6STY

Human REXO2 exonuclease in complex with RNA.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000175	molecular_function	3'-5'-RNA exonuclease activity
A	0000287	molecular_function	magnesium ion binding
A	0003676	molecular_function	nucleic acid binding
A	0004518	molecular_function	nuclease activity
A	0004527	molecular_function	exonuclease activity
A	0005634	cellular_component	nucleus
A	0005737	cellular_component	cytoplasm
A	0005739	cellular_component	mitochondrion
A	0005758	cellular_component	mitochondrial intermembrane space
A	0005759	cellular_component	mitochondrial matrix
A	0006139	biological_process	nucleobase-containing compound metabolic process
A	0006259	biological_process	DNA metabolic process
A	0008296	molecular_function	3'-5'-DNA exonuclease activity
A	0008408	molecular_function	3'-5' exonuclease activity
A	0009117	biological_process	nucleotide metabolic process
A	0016787	molecular_function	hydrolase activity
A	0046872	molecular_function	metal ion binding
A	2000827	biological_process	mitochondrial RNA surveillance
B	0000175	molecular_function	3'-5'-RNA exonuclease activity
B	0000287	molecular_function	magnesium ion binding
B	0003676	molecular_function	nucleic acid binding
B	0004518	molecular_function	nuclease activity
B	0004527	molecular_function	exonuclease activity
B	0005634	cellular_component	nucleus
B	0005737	cellular_component	cytoplasm
B	0005739	cellular_component	mitochondrion
B	0005758	cellular_component	mitochondrial intermembrane space
B	0005759	cellular_component	mitochondrial matrix
B	0006139	biological_process	nucleobase-containing compound metabolic process
B	0006259	biological_process	DNA metabolic process
B	0008296	molecular_function	3'-5'-DNA exonuclease activity
B	0008408	molecular_function	3'-5' exonuclease activity
B	0009117	biological_process	nucleotide metabolic process
B	0016787	molecular_function	hydrolase activity
B	0046872	molecular_function	metal ion binding
B	2000827	biological_process	mitochondrial RNA surveillance
D	0000175	molecular_function	3'-5'-RNA exonuclease activity
D	0000287	molecular_function	magnesium ion binding
D	0003676	molecular_function	nucleic acid binding
D	0004518	molecular_function	nuclease activity
D	0004527	molecular_function	exonuclease activity
D	0005634	cellular_component	nucleus
D	0005737	cellular_component	cytoplasm
D	0005739	cellular_component	mitochondrion
D	0005758	cellular_component	mitochondrial intermembrane space
D	0005759	cellular_component	mitochondrial matrix
D	0006139	biological_process	nucleobase-containing compound metabolic process
D	0006259	biological_process	DNA metabolic process
D	0008296	molecular_function	3'-5'-DNA exonuclease activity
D	0008408	molecular_function	3'-5' exonuclease activity
D	0009117	biological_process	nucleotide metabolic process
D	0016787	molecular_function	hydrolase activity
D	0046872	molecular_function	metal ion binding
D	2000827	biological_process	mitochondrial RNA surveillance
E	0000175	molecular_function	3'-5'-RNA exonuclease activity
E	0000287	molecular_function	magnesium ion binding
E	0003676	molecular_function	nucleic acid binding
E	0004518	molecular_function	nuclease activity
E	0004527	molecular_function	exonuclease activity
E	0005634	cellular_component	nucleus
E	0005737	cellular_component	cytoplasm
E	0005739	cellular_component	mitochondrion
E	0005758	cellular_component	mitochondrial intermembrane space
E	0005759	cellular_component	mitochondrial matrix
E	0006139	biological_process	nucleobase-containing compound metabolic process
E	0006259	biological_process	DNA metabolic process
E	0008296	molecular_function	3'-5'-DNA exonuclease activity
E	0008408	molecular_function	3'-5' exonuclease activity
E	0009117	biological_process	nucleotide metabolic process
E	0016787	molecular_function	hydrolase activity
E	0046872	molecular_function	metal ion binding
E	2000827	biological_process	mitochondrial RNA surveillance

Functional Information from PDB Data

site_id	AC1
Number of Residues	3
Details	binding site for residue CA B 301

Chain	Residue
B	ASP47
C	U1
C	C2

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	3
Details	Active site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31588022","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	8
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31588022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6RCN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31588022","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6RCN","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Binding site: {"evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6J7Y","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	12
Details	Site: {"description":"Important for dinucleotide binding","evidences":[{"source":"PubMed","id":"30926754","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32365187","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	4
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"24275569","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	4
Details	Modified residue: {"description":"Phosphotyrosine","evidences":[{"source":"PubMed","id":"15592455","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	4
Details	Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"UniProtKB","id":"Q9D8S4","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI9
Number of Residues	328
Details	Domain: {"description":"Exonuclease"}

Chain

Residue

Details

---