6TGE
NADP dependent methylene-tetrahydromethanopterin dehydrogenase-NADP+-methenyl-H4MPT+ complex
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046294 | biological_process | formaldehyde catabolic process |
| B | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006730 | biological_process | one-carbon metabolic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0046294 | biological_process | formaldehyde catabolic process |
| C | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| C | 0005737 | cellular_component | cytoplasm |
| C | 0006730 | biological_process | one-carbon metabolic process |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0046294 | biological_process | formaldehyde catabolic process |
| D | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| D | 0005737 | cellular_component | cytoplasm |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0046294 | biological_process | formaldehyde catabolic process |
| E | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| E | 0005737 | cellular_component | cytoplasm |
| E | 0006730 | biological_process | one-carbon metabolic process |
| E | 0016491 | molecular_function | oxidoreductase activity |
| E | 0046294 | biological_process | formaldehyde catabolic process |
| F | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| F | 0005737 | cellular_component | cytoplasm |
| F | 0006730 | biological_process | one-carbon metabolic process |
| F | 0016491 | molecular_function | oxidoreductase activity |
| F | 0046294 | biological_process | formaldehyde catabolic process |
| G | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| G | 0005737 | cellular_component | cytoplasm |
| G | 0006730 | biological_process | one-carbon metabolic process |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0046294 | biological_process | formaldehyde catabolic process |
| H | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| H | 0005737 | cellular_component | cytoplasm |
| H | 0006730 | biological_process | one-carbon metabolic process |
| H | 0016491 | molecular_function | oxidoreductase activity |
| H | 0046294 | biological_process | formaldehyde catabolic process |
| I | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| I | 0005737 | cellular_component | cytoplasm |
| I | 0006730 | biological_process | one-carbon metabolic process |
| I | 0016491 | molecular_function | oxidoreductase activity |
| I | 0046294 | biological_process | formaldehyde catabolic process |
| J | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| J | 0005737 | cellular_component | cytoplasm |
| J | 0006730 | biological_process | one-carbon metabolic process |
| J | 0016491 | molecular_function | oxidoreductase activity |
| J | 0046294 | biological_process | formaldehyde catabolic process |
| K | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| K | 0005737 | cellular_component | cytoplasm |
| K | 0006730 | biological_process | one-carbon metabolic process |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0046294 | biological_process | formaldehyde catabolic process |
| L | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| L | 0005737 | cellular_component | cytoplasm |
| L | 0006730 | biological_process | one-carbon metabolic process |
| L | 0016491 | molecular_function | oxidoreductase activity |
| L | 0046294 | biological_process | formaldehyde catabolic process |
| M | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| M | 0005737 | cellular_component | cytoplasm |
| M | 0006730 | biological_process | one-carbon metabolic process |
| M | 0016491 | molecular_function | oxidoreductase activity |
| M | 0046294 | biological_process | formaldehyde catabolic process |
| N | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| N | 0005737 | cellular_component | cytoplasm |
| N | 0006730 | biological_process | one-carbon metabolic process |
| N | 0016491 | molecular_function | oxidoreductase activity |
| N | 0046294 | biological_process | formaldehyde catabolic process |
| O | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| O | 0005737 | cellular_component | cytoplasm |
| O | 0006730 | biological_process | one-carbon metabolic process |
| O | 0016491 | molecular_function | oxidoreductase activity |
