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6TA6

MexAB assembly of the Pseudomonas MexAB-OprM efflux pump reconstituted in nanodiscs

Functional Information from GO Data
ChainGOidnamespacecontents
A0009279cellular_componentcell outer membrane
A0015562molecular_functionefflux transmembrane transporter activity
A0016020cellular_componentmembrane
A0022857molecular_functiontransmembrane transporter activity
A0046677biological_processresponse to antibiotic
A0055085biological_processtransmembrane transport
B0009279cellular_componentcell outer membrane
B0015562molecular_functionefflux transmembrane transporter activity
B0016020cellular_componentmembrane
B0022857molecular_functiontransmembrane transporter activity
B0046677biological_processresponse to antibiotic
B0055085biological_processtransmembrane transport
C0009279cellular_componentcell outer membrane
C0015562molecular_functionefflux transmembrane transporter activity
C0016020cellular_componentmembrane
C0022857molecular_functiontransmembrane transporter activity
C0046677biological_processresponse to antibiotic
C0055085biological_processtransmembrane transport
D0005886cellular_componentplasma membrane
D0015562molecular_functionefflux transmembrane transporter activity
D0015721biological_processbile acid and bile salt transport
D0016020cellular_componentmembrane
D0022857molecular_functiontransmembrane transporter activity
D0042221biological_processresponse to chemical
D0042802molecular_functionidentical protein binding
D0046677biological_processresponse to antibiotic
D0051260biological_processprotein homooligomerization
D0055085biological_processtransmembrane transport
E0005886cellular_componentplasma membrane
E0015562molecular_functionefflux transmembrane transporter activity
E0015721biological_processbile acid and bile salt transport
E0016020cellular_componentmembrane
E0022857molecular_functiontransmembrane transporter activity
E0042221biological_processresponse to chemical
E0042802molecular_functionidentical protein binding
E0046677biological_processresponse to antibiotic
E0051260biological_processprotein homooligomerization
E0055085biological_processtransmembrane transport
F0005886cellular_componentplasma membrane
F0015562molecular_functionefflux transmembrane transporter activity
F0015721biological_processbile acid and bile salt transport
F0016020cellular_componentmembrane
F0022857molecular_functiontransmembrane transporter activity
F0042221biological_processresponse to chemical
F0042802molecular_functionidentical protein binding
F0046677biological_processresponse to antibiotic
F0051260biological_processprotein homooligomerization
F0055085biological_processtransmembrane transport
G0005886cellular_componentplasma membrane
G0015562molecular_functionefflux transmembrane transporter activity
G0015721biological_processbile acid and bile salt transport
G0016020cellular_componentmembrane
G0022857molecular_functiontransmembrane transporter activity
G0042221biological_processresponse to chemical
G0042802molecular_functionidentical protein binding
G0046677biological_processresponse to antibiotic
G0051260biological_processprotein homooligomerization
G0055085biological_processtransmembrane transport
H0005886cellular_componentplasma membrane
H0015562molecular_functionefflux transmembrane transporter activity
H0015721biological_processbile acid and bile salt transport
H0016020cellular_componentmembrane
H0022857molecular_functiontransmembrane transporter activity
H0042221biological_processresponse to chemical
H0042802molecular_functionidentical protein binding
H0046677biological_processresponse to antibiotic
H0051260biological_processprotein homooligomerization
H0055085biological_processtransmembrane transport
I0005886cellular_componentplasma membrane
I0015562molecular_functionefflux transmembrane transporter activity
I0015721biological_processbile acid and bile salt transport
I0016020cellular_componentmembrane
I0022857molecular_functiontransmembrane transporter activity
I0042221biological_processresponse to chemical
I0042802molecular_functionidentical protein binding
I0046677biological_processresponse to antibiotic
I0051260biological_processprotein homooligomerization
I0055085biological_processtransmembrane transport
J0005515molecular_functionprotein binding
J0005886cellular_componentplasma membrane
J0015562molecular_functionefflux transmembrane transporter activity
J0016020cellular_componentmembrane
J0022857molecular_functiontransmembrane transporter activity
J0042908biological_processxenobiotic transport
J0042910molecular_functionxenobiotic transmembrane transporter activity
J0046677biological_processresponse to antibiotic
J0055085biological_processtransmembrane transport
K0005515molecular_functionprotein binding
K0005886cellular_componentplasma membrane
K0015562molecular_functionefflux transmembrane transporter activity
K0016020cellular_componentmembrane
K0022857molecular_functiontransmembrane transporter activity
K0042908biological_processxenobiotic transport
K0042910molecular_functionxenobiotic transmembrane transporter activity
K0046677biological_processresponse to antibiotic
K0055085biological_processtransmembrane transport
L0005515molecular_functionprotein binding
L0005886cellular_componentplasma membrane
L0015562molecular_functionefflux transmembrane transporter activity
L0016020cellular_componentmembrane
L0022857molecular_functiontransmembrane transporter activity
L0042908biological_processxenobiotic transport
L0042910molecular_functionxenobiotic transmembrane transporter activity
L0046677biological_processresponse to antibiotic
L0055085biological_processtransmembrane transport
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues390
DetailsTOPO_DOM: Cytoplasmic => ECO:0000269|PubMed:10187844
ChainResidueDetails
JMET1-PRO9
KGLU414-ALA441
KLEU497-ARG538
KGLU892-PRO897
KGLU946-PRO972
KSER1028-GLN1046
LMET1-PRO9
LGLN360-THR365
LGLU414-ALA441
LLEU497-ARG538
LGLU892-PRO897
JGLN360-THR365
LGLU946-PRO972
LSER1028-GLN1046
JGLU414-ALA441
JLEU497-ARG538
JGLU892-PRO897
JGLU946-PRO972
JSER1028-GLN1046
KMET1-PRO9
KGLN360-THR365

site_idSWS_FT_FI2
Number of Residues702
DetailsTRANSMEM: Helical
ChainResidueDetails
JILE10-LEU28
JVAL924-VAL945
JILE973-THR991
JVAL1005-VAL1027
KILE10-LEU28
KVAL340-LEU359
KLEU366-ALA385
KTHR392-VAL413
KLEU442-GLY460
KILE474-MET496
KALA539-THR557
JVAL340-LEU359
KALA872-TYR891
KPHE898-MET917
KVAL924-VAL945
KILE973-THR991
KVAL1005-VAL1027
LILE10-LEU28
LVAL340-LEU359
LLEU366-ALA385
LTHR392-VAL413
LLEU442-GLY460
JLEU366-ALA385
LILE474-MET496
LALA539-THR557
LALA872-TYR891
LPHE898-MET917
LVAL924-VAL945
LILE973-THR991
LVAL1005-VAL1027
JTHR392-VAL413
JLEU442-GLY460
JILE474-MET496
JALA539-THR557
JALA872-TYR891
JPHE898-MET917

site_idSWS_FT_FI3
Number of Residues1971
DetailsTOPO_DOM: Periplasmic => ECO:0000269|PubMed:10187844
ChainResidueDetails
JSER29-GLU339
KARG558-GLN871
KARG918-ASP923
KGLY992-GLY1004
LSER29-GLU339
LPHE386-ASN391
LGLY461-THR473
LARG558-GLN871
LARG918-ASP923
LGLY992-GLY1004
JPHE386-ASN391
JGLY461-THR473
JARG558-GLN871
JARG918-ASP923
JGLY992-GLY1004
KSER29-GLU339
KPHE386-ASN391
KGLY461-THR473

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PDB entries from 2024-04-24

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