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6TD6

Structure of Drosophila melanogaster Dispatched bound to a modified Hedgehog ligand, HhN-C85II

Functional Information from GO Data
ChainGOidnamespacecontents
A0005886cellular_componentplasma membrane
A0007224biological_processsmoothened signaling pathway
A0007225biological_processpatched ligand maturation
A0007367biological_processsegment polarity determination
A0008354biological_processgerm cell migration
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0035222biological_processwing disc pattern formation
A0035230cellular_componentcytoneme
A0055085biological_processtransmembrane transport
B0001708biological_processcell fate specification
B0001745biological_processcompound eye morphogenesis
B0001746biological_processBolwig's organ morphogenesis
B0001751biological_processcompound eye photoreceptor cell differentiation
B0002052biological_processpositive regulation of neuroblast proliferation
B0002385biological_processmucosal immune response
B0005113molecular_functionpatched binding
B0005509molecular_functioncalcium ion binding
B0005515molecular_functionprotein binding
B0005576cellular_componentextracellular region
B0005615cellular_componentextracellular space
B0005634cellular_componentnucleus
B0005737cellular_componentcytoplasm
B0005768cellular_componentendosome
B0005829cellular_componentcytosol
B0005886cellular_componentplasma membrane
B0006508biological_processproteolysis
B0007224biological_processsmoothened signaling pathway
B0007267biological_processcell-cell signaling
B0007275biological_processmulticellular organism development
B0007346biological_processregulation of mitotic cell cycle
B0007367biological_processsegment polarity determination
B0007386biological_processcompartment pattern specification
B0007418biological_processventral midline development
B0007427biological_processepithelial cell migration, open tracheal system
B0007440biological_processforegut morphogenesis
B0007442biological_processhindgut morphogenesis
B0007446biological_processimaginal disc growth
B0007458biological_processprogression of morphogenetic furrow involved in compound eye morphogenesis
B0007473biological_processwing disc proximal/distal pattern formation
B0007476biological_processimaginal disc-derived wing morphogenesis
B0007478biological_processleg disc morphogenesis
B0007487biological_processanalia development
B0007506biological_processgonadal mesoderm development
B0007507biological_processheart development
B0008233molecular_functionpeptidase activity
B0008347biological_processglial cell migration
B0008354biological_processgerm cell migration
B0008544biological_processepidermis development
B0009653biological_processanatomical structure morphogenesis
B0009880biological_processembryonic pattern specification
B0010468biological_processregulation of gene expression
B0016015molecular_functionmorphogen activity
B0016335biological_processmorphogenesis of larval imaginal disc epithelium
B0016539biological_processintein-mediated protein splicing
B0016540biological_processprotein autoprocessing
B0016740molecular_functiontransferase activity
B0030139cellular_componentendocytic vesicle
B0031410cellular_componentcytoplasmic vesicle
B0034111biological_processnegative regulation of homotypic cell-cell adhesion
B0035154biological_processterminal cell fate specification, open tracheal system
B0035215biological_processgenital disc development
B0035217biological_processlabial disc development
B0035222biological_processwing disc pattern formation
B0035224biological_processgenital disc anterior/posterior pattern formation
B0035231biological_processcytoneme assembly
B0035232biological_processgerm cell attraction
B0035277biological_processspiracle morphogenesis, open tracheal system
B0035288biological_processanterior head segmentation
B0035289biological_processposterior head segmentation
B0035290biological_processtrunk segmentation
B0045168biological_processcell-cell signaling involved in cell fate commitment
B0045861biological_processnegative regulation of proteolysis
B0046872molecular_functionmetal ion binding
B0048066biological_processdevelopmental pigmentation
B0048099biological_processanterior/posterior lineage restriction, imaginal disc
B0048100biological_processwing disc anterior/posterior pattern formation
B0048731biological_processsystem development
B0060914biological_processheart formation
B0097264biological_processself proteolysis
B0140853molecular_functioncholesterol-protein transferase activity
B2000010biological_processpositive regulation of protein localization to cell surface
B2000274biological_processregulation of epithelial cell migration, open tracheal system
B2000495biological_processregulation of cell proliferation involved in compound eye morphogenesis
Functional Information from PROSITE/UniProt
site_idPS00435
Number of Residues11
DetailsPEROXIDASE_1 Peroxidases proximal heme-ligand signature. TTEDVTSLHTL
ChainResidueDetails
ATHR327-LEU337

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues7
DetailsBINDING: BINDING => ECO:0000250|UniProtKB:Q15465
ChainResidueDetails
BGLU149
AILE1019-TYR1039
AILE1058-ALA1078
AILE1087-MET1107
BGLU150
BASP155
BTHR185
BGLU186
BASP189
BASP191
ALEU975-VAL995
ASER996-LEU1016

site_idSWS_FT_FI2
Number of Residues1
DetailsSITE: Cleavage; by autolysis => ECO:0000269|PubMed:7885476
ChainResidueDetails
BGLY257
AASN176
AASN197
AASN264
AASN319
AASN767
AASN883
AASN891

site_idSWS_FT_FI3
Number of Residues1
DetailsSITE: Involved in cholesterol transfer => ECO:0000269|PubMed:9335337
ChainResidueDetails
BASP303

site_idSWS_FT_FI4
Number of Residues1
DetailsSITE: Involved in auto-cleavage => ECO:0000269|PubMed:9335337
ChainResidueDetails
BTHR326

site_idSWS_FT_FI5
Number of Residues1
DetailsSITE: Essential for auto-cleavage => ECO:0000269|PubMed:7885476, ECO:0000269|PubMed:9335337
ChainResidueDetails
BHIS329

site_idSWS_FT_FI6
Number of Residues1
DetailsLIPID: N-palmitoyl cysteine => ECO:0000269|PubMed:11486055
ChainResidueDetails
BCYS85

site_idSWS_FT_FI7
Number of Residues1
DetailsLIPID: Cholesterol glycine ester => ECO:0000269|PubMed:11486055
ChainResidueDetails
BGLY257

220113

PDB entries from 2024-05-22

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