6SY1
Crystal structure of the human 2-oxoadipate dehydrogenase DHTKD1 (E1)
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| A | 0004591 | molecular_function | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| A | 0005515 | molecular_function | protein binding |
| A | 0005739 | cellular_component | mitochondrion |
| A | 0005759 | cellular_component | mitochondrial matrix |
| A | 0006091 | biological_process | generation of precursor metabolites and energy |
| A | 0006096 | biological_process | glycolytic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| A | 0030976 | molecular_function | thiamine pyrophosphate binding |
| A | 0160166 | molecular_function | 2-oxoadipate dehydrogenase activity |
| A | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
| B | 0002244 | biological_process | hematopoietic progenitor cell differentiation |
| B | 0004591 | molecular_function | oxoglutarate dehydrogenase (succinyl-transferring) activity |
| B | 0005515 | molecular_function | protein binding |
| B | 0005739 | cellular_component | mitochondrion |
| B | 0005759 | cellular_component | mitochondrial matrix |
| B | 0006091 | biological_process | generation of precursor metabolites and energy |
| B | 0006096 | biological_process | glycolytic process |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0016624 | molecular_function | oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor |
| B | 0030976 | molecular_function | thiamine pyrophosphate binding |
| B | 0160166 | molecular_function | 2-oxoadipate dehydrogenase activity |
| B | 0160167 | cellular_component | oxoadipate dehydrogenase complex |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 23 |
| Details | binding site for residue TPP A 1001 |
| Chain | Residue |
| A | HIS223 |
| A | ASN366 |
| A | LEU368 |
| A | GLY369 |
| A | HIS435 |
| A | MG1002 |
| A | HOH1133 |
| A | HOH1308 |
| A | HOH1431 |
| A | HOH1451 |
| B | GLN594 |
| A | ARG224 |
| B | LEU638 |
| B | GLU640 |
| B | GLN664 |
| B | PHE668 |
| A | SER288 |
| A | HIS289 |
| A | LEU290 |
| A | GLY332 |
| A | ASP333 |
| A | ALA334 |
| A | SER335 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue MG A 1002 |
| Chain | Residue |
| A | ASP333 |
| A | ASN366 |
| A | LEU368 |
| A | TPP1001 |
| A | HOH1133 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | binding site for residue MG A 1003 |
| Chain | Residue |
| A | GLU641 |
| A | HOH1378 |
| B | GLU641 |
| B | HOH1171 |
| B | HOH1237 |
| B | HOH1378 |
| site_id | AC4 |
| Number of Residues | 23 |
| Details | binding site for residue TPP B 1001 |
| Chain | Residue |
| A | GLN594 |
| A | LEU638 |
| A | GLU640 |
| A | GLN664 |
| A | PHE668 |
| B | HIS223 |
| B | ARG224 |
| B | SER288 |
| B | HIS289 |
| B | LEU290 |
| B | GLY332 |
| B | ASP333 |
| B | ALA334 |
| B | SER335 |
| B | ASN366 |
| B | LEU368 |
| B | GLY369 |
| B | HIS435 |
| B | MG1002 |
| B | HOH1225 |
| B | HOH1228 |
| B | HOH1295 |
| B | HOH1455 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue MG B 1002 |
| Chain | Residue |
| B | ASP333 |
| B | ASN366 |
| B | LEU368 |
| B | TPP1001 |
| B | HOH1228 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 42 |
| Details | Region: {"description":"Disordered","evidences":[{"source":"SAM","id":"MobiDB-lite","evidenceCode":"ECO:0000256"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | Modified residue: {"description":"N6-succinyllysine","evidences":[{"source":"UniProtKB","id":"A2ATU0","evidenceCode":"ECO:0000250"}]} |
| Chain | Residue | Details |
