Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6T0B

The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004222	molecular_function	metalloendopeptidase activity
A	0005515	molecular_function	protein binding
A	0005739	cellular_component	mitochondrion
A	0005743	cellular_component	mitochondrial inner membrane
A	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
A	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
A	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
A	0009060	biological_process	aerobic respiration
A	0016020	cellular_component	membrane
A	0045275	cellular_component	respiratory chain complex III
A	0045333	biological_process	cellular respiration
A	0046872	molecular_function	metal ion binding
A	1902600	biological_process	proton transmembrane transport
B	0004222	molecular_function	metalloendopeptidase activity
B	0005515	molecular_function	protein binding
B	0005739	cellular_component	mitochondrion
B	0005743	cellular_component	mitochondrial inner membrane
B	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
B	0006508	biological_process	proteolysis
B	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
B	0009060	biological_process	aerobic respiration
B	0016020	cellular_component	membrane
B	0030061	cellular_component	mitochondrial crista
B	0045275	cellular_component	respiratory chain complex III
B	0045333	biological_process	cellular respiration
B	0046872	molecular_function	metal ion binding
B	1902600	biological_process	proton transmembrane transport
C	0005739	cellular_component	mitochondrion
C	0005743	cellular_component	mitochondrial inner membrane
C	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
C	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
C	0009055	molecular_function	electron transfer activity
C	0009060	biological_process	aerobic respiration
C	0016020	cellular_component	membrane
C	0016491	molecular_function	oxidoreductase activity
C	0022904	biological_process	respiratory electron transport chain
C	0045275	cellular_component	respiratory chain complex III
C	0045333	biological_process	cellular respiration
C	0046872	molecular_function	metal ion binding
C	1902600	biological_process	proton transmembrane transport
D	0009055	molecular_function	electron transfer activity
D	0020037	molecular_function	heme binding
E	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
E	0016020	cellular_component	membrane
E	0051537	molecular_function	2 iron, 2 sulfur cluster binding
F	0005739	cellular_component	mitochondrion
F	0005743	cellular_component	mitochondrial inner membrane
F	0005758	cellular_component	mitochondrial intermembrane space
F	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
F	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
F	0009060	biological_process	aerobic respiration
F	0016020	cellular_component	membrane
F	0034399	cellular_component	nuclear periphery
F	0045275	cellular_component	respiratory chain complex III
F	0045333	biological_process	cellular respiration
F	1902600	biological_process	proton transmembrane transport
G	0005739	cellular_component	mitochondrion
G	0005743	cellular_component	mitochondrial inner membrane
G	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
G	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
G	0009060	biological_process	aerobic respiration
G	0016020	cellular_component	membrane
G	0034551	biological_process	mitochondrial respiratory chain complex III assembly
G	0045275	cellular_component	respiratory chain complex III
G	0045333	biological_process	cellular respiration
G	0099617	cellular_component	matrix side of mitochondrial inner membrane
G	1902600	biological_process	proton transmembrane transport
H	0005739	cellular_component	mitochondrion
H	0005743	cellular_component	mitochondrial inner membrane
H	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
H	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
H	0009060	biological_process	aerobic respiration
H	0016020	cellular_component	membrane
H	0045275	cellular_component	respiratory chain complex III
H	0045333	biological_process	cellular respiration
H	1902600	biological_process	proton transmembrane transport
I	0005739	cellular_component	mitochondrion
I	0005743	cellular_component	mitochondrial inner membrane
I	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
I	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
I	0009060	biological_process	aerobic respiration
I	0016020	cellular_component	membrane
I	0034551	biological_process	mitochondrial respiratory chain complex III assembly
I	0045275	cellular_component	respiratory chain complex III
I	0045333	biological_process	cellular respiration
I	1902600	biological_process	proton transmembrane transport
J	0005739	cellular_component	mitochondrion
J	0005743	cellular_component	mitochondrial inner membrane
J	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
J	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
J	0009060	biological_process	aerobic respiration
J	0016020	cellular_component	membrane
J	0045275	cellular_component	respiratory chain complex III
J	0045333	biological_process	cellular respiration
J	1902600	biological_process	proton transmembrane transport
L	0004222	molecular_function	metalloendopeptidase activity
L	0005515	molecular_function	protein binding
L	0005739	cellular_component	mitochondrion
L	0005743	cellular_component	mitochondrial inner membrane
L	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
L	0006627	biological_process	protein processing involved in protein targeting to mitochondrion
L	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
L	0009060	biological_process	aerobic respiration
L	0016020	cellular_component	membrane
L	0045275	cellular_component	respiratory chain complex III
L	0045333	biological_process	cellular respiration
L	0046872	molecular_function	metal ion binding
L	1902600	biological_process	proton transmembrane transport
M	0004222	molecular_function	metalloendopeptidase activity
M	0005515	molecular_function	protein binding
M	0005739	cellular_component	mitochondrion
M	0005743	cellular_component	mitochondrial inner membrane
M	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
M	0006508	biological_process	proteolysis
M	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
M	0009060	biological_process	aerobic respiration
M	0016020	cellular_component	membrane
M	0030061	cellular_component	mitochondrial crista
M	0045275	cellular_component	respiratory chain complex III
M	0045333	biological_process	cellular respiration
M	0046872	molecular_function	metal ion binding
M	1902600	biological_process	proton transmembrane transport
N	0005739	cellular_component	mitochondrion
N	0005743	cellular_component	mitochondrial inner membrane
N	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
N	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
N	0009055	molecular_function	electron transfer activity
N	0009060	biological_process	aerobic respiration
N	0016020	cellular_component	membrane
N	0016491	molecular_function	oxidoreductase activity
N	0022904	biological_process	respiratory electron transport chain
N	0045275	cellular_component	respiratory chain complex III
N	0045333	biological_process	cellular respiration
N	0046872	molecular_function	metal ion binding
N	1902600	biological_process	proton transmembrane transport
O	0009055	molecular_function	electron transfer activity
O	0020037	molecular_function	heme binding
P	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
P	0016020	cellular_component	membrane
P	0051537	molecular_function	2 iron, 2 sulfur cluster binding
