Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6T15

The III2-IV(5B)1 respiratory supercomplex from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0005515	molecular_function	protein binding
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0006119	biological_process	oxidative phosphorylation
a	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
a	0009060	biological_process	aerobic respiration
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0022904	biological_process	respiratory electron transport chain
a	0031966	cellular_component	mitochondrial membrane
a	0045277	cellular_component	respiratory chain complex IV
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	1902600	biological_process	proton transmembrane transport
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	quinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0045275	cellular_component	respiratory chain complex III
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0031966	cellular_component	mitochondrial membrane
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0045277	cellular_component	respiratory chain complex IV
b	0046872	molecular_function	metal ion binding
b	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	quinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0016020	cellular_component	membrane
B	0030061	cellular_component	mitochondrial crista
B	0045275	cellular_component	respiratory chain complex III
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0009055	molecular_function	electron transfer activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045277	cellular_component	respiratory chain complex IV
c	0045333	biological_process	cellular respiration
c	0048039	molecular_function	ubiquinone binding
c	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	quinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
d	0005740	cellular_component	mitochondrial envelope
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
d	0045277	cellular_component	respiratory chain complex IV
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
e	0045277	cellular_component	respiratory chain complex IV
E	0008121	molecular_function	quinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
f	0005743	cellular_component	mitochondrial inner membrane
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
f	0045277	cellular_component	respiratory chain complex IV
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	quinol-cytochrome-c reductase activity
F	0009060	biological_process	aerobic respiration
F	0016020	cellular_component	membrane
F	0034399	cellular_component	nuclear periphery
F	0045275	cellular_component	respiratory chain complex III
F	0045333	biological_process	cellular respiration
F	1902600	biological_process	proton transmembrane transport
g	0004129	molecular_function	cytochrome-c oxidase activity
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0006119	biological_process	oxidative phosphorylation
g	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0016020	cellular_component	membrane
g	0016491	molecular_function	oxidoreductase activity
g	0031966	cellular_component	mitochondrial membrane
g	0045277	cellular_component	respiratory chain complex IV
g	0045333	biological_process	cellular respiration
g	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	quinol-cytochrome-c reductase activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0034551	biological_process	mitochondrial respiratory chain complex III assembly
G	0045275	cellular_component	respiratory chain complex III
G	0045333	biological_process	cellular respiration
G	0099617	cellular_component	matrix side of mitochondrial inner membrane
G	1902600	biological_process	proton transmembrane transport
h	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
h	0045277	cellular_component	respiratory chain complex IV
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	quinol-cytochrome-c reductase activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0045275	cellular_component	respiratory chain complex III
H	0045333	biological_process	cellular respiration
H	1902600	biological_process	proton transmembrane transport
i	0004129	molecular_function	cytochrome-c oxidase activity
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006119	biological_process	oxidative phosphorylation
i	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0016020	cellular_component	membrane
i	0016491	molecular_function	oxidoreductase activity
i	0045277	cellular_component	respiratory chain complex IV
i	1902600	biological_process	proton transmembrane transport
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	quinol-cytochrome-c reductase activity
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0034551	biological_process	mitochondrial respiratory chain complex III assembly
I	0045275	cellular_component	respiratory chain complex III
I	0045333	biological_process	cellular respiration
I	1902600	biological_process	proton transmembrane transport
j	0004129	molecular_function	cytochrome-c oxidase activity
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005758	cellular_component	mitochondrial intermembrane space
j	0006119	biological_process	oxidative phosphorylation
j	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
j	0016020	cellular_component	membrane
