6SZP
High resolution crystal structure of human DDAH-1 in complex with N-(4-Aminobutyl)-N'-(2-Methoxyethyl)guanidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000052 | biological_process | citrulline metabolic process |
| A | 0003073 | biological_process | regulation of systemic arterial blood pressure |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0006527 | biological_process | L-arginine catabolic process |
| A | 0007263 | biological_process | nitric oxide mediated signal transduction |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016403 | molecular_function | dimethylargininase activity |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0030235 | molecular_function | nitric-oxide synthase regulator activity |
| A | 0043116 | biological_process | negative regulation of vascular permeability |
| A | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0046209 | biological_process | nitric oxide metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1900038 | biological_process | negative regulation of cellular response to hypoxia |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue M3B A 300 |
| Chain | Residue |
| A | LEU30 |
| A | CYS274 |
| A | HOH462 |
| A | ASP73 |
| A | PHE76 |
| A | ASP79 |
| A | ARG98 |
| A | HIS173 |
| A | SER176 |
| A | VAL268 |
| A | ASP269 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | PHE10 |
| A | TYR224 |
| A | LEU278 |
| A | HOH411 |
| A | HOH424 |
| A | HOH432 |
| A | HOH465 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | LYS159 |
| A | ASP160 |
| A | ALA162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Proton donor","evidences":[{"source":"PubMed","id":"19663506","evidenceCode":"ECO:0000305"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"19663506","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | Binding site: {} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"S-nitrosocysteine","evidences":[{"source":"UniProtKB","id":"P56965","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
