6SXA

XPF-ERCC1 Cryo-EM Structure, Apo-form

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
F	0000109	cellular_component	nucleotide-excision repair complex
F	0000110	cellular_component	nucleotide-excision repair factor 1 complex
F	0000712	biological_process	resolution of meiotic recombination intermediates
F	0000723	biological_process	telomere maintenance
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000781	cellular_component	chromosome, telomeric region
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0004520	molecular_function	DNA endonuclease activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0009411	biological_process	response to UV
F	0009650	biological_process	UV protection
F	0010506	biological_process	regulation of autophagy
F	0010521	molecular_function	telomerase inhibitor activity
F	0032205	biological_process	negative regulation of telomere maintenance
F	0034644	biological_process	cellular response to UV
F	0042802	molecular_function	identical protein binding
F	0051974	biological_process	negative regulation of telomerase activity
F	0061819	biological_process	telomeric DNA-containing double minutes formation
F	0070522	cellular_component	ERCC4-ERCC1 complex
F	1901255	biological_process	nucleotide-excision repair involved in interstrand cross-link repair
F	1904357	biological_process	negative regulation of telomere maintenance via telomere lengthening
F	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
F	1905768	biological_process	negative regulation of double-stranded telomeric DNA binding
F	1990599	molecular_function	3' overhang single-stranded DNA endodeoxyribonuclease activity
F	1990841	molecular_function	promoter-specific chromatin binding
G	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
G	0000109	cellular_component	nucleotide-excision repair complex
G	0000110	cellular_component	nucleotide-excision repair factor 1 complex
G	0000720	biological_process	pyrimidine dimer repair by nucleotide-excision repair
G	0000781	cellular_component	chromosome, telomeric region
G	0001094	molecular_function	TFIID-class transcription factor complex binding
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006289	biological_process	nucleotide-excision repair
G	0006302	biological_process	double-strand break repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006310	biological_process	DNA recombination
G	0006312	biological_process	mitotic recombination
G	0006949	biological_process	syncytium formation
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0007281	biological_process	germ cell development
G	0007283	biological_process	spermatogenesis
G	0007584	biological_process	response to nutrient
G	0008283	biological_process	cell population proliferation
G	0008340	biological_process	determination of adult lifespan
G	0008584	biological_process	male gonad development
G	0009650	biological_process	UV protection
G	0009744	biological_process	response to sucrose
G	0010165	biological_process	response to X-ray
G	0032205	biological_process	negative regulation of telomere maintenance
G	0035166	biological_process	post-embryonic hemopoiesis
G	0035264	biological_process	multicellular organism growth
G	0035902	biological_process	response to immobilization stress
G	0036297	biological_process	interstrand cross-link repair
G	0045190	biological_process	isotype switching
G	0046686	biological_process	response to cadmium ion
G	0048009	biological_process	insulin-like growth factor receptor signaling pathway
G	0048468	biological_process	cell development
G	0048477	biological_process	oogenesis
G	0048568	biological_process	embryonic organ development
G	0051276	biological_process	chromosome organization
G	0060261	biological_process	positive regulation of transcription initiation by RNA polymerase II
G	0061819	biological_process	telomeric DNA-containing double minutes formation
G	0070522	cellular_component	ERCC4-ERCC1 complex
G	0070914	biological_process	UV-damage excision repair
G	0090399	biological_process	replicative senescence
G	0090656	biological_process	t-circle formation
G	1904431	biological_process	positive regulation of t-circle formation
G	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
G	1990599	molecular_function	3' overhang single-stranded DNA endodeoxyribonuclease activity
G	1990841	molecular_function	promoter-specific chromatin binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861

Chain	Residue	Details
F	LYS289

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site_id	SWS_FT_FI2
Number of Residues	2
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q9QZD4

Chain	Residue	Details
F	SER521
F	SER764

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site_id	SWS_FT_FI3
Number of Residues	1
Details	MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:32034146

Chain	Residue	Details
F	LYS911
G	LYS37
G	LYS243

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site_id	SWS_FT_FI4
Number of Residues	2
Details	CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733

Chain	Residue	Details
F	LYS500

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