j	0016491	molecular_function	oxidoreductase activity
j	0031966	cellular_component	mitochondrial membrane
j	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
j	0045277	cellular_component	respiratory chain complex IV
j	0045333	biological_process	cellular respiration
j	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0008121	molecular_function	quinol-cytochrome-c reductase activity
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III
J	0045333	biological_process	cellular respiration
J	1902600	biological_process	proton transmembrane transport
k	0004129	molecular_function	cytochrome-c oxidase activity
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0006119	biological_process	oxidative phosphorylation
k	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
k	0009060	biological_process	aerobic respiration
k	0016020	cellular_component	membrane
k	0016491	molecular_function	oxidoreductase activity
k	0030234	molecular_function	enzyme regulator activity
k	0045277	cellular_component	respiratory chain complex IV
k	0097250	biological_process	mitochondrial respirasome assembly
k	1902600	biological_process	proton transmembrane transport
l	0003674	molecular_function	molecular_function
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0008150	biological_process	biological_process
l	0016020	cellular_component	membrane
l	0045277	cellular_component	respiratory chain complex IV
l	0098803	cellular_component	respiratory chain complex
L	0004222	molecular_function	metalloendopeptidase activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
L	0008121	molecular_function	quinol-cytochrome-c reductase activity
L	0009060	biological_process	aerobic respiration
L	0016020	cellular_component	membrane
L	0045275	cellular_component	respiratory chain complex III
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	1902600	biological_process	proton transmembrane transport
m	0003674	molecular_function	molecular_function
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0016020	cellular_component	membrane
m	0031334	biological_process	positive regulation of protein-containing complex assembly
m	0031966	cellular_component	mitochondrial membrane
m	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
m	0098803	cellular_component	respiratory chain complex
M	0004222	molecular_function	metalloendopeptidase activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0006508	biological_process	proteolysis
M	0008121	molecular_function	quinol-cytochrome-c reductase activity
M	0009060	biological_process	aerobic respiration
M	0016020	cellular_component	membrane
M	0030061	cellular_component	mitochondrial crista
M	0045275	cellular_component	respiratory chain complex III
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0008121	molecular_function	quinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0045275	cellular_component	respiratory chain complex III
N	0045333	biological_process	cellular respiration
N	0046872	molecular_function	metal ion binding
N	1902600	biological_process	proton transmembrane transport
O	0009055	molecular_function	electron transfer activity
O	0020037	molecular_function	heme binding
P	0008121	molecular_function	quinol-cytochrome-c reductase activity
P	0016020	cellular_component	membrane
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005758	cellular_component	mitochondrial intermembrane space
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	quinol-cytochrome-c reductase activity
Q	0009060	biological_process	aerobic respiration
Q	0016020	cellular_component	membrane
Q	0034399	cellular_component	nuclear periphery
Q	0045275	cellular_component	respiratory chain complex III
Q	0045333	biological_process	cellular respiration
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	quinol-cytochrome-c reductase activity
R	0009060	biological_process	aerobic respiration
R	0016020	cellular_component	membrane
R	0034551	biological_process	mitochondrial respiratory chain complex III assembly
R	0045275	cellular_component	respiratory chain complex III
R	0045333	biological_process	cellular respiration
R	0099617	cellular_component	matrix side of mitochondrial inner membrane
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0008121	molecular_function	quinol-cytochrome-c reductase activity
S	0009060	biological_process	aerobic respiration
S	0016020	cellular_component	membrane
S	0045275	cellular_component	respiratory chain complex III
S	0045333	biological_process	cellular respiration
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0008121	molecular_function	quinol-cytochrome-c reductase activity
T	0009060	biological_process	aerobic respiration
T	0016020	cellular_component	membrane
T	0034551	biological_process	mitochondrial respiratory chain complex III assembly
T	0045275	cellular_component	respiratory chain complex III
T	0045333	biological_process	cellular respiration
T	1902600	biological_process	proton transmembrane transport
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0008121	molecular_function	quinol-cytochrome-c reductase activity
U	0009060	biological_process	aerobic respiration
U	0016020	cellular_component	membrane
U	0045275	cellular_component	respiratory chain complex III
U	0045333	biological_process	cellular respiration
U	1902600	biological_process	proton transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue PEF A 501

