6T5K

ECV-1 from Echinicola vietnamensis. Environmental metallo-beta-lactamases exhibit high enzymatic activity under zinc deprivation

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0008270	molecular_function	zinc ion binding
C	0008800	molecular_function	beta-lactamase activity
C	0016787	molecular_function	hydrolase activity
C	0017001	biological_process	antibiotic catabolic process
C	0042597	cellular_component	periplasmic space
C	0046677	biological_process	response to antibiotic
C	0046872	molecular_function	metal ion binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	8
Details	binding site for residue EDO C 1201

Chain	Residue
C	GLU194
C	ASP236
C	ALA237
C	ASN238
C	LYS280
C	HIS284
C	HOH1363
C	HOH1482

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site_id	AC2
Number of Residues	8
Details	binding site for residue EDO C 1202

Chain	Residue
C	HIS190
C	TYR204
C	ALA252
C	HOH1317
C	HOH1317
C	HOH1352
C	HOH1352
C	GLU174

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site_id	AC3
Number of Residues	7
Details	binding site for residue EDO C 1203

Chain	Residue
C	GLU100
C	GLU126
C	HIS129
C	ALA130
C	ARG131
C	ASN133
C	HOH1468

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site_id	AC4
Number of Residues	5
Details	binding site for residue EDO C 1204

Chain	Residue
C	ASN110
C	LEU177
C	LYS178
C	HOH1311
C	HOH1316

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site_id	AC5
Number of Residues	4
Details	binding site for residue EDO C 1205

Chain	Residue
C	GLU126
C	HIS129
C	PRO166
C	GLN167

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site_id	AC6
Number of Residues	5
Details	binding site for residue ZN C 1206

Chain	Residue
C	HIS116
C	HIS118
C	HIS196
C	ZN1207
C	HOH1336

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site_id	AC7
Number of Residues	6
Details	binding site for residue ZN C 1207

Chain	Residue
C	ASP120
C	CYS221
C	HIS263
C	ZN1206
C	HOH1336
C	HOH1438

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Functional Information from PROSITE/UniProt

site_id	PS00744
Number of Residues	13
Details	BETA_LACTAMASE_B_2 Beta-lactamases class B signature 2. PddqVLfGgCLIK

Chain	Residue	Details
C	PRO209-LYS224

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