| O | 0046294 | biological_process | formaldehyde catabolic process |
| P | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| P | 0005737 | cellular_component | cytoplasm |
| P | 0006730 | biological_process | one-carbon metabolic process |
| P | 0016491 | molecular_function | oxidoreductase activity |
| P | 0046294 | biological_process | formaldehyde catabolic process |
| Q | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| Q | 0005737 | cellular_component | cytoplasm |
| Q | 0006730 | biological_process | one-carbon metabolic process |
| Q | 0016491 | molecular_function | oxidoreductase activity |
| Q | 0046294 | biological_process | formaldehyde catabolic process |
| R | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| R | 0005737 | cellular_component | cytoplasm |
| R | 0006730 | biological_process | one-carbon metabolic process |
| R | 0016491 | molecular_function | oxidoreductase activity |
| R | 0046294 | biological_process | formaldehyde catabolic process |
| S | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| S | 0005737 | cellular_component | cytoplasm |
| S | 0006730 | biological_process | one-carbon metabolic process |
| S | 0016491 | molecular_function | oxidoreductase activity |
| S | 0046294 | biological_process | formaldehyde catabolic process |
| T | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| T | 0005737 | cellular_component | cytoplasm |
| T | 0006730 | biological_process | one-carbon metabolic process |
| T | 0016491 | molecular_function | oxidoreductase activity |
| T | 0046294 | biological_process | formaldehyde catabolic process |
| U | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| U | 0005737 | cellular_component | cytoplasm |
| U | 0006730 | biological_process | one-carbon metabolic process |
| U | 0016491 | molecular_function | oxidoreductase activity |
| U | 0046294 | biological_process | formaldehyde catabolic process |
| V | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| V | 0005737 | cellular_component | cytoplasm |
| V | 0006730 | biological_process | one-carbon metabolic process |
| V | 0016491 | molecular_function | oxidoreductase activity |
| V | 0046294 | biological_process | formaldehyde catabolic process |
| W | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| W | 0005737 | cellular_component | cytoplasm |
| W | 0006730 | biological_process | one-carbon metabolic process |
| W | 0016491 | molecular_function | oxidoreductase activity |
| W | 0046294 | biological_process | formaldehyde catabolic process |
| X | 0004488 | molecular_function | methylenetetrahydrofolate dehydrogenase (NADP+) activity |
| X | 0005737 | cellular_component | cytoplasm |
| X | 0006730 | biological_process | one-carbon metabolic process |
| X | 0016491 | molecular_function | oxidoreductase activity |
| X | 0046294 | biological_process | formaldehyde catabolic process |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 31 |
| Details | binding site for residue NAP A 301 |
| Chain | Residue |
| A | ASN97 |
| A | ALA196 |
| A | GLY197 |
| A | ALA198 |
| A | ILE199 |
| A | LEU201 |
| A | TYR221 |
| A | ALA249 |
| A | GLY253 |
| A | H4M302 |
| A | HOH435 |
| A | THR102 |
| A | HOH467 |
| A | HOH478 |
| A | HOH485 |
| A | HOH487 |
| A | HOH519 |
| A | HOH543 |
| A | HOH544 |
| A | HOH548 |
| A | HOH554 |
| A | HOH558 |
| A | THR129 |
| A | HOH597 |
| A | HOH623 |
| A | GLY130 |
| A | PRO131 |
| A | VAL132 |
| A | GLY151 |
| A | ARG152 |
| A | LYS156 |
| site_id | AC2 |
| Number of Residues | 18 |
| Details | binding site for residue H4M A 302 |
| Chain | Residue |
| A | SER16 |
| A | PHE18 |
| A | ASP19 |
| A | ASN97 |
| A | GLY98 |
| A | LEU250 |
| A | GLY253 |
| A | LYS256 |
| A | LEU257 |
| A | NAP301 |
| A | HOH418 |
| A | HOH432 |
| A | HOH470 |
| A | HOH502 |
| A | HOH601 |
| A | HOH641 |
| C | TYR51 |
| C | GLY54 |
| site_id | AC3 |
| Number of Residues | 11 |
| Details | binding site for residue SO4 A 303 |
| Chain | Residue |
| A | TYR24 |
| A | HIS30 |
| A | ILE31 |
| A | HOH421 |
| B | TYR24 |
| B | HIS30 |
| B | ILE31 |
| B | HOH407 |
| C | TYR24 |
| C | HIS30 |
| C | HOH434 |
| site_id | AC4 |
| Number of Residues | 33 |
| Details | binding site for residue NAP B 301 |
| Chain | Residue |