Chain	Residue
A	HIS345
A	TRP457
C	ALA2
C	PHE3
C	CDL603

site_id	AC2
Number of Residues	15
Details	binding site for residue HEM C 601

Chain	Residue
C	ARG79
C	HIS82
C	ALA83
C	ALA86
C	GLY131
C	VAL135
C	HIS183
C	TYR184
C	PRO187
C	GLU272
C	TYR274
C	GLY47
C	ILE48
C	MET50
C	VAL65

site_id	AC3
Number of Residues	17
Details	binding site for residue HEM C 602

Chain	Residue
C	TRP30
C	GLY33
C	LEU36
C	MET93
C	HIS96
C	MET97
C	LYS99
C	SER105
C	LEU113
C	GLY117
C	VAL118
C	ILE120
C	VAL194
C	HIS197
C	LEU201
C	SER206
C	SER207

site_id	AC4
Number of Residues	7
Details	binding site for residue CDL C 603

Chain	Residue
A	HIS345
A	MET454
A	MET455
A	TRP457
A	PEF501
C	ARG4
C	HIS222

site_id	AC5
Number of Residues	4
Details	binding site for residue PEF C 605

Chain	Residue
C	PHE3
C	ASN7
N	THR112
N	ASN115

site_id	AC6
Number of Residues	5
Details	binding site for residue PCF C 606

Chain	Residue
C	TRP29
C	TYR102
C	TYR103
C	PHE327
H	CDL601

site_id	AC7
Number of Residues	12
Details	binding site for residue HEC D 401

Chain	Residue
D	VAL100
D	CYS101
D	CYS104
D	HIS105
D	ALA172
D	ILE180
D	ARG184
D	TYR190
D	ILE191
D	PHE218
D	MET225
D	VAL228

site_id	AC8
Number of Residues	13
Details	binding site for residue CDL D 402

Chain	Residue
C	TYR28
C	LEU235
D	LEU282
D	TRP286
D	LYS288
D	LYS289
G	HIS85
H	ILE40
H	ASN43
H	ALA44
H	ASN47
H	SER48
H	CDL601

site_id	AC9
Number of Residues	7
Details	binding site for residue FES E 301

Chain	Residue
E	CYS159
E	HIS161
E	LEU162
E	GLY163
E	CYS164
E	CYS178
E	HIS181

site_id	AD1
Number of Residues	8
Details	binding site for residue PEF E 302

Chain	Residue
D	LEU269
D	LYS272
D	THR273
D	ILE276
E	SER73
E	THR74
E	THR77
E	PHE78