Q	0005739	cellular_component	mitochondrion
Q	0005743	cellular_component	mitochondrial inner membrane
Q	0005758	cellular_component	mitochondrial intermembrane space
Q	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
Q	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
Q	0009060	biological_process	aerobic respiration
Q	0016020	cellular_component	membrane
Q	0034399	cellular_component	nuclear periphery
Q	0045275	cellular_component	respiratory chain complex III
Q	0045333	biological_process	cellular respiration
Q	1902600	biological_process	proton transmembrane transport
R	0005739	cellular_component	mitochondrion
R	0005743	cellular_component	mitochondrial inner membrane
R	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
R	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
R	0009060	biological_process	aerobic respiration
R	0016020	cellular_component	membrane
R	0034551	biological_process	mitochondrial respiratory chain complex III assembly
R	0045275	cellular_component	respiratory chain complex III
R	0045333	biological_process	cellular respiration
R	0099617	cellular_component	matrix side of mitochondrial inner membrane
R	1902600	biological_process	proton transmembrane transport
S	0005739	cellular_component	mitochondrion
S	0005743	cellular_component	mitochondrial inner membrane
S	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
S	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
S	0009060	biological_process	aerobic respiration
S	0016020	cellular_component	membrane
S	0045275	cellular_component	respiratory chain complex III
S	0045333	biological_process	cellular respiration
S	1902600	biological_process	proton transmembrane transport
T	0005739	cellular_component	mitochondrion
T	0005743	cellular_component	mitochondrial inner membrane
T	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
T	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
T	0009060	biological_process	aerobic respiration
T	0016020	cellular_component	membrane
T	0034551	biological_process	mitochondrial respiratory chain complex III assembly
T	0045275	cellular_component	respiratory chain complex III
T	0045333	biological_process	cellular respiration
T	1902600	biological_process	proton transmembrane transport
U	0005739	cellular_component	mitochondrion
U	0005743	cellular_component	mitochondrial inner membrane
U	0006122	biological_process	mitochondrial electron transport, ubiquinol to cytochrome c
U	0008121	molecular_function	ubiquinol-cytochrome-c reductase activity
U	0009060	biological_process	aerobic respiration
U	0016020	cellular_component	membrane
U	0045275	cellular_component	respiratory chain complex III
U	0045333	biological_process	cellular respiration
U	1902600	biological_process	proton transmembrane transport
a	0004129	molecular_function	cytochrome-c oxidase activity
a	0005515	molecular_function	protein binding
a	0005739	cellular_component	mitochondrion
a	0005743	cellular_component	mitochondrial inner membrane
a	0006119	biological_process	oxidative phosphorylation
a	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
a	0009060	biological_process	aerobic respiration
a	0016020	cellular_component	membrane
a	0020037	molecular_function	heme binding
a	0022904	biological_process	respiratory electron transport chain
a	0031966	cellular_component	mitochondrial membrane
a	0045277	cellular_component	respiratory chain complex IV
a	0045333	biological_process	cellular respiration
a	0046872	molecular_function	metal ion binding
a	1902600	biological_process	proton transmembrane transport
b	0004129	molecular_function	cytochrome-c oxidase activity
b	0005507	molecular_function	copper ion binding
b	0005515	molecular_function	protein binding
b	0005739	cellular_component	mitochondrion
b	0005743	cellular_component	mitochondrial inner membrane
b	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
b	0009060	biological_process	aerobic respiration
b	0016020	cellular_component	membrane
b	0016491	molecular_function	oxidoreductase activity
b	0022900	biological_process	electron transport chain
b	0031966	cellular_component	mitochondrial membrane
b	0042773	biological_process	ATP synthesis coupled electron transport
b	0045277	cellular_component	respiratory chain complex IV
b	0046872	molecular_function	metal ion binding
b	1902600	biological_process	proton transmembrane transport
c	0004129	molecular_function	cytochrome-c oxidase activity
c	0005739	cellular_component	mitochondrion
c	0005743	cellular_component	mitochondrial inner membrane
c	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
c	0009055	molecular_function	electron transfer activity
c	0009060	biological_process	aerobic respiration
c	0016020	cellular_component	membrane
c	0019646	biological_process	aerobic electron transport chain
c	0022904	biological_process	respiratory electron transport chain
c	0031966	cellular_component	mitochondrial membrane
c	0045277	cellular_component	respiratory chain complex IV
c	0045333	biological_process	cellular respiration
c	0048039	molecular_function	ubiquinone binding
c	1902600	biological_process	proton transmembrane transport
d	0005740	cellular_component	mitochondrial envelope
d	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
d	0045277	cellular_component	respiratory chain complex IV
e	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
e	0045277	cellular_component	respiratory chain complex IV
f	0005743	cellular_component	mitochondrial inner membrane
f	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
f	0045277	cellular_component	respiratory chain complex IV
g	0004129	molecular_function	cytochrome-c oxidase activity
g	0005739	cellular_component	mitochondrion
g	0005743	cellular_component	mitochondrial inner membrane
g	0006119	biological_process	oxidative phosphorylation
g	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
g	0016020	cellular_component	membrane
g	0016491	molecular_function	oxidoreductase activity
g	0031966	cellular_component	mitochondrial membrane
g	0045277	cellular_component	respiratory chain complex IV
g	0045333	biological_process	cellular respiration
g	1902600	biological_process	proton transmembrane transport
h	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
h	0045277	cellular_component	respiratory chain complex IV
i	0004129	molecular_function	cytochrome-c oxidase activity
i	0005739	cellular_component	mitochondrion
i	0005743	cellular_component	mitochondrial inner membrane
i	0006119	biological_process	oxidative phosphorylation
i	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
i	0016020	cellular_component	membrane
i	0016491	molecular_function	oxidoreductase activity
i	0045277	cellular_component	respiratory chain complex IV
i	1902600	biological_process	proton transmembrane transport
j	0004129	molecular_function	cytochrome-c oxidase activity
j	0005739	cellular_component	mitochondrion
j	0005743	cellular_component	mitochondrial inner membrane
j	0005758	cellular_component	mitochondrial intermembrane space
j	0006119	biological_process	oxidative phosphorylation
j	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
j	0016020	cellular_component	membrane
j	0016491	molecular_function	oxidoreductase activity
j	0031966	cellular_component	mitochondrial membrane
j	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
j	0045277	cellular_component	respiratory chain complex IV
j	0045333	biological_process	cellular respiration
j	1902600	biological_process	proton transmembrane transport
k	0004129	molecular_function	cytochrome-c oxidase activity
