6TAJ
Crystal structure of Escherichia coli Orotate Phosphoribosyltransferase in complex with Orotic acid 1.60 Angstrom resolution
This is a non-PDB format compatible entry.
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| AAA | 0000287 | molecular_function | magnesium ion binding |
| AAA | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| AAA | 0005737 | cellular_component | cytoplasm |
| AAA | 0005829 | cellular_component | cytosol |
| AAA | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| AAA | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| AAA | 0016740 | molecular_function | transferase activity |
| AAA | 0016757 | molecular_function | glycosyltransferase activity |
| AAA | 0042803 | molecular_function | protein homodimerization activity |
| AAA | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| AAA | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| AAA | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| AAA | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
| BBB | 0000287 | molecular_function | magnesium ion binding |
| BBB | 0004588 | molecular_function | orotate phosphoribosyltransferase activity |
| BBB | 0005737 | cellular_component | cytoplasm |
| BBB | 0005829 | cellular_component | cytosol |
| BBB | 0006207 | biological_process | 'de novo' pyrimidine nucleobase biosynthetic process |
| BBB | 0006221 | biological_process | pyrimidine nucleotide biosynthetic process |
| BBB | 0016740 | molecular_function | transferase activity |
| BBB | 0016757 | molecular_function | glycosyltransferase activity |
| BBB | 0042803 | molecular_function | protein homodimerization activity |
| BBB | 0044205 | biological_process | 'de novo' UMP biosynthetic process |
| BBB | 0046132 | biological_process | pyrimidine ribonucleoside biosynthetic process |
| BBB | 0055086 | biological_process | nucleobase-containing small molecule metabolic process |
| BBB | 0072528 | biological_process | pyrimidine-containing compound biosynthetic process |
Functional Information from PROSITE/UniProt
| site_id | PS00103 |
| Number of Residues | 13 |
| Details | PUR_PYR_PR_TRANSFER Purine/pyrimidine phosphoribosyl transferases signature. VMLVDDVITAGtA |
| Chain | Residue | Details |
| AAA | VAL120-ALA132 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01208 |
| Chain | Residue | Details |
| AAA | LYS26 | |
| AAA | ASP124 | |
| BBB | LYS26 | |
| BBB | ASP124 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01208 |
| Chain | Residue | Details |
| AAA | PHE34 | |
| AAA | HIS105 | |
| AAA | THR128 | |
| AAA | ARG156 | |
| BBB | PHE34 | |
| BBB | HIS105 | |
| BBB | THR128 | |
| BBB | ARG156 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | BINDING: in other chain => ECO:0000255|HAMAP-Rule:MF_01208, ECO:0000305|PubMed:8620002 |
| Chain | Residue | Details |
| AAA | TYR72 | |
| AAA | LYS100 | |
| BBB | TYR72 | |
| BBB | LYS100 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01208, ECO:0000305|PubMed:8620002 |
| Chain | Residue | Details |
| AAA | ARG99 | |
| AAA | LYS103 | |
| BBB | ARG99 | |
| BBB | LYS103 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 2 |
| Details | M-CSA 873 |
| Chain | Residue | Details |
| AAA | LYS103 | electrostatic stabiliser, proton acceptor, proton donor |
| AAA | HIS105 | electrostatic stabiliser |
| site_id | MCSA2 |
| Number of Residues | 2 |
| Details | M-CSA 873 |
| Chain | Residue | Details |
| BBB | LYS103 | electrostatic stabiliser, proton acceptor, proton donor |
| BBB | HIS105 | electrostatic stabiliser |
