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6SYF

Human Ubc9 with covalent isopeptide ligand

Functional Information from GO Data
ChainGOidnamespacecontents
A0000122biological_processnegative regulation of transcription by RNA polymerase II
A0000795cellular_componentsynaptonemal complex
A0001221molecular_functiontranscription coregulator binding
A0003723molecular_functionRNA binding
A0005515molecular_functionprotein binding
A0005524molecular_functionATP binding
A0005634cellular_componentnucleus
A0005635cellular_componentnuclear envelope
A0005643cellular_componentnuclear pore
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006511biological_processubiquitin-dependent protein catabolic process
A0007059biological_processchromosome segregation
A0007084biological_processmitotic nuclear membrane reassembly
A0008134molecular_functiontranscription factor binding
A0016605cellular_componentPML body
A0016740molecular_functiontransferase activity
A0016925biological_processprotein sumoylation
A0019787molecular_functionubiquitin-like protein transferase activity
A0019789molecular_functionSUMO transferase activity
A0019899molecular_functionenzyme binding
A0030335biological_processpositive regulation of cell migration
A0032446biological_processprotein modification by small protein conjugation
A0036211biological_processprotein modification process
A0044388molecular_functionsmall protein activating enzyme binding
A0045892biological_processnegative regulation of DNA-templated transcription
A0048471cellular_componentperinuclear region of cytoplasm
A0051168biological_processnuclear export
A0051301biological_processcell division
A0061656molecular_functionSUMO conjugating enzyme activity
A0071535molecular_functionRING-like zinc finger domain binding
A0106068cellular_componentSUMO ligase complex
A1903755biological_processpositive regulation of SUMO transferase activity
A1990234cellular_componenttransferase complex
B0000122biological_processnegative regulation of transcription by RNA polymerase II
B0000795cellular_componentsynaptonemal complex
B0001221molecular_functiontranscription coregulator binding
B0003723molecular_functionRNA binding
B0005515molecular_functionprotein binding
B0005524molecular_functionATP binding
B0005634cellular_componentnucleus
B0005635cellular_componentnuclear envelope
B0005643cellular_componentnuclear pore
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005829cellular_componentcytosol
B0006511biological_processubiquitin-dependent protein catabolic process
B0007059biological_processchromosome segregation
B0007084biological_processmitotic nuclear membrane reassembly
B0008134molecular_functiontranscription factor binding
B0016605cellular_componentPML body
B0016740molecular_functiontransferase activity
B0016925biological_processprotein sumoylation
B0019787molecular_functionubiquitin-like protein transferase activity
B0019789molecular_functionSUMO transferase activity
B0019899molecular_functionenzyme binding
B0030335biological_processpositive regulation of cell migration
B0032446biological_processprotein modification by small protein conjugation
B0036211biological_processprotein modification process
B0044388molecular_functionsmall protein activating enzyme binding
B0045892biological_processnegative regulation of DNA-templated transcription
B0048471cellular_componentperinuclear region of cytoplasm
B0051168biological_processnuclear export
B0051301biological_processcell division
B0061656molecular_functionSUMO conjugating enzyme activity
B0071535molecular_functionRING-like zinc finger domain binding
B0106068cellular_componentSUMO ligase complex
B1903755biological_processpositive regulation of SUMO transferase activity
B1990234cellular_componenttransferase complex
C0000122biological_processnegative regulation of transcription by RNA polymerase II
C0000795cellular_componentsynaptonemal complex
C0001221molecular_functiontranscription coregulator binding
C0003723molecular_functionRNA binding
C0005515molecular_functionprotein binding
C0005524molecular_functionATP binding
C0005634cellular_componentnucleus
C0005635cellular_componentnuclear envelope
C0005643cellular_componentnuclear pore
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005829cellular_componentcytosol
C0006511biological_processubiquitin-dependent protein catabolic process
C0007059biological_processchromosome segregation
C0007084biological_processmitotic nuclear membrane reassembly
C0008134molecular_functiontranscription factor binding
C0016605cellular_componentPML body
C0016740molecular_functiontransferase activity
C0016925biological_processprotein sumoylation
C0019787molecular_functionubiquitin-like protein transferase activity
C0019789molecular_functionSUMO transferase activity
C0019899molecular_functionenzyme binding
C0030335biological_processpositive regulation of cell migration
C0032446biological_processprotein modification by small protein conjugation
C0036211biological_processprotein modification process
C0044388molecular_functionsmall protein activating enzyme binding
C0045892biological_processnegative regulation of DNA-templated transcription
C0048471cellular_componentperinuclear region of cytoplasm
C0051168biological_processnuclear export
C0051301biological_processcell division
C0061656molecular_functionSUMO conjugating enzyme activity
C0071535molecular_functionRING-like zinc finger domain binding
C0106068cellular_componentSUMO ligase complex
C1903755biological_processpositive regulation of SUMO transferase activity
C1990234cellular_componenttransferase complex
D0000122biological_processnegative regulation of transcription by RNA polymerase II
D0000795cellular_componentsynaptonemal complex
D0001221molecular_functiontranscription coregulator binding
D0003723molecular_functionRNA binding
D0005515molecular_functionprotein binding
D0005524molecular_functionATP binding
D0005634cellular_componentnucleus
D0005635cellular_componentnuclear envelope
D0005643cellular_componentnuclear pore
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005829cellular_componentcytosol
D0006511biological_processubiquitin-dependent protein catabolic process
D0007059biological_processchromosome segregation
D0007084biological_processmitotic nuclear membrane reassembly
D0008134molecular_functiontranscription factor binding
D0016605cellular_componentPML body
D0016740molecular_functiontransferase activity
D0016925biological_processprotein sumoylation
D0019787molecular_functionubiquitin-like protein transferase activity
D0019789molecular_functionSUMO transferase activity
D0019899molecular_functionenzyme binding
D0030335biological_processpositive regulation of cell migration
D0032446biological_processprotein modification by small protein conjugation
D0036211biological_processprotein modification process
D0044388molecular_functionsmall protein activating enzyme binding
D0045892biological_processnegative regulation of DNA-templated transcription
D0048471cellular_componentperinuclear region of cytoplasm
D0051168biological_processnuclear export
D0051301biological_processcell division
D0061656molecular_functionSUMO conjugating enzyme activity
D0071535molecular_functionRING-like zinc finger domain binding
D0106068cellular_componentSUMO ligase complex
D1903755biological_processpositive regulation of SUMO transferase activity
D1990234cellular_componenttransferase complex
Functional Information from PROSITE/UniProt
site_idPS00183
Number of Residues16
DetailsUBC_1 Ubiquitin-conjugating (UBC) active site signature. FHPNVyps.GtVCLsiL
ChainResidueDetails
APHE82-LEU97