k	0005739	cellular_component	mitochondrion
k	0005743	cellular_component	mitochondrial inner membrane
k	0006119	biological_process	oxidative phosphorylation
k	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
k	0009060	biological_process	aerobic respiration
k	0016020	cellular_component	membrane
k	0016491	molecular_function	oxidoreductase activity
k	0030234	molecular_function	enzyme regulator activity
k	0045277	cellular_component	respiratory chain complex IV
k	0097250	biological_process	mitochondrial respirasome assembly
k	1902600	biological_process	proton transmembrane transport
l	0003674	molecular_function	molecular_function
l	0005739	cellular_component	mitochondrion
l	0005743	cellular_component	mitochondrial inner membrane
l	0008150	biological_process	biological_process
l	0016020	cellular_component	membrane
l	0045277	cellular_component	respiratory chain complex IV
l	0098803	cellular_component	respiratory chain complex
m	0003674	molecular_function	molecular_function
m	0005739	cellular_component	mitochondrion
m	0005743	cellular_component	mitochondrial inner membrane
m	0016020	cellular_component	membrane
m	0031334	biological_process	positive regulation of protein-containing complex assembly
m	0031966	cellular_component	mitochondrial membrane
m	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
m	0098803	cellular_component	respiratory chain complex
n	0004129	molecular_function	cytochrome-c oxidase activity
n	0005515	molecular_function	protein binding
n	0005739	cellular_component	mitochondrion
n	0005743	cellular_component	mitochondrial inner membrane
n	0006119	biological_process	oxidative phosphorylation
n	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
n	0009060	biological_process	aerobic respiration
n	0016020	cellular_component	membrane
n	0020037	molecular_function	heme binding
n	0022904	biological_process	respiratory electron transport chain
n	0031966	cellular_component	mitochondrial membrane
n	0045277	cellular_component	respiratory chain complex IV
n	0045333	biological_process	cellular respiration
n	0046872	molecular_function	metal ion binding
n	1902600	biological_process	proton transmembrane transport
o	0004129	molecular_function	cytochrome-c oxidase activity
o	0005507	molecular_function	copper ion binding
o	0005515	molecular_function	protein binding
o	0005739	cellular_component	mitochondrion
o	0005743	cellular_component	mitochondrial inner membrane
o	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
o	0009060	biological_process	aerobic respiration
o	0016020	cellular_component	membrane
o	0016491	molecular_function	oxidoreductase activity
o	0022900	biological_process	electron transport chain
o	0031966	cellular_component	mitochondrial membrane
o	0042773	biological_process	ATP synthesis coupled electron transport
o	0045277	cellular_component	respiratory chain complex IV
o	0046872	molecular_function	metal ion binding
o	1902600	biological_process	proton transmembrane transport
p	0004129	molecular_function	cytochrome-c oxidase activity
p	0005739	cellular_component	mitochondrion
p	0005743	cellular_component	mitochondrial inner membrane
p	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
p	0009055	molecular_function	electron transfer activity
p	0009060	biological_process	aerobic respiration
p	0016020	cellular_component	membrane
p	0019646	biological_process	aerobic electron transport chain
p	0022904	biological_process	respiratory electron transport chain
p	0031966	cellular_component	mitochondrial membrane
p	0045277	cellular_component	respiratory chain complex IV
p	0045333	biological_process	cellular respiration
p	0048039	molecular_function	ubiquinone binding
p	1902600	biological_process	proton transmembrane transport
q	0005740	cellular_component	mitochondrial envelope
q	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
q	0045277	cellular_component	respiratory chain complex IV
r	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
r	0045277	cellular_component	respiratory chain complex IV
s	0005743	cellular_component	mitochondrial inner membrane
s	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
s	0045277	cellular_component	respiratory chain complex IV
t	0004129	molecular_function	cytochrome-c oxidase activity
t	0005739	cellular_component	mitochondrion
t	0005743	cellular_component	mitochondrial inner membrane
t	0006119	biological_process	oxidative phosphorylation
t	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
t	0016020	cellular_component	membrane
t	0016491	molecular_function	oxidoreductase activity
t	0031966	cellular_component	mitochondrial membrane
t	0045277	cellular_component	respiratory chain complex IV
t	0045333	biological_process	cellular respiration
t	1902600	biological_process	proton transmembrane transport
u	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
u	0045277	cellular_component	respiratory chain complex IV
v	0004129	molecular_function	cytochrome-c oxidase activity
v	0005739	cellular_component	mitochondrion
v	0005743	cellular_component	mitochondrial inner membrane
v	0006119	biological_process	oxidative phosphorylation
v	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
v	0016020	cellular_component	membrane
v	0016491	molecular_function	oxidoreductase activity
v	0045277	cellular_component	respiratory chain complex IV
v	1902600	biological_process	proton transmembrane transport
w	0004129	molecular_function	cytochrome-c oxidase activity
w	0005739	cellular_component	mitochondrion
w	0005743	cellular_component	mitochondrial inner membrane
w	0005758	cellular_component	mitochondrial intermembrane space
w	0006119	biological_process	oxidative phosphorylation
w	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
w	0016020	cellular_component	membrane
w	0016491	molecular_function	oxidoreductase activity
w	0031966	cellular_component	mitochondrial membrane
w	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
w	0045277	cellular_component	respiratory chain complex IV
w	0045333	biological_process	cellular respiration
w	1902600	biological_process	proton transmembrane transport
x	0004129	molecular_function	cytochrome-c oxidase activity
x	0005739	cellular_component	mitochondrion
x	0005743	cellular_component	mitochondrial inner membrane
x	0006119	biological_process	oxidative phosphorylation
x	0006123	biological_process	mitochondrial electron transport, cytochrome c to oxygen
x	0009060	biological_process	aerobic respiration
x	0016020	cellular_component	membrane
x	0016491	molecular_function	oxidoreductase activity
x	0030234	molecular_function	enzyme regulator activity
x	0045277	cellular_component	respiratory chain complex IV
x	0097250	biological_process	mitochondrial respirasome assembly
x	1902600	biological_process	proton transmembrane transport
y	0003674	molecular_function	molecular_function
y	0005739	cellular_component	mitochondrion
y	0005743	cellular_component	mitochondrial inner membrane
y	0008150	biological_process	biological_process
y	0016020	cellular_component	membrane
y	0045277	cellular_component	respiratory chain complex IV
y	0098803	cellular_component	respiratory chain complex
z	0003674	molecular_function	molecular_function
z	0005739	cellular_component	mitochondrion
z	0005743	cellular_component	mitochondrial inner membrane
z	0016020	cellular_component	membrane
z	0031334	biological_process	positive regulation of protein-containing complex assembly
z	0031966	cellular_component	mitochondrial membrane
z	0033617	biological_process	mitochondrial cytochrome c oxidase assembly
z	0098803	cellular_component	respiratory chain complex

