6T0K
Crystal structure of CYP124 in complex with inhibitor carbethoxyhexyl imidazole
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0004497 | molecular_function | monooxygenase activity |
A | 0005506 | molecular_function | iron ion binding |
A | 0006631 | biological_process | fatty acid metabolic process |
A | 0006707 | biological_process | cholesterol catabolic process |
A | 0008395 | molecular_function | steroid hydroxylase activity |
A | 0010430 | biological_process | fatty acid omega-oxidation |
A | 0016705 | molecular_function | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen |
A | 0020037 | molecular_function | heme binding |
A | 0031073 | molecular_function | cholesterol 26-hydroxylase activity |
A | 0036199 | molecular_function | cholest-4-en-3-one 26-monooxygenase activity |
A | 0046872 | molecular_function | metal ion binding |
A | 0070402 | molecular_function | NADPH binding |
A | 0097089 | biological_process | methyl-branched fatty acid metabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 24 |
Details | binding site for residue HEM A 501 |
Chain | Residue |
A | MET110 |
A | PRO314 |
A | VAL315 |
A | ARG320 |
A | TYR343 |
A | GLY370 |
A | PHE371 |
A | GLY372 |
A | HIS377 |
A | CYS379 |
A | GLY381 |
A | ILE111 |
A | M65502 |
A | HOH662 |
A | HOH737 |
A | HOH801 |
A | HOH839 |
A | HIS118 |
A | ARG122 |
A | LEU264 |
A | ALA267 |
A | GLY268 |
A | THR271 |
A | THR272 |
site_id | AC2 |
Number of Residues | 8 |
Details | binding site for residue M65 A 502 |
Chain | Residue |
A | PHE107 |
A | ILE197 |
A | VAL266 |
A | ALA267 |
A | THR271 |
A | HEM501 |
A | GOL504 |
A | HOH472 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue GOL A 503 |
Chain | Residue |
A | TRP294 |
A | ARG397 |
A | HOH884 |
site_id | AC4 |
Number of Residues | 8 |
Details | binding site for residue GOL A 504 |
Chain | Residue |
A | ASN93 |
A | THR95 |
A | ASN97 |
A | GLN99 |
A | PHE107 |
A | M65502 |
A | GOL506 |
A | HOH472 |
site_id | AC5 |
Number of Residues | 12 |
Details | binding site for residue GOL A 505 |
Chain | Residue |
A | ASP36 |
A | ASP40 |
A | HIS278 |
A | ARG285 |
A | TRP311 |
A | HIS418 |
A | CL509 |
A | HOH606 |
A | HOH645 |
A | HOH840 |
A | HOH878 |
A | HOH1114 |
site_id | AC6 |
Number of Residues | 10 |
Details | binding site for residue GOL A 506 |
Chain | Residue |
A | PHE63 |
A | THR95 |
A | ILE197 |
A | LEU198 |
A | PHE200 |
A | PHE416 |
A | GOL504 |
A | HOH642 |
A | HOH814 |
A | HOH831 |
site_id | AC7 |
Number of Residues | 6 |
Details | binding site for residue MG A 507 |
Chain | Residue |
A | HOH678 |
A | HOH799 |
A | HOH1087 |
A | HOH1104 |
A | HOH1239 |
A | HOH1260 |
site_id | AC8 |
Number of Residues | 5 |
Details | binding site for residue MG A 508 |
Chain | Residue |
A | HOH661 |
A | HOH803 |
A | HOH1103 |
A | HOH1137 |
A | HOH1183 |
site_id | AC9 |
Number of Residues | 5 |
Details | binding site for residue CL A 509 |
Chain | Residue |
A | ARG285 |
A | TRP311 |
A | GOL505 |
A | HOH699 |
A | HOH878 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 1 |
Details | BINDING: axial binding residue => ECO:0000269|PubMed:19933331, ECO:0007744|PDB:2WM4, ECO:0007744|PDB:2WM5 |
Chain | Residue | Details |
A | CYS379 |