| B | ASN97 |
| B | THR102 |
| B | ALA127 |
| B | THR129 |
| B | GLY130 |
| B | PRO131 |
| B | VAL132 |
| B | ARG152 |
| B | LYS156 |
| B | ALA196 |
| B | GLY197 |
| B | ALA198 |
| B | ILE199 |
| B | LEU201 |
| B | TYR221 |
| B | ASN222 |
| B | LYS256 |
| B | H4M302 |
| B | HOH411 |
| B | HOH427 |
| B | HOH428 |
| B | HOH460 |
| B | HOH476 |
| B | HOH491 |
| B | HOH499 |
| B | HOH501 |
| B | HOH503 |
| B | HOH504 |
| B | HOH511 |
| B | HOH533 |
| B | HOH550 |
| B | HOH557 |
| B | HOH613 |
| site_id | AC5 |
| Number of Residues | 16 |
| Details | binding site for residue H4M B 302 |
| Chain | Residue |
| B | LEU250 |
| B | GLY253 |
| B | GLY254 |
| B | LYS256 |
| B | LEU257 |
| B | NAP301 |
| B | HOH435 |
| B | HOH471 |
| B | HOH477 |
| B | HOH531 |
| A | TYR51 |
| B | SER16 |
| B | PHE18 |
| B | ASP19 |
| B | ASN97 |
| B | GLY98 |
| site_id | AC6 |
| Number of Residues | 31 |
| Details | binding site for residue NAP C 301 |
| Chain | Residue |
| C | ASN97 |
| C | THR102 |
| C | ALA127 |
| C | THR129 |
| C | GLY130 |
| C | PRO131 |
| C | VAL132 |
| C | GLY151 |
| C | ARG152 |
| C | LYS156 |
| C | ALA196 |
| C | GLY197 |
| C | ALA198 |
| C | ILE199 |
| C | LEU201 |
| C | TYR221 |
| C | ASN222 |
| C | LYS256 |
| C | H4M302 |
| C | HOH404 |
| C | HOH444 |
| C | HOH462 |
| C | HOH469 |
| C | HOH482 |
| C | HOH511 |
| C | HOH516 |
| C | HOH545 |
| C | HOH558 |
| C | HOH570 |
| C | HOH579 |
| C | HOH597 |
| site_id | AC7 |
| Number of Residues | 17 |
| Details | binding site for residue H4M C 302 |
| Chain | Residue |
| B | GLY54 |
| C | SER16 |
| C | PHE18 |
| C | ASP19 |
| C | ASN97 |
| C | GLY98 |
| C | LEU250 |
| C | GLY253 |
| C | GLY254 |
| C | LYS256 |
| C | LEU257 |
| C | NAP301 |
| C | HOH439 |
| C | HOH473 |
| C | HOH487 |
| C | HOH500 |
| C | HOH641 |
| site_id | AC8 |
| Number of Residues | 21 |
| Details | binding site for residue H4M D 301 |
| Chain | Residue |
| D | SER16 |
| D | PHE18 |
| D | ASP19 |
| D | ASN97 |
| D | GLY98 |
| D | THR102 |
| D | LEU250 |
| D | GLY253 |
| D | LYS256 |
| D | LEU257 |
| D | NAP302 |
| D | HOH405 |
| D | HOH430 |
| D | HOH442 |
| D | HOH487 |
| F | TYR51 |
| F | GLY55 |
| F | LYS58 |
| F | PRO87 |
| F | PHE88 |
| F | HOH445 |
| site_id | AC9 |
| Number of Residues | 31 |
| Details | binding site for residue NAP D 302 |
| Chain | Residue |
| D | ASN97 |
| D | THR102 |
| D | THR129 |
| D | GLY130 |
| D | PRO131 |
| D | VAL132 |
| D | GLY151 |
| D | ARG152 |
| D | LYS156 |
| D | ALA196 |
| D | GLY197 |
| D | ALA198 |
| D | ILE199 |
| D | LEU201 |
| D | TYR221 |
| D | ALA249 |
| D | GLY253 |
| D | LYS256 |
| D | H4M301 |
| D | HOH408 |
| D | HOH428 |
| D | HOH452 |
| D | HOH455 |
| D | HOH456 |
| D | HOH485 |
| D | HOH500 |
| D | HOH501 |
| D | HOH521 |
| D | HOH526 |
| D | HOH529 |
| D | HOH572 |
| site_id | AD1 |
| Number of Residues | 12 |
| Details | binding site for residue SO4 D 303 |
| Chain | Residue |
| D | TYR24 |
| D | HIS30 |
| D | ILE31 |
| D | HOH409 |
| D | HOH423 |
| E | TYR24 |
| E | ASP29 |
| E | HIS30 |
| E | ILE31 |
| E | HOH403 |
| F | TYR24 |
| F | HIS30 |
| site_id | AD2 |
| Number of Residues | 38 |
| Details | binding site for residue NAP E 301 |
| Chain | Residue |
| E | ASN97 |
| E | THR102 |
| E | ALA127 |
| E | THR129 |
| E | GLY130 |
| E | PRO131 |
| E | VAL132 |
| E | GLY151 |
| E | ARG152 |
| E | LYS153 |
| E | LYS156 |
| E | ALA196 |
| E | GLY197 |
| E | ALA198 |
| E | ILE199 |
| E | LEU201 |
| E | TYR221 |
| E | ASN222 |
| E | LYS256 |
| E | H4M302 |
| E | HOH423 |
| E | HOH449 |
| E | HOH491 |
| E | HOH494 |
| E | HOH503 |
| E | HOH507 |
| E | HOH508 |
| E | HOH512 |
| E | HOH534 |
| E | HOH545 |
| E | HOH558 |
| E | HOH574 |
| E | HOH582 |
| E | HOH601 |
| E | HOH621 |
| E | HOH623 |
| E | HOH645 |
| N | GLN158 |
| site_id | AD3 |
| Number of Residues | 19 |
| Details | binding site for residue H4M E 302 |
| Chain | Residue |
| D | TYR51 |
| E | SER16 |
| E | PHE18 |
| E | ASP19 |
| E | ASN97 |
| E | GLY98 |
| E | LEU250 |
| E | GLY253 |
| E | GLY254 |
| E | LYS256 |
| E | LEU257 |
| E | NAP301 |
| E | HOH470 |
| E | HOH483 |
| E | HOH503 |
| E | HOH553 |
| E | HOH583 |
| E | HOH599 |
| E | HOH651 |
| site_id | AD4 |
| Number of Residues | 30 |
| Details | binding site for residue NAP F 301 |