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	binding site for residue CDL A 501

Chain	Residue
A	HIS345
J	TRP33
A	MET454
A	MET455
A	TRP457
A	PEF502
C	ARG4
C	ILE18
C	HIS222
I	PCF101

site_id	AC2
Number of Residues	4
Details	binding site for residue PEF A 502

Chain	Residue
A	HIS345
A	TRP457
A	CDL501
C	PHE3

site_id	AC3
Number of Residues	13
Details	binding site for residue HEM C 601

Chain	Residue
C	GLN43
C	GLY47
C	ILE48
C	MET50
C	ARG79
C	HIS82
C	ALA86
C	THR127
C	GLY131
C	HIS183
C	TYR184
C	PRO187
C	TYR274

site_id	AC4
Number of Residues	17
Details	binding site for residue HEM C 602

Chain	Residue
C	TRP30
C	GLY33
C	MET93
C	HIS96
C	MET97
C	LYS99
C	SER105
C	LEU113
C	TRP114
C	GLY117
C	VAL118
C	ILE120
C	VAL194
C	HIS197
C	LEU201
C	SER206
C	SER207

site_id	AC5
Number of Residues	11
Details	binding site for residue CDL C 603

Chain	Residue
C	ASN27
C	TYR28
C	TRP29
C	MET32
C	PCF606
D	CDL402
G	HIS85
H	SER48
H	ARG51
H	PHE52
H	GLN55

site_id	AC6
Number of Residues	6
Details	binding site for residue PEF C 604

Chain	Residue
A	SER450
C	HIS222
C	ILE226
D	LYS291
E	SER67
I	PCF101

site_id	AC7
Number of Residues	6
Details	binding site for residue PEF C 605

Chain	Residue
C	PHE3
C	SER6
C	ASN7
C	TYR9
N	ASN115
N	MET196

site_id	AC8
Number of Residues	9
Details	binding site for residue PCF C 606

Chain	Residue
C	TRP29
C	PHE94
C	TYR102
C	TYR103
C	PHE326
C	CDL603
G	GLU82
H	GLN55
H	VAL59

