Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6TDS

Crystal structure of the disulfide engineered HLA-A0201 molecule without peptide bound after NaCl wash

Functional Information from GO Data

Chain	GOid	namespace	contents
B	0000139	cellular_component	Golgi membrane
B	0001913	biological_process	T cell mediated cytotoxicity
B	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
B	0002237	biological_process	response to molecule of bacterial origin
B	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
B	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
B	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
B	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
B	0002726	biological_process	positive regulation of T cell cytokine production
B	0005198	molecular_function	structural molecule activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005765	cellular_component	lysosomal membrane
B	0005783	cellular_component	endoplasmic reticulum
B	0005788	cellular_component	endoplasmic reticulum lumen
B	0005794	cellular_component	Golgi apparatus
B	0005829	cellular_component	cytosol
B	0005886	cellular_component	plasma membrane
B	0005925	cellular_component	focal adhesion
B	0006826	biological_process	iron ion transport
B	0006879	biological_process	intracellular iron ion homeostasis
B	0006955	biological_process	immune response
B	0007608	biological_process	sensory perception of smell
B	0007611	biological_process	learning or memory
B	0009897	cellular_component	external side of plasma membrane
B	0009986	cellular_component	cell surface
B	0010977	biological_process	negative regulation of neuron projection development
B	0012507	cellular_component	ER to Golgi transport vesicle membrane
B	0016020	cellular_component	membrane
B	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
B	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
B	0023026	molecular_function	MHC class II protein complex binding
B	0030670	cellular_component	phagocytic vesicle membrane
B	0031901	cellular_component	early endosome membrane
B	0031902	cellular_component	late endosome membrane
B	0031905	cellular_component	early endosome lumen
B	0032092	biological_process	positive regulation of protein binding
B	0033077	biological_process	T cell differentiation in thymus
B	0034756	biological_process	regulation of iron ion transport
B	0035580	cellular_component	specific granule lumen
B	0042026	biological_process	protein refolding
B	0042605	molecular_function	peptide antigen binding
B	0042612	cellular_component	MHC class I protein complex
B	0042613	cellular_component	MHC class II protein complex
B	0042802	molecular_function	identical protein binding
B	0042803	molecular_function	protein homodimerization activity
B	0042824	cellular_component	MHC class I peptide loading complex
B	0045646	biological_process	regulation of erythrocyte differentiation
B	0048260	biological_process	positive regulation of receptor-mediated endocytosis
B	0050680	biological_process	negative regulation of epithelial cell proliferation
B	0050768	biological_process	negative regulation of neurogenesis
B	0050778	biological_process	positive regulation of immune response
B	0050870	biological_process	positive regulation of T cell activation
B	0051289	biological_process	protein homotetramerization
B	0055038	cellular_component	recycling endosome membrane
B	0060586	biological_process	multicellular organismal-level iron ion homeostasis
B	0070062	cellular_component	extracellular exosome
B	0071281	biological_process	cellular response to iron ion
B	0071283	biological_process	cellular response to iron(III) ion
B	0071316	biological_process	cellular response to nicotine
B	1900121	biological_process	negative regulation of receptor binding
B	1900122	biological_process	positive regulation of receptor binding
B	1904434	biological_process	positive regulation of ferrous iron binding
B	1904437	biological_process	positive regulation of transferrin receptor binding
B	1904724	cellular_component	tertiary granule lumen
B	1990000	biological_process	amyloid fibril formation
B	1990712	cellular_component	HFE-transferrin receptor complex
B	2000774	biological_process	positive regulation of cellular senescence
B	2000978	biological_process	negative regulation of forebrain neuron differentiation
