Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TH7

Structure of porcine pancreatic elastase in complex with tutuilamide

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0006508	biological_process	proteolysis
A	0006954	biological_process	inflammatory response
A	0008233	molecular_function	peptidase activity
A	0008236	molecular_function	serine-type peptidase activity
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
B	0004252	molecular_function	serine-type endopeptidase activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0006508	biological_process	proteolysis
B	0006954	biological_process	inflammatory response
B	0008233	molecular_function	peptidase activity
B	0008236	molecular_function	serine-type peptidase activity
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue CA A 301

Chain	Residue
A	GLU85
A	ASN87
A	GLN90
A	ASP92
A	GLU95
A	HOH501

site_id	AC2
Number of Residues	5
Details	binding site for residue CA B 301

Chain	Residue
B	ASP92
B	GLU95
B	GLU85
B	ASN87
B	GLN90

site_id	AC3
Number of Residues	15
Details	binding site for Di-peptide ABA A 301 and ILE A 306

Chain	Residue
A	HIS71
A	VAL114
A	SER233
A	PHE234
A	VAL235
A	SER236
A	ARG237
C	VAL302
C	5XU309
C	N9K303
C	AA4305
C	ABA306
C	HOH401
C	HOH403
C	HOH405

site_id	AC4
Number of Residues	13
Details	binding site for residues ABA A 301 and ABA A 310

Chain	Residue
A	HIS71
A	VAL114
A	GLN211
A	GLY212
A	SER214
A	SER233
A	PHE234
A	VAL235
C	VAL302
C	ILE308
C	AA4305
C	HOH401
C	HOH403

site_id	AC5
Number of Residues	9
Details	binding site for Di-peptide ABA A 301 and VAL A 302

Chain	Residue
A	HIS71
A	VAL114
A	SER233
C	ILE308
C	N9K303
C	AA4305
C	ABA306
C	HOH401
C	HOH403

site_id	AC6
Number of Residues	8
Details	binding site for Di-peptide VAL A 302 and N9K A 307

Chain	Residue
A	HIS71
A	PRO107
A	TRP258
C	ABA307
C	ILE308
C	PHE304
C	AA4305
C	HOH402

site_id	AC7
Number of Residues	5
Details	binding site for residues O4Q A 304 and 5XU A 305

Chain	Residue
A	PHE234
A	VAL235
A	SER236
A	ARG237
C	ILE308

site_id	AC8
Number of Residues	9
Details	binding site for Di-peptide 5XU A 305 and ILE A 306

Chain	Residue
A	PHE234
A	VAL235
A	SER236
A	ARG237
C	ABA307
C	O4Q310
C	N9K303
C	ABA306
C	HOH405

site_id	AC9
Number of Residues	8
Details	binding site for residues N9K A 307 and PHA A 308

Chain	Residue
A	PRO107
A	GLN211
A	GLY212
A	TRP258
C	VAL302
C	ILE308
C	AA4305
C	HOH402

site_id	AD1
Number of Residues	12
Details	binding site for residues PHA A 308 and AA4 A 309

Chain	Residue
A	THR55
A	HIS71
A	PRO107
A	GLN211
A	GLY212
A	SER214
C	ABA307
C	VAL302
C	N9K303
C	ABA306
C	HOH401
C	HOH404

site_id	AD2
Number of Residues	12
Details	binding site for residues PHA A 308 and AA4 A 309

Chain	Residue
C	ABA306
C	HOH401
C	HOH404
A	THR55
A	HIS71
A	PRO107
A	GLN211
A	GLY212
A	SER214
C	ABA307
C	VAL302
C	N9K303

site_id	AD3
Number of Residues	15
Details	binding site for residues AA4 A 309 and ABA A 310

Chain	Residue
A	THR55
A	HIS71
A	GLN211
A	GLY212
A	SER214
A	SER233
A	PHE234
A	VAL235
C	ABA307
C	VAL302
C	ILE308
C	N9K303
C	PHE304
C	HOH401
C	HOH404

site_id	AD4
Number of Residues	12
Details	binding site for residues ABA B 301 and ABA B 310

Chain	Residue
B	HIS71
B	VAL114
B	GLN211
B	GLY212
B	SER214
B	SER233
B	VAL235
D	VAL314
D	ILE316
D	AA4311
B	HOH420
D	HOH401

site_id	AD5
Number of Residues	8
Details	binding site for Di-peptide ABA B 301 and VAL B 302

Chain	Residue
B	HIS71
B	VAL114
B	SER233
D	ILE316
D	YNM313
D	AA4311
D	ABA310
D	HOH401

site_id	AD6
Number of Residues	13
Details	binding site for Di-peptide ABA B 301 and ILE B 306

Chain	Residue
A	ALA126
A	GLN127
B	HIS71
B	VAL114
B	SER233
B	PHE234
B	VAL235
D	VAL314
D	5XU317
D	YNM313
D	AA4311
D	ABA310
D	HOH401

site_id	AD7
Number of Residues	10
Details	binding site for Di-peptide VAL B 302 and YNM B 307

Chain	Residue
A	PHE79
A	GLY99
A	VAL100
B	HIS71
D	ABA315
D	ILE316
D	PHE312
D	AA4311
D	ABA310
D	HOH402

site_id	AD8
Number of Residues	6
Details	binding site for residues O4Q B 304 and 5XU B 305

Chain	Residue
B	TRP190
B	PHE234
B	VAL235
B	SER236
B	ARG237
D	ILE316

site_id	AD9
Number of Residues	8
Details	binding site for Di-peptide 5XU B 305 and ILE B 306

Chain	Residue
A	ALA126
A	GLN127
B	PHE234
B	VAL235
D	ABA315
D	O4Q318
D	YNM313
D	ABA310

site_id	AE1
Number of Residues	10
Details	binding site for residues YNM B 307 and PHA B 308

Chain	Residue
A	ARG47
A	PHE79
A	GLY99
A	VAL100
B	THR55
B	GLY212
D	VAL314
D	ILE316
D	AA4311
D	HOH402

site_id	AE2
Number of Residues	11
Details	binding site for residues PHA B 308 and AA4 B 309

Chain	Residue
A	ARG47
B	THR55
B	HIS71
B	GLN211
B	GLY212
B	SER214
D	ABA315
D	VAL314
D	YNM313
D	ABA310
D	HOH401

site_id	AE3
Number of Residues	11
Details	binding site for residues PHA B 308 and AA4 B 309

Chain	Residue
A	ARG47
B	THR55
B	HIS71
B	GLN211
B	GLY212
B	SER214
D	ABA315
D	VAL314
D	YNM313
D	ABA310
D	HOH401

site_id	AE4
Number of Residues	14
Details	binding site for residues AA4 B 309 and ABA B 310

Chain	Residue
B	THR55
B	HIS71
B	GLN211
B	GLY212
B	SER214
B	SER233
B	VAL235
D	ABA315
D	VAL314
D	ILE316
D	YNM313
D	PHE312
B	HOH420
D	HOH401

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. MTAAHC

Chain	Residue	Details
A	MET67-CYS72

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. SGcqGDSGGPLH

Chain	Residue	Details
A	SER208-HIS219

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	474
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"4578945","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	4
Details	Active site: {"description":"Charge relay system","evidences":[{"source":"PubMed","id":"5415110","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"7656008","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1ELA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"1ELC","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)