| Chain | Residue |
| F | ASN97 |
| F | THR102 |
| F | ALA127 |
| F | THR129 |
| F | GLY130 |
| F | PRO131 |
| F | VAL132 |
| F | GLY151 |
| F | ARG152 |
| F | LYS156 |
| F | ALA196 |
| F | GLY197 |
| F | ALA198 |
| F | ILE199 |
| F | LEU201 |
| F | TYR221 |
| F | ASN222 |
| F | LYS256 |
| F | H4M302 |
| F | HOH404 |
| F | HOH428 |
| F | HOH440 |
| F | HOH442 |
| F | HOH455 |
| F | HOH501 |
| F | HOH519 |
| F | HOH544 |
| F | HOH565 |
| F | HOH566 |
| F | HOH567 |
| site_id | AD5 |
| Number of Residues | 14 |
| Details | binding site for residue H4M F 302 |
| Chain | Residue |
| E | TYR51 |
| F | SER16 |
| F | PHE18 |
| F | ASP19 |
| F | ASN97 |
| F | GLY98 |
| F | LEU250 |
| F | GLY254 |
| F | LYS256 |
| F | NAP301 |
| F | HOH466 |
| F | HOH479 |
| F | HOH560 |
| F | HOH583 |
| site_id | AD6 |
| Number of Residues | 32 |
| Details | binding site for residue NAP G 301 |
| Chain | Residue |
| G | ASN97 |
| G | THR102 |
| G | THR129 |
| G | GLY130 |
| G | PRO131 |
| G | VAL132 |
| G | GLY151 |
| G | ARG152 |
| G | LYS156 |
| G | ALA196 |
| G | GLY197 |
| G | ALA198 |
| G | ILE199 |
| G | LEU201 |
| G | TYR221 |
| G | ALA249 |
| G | GLY253 |
| G | H4M302 |
| G | HOH413 |
| G | HOH480 |
| G | HOH484 |
| G | HOH490 |
| G | HOH491 |
| G | HOH499 |
| G | HOH506 |
| G | HOH511 |
| G | HOH523 |
| G | HOH524 |
| G | HOH552 |
| G | HOH566 |
| G | HOH567 |
| G | HOH595 |
| site_id | AD7 |
| Number of Residues | 18 |
| Details | binding site for residue H4M G 302 |
| Chain | Residue |
| G | SER16 |
| G | PHE18 |
| G | ASP19 |
| G | ASN97 |
| G | GLY98 |
| G | LEU250 |
| G | GLY253 |
| G | LYS256 |
| G | LEU257 |
| G | NAP301 |
| G | HOH403 |
| G | HOH454 |
| G | HOH459 |
| G | HOH562 |
| I | TYR51 |
| I | GLY55 |
| I | LYS58 |
| I | PHE88 |
| site_id | AD8 |
| Number of Residues | 34 |
| Details | binding site for residue NAP H 301 |
| Chain | Residue |
| H | ASN97 |
| H | THR102 |
| H | ALA127 |
| H | THR129 |
| H | GLY130 |
| H | PRO131 |
| H | VAL132 |
| H | GLY151 |
| H | ARG152 |
| H | LYS156 |
| H | ALA196 |
| H | GLY197 |
| H | ALA198 |
| H | ILE199 |
| H | LEU201 |
| H | TYR221 |
| H | ASN222 |
| H | LYS256 |
| H | H4M302 |
| H | HOH414 |
| H | HOH418 |
| H | HOH472 |
| H | HOH510 |
| H | HOH544 |
| H | HOH545 |
| H | HOH547 |
| H | HOH567 |
| H | HOH569 |
| H | HOH570 |
| H | HOH572 |
| H | HOH577 |
| H | HOH623 |
| H | HOH626 |
| H | HOH627 |
| site_id | AD9 |
| Number of Residues | 17 |
| Details | binding site for residue H4M H 302 |
| Chain | Residue |
| G | TYR51 |
| H | SER16 |
| H | PHE18 |
| H | ASP19 |
| H | ASN97 |
| H | GLY98 |
| H | LEU250 |
| H | GLY253 |
| H | GLY254 |
| H | LYS256 |
| H | LEU257 |
| H | NAP301 |
| H | HOH470 |
| H | HOH508 |
| H | HOH597 |
| H | HOH627 |
| H | HOH657 |
| site_id | AE1 |
| Number of Residues | 12 |
| Details | binding site for residue SO4 H 303 |
| Chain | Residue |
| G | TYR24 |
| G | HIS30 |
| G | ILE31 |
| G | HOH408 |
| H | TYR24 |
| H | HIS30 |
| H | ILE31 |
| H | HOH422 |
| I | TYR24 |
| I | HIS30 |
| I | ILE31 |
| I | HOH407 |
| site_id | AE2 |
| Number of Residues | 33 |
| Details | binding site for residue NAP I 301 |
| Chain | Residue |
| I | ASN97 |
| I | THR102 |
| I | ALA127 |
| I | THR129 |
| I | GLY130 |
| I | PRO131 |
| I | VAL132 |
| I | GLY151 |
| I | ARG152 |
| I | LYS156 |
| I | ALA196 |
| I | GLY197 |
| I | ALA198 |
| I | ILE199 |
| I | LEU201 |
| I | TYR221 |
| I | ASN222 |
| I | LYS256 |
| I | H4M302 |
| I | HOH401 |
| I | HOH418 |
| I | HOH423 |
| I | HOH471 |
| I | HOH473 |
| I | HOH478 |
| I | HOH524 |
| I | HOH530 |
| I | HOH539 |
| I | HOH546 |
| I | HOH552 |
| I | HOH556 |
| I | HOH569 |
| I | HOH571 |
| site_id | AE3 |
| Number of Residues | 14 |
| Details | binding site for residue H4M I 302 |
| Chain | Residue |
| I | SER16 |
| I | PHE18 |
| I | ASP19 |
| I | ASN97 |
| I | GLY98 |
| I | LEU250 |
| I | GLY254 |
| I | LYS256 |
| I | LEU257 |
| I | NAP301 |
| I | HOH441 |
| I | HOH446 |
| I | HOH475 |
| I | HOH493 |
| site_id | AE4 |
| Number of Residues | 32 |
| Details | binding site for residue NAP J 301 |
| Chain | Residue |
| J | ASN97 |
| J | THR102 |
| J | THR129 |
| J | GLY130 |
| J | PRO131 |
| J | VAL132 |
| J | GLY151 |
| J | ARG152 |
| J | LYS156 |