site_id	AD2
Number of Residues	12
Details	binding site for residue CDL H 601

Chain	Residue
D	CDL402
G	HIS85
H	SER48
H	ARG51
H	PHE52
H	GLN55
C	ASN27
C	TYR28
C	TRP29
C	MET32
C	PHE88
C	PCF606

site_id	AD3
Number of Residues	7
Details	binding site for residue PEF H 602

Chain	Residue
C	PHE324
G	LEU35
H	LYS53
H	SER54
H	PHE56
H	LEU57
H	TYR58

site_id	AD4
Number of Residues	7
Details	binding site for residue PEF J 101

Chain	Residue
C	HIS73
E	ILE79
E	SER80
J	PHE44
J	GLY47
J	TRP48
N	TRP164

site_id	AD5
Number of Residues	10
Details	binding site for residue CDL L 501

Chain	Residue
L	HIS345
L	LYS349
L	MET454
L	MET455
L	TRP457
L	PEF502
N	ARG4
N	HIS222
N	PEF604
U	TRP33

site_id	AD6
Number of Residues	6
Details	binding site for residue PEF L 502

Chain	Residue
L	HIS345
L	PHE346
L	TRP457
L	CDL501
N	ALA2
N	PHE3

site_id	AD7
Number of Residues	12
Details	binding site for residue HEM N 601

Chain	Residue
N	GLY47
N	ILE48
N	MET50
N	ARG79
N	HIS82
N	ALA86
N	THR127
N	GLY131
N	VAL135
N	HIS183
N	TYR184
N	PRO187

site_id	AD8
Number of Residues	16
Details	binding site for residue HEM N 602

Chain	Residue
N	TRP30
N	GLY33
N	MET93
N	HIS96
N	MET97
N	LYS99
N	SER105
N	LEU113
N	GLY117
N	VAL118
N	ILE120
N	VAL194
N	HIS197
N	LEU201
N	SER206
N	SER207

site_id	AD9
Number of Residues	9
Details	binding site for residue PEF N 604

Chain	Residue
L	SER450
L	CDL501
N	SER34
N	HIS222
N	PHE227
N	ASP229
O	LYS291
P	SER67
T	PCF101

site_id	AE1
Number of Residues	4
Details	binding site for residue PEF N 605

Chain	Residue
C	SER108
C	THR112
C	ASN115
N	ASN7

site_id	AE2
Number of Residues	6
Details	binding site for residue PCF N 606

Chain	Residue
N	TRP29
N	TYR102
N	TYR103
N	THR317
N	PHE327
N	CDL603

site_id	AE3
Number of Residues	13
Details	binding site for residue HEC O 401

Chain	Residue
O	VAL100
O	CYS101
O	CYS104
O	HIS105
O	ALA172
O	ILE180
O	ARG184
O	TYR190
O	LEU194
O	LEU195
O	PHE218
O	MET225
O	VAL228

site_id	AE4
Number of Residues	8
Details	binding site for residue FES P 301

Chain	Residue
P	CYS159
P	HIS161
P	LEU162
P	GLY163
P	CYS164
P	CYS178
P	HIS181
P	SER183

site_id	AE5
Number of Residues	11
Details	binding site for residue PEF P 302

Chain	Residue
N	ILE42
N	ASN74
N	ILE77
O	LEU269
O	LYS272
O	THR273
P	GLY70
P	SER73
P	THR74
P	THR77
P	PHE78

site_id	AE6
Number of Residues	6
Details	binding site for residue CDL S 101

Chain	Residue
P	LYS44
P	TYR55
P	PHE58
P	MET59
S	PRO36
T	PHE3

site_id	AE7
Number of Residues	4
Details	binding site for residue PEF S 102

Chain	Residue
N	PHE324
S	LYS53
S	SER54
S	TYR58

site_id	AE8
Number of Residues	7
Details	binding site for residue PCF S 103

Chain	Residue
S	GLY39
S	ILE40
S	PHE41
S	HIS42
S	VAL45
e	ALA90
e	THR93

site_id	AE9
Number of Residues	8
Details	binding site for residue PCF T 101

Chain	Residue
L	SER453
L	MET455
N	PEF604
P	GLY64
P	SER67
T	PHE11
T	ASN14
T	PHE17

site_id	AF1
Number of Residues	8
Details	binding site for residue PEF U 101

Chain	Residue
C	ASP160
P	ILE79
P	SER80
P	THR83
U	PHE44
U	GLY47
U	TRP48
U	PRO49

site_id	AF2
Number of Residues	3
Details	binding site for residue CU a 601

Chain	Residue
a	HIS241
a	HIS290
a	HIS291

site_id	AF3
Number of Residues	24
Details	binding site for residue HEA a 602

Chain	Residue
a	PHE19
a	GLY26
a	THR30
a	SER33
a	ARG37
a	HIS62
a	ALA63
a	MET66
a	GLY126
a	TRP127
a	TYR371
a	PHE377
a	HIS378
a	LEU381
a	SER382
a	ILE386
a	LEU389
a	PHE390
a	PHE425
a	MET428
a	ARG439
a	SER458
a	ALA461
a	LEU465

