6SXA

XPF-ERCC1 Cryo-EM Structure, Apo-form

Functional Information from GO Data

Chain	GOid	namespace	contents
F	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
F	0000109	cellular_component	nucleotide-excision repair complex
F	0000110	cellular_component	nucleotide-excision repair factor 1 complex
F	0000712	biological_process	resolution of meiotic recombination intermediates
F	0000723	biological_process	telomere maintenance
F	0000724	biological_process	double-strand break repair via homologous recombination
F	0000781	cellular_component	chromosome, telomeric region
F	0001094	molecular_function	TFIID-class transcription factor complex binding
F	0003677	molecular_function	DNA binding
F	0003684	molecular_function	damaged DNA binding
F	0003697	molecular_function	single-stranded DNA binding
F	0004518	molecular_function	nuclease activity
F	0004519	molecular_function	endonuclease activity
F	0004520	molecular_function	DNA endonuclease activity
F	0005515	molecular_function	protein binding
F	0005634	cellular_component	nucleus
F	0005654	cellular_component	nucleoplasm
F	0005694	cellular_component	chromosome
F	0006281	biological_process	DNA repair
F	0006289	biological_process	nucleotide-excision repair
F	0006303	biological_process	double-strand break repair via nonhomologous end joining
F	0006974	biological_process	DNA damage response
F	0009411	biological_process	response to UV
F	0010521	molecular_function	telomerase inhibitor activity
F	0016604	cellular_component	nuclear body
F	0016787	molecular_function	hydrolase activity
F	0032205	biological_process	negative regulation of telomere maintenance
F	0034644	biological_process	cellular response to UV
F	0042802	molecular_function	identical protein binding
F	0061819	biological_process	telomeric DNA-containing double minutes formation
F	0070522	cellular_component	ERCC4-ERCC1 complex
F	1901255	biological_process	nucleotide-excision repair involved in interstrand cross-link repair
F	1904357	biological_process	negative regulation of telomere maintenance via telomere lengthening
F	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
F	1990599	molecular_function	3' overhang single-stranded DNA endodeoxyribonuclease activity
F	1990841	molecular_function	promoter-specific chromatin binding
G	0000014	molecular_function	single-stranded DNA endodeoxyribonuclease activity
G	0000109	cellular_component	nucleotide-excision repair complex
G	0000110	cellular_component	nucleotide-excision repair factor 1 complex
G	0000723	biological_process	telomere maintenance
G	0000781	cellular_component	chromosome, telomeric region
G	0001094	molecular_function	TFIID-class transcription factor complex binding
G	0003677	molecular_function	DNA binding
G	0003684	molecular_function	damaged DNA binding
G	0003697	molecular_function	single-stranded DNA binding
G	0005515	molecular_function	protein binding
G	0005634	cellular_component	nucleus
G	0005654	cellular_component	nucleoplasm
G	0005737	cellular_component	cytoplasm
G	0006281	biological_process	DNA repair
G	0006289	biological_process	nucleotide-excision repair
G	0006302	biological_process	double-strand break repair
G	0006303	biological_process	double-strand break repair via nonhomologous end joining
G	0006310	biological_process	DNA recombination
G	0006312	biological_process	mitotic recombination
G	0006974	biological_process	DNA damage response
G	0006979	biological_process	response to oxidative stress
G	0032204	biological_process	regulation of telomere maintenance
G	0032205	biological_process	negative regulation of telomere maintenance
G	0061819	biological_process	telomeric DNA-containing double minutes formation
G	0070522	cellular_component	ERCC4-ERCC1 complex
G	0070914	biological_process	UV-damage excision repair
G	0090656	biological_process	t-circle formation
G	1904431	biological_process	positive regulation of t-circle formation
G	1905765	biological_process	negative regulation of protection from non-homologous end joining at telomere
G	1990599	molecular_function	3' overhang single-stranded DNA endodeoxyribonuclease activity
G	1990841	molecular_function	promoter-specific chromatin binding

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	80
Details	Domain: {"description":"ERCC4"}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	21
Details	Region: {"description":"Leucine-zipper 1","evidences":[{"source":"PubMed","id":"8887684","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	28
Details	Region: {"description":"Leucine-zipper 2","evidences":[{"source":"PubMed","id":"8887684","evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	68
Details	Region: {"description":"HhH2, dimerization with ERCC1","evidences":[{"source":"PubMed","id":"16076955","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	1
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI6
Number of Residues	1
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"Q9QZD4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI7
Number of Residues	22
Details	DNA binding: {"evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI8
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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