| J | ALA196 |
| J | GLY197 |
| J | ALA198 |
| J | ILE199 |
| J | LEU201 |
| J | TYR221 |
| J | ALA249 |
| J | GLY253 |
| J | H4M302 |
| J | HOH407 |
| J | HOH446 |
| J | HOH486 |
| J | HOH495 |
| J | HOH502 |
| J | HOH505 |
| J | HOH510 |
| J | HOH537 |
| J | HOH545 |
| J | HOH550 |
| J | HOH563 |
| J | HOH583 |
| J | HOH614 |
| J | HOH623 |
| site_id | AE5 |
| Number of Residues | 17 |
| Details | binding site for residue H4M J 302 |
| Chain | Residue |
| J | SER16 |
| J | PHE18 |
| J | ASP19 |
| J | ASN97 |
| J | GLY98 |
| J | LEU250 |
| J | GLY253 |
| J | LYS256 |
| J | NAP301 |
| J | HOH402 |
| J | HOH462 |
| J | HOH467 |
| J | HOH568 |
| L | TYR51 |
| L | GLY54 |
| L | GLY55 |
| L | LYS58 |
| site_id | AE6 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 J 303 |
| Chain | Residue |
| J | TYR24 |
| J | HIS30 |
| J | ILE31 |
| K | TYR24 |
| K | HIS30 |
| K | HOH417 |
| L | TYR24 |
| L | HIS30 |
| L | HOH420 |
| site_id | AE7 |
| Number of Residues | 33 |
| Details | binding site for residue NAP K 301 |
| Chain | Residue |
| K | ASN97 |
| K | THR102 |
| K | ALA127 |
| K | THR129 |
| K | GLY130 |
| K | PRO131 |
| K | VAL132 |
| K | GLY151 |
| K | ARG152 |
| K | LYS156 |
| K | ALA196 |
| K | GLY197 |
| K | ALA198 |
| K | ILE199 |
| K | LEU201 |
| K | TYR221 |
| K | ASN222 |
| K | LYS256 |
| K | H4M302 |
| K | HOH418 |
| K | HOH437 |
| K | HOH463 |
| K | HOH469 |
| K | HOH482 |
| K | HOH502 |
| K | HOH516 |
| K | HOH522 |
| K | HOH524 |
| K | HOH528 |
| K | HOH534 |
| K | HOH556 |
| K | HOH576 |
| K | HOH603 |
| site_id | AE8 |
| Number of Residues | 14 |
| Details | binding site for residue H4M K 302 |
| Chain | Residue |
| J | TYR51 |
| K | SER16 |
| K | PHE18 |
| K | ASP19 |
| K | ASN97 |
| K | GLY98 |
| K | LEU250 |
| K | GLY253 |
| K | GLY254 |
| K | LYS256 |
| K | NAP301 |
| K | HOH487 |
| K | HOH557 |
| K | HOH571 |
| site_id | AE9 |
| Number of Residues | 31 |
| Details | binding site for residue NAP L 301 |
| Chain | Residue |
| L | ASN97 |
| L | THR102 |
| L | ALA127 |
| L | THR129 |
| L | GLY130 |
| L | PRO131 |
| L | VAL132 |
| L | GLY151 |
| L | ARG152 |
| L | LYS156 |
| L | ALA196 |
| L | GLY197 |
| L | ALA198 |
| L | ILE199 |
| L | LEU201 |
| L | TYR221 |
| L | ASN222 |
| L | LYS256 |
| L | H4M302 |
| L | HOH402 |
| L | HOH426 |
| L | HOH430 |
| L | HOH455 |
| L | HOH479 |
| L | HOH518 |
| L | HOH527 |
| L | HOH534 |
| L | HOH563 |
| L | HOH572 |
| L | HOH583 |
| L | HOH598 |
| site_id | AF1 |
| Number of Residues | 14 |
| Details | binding site for residue H4M L 302 |
| Chain | Residue |
| L | SER16 |
| L | PHE18 |
| L | ASP19 |
| L | ASN97 |
| L | GLY98 |
| L | LEU250 |
| L | GLY253 |
| L | GLY254 |
| L | LYS256 |
| L | NAP301 |
| L | HOH451 |
| L | HOH484 |
| L | HOH546 |
| L | HOH590 |
| site_id | AF2 |
| Number of Residues | 33 |
| Details | binding site for residue NAP M 301 |
| Chain | Residue |
| M | ASN97 |
| M | THR102 |
| M | THR129 |
| M | GLY130 |
| M | PRO131 |
| M | VAL132 |
| M | GLY151 |
| M | ARG152 |
| M | LYS156 |
| M | ALA196 |
| M | GLY197 |
| M | ALA198 |
| M | ILE199 |
| M | LEU201 |
| M | TYR221 |
| M | ALA249 |
| M | GLY253 |
| M | LYS256 |
| M | H4M302 |
| M | HOH412 |
| M | HOH440 |
| M | HOH461 |
| M | HOH472 |
| M | HOH493 |
| M | HOH499 |
| M | HOH528 |
| M | HOH543 |
| M | HOH548 |
| M | HOH558 |
| M | HOH559 |
| M | HOH572 |
| M | HOH612 |
| M | HOH628 |
| site_id | AF3 |
| Number of Residues | 17 |
| Details | binding site for residue H4M M 302 |
| Chain | Residue |
| M | SER16 |
| M | PHE18 |
| M | ASP19 |
| M | ASN97 |
| M | GLY98 |
| M | LEU250 |
| M | GLY253 |
| M | LYS256 |
| M | LEU257 |
| M | NAP301 |
| M | HOH470 |
| M | HOH474 |
| M | HOH622 |
| M | HOH651 |
| O | TYR51 |
| O | GLY55 |
| O | LYS58 |
| site_id | AF4 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 M 303 |
| Chain | Residue |
| M | TYR24 |
| M | HIS30 |
| M | ILE31 |
| M | HOH417 |
| N | TYR24 |
| N | HIS30 |
| N | ILE31 |
| O | TYR24 |
| O | HIS30 |
| O | HOH446 |
| site_id | AF5 |
| Number of Residues | 33 |
| Details | binding site for residue NAP N 301 |
| Chain | Residue |
| N | ASN97 |
| N | THR102 |
| N | ALA127 |
| N | THR129 |
| N | GLY130 |
| N | PRO131 |
| N | VAL132 |
| N | GLY151 |
| N | ARG152 |
| N | LYS156 |