D	0000139	cellular_component	Golgi membrane
D	0001913	biological_process	T cell mediated cytotoxicity
D	0001916	biological_process	positive regulation of T cell mediated cytotoxicity
D	0002237	biological_process	response to molecule of bacterial origin
D	0002474	biological_process	antigen processing and presentation of peptide antigen via MHC class I
D	0002481	biological_process	antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent
D	0002502	biological_process	peptide antigen assembly with MHC class I protein complex
D	0002503	biological_process	peptide antigen assembly with MHC class II protein complex
D	0002726	biological_process	positive regulation of T cell cytokine production
D	0005198	molecular_function	structural molecule activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005765	cellular_component	lysosomal membrane
D	0005783	cellular_component	endoplasmic reticulum
D	0005788	cellular_component	endoplasmic reticulum lumen
D	0005794	cellular_component	Golgi apparatus
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0005925	cellular_component	focal adhesion
D	0006826	biological_process	iron ion transport
D	0006879	biological_process	intracellular iron ion homeostasis
D	0006955	biological_process	immune response
D	0007608	biological_process	sensory perception of smell
D	0007611	biological_process	learning or memory
D	0009897	cellular_component	external side of plasma membrane
D	0009986	cellular_component	cell surface
D	0010977	biological_process	negative regulation of neuron projection development
D	0012507	cellular_component	ER to Golgi transport vesicle membrane
D	0016020	cellular_component	membrane
D	0019885	biological_process	antigen processing and presentation of endogenous peptide antigen via MHC class I
D	0019886	biological_process	antigen processing and presentation of exogenous peptide antigen via MHC class II
D	0023026	molecular_function	MHC class II protein complex binding
D	0030670	cellular_component	phagocytic vesicle membrane
D	0031901	cellular_component	early endosome membrane
D	0031902	cellular_component	late endosome membrane
D	0031905	cellular_component	early endosome lumen
D	0032092	biological_process	positive regulation of protein binding
D	0033077	biological_process	T cell differentiation in thymus
D	0034756	biological_process	regulation of iron ion transport
D	0035580	cellular_component	specific granule lumen
D	0042026	biological_process	protein refolding
D	0042605	molecular_function	peptide antigen binding
D	0042612	cellular_component	MHC class I protein complex
D	0042613	cellular_component	MHC class II protein complex
D	0042802	molecular_function	identical protein binding
D	0042803	molecular_function	protein homodimerization activity
D	0042824	cellular_component	MHC class I peptide loading complex
D	0045646	biological_process	regulation of erythrocyte differentiation
D	0048260	biological_process	positive regulation of receptor-mediated endocytosis
D	0050680	biological_process	negative regulation of epithelial cell proliferation
D	0050768	biological_process	negative regulation of neurogenesis
D	0050778	biological_process	positive regulation of immune response
D	0050870	biological_process	positive regulation of T cell activation
D	0051289	biological_process	protein homotetramerization
D	0055038	cellular_component	recycling endosome membrane
D	0060586	biological_process	multicellular organismal-level iron ion homeostasis
D	0070062	cellular_component	extracellular exosome
D	0071281	biological_process	cellular response to iron ion
D	0071283	biological_process	cellular response to iron(III) ion
D	0071316	biological_process	cellular response to nicotine
D	1900121	biological_process	negative regulation of receptor binding
D	1900122	biological_process	positive regulation of receptor binding
D	1904434	biological_process	positive regulation of ferrous iron binding
D	1904437	biological_process	positive regulation of transferrin receptor binding
D	1904724	cellular_component	tertiary granule lumen
D	1990000	biological_process	amyloid fibril formation
D	1990712	cellular_component	HFE-transferrin receptor complex
D	2000774	biological_process	positive regulation of cellular senescence
D	2000978	biological_process	negative regulation of forebrain neuron differentiation