site_id	AF4
Number of Residues	20
Details	binding site for residue HEA a 603

Chain	Residue
a	TRP127
a	TRP237
a	VAL244
a	TYR245
a	ILE248
a	HIS290
a	THR316
a	GLY317
a	ILE320
a	GLY352
a	GLY355
a	VAL356
a	ALA359
a	ASP364
a	HIS368
a	VAL373
a	HIS376
a	PHE377
a	LEU381
a	ARG438

site_id	AF5
Number of Residues	3
Details	binding site for residue MG a 604

Chain	Residue
a	HIS368
a	ASP369
b	GLU223

site_id	AF6
Number of Residues	8
Details	binding site for residue PEF a 605

Chain	Residue
a	PHE95
a	PRO96
a	ARG97
a	ILE98
c	HIS15
c	TRP65
c	ILE69
c	PHE94

site_id	AF7
Number of Residues	6
Details	binding site for residue CUA b 301

Chain	Residue
b	HIS186
b	CYS221
b	GLU223
b	CYS225
b	HIS229
b	MET232

site_id	AF8
Number of Residues	13
Details	binding site for residue PEF b 302

Chain	Residue
a	TYR372
a	HIS429
a	PHE430
a	TRP450
b	PRO20
b	TYR21
b	CYS23
e	SER146
i	TRP32
i	PHE36
l	LEU51
l	PRO54
l	GLY55

site_id	AF9
Number of Residues	5
Details	binding site for residue PEF b 303

Chain	Residue
a	ILE456
b	TYR21
e	PCF202
l	VAL57
l	PHE60

site_id	AG1
Number of Residues	9
Details	binding site for residue PEF c 301

Chain	Residue
c	PHE66
c	THR74
c	ILE87
c	ARG229
c	HIS234
c	THR236
c	HIS239
c	VAL241
c	GLY242

site_id	AG2
Number of Residues	15
Details	binding site for residue PEF c 302

Chain	Residue
a	PHE216
c	ILE101
c	TYR189
c	ALA192
c	PHE194
c	THR195
c	ILE196
c	TYR206
c	ALA207
c	GLY210
k	THR114
k	LEU115
k	PHE116
k	TRP117
k	ASN122

site_id	AG3
Number of Residues	5
Details	binding site for residue ZN d 200

Chain	Residue
d	CYS111
d	GLY113
d	HIS119
d	CYS134
d	CYS137

site_id	AG4
Number of Residues	9
Details	binding site for residue PEF e 201

Chain	Residue
a	LEU334
a	ALA343
a	TRP415
a	PHE418
b	SER55
b	TYR59
e	HIS84
e	VAL89
e	ILE92

site_id	AG5
Number of Residues	19
Details	binding site for residues PEF C 604 and PCF I 101

Chain	Residue
A	SER450
A	SER453
A	MET455
C	SER34
C	MET97
C	ALA98
C	LYS99
C	GLY100
C	TYR102
C	TYR106
C	HIS222
C	ILE226
C	PHE326
D	LYS291
E	GLY64
I	PHE11
I	LYS12
I	ASN14
I	PHE17

site_id	AG6
Number of Residues	19
Details	binding site for residues CDL N 603 and CDL O 402

Chain	Residue
N	ASN27
N	TYR28
N	TRP29
N	PHE88
N	THR232
N	LEU235
N	PCF606
O	TYR281
O	ILE285
O	LYS288
O	LYS289
R	HIS85
S	ILE40
S	ASN43
S	ASN47
S	SER48
S	ARG51
S	PHE52
S	GLN55

site_id	AG7
Number of Residues	13
Details	binding site for Di-peptide PCF e 202 and PHE e 104

Chain	Residue
a	TYR452
b	PEF303
e	LEU100
e	GLY101
e	ILE102
e	SER103
e	GLY105
e	LEU106
e	PHE107
e	GLY108
e	ARG111
e	LEU112
e	ASN115