| N | ALA196 |
| N | GLY197 |
| N | ALA198 |
| N | ILE199 |
| N | LEU201 |
| N | TYR221 |
| N | ASN222 |
| N | LYS256 |
| N | H4M302 |
| N | HOH404 |
| N | HOH428 |
| N | HOH433 |
| N | HOH451 |
| N | HOH486 |
| N | HOH528 |
| N | HOH530 |
| N | HOH534 |
| N | HOH535 |
| N | HOH553 |
| N | HOH562 |
| N | HOH567 |
| N | HOH575 |
| N | HOH612 |
| site_id | AF6 |
| Number of Residues | 14 |
| Details | binding site for residue H4M N 302 |
| Chain | Residue |
| M | TYR51 |
| N | SER16 |
| N | PHE18 |
| N | ASP19 |
| N | ASN97 |
| N | GLY98 |
| N | LEU250 |
| N | GLY253 |
| N | GLY254 |
| N | LYS256 |
| N | NAP301 |
| N | HOH481 |
| N | HOH513 |
| N | HOH631 |
| site_id | AF7 |
| Number of Residues | 30 |
| Details | binding site for residue NAP O 301 |
| Chain | Residue |
| O | ASN97 |
| O | THR102 |
| O | ALA127 |
| O | THR129 |
| O | GLY130 |
| O | PRO131 |
| O | VAL132 |
| O | GLY151 |
| O | ARG152 |
| O | LYS156 |
| O | ALA196 |
| O | GLY197 |
| O | ALA198 |
| O | ILE199 |
| O | LEU201 |
| O | TYR221 |
| O | ASN222 |
| O | LYS256 |
| O | H4M302 |
| O | HOH409 |
| O | HOH438 |
| O | HOH462 |
| O | HOH485 |
| O | HOH508 |
| O | HOH522 |
| O | HOH536 |
| O | HOH554 |
| O | HOH565 |
| O | HOH570 |
| O | HOH597 |
| site_id | AF8 |
| Number of Residues | 15 |
| Details | binding site for residue H4M O 302 |
| Chain | Residue |
| N | TYR51 |
| O | SER16 |
| O | PHE18 |
| O | ASP19 |
| O | ASN97 |
| O | GLY98 |
| O | LEU250 |
| O | GLY253 |
| O | GLY254 |
| O | LYS256 |
| O | NAP301 |
| O | HOH423 |
| O | HOH476 |
| O | HOH615 |
| O | HOH636 |
| site_id | AF9 |
| Number of Residues | 31 |
| Details | binding site for residue NAP P 301 |
| Chain | Residue |
| P | ASN97 |
| P | THR102 |
| P | THR129 |
| P | GLY130 |
| P | PRO131 |
| P | VAL132 |
| P | GLY151 |
| P | ARG152 |
| P | LYS156 |
| P | ALA196 |
| P | GLY197 |
| P | ALA198 |
| P | ILE199 |
| P | LEU201 |
| P | TYR221 |
| P | ALA249 |
| P | GLY253 |
| P | LYS256 |
| P | H4M302 |
| P | HOH407 |
| P | HOH437 |
| P | HOH444 |
| P | HOH463 |
| P | HOH470 |
| P | HOH475 |
| P | HOH482 |
| P | HOH505 |
| P | HOH514 |
| P | HOH525 |
| P | HOH558 |
| P | HOH568 |
| site_id | AG1 |
| Number of Residues | 20 |
| Details | binding site for residue H4M P 302 |
| Chain | Residue |
| C | LYS56 |
| P | SER16 |
| P | PHE18 |
| P | ASP19 |
| P | ASN97 |
| P | GLY98 |
| P | THR102 |
| P | LEU250 |
| P | GLY253 |
| P | LYS256 |
| P | NAP301 |
| P | HOH401 |
| P | HOH438 |
| P | HOH499 |
| R | TYR51 |
| R | GLY54 |
| R | GLY55 |
| R | LYS58 |
| R | PRO87 |
| R | PHE88 |
| site_id | AG2 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 P 303 |
| Chain | Residue |
| P | TYR24 |
| P | HIS30 |
| P | ILE31 |
| P | HOH404 |
| Q | TYR24 |
| Q | HIS30 |
| Q | ILE31 |
| R | TYR24 |
| R | HIS30 |
| R | HOH429 |
| site_id | AG3 |
| Number of Residues | 39 |
| Details | binding site for residue NAP Q 301 |
| Chain | Residue |
| H | GLN158 |
| H | ALA174 |
| Q | ASN97 |
| Q | THR102 |
| Q | ALA127 |
| Q | THR129 |
| Q | GLY130 |
| Q | PRO131 |
| Q | VAL132 |
| Q | GLY151 |
| Q | ARG152 |
| Q | LYS156 |
| Q | ALA196 |
| Q | GLY197 |
| Q | ALA198 |
| Q | ILE199 |
| Q | LEU201 |
| Q | TYR221 |
| Q | ASN222 |
| Q | LYS256 |
| Q | H4M302 |
| Q | HOH430 |
| Q | HOH445 |
| Q | HOH447 |
| Q | HOH461 |
| Q | HOH471 |
| Q | HOH486 |
| Q | HOH498 |
| Q | HOH502 |
| Q | HOH506 |
| Q | HOH507 |
| Q | HOH532 |
| Q | HOH538 |
| Q | HOH589 |
| Q | HOH590 |
| Q | HOH614 |
| Q | HOH624 |
| Q | HOH639 |
| Q | HOH646 |
| site_id | AG4 |
| Number of Residues | 21 |
| Details | binding site for residue H4M Q 302 |
| Chain | Residue |
| P | GLY54 |
| Q | SER16 |
| Q | PHE18 |
| Q | ASP19 |
| Q | ASN97 |
| Q | GLY98 |
| Q | LEU250 |
| Q | GLY253 |
| Q | GLY254 |
| Q | LYS256 |
| Q | LEU257 |
| Q | LYS258 |
| Q | NAP301 |
| Q | HOH508 |
| Q | HOH526 |
| Q | HOH542 |
| Q | HOH577 |
| Q | HOH590 |
| Q | HOH602 |
| Q | HOH617 |
| Q | HOH640 |
| site_id | AG5 |
| Number of Residues | 31 |
| Details | binding site for residue NAP R 301 |
| Chain | Residue |
| R | ASN97 |
| R | THR102 |
| R | ALA127 |
| R | THR129 |
| R | GLY130 |
| R | PRO131 |
| R | VAL132 |
| R | GLY151 |
| R | ARG152 |
| R | LYS156 |
| R | ALA196 |
| R | GLY197 |
| R | ALA198 |
| R | ILE199 |