Functional Information from PDB Data

site_id	AC1
Number of Residues	7
Details	binding site for residue EDO A 501

Chain	Residue
A	MET5
A	TYR7
A	GLU63
A	TYR159
A	TRP167
A	TYR171
A	EDO502

site_id	AC2
Number of Residues	3
Details	binding site for residue EDO A 502

Chain	Residue
A	EDO501
A	TYR99
A	TYR159

site_id	AC3
Number of Residues	3
Details	binding site for residue NA A 503

Chain	Residue
A	LEU270
A	THR271
A	NA507

site_id	AC4
Number of Residues	6
Details	binding site for residue NA A 504

Chain	Residue
A	THR94
A	GLN96
A	ALA117
A	TYR118
A	ASP119
A	GLY120

site_id	AC5
Number of Residues	4
Details	binding site for residue NA A 505

Chain	Residue
A	TYR7
A	VAL34
A	TYR59
A	GLU63

site_id	AC6
Number of Residues	4
Details	binding site for residue NA A 506

Chain	Residue
A	LYS176
A	GLU177
A	GLN180
A	ARG181

site_id	AC7
Number of Residues	2
Details	binding site for residue NA A 507

Chain	Residue
A	PRO269
A	NA503

site_id	AC8
Number of Residues	6
Details	binding site for residue CL A 509

Chain	Residue
A	HIS188
A	THR190
A	TRP204
A	HOH680
A	HOH700
B	MET100

site_id	AC9
Number of Residues	5
Details	binding site for residue EDO B 201

Chain	Residue
A	ARG21
A	ILE23
B	SER34
B	EDO202
B	HOH306

site_id	AD1
Number of Residues	4
Details	binding site for residue EDO B 202

Chain	Residue
A	VAL12
B	SER34
B	ASP35
B	EDO201

site_id	AD2
Number of Residues	3
Details	binding site for residue NA B 203

Chain	Residue
B	ILE2
B	GLN3
B	HOH347

site_id	AD3
Number of Residues	3
Details	binding site for residue NA B 204

Chain	Residue
B	ILE8
B	HOH318
B	HOH348

site_id	AD4
Number of Residues	3
Details	binding site for residue CL B 205

Chain	Residue
B	ARG4
B	THR5
B	HOH319

site_id	AD5
Number of Residues	3
Details	binding site for residue EDO C 401

Chain	Residue
C	GLU166
C	TRP167
C	ARG170

site_id	AD6
Number of Residues	6
Details	binding site for residue EDO C 402

Chain	Residue
C	TYR7
C	GLU63
C	TYR99
C	TYR159
C	EDO403
C	HOH558

site_id	AD7
Number of Residues	6
Details	binding site for residue EDO C 403

Chain	Residue
C	MET5
C	TYR7
C	TYR159
C	TRP167
C	TYR171
C	EDO402

site_id	AD8
Number of Residues	4
Details	binding site for residue NA C 404

Chain	Residue
C	LYS186
C	HIS188
C	LEU206
C	HOH573

site_id	AD9
Number of Residues	3
Details	binding site for residue NA C 405

Chain	Residue
C	THR10
C	ILE23
D	LEU55

site_id	AE1
Number of Residues	4
Details	binding site for residue NA C 406

Chain	Residue
C	ARG202
C	GLU229
C	TRP244
C	CL411

site_id	AE2
Number of Residues	2
Details	binding site for residue NA C 407

Chain	Residue
C	GLU229
C	TRP244

site_id	AE3
Number of Residues	3
Details	binding site for residue NA C 408

Chain	Residue
C	GLN32
C	ARG48
D	ASP54

site_id	AE4
Number of Residues	3
Details	binding site for residue NA C 409

Chain	Residue
C	ALA40
C	SER42
C	GLU46

site_id	AE5
Number of Residues	1
Details	binding site for residue CL C 410

Chain	Residue
C	ARG169

site_id	AE6
Number of Residues	2
Details	binding site for residue CL C 411

Chain	Residue
C	ARG202
C	NA406

site_id	AE7
Number of Residues	3
Details	binding site for residue CL C 412

Chain	Residue
C	TRP204
C	ARG234
C	TRP244

site_id	AE8
Number of Residues	4
Details	binding site for residue CL C 413

Chain	Residue
C	LEU78
C	ARG82
C	HIS93
C	TYR118

site_id	AE9
Number of Residues	1
Details	binding site for residue CL C 414

Chain	Residue
C	ASP77

site_id	AF1
Number of Residues	6
Details	binding site for residue NA D 201

Chain	Residue
D	HIS85
D	LEU88
D	HOH344
D	HOH345
D	HOH346
D	ASN84

Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACRVNH

Chain	Residue	Details
B	TYR79-HIS85
A	TYR257-HIS263

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269\|PubMed:7554280

Chain	Residue	Details
B	GLN3
D	GLN3

site_id	SWS_FT_FI2
Number of Residues	2
Details	CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	ILE2
D	ILE2

site_id	SWS_FT_FI3
Number of Residues	12
Details	CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269\|PubMed:7918443

Chain	Residue	Details
B	LYS20
D	LYS59
D	LYS92
D	LYS95
B	LYS42
B	LYS49
B	LYS59
B	LYS92
B	LYS95
D	LYS20
D	LYS42
D	LYS49

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)