6T7P

human plasmakallikrein protease domain in complex with active site directed inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue GSH A 301

Chain	Residue
A	TRP29
A	HOH407
A	HOH414
A	HOH415
A	HOH433
A	HOH503
A	HOH561
A	PRO60
A	GLN62
A	GLU87
A	ILE88
A	PRO120
A	CYS122
A	MET206
A	TRP207

---

site_id	AC2
Number of Residues	4
Details	binding site for residue DMS A 302

Chain	Residue
A	GLY69
A	THR115
A	PHE117
A	HOH475

---

site_id	AC3
Number of Residues	6
Details	binding site for residue DMS A 303

Chain	Residue
A	TRP24
A	ASN159
A	TYR184
A	HOH410
A	HOH574
A	HOH588

---

site_id	AC4
Number of Residues	4
Details	binding site for residue DMS A 304

Chain	Residue
A	ASP63
A	TRP65
A	ARG65
A	GLN84

---

site_id	AC5
Number of Residues	4
Details	binding site for residue DMS A 305

Chain	Residue
A	GLN34
A	GLN38
A	LEU73
A	ILE76

---

site_id	AC6
Number of Residues	7
Details	binding site for residue DMS A 306

Chain	Residue
A	GLY25
A	TRP27
A	ILE70
A	LEU71
A	PHE117
A	LEU155
A	HOH520

---

site_id	AC7
Number of Residues	1
Details	binding site for residue DMS A 307

Chain	Residue
A	LEU60

---

site_id	AC8
Number of Residues	5
Details	binding site for residue DMS A 308

Chain	Residue
A	GLU150
A	ILE151
A	GLN152
A	ASN153
A	HOH466

---

site_id	AC9
Number of Residues	5
Details	binding site for residue DMS A 309

Chain	Residue
A	TYR184
A	GLY187
A	LYS188
A	HOH525
A	HOH633

---

site_id	AD1
Number of Residues	7
Details	binding site for residue DMS A 310

Chain	Residue
A	LYS126
A	ALA232
A	GLU233
A	TYR234
A	MET235
A	ASP236
A	HOH544

---

site_id	AD2
Number of Residues	6
Details	binding site for residue DMS A 311

Chain	Residue
A	SER74
A	LYS202
A	HIS203
A	ASN204
A	HOH406
A	HOH477

---

site_id	AD3
Number of Residues	6
Details	binding site for residue PO4 A 312

Chain	Residue
A	HIS91
A	GLN92
A	ARG179
A	TRP237
A	HOH449
A	HOH544

---

site_id	AD4
Number of Residues	7
Details	binding site for residue GOL A 313

Chain	Residue
A	GLU26
A	TRP27
A	TRP137
A	LYS157
A	HOH401
A	HOH510
A	HOH583

---

site_id	AD5
Number of Residues	19
Details	binding site for residue MU8 A 314

Chain	Residue
A	HIS40
A	LEU41
A	HIS57
A	PHE143
A	ASP189
A	ALA190
A	CYS191
A	LYS192
A	GLY193
A	SER195
A	THR213
A	SER214
A	TRP215
A	GLY216
A	GLY219
A	CYS220
A	HOH448
A	HOH454
A	HOH580

---

Functional Information from PROSITE/UniProt

site_id	PS00134
Number of Residues	6
Details	TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC

Chain	Residue	Details
A	LEU53-CYS58

---

site_id	PS00135
Number of Residues	12
Details	TRYPSIN_SER Serine proteases, trypsin family, serine active site. DAckGDSGGPLV

Chain	Residue	Details
A	ASP189-VAL200

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	235
Details	Domain: {"description":"Peptidase S1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00274","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	3
Details	Active site: {"description":"Charge relay system"}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3521732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	1
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"12754519","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16335952","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"3521732","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---