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues4
DetailsACT_SITE: Glycyl thioester intermediate
ChainResidueDetails
ACYS93
BCYS93
CCYS93
DCYS93

site_idSWS_FT_FI2
Number of Residues12
DetailsSITE: Interaction with RANBP2
ChainResidueDetails
AILE4
DILE4
DVAL25
DLEU57
AVAL25
ALEU57
BILE4
BVAL25
BLEU57
CILE4
CVAL25
CLEU57

site_idSWS_FT_FI3
Number of Residues4
DetailsSITE: Substrate binding
ChainResidueDetails
AASP100
BASP100
CASP100
DASP100

site_idSWS_FT_FI4
Number of Residues4
DetailsMOD_RES: N-acetylserine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22814378
ChainResidueDetails
ASER2
BSER2
CSER2
DSER2

site_idSWS_FT_FI5
Number of Residues4
DetailsMOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861
ChainResidueDetails
ALYS65
BLYS65
CLYS65
DLYS65

site_idSWS_FT_FI6
Number of Residues4
DetailsMOD_RES: Phosphoserine; by CDK1 => ECO:0000269|PubMed:22509284, ECO:0007744|PubMed:23186163
ChainResidueDetails
ASER71
BSER71
CSER71
DSER71

site_idSWS_FT_FI7
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate
ChainResidueDetails
ALYS18
BLYS18
CLYS18
DLYS18

site_idSWS_FT_FI8
Number of Residues8
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733
ChainResidueDetails
ALYS101
BLYS101
CLYS101
DLYS101

site_idSWS_FT_FI9
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:28112733
ChainResidueDetails
AALA48
BALA48
CALA48
DALA48

site_idSWS_FT_FI10
Number of Residues4
DetailsCROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternate => ECO:0007744|PubMed:25114211, ECO:0007744|PubMed:25218447, ECO:0007744|PubMed:25755297, ECO:0007744|PubMed:25772364, ECO:0007744|PubMed:28112733
ChainResidueDetails
AALA49
BALA49
CALA49
DALA49

220113

PDB entries from 2024-05-22

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