| R | LEU201 |
| R | TYR221 |
| R | ASN222 |
| R | LYS256 |
| R | H4M302 |
| R | HOH408 |
| R | HOH441 |
| R | HOH448 |
| R | HOH452 |
| R | HOH462 |
| R | HOH468 |
| R | HOH485 |
| R | HOH501 |
| R | HOH508 |
| R | HOH518 |
| R | HOH538 |
| R | HOH540 |
| site_id | AG6 |
| Number of Residues | 12 |
| Details | binding site for residue H4M R 302 |
| Chain | Residue |
| Q | TYR51 |
| Q | PHE88 |
| R | SER16 |
| R | PHE18 |
| R | ASP19 |
| R | ASN97 |
| R | GLY98 |
| R | LEU250 |
| R | LYS256 |
| R | NAP301 |
| R | HOH457 |
| R | HOH469 |
| site_id | AG7 |
| Number of Residues | 30 |
| Details | binding site for residue NAP S 301 |
| Chain | Residue |
| S | ASN97 |
| S | THR102 |
| S | ALA127 |
| S | THR129 |
| S | GLY130 |
| S | PRO131 |
| S | VAL132 |
| S | GLY151 |
| S | ARG152 |
| S | LYS156 |
| S | ALA196 |
| S | GLY197 |
| S | ALA198 |
| S | ILE199 |
| S | LEU201 |
| S | TYR221 |
| S | ALA249 |
| S | GLY253 |
| S | LYS256 |
| S | H4M302 |
| S | HOH436 |
| S | HOH473 |
| S | HOH478 |
| S | HOH479 |
| S | HOH488 |
| S | HOH491 |
| S | HOH497 |
| S | HOH505 |
| S | HOH544 |
| S | HOH560 |
| site_id | AG8 |
| Number of Residues | 16 |
| Details | binding site for residue H4M S 302 |
| Chain | Residue |
| S | SER16 |
| S | PHE18 |
| S | ASP19 |
| S | ASN97 |
| S | GLY98 |
| S | THR102 |
| S | LEU250 |
| S | GLY253 |
| S | LYS256 |
| S | NAP301 |
| S | HOH412 |
| S | HOH448 |
| S | HOH486 |
| U | TYR51 |
| U | GLY54 |
| U | GLY55 |
| site_id | AG9 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 S 303 |
| Chain | Residue |
| T | ILE31 |
| U | TYR24 |
| U | HIS30 |
| U | HOH411 |
| S | TYR24 |
| S | HIS30 |
| S | ILE31 |
| T | TYR24 |
| T | HIS30 |
| site_id | AH1 |
| Number of Residues | 37 |
| Details | binding site for residue NAP T 301 |
| Chain | Residue |
| K | GLN158 |
| T | ASN97 |
| T | THR102 |
| T | ALA127 |
| T | THR129 |
| T | GLY130 |
| T | PRO131 |
| T | VAL132 |
| T | GLY151 |
| T | ARG152 |
| T | LYS156 |
| T | ALA196 |
| T | GLY197 |
| T | ALA198 |
| T | ILE199 |
| T | LEU201 |
| T | TYR221 |
| T | ASN222 |
| T | LYS256 |
| T | H4M302 |
| T | HOH410 |
| T | HOH448 |
| T | HOH453 |
| T | HOH463 |
| T | HOH465 |
| T | HOH474 |
| T | HOH490 |
| T | HOH498 |
| T | HOH501 |
| T | HOH502 |
| T | HOH530 |
| T | HOH532 |
| T | HOH540 |
| T | HOH557 |
| T | HOH567 |
| T | HOH617 |
| T | HOH625 |
| site_id | AH2 |
| Number of Residues | 17 |
| Details | binding site for residue H4M T 302 |
| Chain | Residue |
| S | TYR51 |
| T | SER16 |
| T | PHE18 |
| T | ASP19 |
| T | ASN97 |
| T | GLY98 |
| T | LEU250 |
| T | GLY253 |
| T | GLY254 |
| T | LYS256 |
| T | LEU257 |
| T | NAP301 |
| T | HOH472 |
| T | HOH476 |
| T | HOH537 |
| T | HOH555 |
| T | HOH582 |
| site_id | AH3 |
| Number of Residues | 29 |
| Details | binding site for residue NAP U 301 |
| Chain | Residue |
| U | ASN97 |
| U | THR102 |
| U | ALA127 |
| U | THR129 |
| U | GLY130 |
| U | PRO131 |
| U | VAL132 |
| U | GLY151 |
| U | ARG152 |
| U | LYS156 |
| U | ALA196 |
| U | GLY197 |
| U | ALA198 |
| U | ILE199 |
| U | LEU201 |
| U | TYR221 |
| U | ASN222 |
| U | LYS256 |
| U | H4M302 |
| U | HOH404 |
| U | HOH413 |
| U | HOH443 |
| U | HOH457 |
| U | HOH465 |
| U | HOH467 |
| U | HOH474 |
| U | HOH475 |
| U | HOH533 |
| U | HOH545 |
| site_id | AH4 |
| Number of Residues | 15 |
| Details | binding site for residue H4M U 302 |
| Chain | Residue |
| T | TYR51 |
| T | HOH524 |
| U | SER16 |
| U | PHE18 |
| U | ASP19 |
| U | ASN97 |
| U | GLY98 |
| U | LEU250 |
| U | GLY253 |
| U | GLY254 |
| U | LYS256 |
| U | LEU257 |
| U | NAP301 |
| U | HOH444 |
| U | HOH454 |
| site_id | AH5 |
| Number of Residues | 26 |
| Details | binding site for residue NAP V 301 |
| Chain | Residue |
| V | ASN97 |
| V | THR102 |
| V | THR129 |
| V | GLY130 |
| V | PRO131 |
| V | VAL132 |
| V | GLY151 |
| V | ARG152 |
| V | LYS156 |
| V | ALA196 |
| V | GLY197 |
| V | ALA198 |
| V | ILE199 |
| V | LEU201 |
| V | TYR221 |
| V | ALA249 |
| V | GLY253 |
| V | LYS256 |
| V | H4M302 |
| V | HOH412 |
| V | HOH441 |
| V | HOH457 |
| V | HOH458 |
| V | HOH490 |
| V | HOH497 |
| V | HOH507 |
| site_id | AH6 |
| Number of Residues | 16 |
| Details | binding site for residue H4M V 302 |
| Chain | Residue |
| V | SER16 |
| V | PHE18 |