site_id	AC9
Number of Residues	14
Details	binding site for residue HEC D 401

Chain	Residue
D	VAL100
D	CYS101
D	CYS104
D	HIS105
D	ASN169
D	LEU177
D	ILE180
D	ARG184
D	TYR190
D	ILE191
D	PHE218
D	ALA224
D	MET225
D	VAL228

site_id	AD1
Number of Residues	13
Details	binding site for residue CDL D 402

Chain	Residue
H	ILE40
H	ALA44
H	ASN47
H	ARG51
C	TYR28
C	CDL603
D	TYR281
D	LEU282
D	ILE285
D	LYS288
D	LYS289
D	LYS296
G	HIS85

site_id	AD2
Number of Residues	7
Details	binding site for residue FES E 301

Chain	Residue
E	CYS159
E	HIS161
E	LEU162
E	CYS178
E	CYS180
E	HIS181
E	SER183

site_id	AD3
Number of Residues	8
Details	binding site for residue PEF E 302

Chain	Residue
C	ASN74
D	LEU269
D	LYS272
D	THR273
E	GLY70
E	SER73
E	THR74
E	THR77

site_id	AD4
Number of Residues	9
Details	binding site for residue PEF E 303

Chain	Residue
E	GLU45
E	PEF304
a	ASN406
a	LYS408
a	LEU409
a	PHE466
a	TYR470
a	LYS487
e	PHE91

site_id	AD5
Number of Residues	5
Details	binding site for residue PEF E 304

Chain	Residue
E	GLU45
E	PEF303
e	PHE91
e	LYS94
e	GLY95

site_id	AD6
Number of Residues	10
Details	binding site for residue CDL H 101

Chain	Residue
D	TRP286
E	LYS44
E	LYS51
E	TYR55
E	PHE58
H	PRO36
H	LEU37
I	PHE3
I	PHE11
e	PHE97

site_id	AD7
Number of Residues	5
Details	binding site for residue PEF H 102

Chain	Residue
C	PHE324
H	LYS53
H	SER54
H	LEU57
H	TYR58

site_id	AD8
Number of Residues	8
Details	binding site for residue PCF H 103

Chain	Residue
H	GLY39
H	ILE40
H	PHE41
H	HIS42
H	VAL45
H	PHE46
e	ALA90
e	LYS94

site_id	AD9
Number of Residues	10
Details	binding site for residue PCF I 101

Chain	Residue
A	ASP428
A	SER453
A	MET455
A	CDL501
C	PEF604
E	TYR57
I	PHE11
I	LYS12
I	ASN14
I	VAL18

site_id	AE1
Number of Residues	9
Details	binding site for residue PEF J 101

Chain	Residue
E	GLU76
E	ILE79
E	THR83
J	PHE44
J	GLY47
J	TRP48
J	PRO49
N	ASP160
N	TRP164

site_id	AE2
Number of Residues	9
Details	binding site for residue CDL L 501

Chain	Residue
L	HIS345
L	MET454
L	MET455
L	TRP457
L	PEF502
N	ARG4
N	HIS222
T	PCF101
U	TRP33

site_id	AE3
Number of Residues	5
Details	binding site for residue PEF L 502

Chain	Residue
L	HIS345
L	TRP457
L	CDL501
N	ALA2
N	PHE3

site_id	AE4
Number of Residues	14
Details	binding site for residue HEM N 601

Chain	Residue
N	GLN43
N	GLY47
N	ILE48
N	MET50
N	ARG79
N	HIS82
N	ALA86
N	THR127
N	GLY131
N	TYR132
N	VAL135
N	HIS183
N	TYR184
N	PRO187

site_id	AE5
Number of Residues	17
Details	binding site for residue HEM N 602

Chain	Residue
N	TRP30
N	GLY33
N	LEU36
N	MET93
N	HIS96
N	MET97
N	LYS99
N	SER105
N	LEU113
N	GLY117
N	VAL118
N	ILE120
N	VAL194
N	HIS197
N	LEU201
N	SER206
N	SER207

site_id	AE6
Number of Residues	11
Details	binding site for residue CDL N 603

Chain	Residue
N	ASN27
N	TYR28
N	TRP29
N	MET32
N	CDL604
N	PCF607
R	HIS85
S	SER48
S	ARG51
S	PHE52
S	GLN55

site_id	AE7
Number of Residues	13
Details	binding site for residue CDL N 604

Chain	Residue
N	TYR28
N	VAL231
N	CDL603
O	TYR281
O	LEU282
O	LYS288
O	LYS289
O	LYS296
R	HIS85
S	ASN43
S	ALA44
S	ASN47
S	ARG51

site_id	AE8
Number of Residues	9
Details	binding site for residue PEF N 605

Chain	Residue
L	SER450
L	SER453
N	HIS222
N	SER223
N	ILE226
N	PHE227
O	LYS291
P	SER67
T	PCF101

