6SVM

Crystal structure of human GFAT-1 in complex with Glucose-6-Phosphate, L-Glu, and UDP-GalNAc

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004360	molecular_function	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
A	0097367	molecular_function	carbohydrate derivative binding
A	1901135	biological_process	carbohydrate derivative metabolic process
A	1901137	biological_process	carbohydrate derivative biosynthetic process
B	0004360	molecular_function	glutamine-fructose-6-phosphate transaminase (isomerizing) activity
B	0097367	molecular_function	carbohydrate derivative binding
B	1901135	biological_process	carbohydrate derivative metabolic process
B	1901137	biological_process	carbohydrate derivative biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	16
Details	binding site for residue G6Q A 701

Chain	Residue
A	CYS374
A	SER474
A	LYS558
A	GLU561
A	HOH802
A	HOH809
A	HOH831
B	HIS577
A	GLY375
A	THR376
A	SER377
A	SER421
A	GLN422
A	SER423
A	THR426
A	ALA473

---

site_id	AC2
Number of Residues	11
Details	binding site for residue GLU A 702

Chain	Residue
A	CYS2
A	ARG95
A	TRP96
A	THR98
A	HIS99
A	HIS108
A	HIS122
A	ASN123
A	GLY124
A	ASP148
A	THR149

---

site_id	AC3
Number of Residues	15
Details	binding site for residue UD2 A 703

Chain	Residue
A	GLN310
A	ARG343
A	GLY355
A	GLY445
A	THR447
A	SER455
A	THR458
A	CYS460
A	GLY461
A	VAL462
A	HIS463
A	MG704
A	HOH811
B	TYR535
B	HIS536

---

site_id	AC4
Number of Residues	4
Details	binding site for residue MG A 704

Chain	Residue
A	SER455
A	ARG456
A	THR458
A	UD2703

---

site_id	AC5
Number of Residues	14
Details	binding site for residue G6Q B 701

Chain	Residue
A	HIS577
B	CYS374
B	GLY375
B	THR376
B	SER377
B	SER421
B	GLN422
B	SER423
B	THR426
B	ALA473
B	SER474
B	LYS558
B	GLU561
B	HOH808

---

site_id	AC6
Number of Residues	12
Details	binding site for residue UD2 B 702

Chain	Residue
B	ARG343
B	GLY354
B	GLY355
B	GLY445
B	THR447
B	SER455
B	THR458
B	CYS460
B	GLY461
B	VAL462
B	HIS463
B	MG703

---

site_id	AC7
Number of Residues	4
Details	binding site for residue MG B 703

Chain	Residue
B	SER455
B	ARG456
B	THR458
B	UD2702

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	278
Details	Domain: {"description":"SIS 1","evidences":[{"source":"PROSITE-ProRule","id":"PRU00797","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	282
Details	Domain: {"description":"SIS 2","evidences":[{"source":"PROSITE-ProRule","id":"PRU00797","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	Active site: {"description":"For GATase activity","evidences":[{"source":"UniProtKB","id":"P14742","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	10
Details	Binding site: {"evidences":[{"source":"PubMed","id":"19059404","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"2V4M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2ZJ4","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"16964243","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"18669648","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"19690332","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"},{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---