6SZP
High resolution crystal structure of human DDAH-1 in complex with N-(4-Aminobutyl)-N'-(2-Methoxyethyl)guanidine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000052 | biological_process | citrulline metabolic process |
| A | 0003073 | biological_process | regulation of systemic arterial blood pressure |
| A | 0003824 | molecular_function | catalytic activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006525 | biological_process | arginine metabolic process |
| A | 0006527 | biological_process | arginine catabolic process |
| A | 0007263 | biological_process | nitric oxide mediated signal transduction |
| A | 0008285 | biological_process | negative regulation of cell population proliferation |
| A | 0016403 | molecular_function | dimethylargininase activity |
| A | 0016597 | molecular_function | amino acid binding |
| A | 0016787 | molecular_function | hydrolase activity |
| A | 0043116 | biological_process | negative regulation of vascular permeability |
| A | 0045429 | biological_process | positive regulation of nitric oxide biosynthetic process |
| A | 0045766 | biological_process | positive regulation of angiogenesis |
| A | 0046209 | biological_process | nitric oxide metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 1900038 | biological_process | negative regulation of cellular response to hypoxia |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 11 |
| Details | binding site for residue M3B A 300 |
| Chain | Residue |
| A | LEU30 |
| A | CYS274 |
| A | HOH462 |
| A | ASP73 |
| A | PHE76 |
| A | ASP79 |
| A | ARG98 |
| A | HIS173 |
| A | SER176 |
| A | VAL268 |
| A | ASP269 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue GOL A 301 |
| Chain | Residue |
| A | PHE10 |
| A | TYR224 |
| A | LEU278 |
| A | HOH411 |
| A | HOH424 |
| A | HOH432 |
| A | HOH465 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 302 |
| Chain | Residue |
| A | LYS159 |
| A | ASP160 |
| A | ALA162 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | ACT_SITE: Proton donor => ECO:0000305|PubMed:19663506 |
| Chain | Residue | Details |
| A | HIS173 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:19663506 |
| Chain | Residue | Details |
| A | CYS274 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | BINDING: |
| Chain | Residue | Details |
| A | ASP73 | |
| A | GLU78 | |
| A | ARG98 | |
| A | ARG145 | |
| A | VAL268 | |
| A | LEU30 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000250 |
| Chain | Residue | Details |
| A | CYS274 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 1 |
| Details | MOD_RES: N-acetylalanine => ECO:0000269|PubMed:9874257, ECO:0007744|PubMed:19413330 |
| Chain | Residue | Details |
| A | ALA2 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | MOD_RES: S-nitrosocysteine => ECO:0000250|UniProtKB:P56965 |
| Chain | Residue | Details |
| A | CYS274 | |
| A | CYS222 |