site_id	AE9
Number of Residues	5
Details	binding site for residue PEF N 606

Chain	Residue
C	THR112
C	ASN115
C	MET193
C	MET196
N	ASN7

site_id	AF1
Number of Residues	11
Details	binding site for residue PCF N 607

Chain	Residue
N	TRP29
N	MET97
N	TYR102
N	TYR103
N	THR317
N	PHE327
N	PHE331
N	CDL603
R	GLU82
S	GLN55
S	VAL59

site_id	AF2
Number of Residues	13
Details	binding site for residue HEC O 401

Chain	Residue
O	VAL100
O	CYS101
O	CYS104
O	HIS105
O	ASN169
O	ILE180
O	ARG184
O	TYR190
O	ILE191
O	PHE218
O	ALA224
O	MET225
O	VAL228

site_id	AF3
Number of Residues	8
Details	binding site for residue PEF O 402

Chain	Residue
N	MET237
O	LEU269
O	LYS272
O	THR273
P	GLY70
P	SER73
P	THR74
P	THR77

site_id	AF4
Number of Residues	5
Details	binding site for residue FES P 301

Chain	Residue
P	CYS159
P	HIS161
P	CYS178
P	CYS180
P	HIS181

site_id	AF5
Number of Residues	9
Details	binding site for residue CDL S 101

Chain	Residue
P	LYS44
P	LYS51
P	SER54
P	TYR55
P	PHE58
S	LYS35
S	PRO36
S	LEU37
T	PHE3

site_id	AF6
Number of Residues	4
Details	binding site for residue PEF S 102

Chain	Residue
R	LYS40
S	LYS53
S	SER54
S	TYR58

site_id	AF7
Number of Residues	10
Details	binding site for residue PCF T 101

Chain	Residue
L	ASP428
L	SER453
L	CDL501
N	PEF605
P	GLY64
T	PHE11
T	ASN14
T	PHE17
T	VAL18
U	PHE44

site_id	AF8
Number of Residues	3
Details	binding site for residue CU a 601

Chain	Residue
a	HIS241
a	HIS290
a	HIS291

site_id	AF9
Number of Residues	23
Details	binding site for residue HEA a 602

Chain	Residue
a	PHE19
a	GLY26
a	SER33
a	ARG37
a	VAL59
a	HIS62
a	ALA63
a	MET66
a	VAL71
a	GLY126
a	TRP127
a	TYR371
a	PHE377
a	HIS378
a	LEU381
a	ILE386
a	LEU389
a	TYR393
a	PHE425
a	MET428
a	ARG438
a	ARG439
a	LEU465

site_id	AG1
Number of Residues	25
Details	binding site for residue HEA a 603

Chain	Residue
a	TRP127
a	TRP237
a	VAL244
a	TYR245
a	HIS290
a	HIS291
a	THR309
a	ALA313
a	THR316
a	GLY317
a	ILE320
a	GLY352
a	GLY355
a	VAL356
a	LEU358
a	ALA359
a	ASP364
a	HIS368
a	HIS376
a	PHE377
a	VAL380
a	LEU381
a	ARG438
b	ILE50
b	ILE92

site_id	AG2
Number of Residues	4
Details	binding site for residue CA a 604

Chain	Residue
a	GLU39
a	ALA42
a	GLY44
a	PRO441

site_id	AG3
Number of Residues	3
Details	binding site for residue MG a 605

Chain	Residue
a	HIS368
a	ASP369
b	GLU223

site_id	AG4
Number of Residues	11
Details	binding site for residue PEF a 606

Chain	Residue
a	PHE95
a	PRO96
a	ARG97
a	ILE98
c	HIS15
c	TRP65
c	PHE66
c	ILE69
c	GLU72
c	HIS79
c	PHE94

site_id	AG5
Number of Residues	6
Details	binding site for residue CUA b 301

Chain	Residue
b	HIS186
b	CYS221
b	GLU223
b	CYS225
b	HIS229
b	MET232

site_id	AG6
Number of Residues	8
Details	binding site for residue PEF b 302

Chain	Residue
a	PHE268
a	LEU324
b	ILE75
b	GLY78
b	THR80
b	ILE81
b	ILE84
i	PHE22

site_id	AG7
Number of Residues	8
Details	binding site for residue PEF b 303

Chain	Residue
a	PHE426
b	TYR21
b	CYS23
i	TRP32
i	PHE36
l	LEU51
l	GLY55
l	TYR58

site_id	AG8
Number of Residues	10
Details	binding site for residue PEF c 301

Chain	Residue
c	PHE66
c	ILE69
c	ALA73
c	THR74
c	ARG229
c	HIS234
c	HIS239
c	HIS240
c	VAL241
c	GLY242

site_id	AG9
Number of Residues	11
Details	binding site for residue PEF c 302

Chain	Residue
a	THR208
c	TYR189
c	ALA192
c	PHE194
c	THR195
c	ILE196
c	TYR206
k	THR114
k	LEU115
k	PHE116
k	ASN122

site_id	AH1
Number of Residues	4
Details	binding site for residue ZN d 201

Chain	Residue
d	CYS111
d	HIS119
d	CYS134
d	CYS137

site_id	AH2
Number of Residues	6
Details	binding site for residue PEF e 201

Chain	Residue
a	LEU339
a	PHE414
a	PHE418
e	HIS84
e	VAL89
e	ILE92

site_id	AH3
Number of Residues	5
Details	binding site for residue PCF e 202

Chain	Residue
a	TYR452
e	PHE104
e	GLY108
e	ARG111
e	ASN115

site_id	AH4
Number of Residues	7
Details	binding site for residue PEF l 101

Chain	Residue
a	VAL453
a	ILE456
b	TYR21
l	VAL57
l	PHE60
l	SER61
l	LYS62

site_id	AH5
Number of Residues	3
Details	binding site for residue CU n 601

Chain	Residue
n	HIS241
n	HIS290
n	HIS291

site_id	AH6
Number of Residues	22
Details	binding site for residue HEA n 602

Chain	Residue
n	PHE19
n	GLY26
n	THR30
n	SER33
n	ARG37
n	VAL59
n	HIS62
n	MET66
n	TRP127
n	TYR371
n	PHE377
n	HIS378
n	LEU381
n	ILE386
n	LEU389
n	PHE390
n	ILE424
n	PHE425
n	MET428
n	ARG438
n	ARG439
n	LEU465

