6T02
Crystal structure of YTHDC1 with fragment 15 (DHU_DC1_169)
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 6 |
| Details | binding site for residue M5E A 601 |
| Chain | Residue |
| A | SER378 |
| A | THR379 |
| A | LEU380 |
| A | TRP428 |
| A | SO4603 |
| A | HOH789 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue M5E A 602 |
| Chain | Residue |
| A | HOH730 |
| B | TYR350 |
| B | HIS427 |
| B | TRP428 |
| A | PRO464 |
| A | TRP465 |
| A | HOH720 |
| site_id | AC3 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 603 |
| Chain | Residue |
| A | SER362 |
| A | ASN363 |
| A | ASN367 |
| A | TRP377 |
| A | M5E601 |
| A | HOH705 |
| A | HOH725 |
| site_id | AC4 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 A 604 |
| Chain | Residue |
| A | GLY344 |
| A | THR345 |
| A | SER346 |
| A | LYS347 |
| A | HOH718 |
| A | HOH735 |
| A | HOH811 |
| site_id | AC5 |
| Number of Residues | 10 |
| Details | binding site for residue SO4 A 605 |
| Chain | Residue |
| A | LYS386 |
| A | TRP465 |
| A | GLN478 |
| A | GLU479 |
| A | HOH762 |
| A | HOH770 |
| A | HOH784 |
| B | GLY344 |
| B | LYS347 |
| B | HOH877 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 606 |
| Chain | Residue |
| A | SER417 |
| A | GLU418 |
| A | HIS420 |
| site_id | AC7 |
| Number of Residues | 3 |
| Details | binding site for residue SO4 A 607 |
| Chain | Residue |
| A | HIS420 |
| A | HIS421 |
| A | HOH727 |
| site_id | AC8 |
| Number of Residues | 8 |
| Details | binding site for residue M5E B 601 |
| Chain | Residue |
| B | TRP377 |
| B | SER378 |
| B | THR379 |
| B | LEU380 |
| B | TRP428 |
| B | MET434 |
| B | SO4602 |
| B | HOH763 |
| site_id | AC9 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 602 |
| Chain | Residue |
| B | SER362 |
| B | ASN363 |
| B | ASN364 |
| B | ASN367 |
| B | TRP377 |
| B | M5E601 |
| B | HOH725 |
| B | HOH726 |
| B | HOH735 |
| site_id | AD1 |
| Number of Residues | 7 |
| Details | binding site for residue SO4 B 603 |
| Chain | Residue |
| B | ARG451 |
| B | GLU452 |
| B | HOH742 |
| B | HOH754 |
| B | HOH769 |
| B | HOH792 |
| B | HOH795 |
| site_id | AD2 |
| Number of Residues | 9 |
| Details | binding site for residue SO4 B 604 |
| Chain | Residue |
| B | SER419 |
| B | HIS420 |
| B | HIS421 |
| B | ARG451 |
| B | PRO493 |
| B | HOH718 |
| B | HOH825 |
| B | HOH828 |
| B | HOH842 |
| site_id | AD3 |
| Number of Residues | 5 |
| Details | binding site for residue SO4 B 605 |
| Chain | Residue |
| B | ARG404 |
| B | ARG475 |
| B | ASP476 |
| B | HOH766 |
| B | HOH834 |
| site_id | AD4 |
| Number of Residues | 6 |
| Details | binding site for residue SO4 B 606 |
| Chain | Residue |
| B | PRO454 |
| B | LYS457 |
| B | HOH706 |
| B | HOH711 |
| B | HOH816 |
| B | HOH832 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31670957","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RT4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RT7","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"25242552","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 137 |
| Details | Domain: {"description":"YTH","evidences":[{"source":"PROSITE-ProRule","id":"PRU00225","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