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
a	TRP237-HIS291

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
b	VAL184-MET232

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
d	ILE121-LEU143

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRsKpFfWGDGdKTlFwN

Chain	Residue	Details
k	ILE101-ASN118

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	49
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000250\|UniProtKB:Q03713

Chain	Residue	Details
m	MET1-ARG13
N	ILE365-LYS385
m	ASN76-SER103
m	LYS174-GLU184
d	CYS137
a	HIS328-ALA335
a	LEU401-ASN406
a	GLN475-SER534
N	GLY205-SER223
N	ASP309-LYS319

site_id	SWS_FT_FI2
Number of Residues	24
Details	TRANSMEM: Helical; Name=1 => ECO:0000269\|PubMed:29240987

Chain	Residue	Details
m	SER14-LEU38
N	GLY75-TYR102
N	VAL111-VAL135
N	ASN173-HIS204
N	TYR224-TYR246
N	LYS288-THR308
N	VAL320-GLY340
N	TYR348-LEU364
U	SER22-THR45
C	VAL111-VAL135
C	ASN173-HIS204
C	TYR224-TYR246
C	LYS288-THR308
C	VAL320-GLY340
C	TYR348-LEU364
N	TYR28-ALA51

site_id	SWS_FT_FI3
Number of Residues	35
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000250\|UniProtKB:Q03713

Chain	Residue	Details
m	PRO39-PRO47
m	ILE134-THR142
m	GLY205-SER224
c	TRP266-VAL269
a	ALA359-THR370
a	GLY432-GLY449
N	SER247-ASP287
N	ALA341-PRO347

site_id	SWS_FT_FI4
Number of Residues	27
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:29240987

Chain	Residue	Details
m	SER48-SER75
E	HIS161
E	CYS178
E	HIS181
P	CYS159
P	HIS161
P	CYS178
P	HIS181

site_id	SWS_FT_FI5
Number of Residues	29
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:29240987

Chain	Residue	Details
m	THR104-VAL133
b	CYS221
b	CYS225
b	MET232
N	HIS82
N	HIS96
N	HIS183
N	HIS197

site_id	SWS_FT_FI6
Number of Residues	30
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:29240987

Chain	Residue	Details
m	LYS143-ASN173
b	HIS229

site_id	SWS_FT_FI7
Number of Residues	19
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:29240987

Chain	Residue	Details
m	MET185-GLU204

site_id	SWS_FT_FI8
Number of Residues	28
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	GLY202-MET230

site_id	SWS_FT_FI9
Number of Residues	16
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	TYR249-TYR265

site_id	SWS_FT_FI10
Number of Residues	28
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	ALA299-ILE327

site_id	SWS_FT_FI11
Number of Residues	22
Details	TRANSMEM: Helical; Name=9 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	THR336-LEU358

site_id	SWS_FT_FI12
Number of Residues	29
Details	TRANSMEM: Helical; Name=10 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	TYR371-ILE400

site_id	SWS_FT_FI13
Number of Residues	24
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	GLU407-LEU431

site_id	SWS_FT_FI14
Number of Residues	24
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	TRP450-ASP474

site_id	SWS_FT_FI15
Number of Residues	9
Details	BINDING: BINDING => ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556

Chain	Residue	Details
a	GLU39
a	ALA42
a	GLY44
a	HIS241
a	HIS290
a	HIS291
a	HIS368
a	ASP369
a	PRO441

site_id	SWS_FT_FI16
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556

Chain	Residue	Details
a	HIS62
a	HIS378

site_id	SWS_FT_FI17
Number of Residues	1
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
a	TYR245

site_id	SWS_FT_FI18
Number of Residues	1
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	HIS376

site_id	SWS_FT_FI19
Number of Residues	2
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	HIS241
a	TYR245

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
E	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
C	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
C	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
O	SER212	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
M	LYS222	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
M	PRO244	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
M	VAL245	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
M	PHE288	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)