site_id	AH7
Number of Residues	26
Details	binding site for residue HEA n 603

Chain	Residue
n	TRP127
n	TRP237
n	VAL244
n	TYR245
n	HIS290
n	HIS291
n	THR309
n	ILE312
n	ALA313
n	THR316
n	GLY317
n	ILE320
n	GLY352
n	GLY355
n	VAL356
n	ALA359
n	ASP364
n	HIS368
n	VAL373
n	HIS376
n	PHE377
n	VAL380
n	LEU381
n	ARG438
o	ILE50
o	ILE92

site_id	AH8
Number of Residues	4
Details	binding site for residue CA n 604

Chain	Residue
n	GLU39
n	ALA42
n	GLY44
n	PRO441

site_id	AH9
Number of Residues	4
Details	binding site for residue MG n 605

Chain	Residue
n	HIS368
n	ASP369
o	ASP187
o	GLU223

site_id	AI1
Number of Residues	14
Details	binding site for residue PEF n 606

Chain	Residue
n	PHE268
n	PHE321
n	ALA325
o	MET57
o	ILE75
o	HIS77
o	GLY78
o	ILE81
o	TRP85
o	PHE88
v	LYS11
v	VAL14
v	ILE15
v	PHE22

site_id	AI2
Number of Residues	6
Details	binding site for residue PEF n 607

Chain	Residue
n	TYR452
n	VAL453
n	ILE456
o	TYR21
y	PHE60
y	LYS62

site_id	AI3
Number of Residues	10
Details	binding site for residue PEF n 608

Chain	Residue
n	PHE95
n	PRO96
n	ARG97
p	HIS15
p	VAL17
p	TRP65
p	ILE69
p	GLU72
p	ILE87
p	PHE94

site_id	AI4
Number of Residues	6
Details	binding site for residue CUA o 301

Chain	Residue
o	HIS186
o	CYS221
o	GLU223
o	CYS225
o	HIS229
o	MET232

site_id	AI5
Number of Residues	9
Details	binding site for residue PEF o 302

Chain	Residue
n	HIS429
n	TRP450
o	TYR21
o	CYS23
v	TRP32
y	LEU51
y	PRO54
y	GLY55
y	TYR58

site_id	AI6
Number of Residues	14
Details	binding site for residue PEF p 301

Chain	Residue
p	PHE66
p	ILE69
p	VAL70
p	ALA73
p	THR74
p	HIS79
p	ILE87
p	ARG229
p	HIS234
p	LEU235
p	THR236
p	HIS239
p	VAL241
p	GLY242

site_id	AI7
Number of Residues	4
Details	binding site for residue ZN q 201

Chain	Residue
q	CYS111
q	HIS119
q	CYS134
q	CYS137

site_id	AI8
Number of Residues	7
Details	binding site for residue PEF r 201

Chain	Residue
n	PHE346
n	PHE414
o	SER55
o	LYS67
r	HIS84
r	LYS86
r	ILE92

site_id	AI9
Number of Residues	4
Details	binding site for residue PCF r 202

Chain	Residue
n	TYR452
r	GLY108
r	ARG111
r	ALA114

Functional Information from PROSITE/UniProt

site_id	PS00077
Number of Residues	55
Details	COX1_CUB Heme-copper oxidase catalytic subunit, copper B binding region signature. WFFGHPeVyiliipgfgiishvvstyskkpvfgeismvyamasigllgflvws..HH

Chain	Residue	Details
n	TRP237-HIS291

site_id	PS00078
Number of Residues	49
Details	COX2 CO II and nitrous oxide reductase dinuclear copper centers signature. ViHdfaipslgikvdatpgrlnqvsaliqregvfyga......CselCgtgHanM

Chain	Residue	Details
o	VAL184-MET232

site_id	PS00143
Number of Residues	23
Details	INSULINASE Insulinase family, zinc-binding region signature. Ggsryatkd.GvAHLLNRFnFqNT

Chain	Residue	Details
B	GLY37-THR59

site_id	PS00848
Number of Residues	23
Details	COX5B_1 Cytochrome c oxidase subunit Vb, zinc binding region signature. IMWlkptvnevarCweCGsvYKL

Chain	Residue	Details
q	ILE121-LEU143

site_id	PS01329
Number of Residues	18
Details	COX6A Cytochrome c oxidase subunit VIa signature. IRsKpFfWGDGdKTlFwN

Chain	Residue	Details
k	ILE101-ASN118

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	134
Details	TOPO_DOM: Mitochondrial matrix => ECO:0000250\|UniProtKB:P00424

