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6TE6

Crystal structure of Dot1L in complex with an inhibitor (compound 3).

Functional Information from GO Data
ChainGOidnamespacecontents
A0031151molecular_functionhistone H3K79 methyltransferase activity
A0051726biological_processregulation of cell cycle
B0031151molecular_functionhistone H3K79 methyltransferase activity
B0051726biological_processregulation of cell cycle
Functional Information from PDB Data
site_idAC1
Number of Residues16
Detailsbinding site for residue N4W A 401
ChainResidue
APRO130
APHE243
ASER268
ASER269
AVAL310
ASER311
ATYR312
AHOH582
APHE131
ASER140
ALEU143
AMET147
AVAL169
APHE239
AVAL240
AASN241

site_idAC2
Number of Residues16
Detailsbinding site for residue N4W B 401
ChainResidue
AARG42
BPRO130
BPHE131
BSER140
BLEU143
BMET147
BVAL169
BPHE239
BVAL240
BASN241
BPHE243
BSER268
BSER269
BVAL310
BSER311
BTYR312

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues8
DetailsBINDING:
ChainResidueDetails
ATYR136
APHE159
AGLU186
AASP222
BTYR136
BPHE159
BGLU186
BASP222

site_idSWS_FT_FI2
Number of Residues2
DetailsMOD_RES: Phosphoserine => ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER297
BSER297

223532

PDB entries from 2024-08-07

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