6T9W
Crystal structure of formate dehydrogenase FDH2 D222A/Q223R enzyme from Granulicella mallensis MP5ACTX8 in complex with NADP and azide.
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000166 | molecular_function | nucleotide binding |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0008863 | molecular_function | formate dehydrogenase (NAD+) activity |
A | 0016491 | molecular_function | oxidoreductase activity |
A | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
A | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
A | 0042183 | biological_process | formate catabolic process |
A | 0051287 | molecular_function | NAD binding |
B | 0000166 | molecular_function | nucleotide binding |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0008863 | molecular_function | formate dehydrogenase (NAD+) activity |
B | 0016491 | molecular_function | oxidoreductase activity |
B | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
B | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
B | 0042183 | biological_process | formate catabolic process |
B | 0051287 | molecular_function | NAD binding |
C | 0000166 | molecular_function | nucleotide binding |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0008863 | molecular_function | formate dehydrogenase (NAD+) activity |
C | 0016491 | molecular_function | oxidoreductase activity |
C | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
C | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
C | 0042183 | biological_process | formate catabolic process |
C | 0051287 | molecular_function | NAD binding |
D | 0000166 | molecular_function | nucleotide binding |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0008863 | molecular_function | formate dehydrogenase (NAD+) activity |
D | 0016491 | molecular_function | oxidoreductase activity |
D | 0016614 | molecular_function | oxidoreductase activity, acting on CH-OH group of donors |
D | 0016616 | molecular_function | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
D | 0042183 | biological_process | formate catabolic process |
D | 0051287 | molecular_function | NAD binding |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 35 |
Details | binding site for residue NAP B 801 |
Chain | Residue |
B | PHE99 |
B | PHE221 |
B | ARG223 |
B | HIS224 |
B | ASN255 |
B | PRO257 |
B | HIS259 |
B | GLY261 |
B | THR262 |
B | THR283 |
B | ALA284 |
B | ILE123 |
B | ARG285 |
B | ASP309 |
B | HIS333 |
B | SER335 |
B | GLY336 |
B | SER381 |
B | TYR382 |
B | AZI802 |
B | HOH922 |
B | HOH925 |
B | ASN147 |
B | HOH929 |
B | HOH975 |
B | HOH1001 |
B | HOH1004 |
B | HOH1022 |
B | HOH1029 |
B | SER148 |
B | VAL151 |
B | ALA199 |
B | GLY201 |
B | ARG202 |
B | ILE203 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue AZI B 802 |
Chain | Residue |
B | PRO98 |
B | PHE99 |
B | GLY122 |
B | ILE123 |
B | ASN147 |
B | ARG285 |
B | HIS333 |
B | NAP801 |
site_id | AC3 |
Number of Residues | 33 |
Details | binding site for residue NAP A 801 |
Chain | Residue |
A | PHE99 |
A | ILE123 |
A | ASN147 |
A | SER148 |
A | VAL151 |
A | ALA199 |
A | GLY201 |
A | ARG202 |
A | ILE203 |
A | PHE221 |
A | ARG223 |
A | HIS224 |
A | ALA256 |
A | PRO257 |
A | HIS259 |
A | GLY261 |
A | THR262 |
A | THR283 |
A | ALA284 |
A | ARG285 |
A | ASP309 |
A | HIS333 |
A | SER335 |
A | GLY336 |
A | HIS380 |
A | SER381 |
A | TYR382 |
A | AZI802 |
A | HOH914 |
A | HOH920 |
A | HOH973 |
A | HOH981 |
A | HOH993 |
site_id | AC4 |
Number of Residues | 7 |
Details | binding site for residue AZI A 802 |
Chain | Residue |
A | PRO98 |
A | PHE99 |
A | ILE123 |
A | ASN147 |
A | ARG285 |
A | HIS333 |
A | NAP801 |
site_id | AC5 |
Number of Residues | 30 |
Details | binding site for residue NAP C 801 |
Chain | Residue |
C | ARG285 |
C | ASP309 |
C | HIS333 |
C | SER335 |
C | GLY336 |
C | HIS380 |
C | SER381 |
C | AZI802 |
C | HOH955 |
C | HOH961 |
C | HOH970 |
C | HOH976 |
C | HOH990 |
C | HOH1001 |
C | PHE99 |
C | ILE123 |
C | ASN147 |
C | SER148 |
C | VAL151 |
C | ALA199 |
C | GLY201 |
C | ARG202 |
C | ILE203 |
C | ARG223 |
C | HIS224 |
C | PRO257 |
C | HIS259 |
C | THR262 |
C | THR283 |
C | ALA284 |
site_id | AC6 |
Number of Residues | 8 |
Details | binding site for residue AZI C 802 |
Chain | Residue |
C | PRO98 |
C | PHE99 |
C | GLY122 |
C | ILE123 |
C | ASN147 |
C | ARG285 |
C | HIS333 |
C | NAP801 |
Functional Information from PROSITE/UniProt
site_id | PS00670 |
Number of Residues | 23 |
Details | D_2_HYDROXYACID_DH_2 D-isomer specific 2-hydroxyacid dehydrogenases signature 2. MVkvCDVVtINaPlhpgTldLfN |
Chain | Residue | Details |
B | MET245-ASN267 |
site_id | PS00671 |
Number of Residues | 17 |
Details | D_2_HYDROXYACID_DH_3 D-isomer specific 2-hydroxyacid dehydrogenases signature 3. MKrGaYLVNtARGkICN |
Chain | Residue | Details |
B | MET274-ASN290 |