6T7Z

KEAP1 IN COMPLEX WITH COMPOUND 44

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008134	molecular_function	transcription factor binding
A	0016567	biological_process	protein ubiquitination
A	0031463	cellular_component	Cul3-RING ubiquitin ligase complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue ACT A 701

Chain	Residue
A	TYR491
A	PRO492
A	GLU493
A	ARG494
A	HOH851

---

site_id	AC2
Number of Residues	5
Details	binding site for residue ACT A 702

Chain	Residue
A	PHE577
A	PHE335
A	THR576
A	THR576
A	PHE577

---

site_id	AC3
Number of Residues	4
Details	binding site for residue ACT A 703

Chain	Residue
A	ASP389
A	SER390
A	SER391
A	HOH890

---

site_id	AC4
Number of Residues	4
Details	binding site for residue ACT A 704

Chain	Residue
A	VAL411
A	HIS432
A	ILE435
A	HIS437

---

site_id	AC5
Number of Residues	6
Details	binding site for residues ACY B 1 and MV5 B 2

Chain	Residue
A	TYR334
A	ASN382
A	HIS575
B	ASP3
B	4FB4
B	GLU8

---

site_id	AC7
Number of Residues	11
Details	binding site for residues ASA B 3 and 4FB B 4

Chain	Residue
A	ARG483
A	TYR525
A	GLN530
A	TYR572
A	HOH850
B	GLU5
B	THR6
B	GLY7
B	GLU8
B	HOH102
B	HOH103

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	45
Details	Repeat: {"description":"Kelch 1"}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	50
Details	Repeat: {"description":"Kelch 2"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	46
Details	Repeat: {"description":"Kelch 3"}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	46
Details	Repeat: {"description":"Kelch 4"}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	46
Details	Repeat: {"description":"Kelch 5"}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	1
Details	Site: {"description":"Sensor for electrophilic agents","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	1
Details	Modified residue: {"description":"S-cGMP-cysteine","evidences":[{"source":"UniProtKB","id":"Q9Z2X8","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---