Chain	Residue	Details
e	VAL18-GLY85
n	MET172-PRO183
n	LYS264-GLY269
n	HIS328-ALA335
n	LEU401-ASN406
n	GLN475-SER534
r	VAL18-GLY85
d	CYS134
d	CYS137
q	CYS111
q	HIS119
q	CYS134
q	CYS137
n	GLY89-ARG97

site_id	SWS_FT_FI2
Number of Residues	44
Details	TRANSMEM: Helical => ECO:0000250\|UniProtKB:P00424

Chain	Residue	Details
e	LYS86-GLY108
N	GLY75-TYR102
N	VAL111-VAL135
N	ASN173-HIS204
N	TYR224-TYR246
N	LYS288-THR308
N	VAL320-GLY340
N	TYR348-LEU364
r	LYS86-GLY108
C	VAL111-VAL135
C	ASN173-HIS204
C	TYR224-TYR246
C	LYS288-THR308
C	VAL320-GLY340
C	TYR348-LEU364
N	TYR28-ALA51

site_id	SWS_FT_FI3
Number of Residues	84
Details	TOPO_DOM: Mitochondrial intermembrane => ECO:0000250\|UniProtKB:P00424

Chain	Residue	Details
e	LEU109-LYS151
n	GLY296-ASP298
n	ALA359-THR370
n	GLY432-GLY449
r	LEU109-LYS151
c	TYR189-TYR201
c	TRP266-VAL269
p	HIS42-MET48
p	SER115-LEU137
p	TYR189-TYR201
p	TRP266-VAL269
n	PHE216-ASP228

site_id	SWS_FT_FI4
Number of Residues	48
Details	TRANSMEM: Helical; Name=2 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	ASN49-ALA73
p	ASN49-ALA73
E	CYS178
E	HIS181
P	CYS159
P	HIS161
P	CYS178
P	HIS181

site_id	SWS_FT_FI5
Number of Residues	66
Details	TRANSMEM: Helical; Name=3 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	MET81-MET114
p	MET81-MET114
b	CYS225
b	MET232
o	HIS186
o	CYS221
o	CYS225
o	MET232

site_id	SWS_FT_FI6
Number of Residues	46
Details	TRANSMEM: Helical; Name=4 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	PRO138-ALA161
p	PRO138-ALA161
o	GLU223
o	HIS229

site_id	SWS_FT_FI7
Number of Residues	46
Details	TRANSMEM: Helical; Name=5 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	ASN165-GLU188
p	ASN165-GLU188

site_id	SWS_FT_FI8
Number of Residues	56
Details	TRANSMEM: Helical; Name=6 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	GLY202-MET230
p	GLY202-MET230

site_id	SWS_FT_FI9
Number of Residues	32
Details	TRANSMEM: Helical; Name=7 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
c	TYR249-TYR265
p	TYR249-TYR265

site_id	SWS_FT_FI10
Number of Residues	56
Details	TRANSMEM: Helical; Name=8 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	ALA299-ILE327
n	ALA299-ILE327

site_id	SWS_FT_FI11
Number of Residues	44
Details	TRANSMEM: Helical; Name=9 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	THR336-LEU358
n	THR336-LEU358

site_id	SWS_FT_FI12
Number of Residues	58
Details	TRANSMEM: Helical; Name=10 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	TYR371-ILE400
n	TYR371-ILE400

site_id	SWS_FT_FI13
Number of Residues	48
Details	TRANSMEM: Helical; Name=11 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	GLU407-LEU431
n	GLU407-LEU431

site_id	SWS_FT_FI14
Number of Residues	48
Details	TRANSMEM: Helical; Name=12 => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	TRP450-ASP474
n	TRP450-ASP474

site_id	SWS_FT_FI15
Number of Residues	18
Details	BINDING: BINDING => ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556

Chain	Residue	Details
a	GLU39
n	GLU39
n	ALA42
n	GLY44
n	HIS241
n	HIS290
n	HIS291
n	HIS368
n	ASP369
n	PRO441
a	ALA42
a	GLY44
a	HIS241
a	HIS290
a	HIS291
a	HIS368
a	ASP369
a	PRO441

site_id	SWS_FT_FI16
Number of Residues	4
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:30598554, ECO:0000269\|PubMed:30598556

Chain	Residue	Details
a	HIS62
a	HIS378
n	HIS62
n	HIS378

site_id	SWS_FT_FI17
Number of Residues	2
Details	BINDING: BINDING => ECO:0000250\|UniProtKB:P00396

Chain	Residue	Details
a	TYR245
n	TYR245

site_id	SWS_FT_FI18
Number of Residues	2
Details	BINDING: axial binding residue => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	HIS376
n	HIS376

site_id	SWS_FT_FI19
Number of Residues	4
Details	CROSSLNK: 1'-histidyl-3'-tyrosine (His-Tyr) => ECO:0000269\|PubMed:30598554

Chain	Residue	Details
a	HIS241
a	TYR245
n	HIS241
n	TYR245

Catalytic Information from CSA

site_id	MCSA1
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
E	HIS181	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	SER206	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
C	LYS228	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
C	ASP229	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
C	GLU272	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

site_id	MCSA2
Number of Residues	1
Details	M-CSA 208

Chain	Residue	Details
O	SER212	covalently attached, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
M	LYS222	electrostatic stabiliser, hydrogen bond donor, radical stabiliser
M	PRO244	electrostatic stabiliser, hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser
M	VAL245	electrostatic stabiliser, hydrogen bond acceptor, radical stabiliser
M	PHE288	hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, radical stabiliser

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)