| V | ASP19 |
| V | ASN97 |
| V | GLY98 |
| V | THR102 |
| V | LEU250 |
| V | GLY253 |
| V | LYS256 |
| V | LEU257 |
| V | NAP301 |
| V | HOH431 |
| V | HOH447 |
| V | HOH468 |
| X | TYR51 |
| X | LYS58 |
| site_id | AH7 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 V 303 |
| Chain | Residue |
| V | TYR24 |
| V | HIS30 |
| V | ILE31 |
| W | TYR24 |
| W | HIS30 |
| W | ILE31 |
| X | TYR24 |
| X | HIS30 |
| X | HOH438 |
| site_id | AH8 |
| Number of Residues | 38 |
| Details | binding site for residue NAP W 301 |
| Chain | Residue |
| B | GLN158 |
| B | ALA174 |
| W | ASN97 |
| W | THR102 |
| W | ALA127 |
| W | THR129 |
| W | GLY130 |
| W | PRO131 |
| W | VAL132 |
| W | GLY151 |
| W | ARG152 |
| W | LYS156 |
| W | ALA196 |
| W | GLY197 |
| W | ALA198 |
| W | ILE199 |
| W | LEU201 |
| W | TYR221 |
| W | ASN222 |
| W | LYS256 |
| W | H4M302 |
| W | HOH417 |
| W | HOH438 |
| W | HOH465 |
| W | HOH476 |
| W | HOH477 |
| W | HOH488 |
| W | HOH494 |
| W | HOH497 |
| W | HOH499 |
| W | HOH529 |
| W | HOH531 |
| W | HOH547 |
| W | HOH548 |
| W | HOH550 |
| W | HOH554 |
| W | HOH595 |
| W | HOH615 |
| site_id | AH9 |
| Number of Residues | 22 |
| Details | binding site for residue H4M W 302 |
| Chain | Residue |
| V | GLY54 |
| V | GLY55 |
| V | LYS56 |
| V | GLU57 |
| W | SER16 |
| W | PHE18 |
| W | ASP19 |
| W | ASN97 |
| W | GLY98 |
| W | LEU250 |
| W | GLY253 |
| W | GLY254 |
| W | LYS256 |
| W | LEU257 |
| W | NAP301 |
| W | HOH456 |
| W | HOH473 |
| W | HOH494 |
| W | HOH516 |
| W | HOH525 |
| W | HOH542 |
| W | HOH616 |
| site_id | AI1 |
| Number of Residues | 32 |
| Details | binding site for residue NAP X 301 |
| Chain | Residue |
| X | ASN97 |
| X | THR102 |
| X | ALA127 |
| X | THR129 |
| X | GLY130 |
| X | PRO131 |
| X | VAL132 |
| X | GLY151 |
| X | ARG152 |
| X | LYS156 |
| X | ALA196 |
| X | GLY197 |
| X | ALA198 |
| X | ILE199 |
| X | LEU201 |
| X | TYR221 |
| X | ASN222 |
| X | LYS256 |
| X | H4M302 |
| X | HOH404 |
| X | HOH408 |
| X | HOH425 |
| X | HOH427 |
| X | HOH431 |
| X | HOH434 |
| X | HOH436 |
| X | HOH443 |
| X | HOH449 |
| X | HOH451 |
| X | HOH452 |
| X | HOH459 |
| X | HOH481 |
| site_id | AI2 |
| Number of Residues | 13 |
| Details | binding site for residue H4M X 302 |
| Chain | Residue |
| W | TYR51 |
| W | PHE88 |
| X | SER16 |
| X | PHE18 |
| X | ASP19 |
| X | ASN97 |
| X | GLY98 |
| X | LEU250 |
| X | LYS256 |
| X | NAP301 |
| X | HOH413 |
| X | HOH439 |
| X | HOH481 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 96 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:11297742 |
| Chain | Residue | Details |
| A | THR129 | |
| C | ARG152 | |
| C | THR195 | |
| C | LYS256 | |
| D | THR129 | |
| D | ARG152 | |
| D | THR195 | |
| D | LYS256 | |
| E | THR129 | |
| E | ARG152 | |
| E | THR195 | |
| A | ARG152 | |
| E | LYS256 | |
| F | THR129 | |
| F | ARG152 | |
| F | THR195 | |
| F | LYS256 | |
| G | THR129 | |
| G | ARG152 | |
| G | THR195 | |
| G | LYS256 | |
| H | THR129 | |
| A | THR195 | |
| H | ARG152 | |
| H | THR195 | |
| H | LYS256 | |
| I | THR129 | |
| I | ARG152 | |
| I | THR195 | |
| I | LYS256 | |
| J | THR129 | |
| J | ARG152 | |
| J | THR195 | |
| A | LYS256 | |
| J | LYS256 | |
| K | THR129 | |
| K | ARG152 | |
| K | THR195 | |
| K | LYS256 | |
| L | THR129 | |
| L | ARG152 | |
| L | THR195 | |
| L | LYS256 | |
| M | THR129 | |
| B | THR129 | |
| M | ARG152 | |
| M | THR195 | |
| M | LYS256 | |
| N | THR129 | |
| N | ARG152 | |
| N | THR195 | |
| N | LYS256 | |
| O | THR129 | |
| O | ARG152 | |
| O | THR195 | |
| B | ARG152 | |
| O | LYS256 | |
| P | THR129 | |
| P | ARG152 | |
| P | THR195 | |
| P | LYS256 | |
| Q | THR129 | |
| Q | ARG152 | |
| Q | THR195 | |
| Q | LYS256 | |
| R | THR129 | |
| B | THR195 | |
| R | ARG152 | |
| R | THR195 | |
| R | LYS256 | |
| S | THR129 | |
| S | ARG152 | |
| S | THR195 | |
| S | LYS256 | |
| T | THR129 | |
| T | ARG152 | |
| T | THR195 | |
| B | LYS256 | |
| T | LYS256 | |
| U | THR129 | |
| U | ARG152 | |
| U | THR195 | |
| U | LYS256 | |
| V | THR129 | |
| V | ARG152 | |
| V | THR195 | |
| V | LYS256 | |
| W | THR129 | |
| C | THR129 | |
| W | ARG152 | |
| W | THR195 | |
| W | LYS256 | |
| X | THR129 | |
| X | ARG152 | |
| X | THR195 | |
| X | LYS256 |
