | 0019264 | biological_process | glycine biosynthetic process from serine |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0035999 | biological_process | tetrahydrofolate interconversion |
| A | 0046653 | biological_process | tetrahydrofolate metabolic process |
| C | 0004372 | molecular_function | glycine hydroxymethyltransferase activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0005829 | cellular_component | cytosol |
| C | 0006544 | biological_process | glycine metabolic process |
| C | 0006545 | biological_process | glycine biosynthetic process |
| C | 0006563 | biological_process | L-serine metabolic process |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0008652 | biological_process | amino acid biosynthetic process |
| C | 0016740 | molecular_function | transferase activity |
| C | 0019264 | biological_process | glycine biosynthetic process from serine |
| C | 0030170 | molecular_function | pyridoxal phosphate binding |
| C | 0035999 | biological_process | tetrahydrofolate interconversion |
| C | 0046653 | biological_process | tetrahydrofolate metabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 9 |
| Details | binding site for residue GOL A 501 |
| Chain | Residue |
| A | TYR156 |
| A | ARG180 |
| A | ASP183 |
| A | HOH663 |
| A | HOH664 |
| A | HOH664 |
| A | HOH676 |
| A | HOH692 |
| A | HOH758 |
| site_id | AC2 |
| Number of Residues | 20 |
| Details | binding site for residue O3Z A 502 |
| Chain | Residue |
| A | SER35 |
| A | SER97 |
| A | GLY98 |
| A | SER99 |
| A | HIS126 |
| A | SER176 |
| A | ASP201 |
| A | ALA203 |
| A | HIS204 |
| A | HIS229 |
| A | LYS230 |
| A | ARG363 |
| A | HOH703 |
| A | HOH760 |
| C | GLU57 |
| C | TYR65 |
| C | GLY261 |
| C | GLY262 |
| C | HOH717 |
| C | HOH758 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 503 |
| Chain | Residue |
| A | HIS213 |
| A | PRO219 |
| A | GLU288 |
| A | ILE291 |
| A | LYS292 |
| A | HOH601 |
| A | HOH783 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 504 |
| Chain | Residue |
| A | SER55 |
| A | ALA56 |
| A | GLU57 |
| A | ARG63 |
| A | TYR64 |
| A | TYR65 |
| site_id | AC5 |
| Number of Residues | 25 |
| Details | binding site for Di-peptide O3Z C 501 and LYS C 230 |
| Chain | Residue |
| A | GLU57 |
| A | TYR65 |
| A | GLY261 |
| A | GLY262 |
| A | HOH723 |
| C | SER35 |
| C | ASN37 |
| C | SER97 |
| C | GLY98 |
| C | SER99 |
| C | HIS126 |
| C | SER176 |
| C | ASP201 |
| C | ALA203 |
| C | HIS204 |
| C | HIS229 |
| C | THR231 |
| C | LEU232 |
| C | ARG233 |
| C | ARG363 |
| C | HOH653 |
| C | HOH673 |
| C | HOH691 |
| C | HOH704 |
| C | HOH745 |
Functional Information from PROSITE/UniProt
| site_id | PS00096 |
| Number of Residues | 17 |
| Details | SHMT Serine hydroxymethyltransferase pyridoxal-phosphate attachment site. HVtTTTTHKTLrGPRGG |
| Chain | Residue | Details |
| A | HIS222-GLY238 |
