6SVL

human Myeloid-derived growth factor (MYDGF) in complex with neutralizing Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
C	0001525	biological_process	angiogenesis
C	0001934	biological_process	positive regulation of protein phosphorylation
C	0001938	biological_process	positive regulation of endothelial cell proliferation
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005783	cellular_component	endoplasmic reticulum
C	0005788	cellular_component	endoplasmic reticulum lumen
C	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
C	0005794	cellular_component	Golgi apparatus
C	0006915	biological_process	apoptotic process
C	0043066	biological_process	negative regulation of apoptotic process
C	0043410	biological_process	positive regulation of MAPK cascade
C	0045766	biological_process	positive regulation of angiogenesis
C	0045944	biological_process	positive regulation of transcription by RNA polymerase II
C	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
F	0001525	biological_process	angiogenesis
F	0001934	biological_process	positive regulation of protein phosphorylation
F	0001938	biological_process	positive regulation of endothelial cell proliferation
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005783	cellular_component	endoplasmic reticulum
F	0005788	cellular_component	endoplasmic reticulum lumen
F	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
F	0005794	cellular_component	Golgi apparatus
F	0006915	biological_process	apoptotic process
F	0043066	biological_process	negative regulation of apoptotic process
F	0043410	biological_process	positive regulation of MAPK cascade
F	0045766	biological_process	positive regulation of angiogenesis
F	0045944	biological_process	positive regulation of transcription by RNA polymerase II
F	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
J	0001525	biological_process	angiogenesis
J	0001934	biological_process	positive regulation of protein phosphorylation
J	0001938	biological_process	positive regulation of endothelial cell proliferation
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005783	cellular_component	endoplasmic reticulum
J	0005788	cellular_component	endoplasmic reticulum lumen
J	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
J	0005794	cellular_component	Golgi apparatus
J	0006915	biological_process	apoptotic process
J	0043066	biological_process	negative regulation of apoptotic process
J	0043410	biological_process	positive regulation of MAPK cascade
J	0045766	biological_process	positive regulation of angiogenesis
J	0045944	biological_process	positive regulation of transcription by RNA polymerase II
J	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
N	0001525	biological_process	angiogenesis
N	0001934	biological_process	positive regulation of protein phosphorylation
N	0001938	biological_process	positive regulation of endothelial cell proliferation
N	0005515	molecular_function	protein binding
N	0005576	cellular_component	extracellular region
N	0005615	cellular_component	extracellular space
N	0005783	cellular_component	endoplasmic reticulum
N	0005788	cellular_component	endoplasmic reticulum lumen
N	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
N	0005794	cellular_component	Golgi apparatus
N	0006915	biological_process	apoptotic process
N	0043066	biological_process	negative regulation of apoptotic process
N	0043410	biological_process	positive regulation of MAPK cascade
N	0045766	biological_process	positive regulation of angiogenesis
N	0045944	biological_process	positive regulation of transcription by RNA polymerase II
N	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Q	0001525	biological_process	angiogenesis
Q	0001934	biological_process	positive regulation of protein phosphorylation
Q	0001938	biological_process	positive regulation of endothelial cell proliferation
Q	0005515	molecular_function	protein binding
Q	0005576	cellular_component	extracellular region
Q	0005615	cellular_component	extracellular space
Q	0005783	cellular_component	endoplasmic reticulum
Q	0005788	cellular_component	endoplasmic reticulum lumen
Q	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
Q	0005794	cellular_component	Golgi apparatus
Q	0006915	biological_process	apoptotic process
Q	0043066	biological_process	negative regulation of apoptotic process
Q	0043410	biological_process	positive regulation of MAPK cascade
Q	0045766	biological_process	positive regulation of angiogenesis
Q	0045944	biological_process	positive regulation of transcription by RNA polymerase II
Q	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
R	0001525	biological_process	angiogenesis
R	0001934	biological_process	positive regulation of protein phosphorylation
R	0001938	biological_process	positive regulation of endothelial cell proliferation
R	0005515	molecular_function	protein binding
R	0005576	cellular_component	extracellular region
R	0005615	cellular_component	extracellular space
R	0005783	cellular_component	endoplasmic reticulum
R	0005788	cellular_component	endoplasmic reticulum lumen
R	0005793	cellular_component	endoplasmic reticulum-Golgi intermediate compartment
R	0005794	cellular_component	Golgi apparatus
R	0006915	biological_process	apoptotic process
R	0043066	biological_process	negative regulation of apoptotic process
R	0043410	biological_process	positive regulation of MAPK cascade
R	0045766	biological_process	positive regulation of angiogenesis
R	0045944	biological_process	positive regulation of transcription by RNA polymerase II
R	0051897	biological_process	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

Functional Information from PDB Data

site_id	AC1
Number of Residues	11
Details	binding site for residue GOL E 301

Chain	Residue
D	PHE174
E	THR179
E	HOH404
D	PRO175
D	SER185
D	LEU186
D	SER187
E	GLN161
E	SER163
E	SER177
E	SER178

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site_id	AC2
Number of Residues	8
Details	binding site for residue GOL M 301

Chain	Residue
M	VAL15
M	GLN79
M	HOH426
M	HOH572
P	THR22
P	GLY66
P	TYR71
P	SER72

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site_id	AC3
Number of Residues	10
Details	binding site for residue GOL R 201

Chain	Residue
O	TYR33
O	ARG50
P	GLY93
P	THR94
P	TRP97
R	ASP10
R	ASN43
R	GLU44
R	GLN45
R	HOH318

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH

Chain	Residue	Details
A	TYR202-HIS208
B	TYR193-HIS199

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