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6SSU

Crystal structure of Human Microsomal Glutathione S-Transferase 2 in complex with co-substrate Glutathione

Functional Information from GO Data
ChainGOidnamespacecontents
A0004364molecular_functionglutathione transferase activity
A0004464molecular_functionleukotriene-C4 synthase activity
A0004602molecular_functionglutathione peroxidase activity
A0005515molecular_functionprotein binding
A0005635cellular_componentnuclear envelope
A0005783cellular_componentendoplasmic reticulum
A0005789cellular_componentendoplasmic reticulum membrane
A0005886cellular_componentplasma membrane
A0006629biological_processlipid metabolic process
A0006691biological_processleukotriene metabolic process
A0006750biological_processglutathione biosynthetic process
A0008047molecular_functionenzyme activator activity
A0010243biological_processresponse to organonitrogen compound
A0016020cellular_componentmembrane
A0016491molecular_functionoxidoreductase activity
A0016740molecular_functiontransferase activity
A0016829molecular_functionlyase activity
A0019370biological_processleukotriene biosynthetic process
A0032496biological_processresponse to lipopolysaccharide
A0042802molecular_functionidentical protein binding
A0043231cellular_componentintracellular membrane-bounded organelle
A0043295molecular_functionglutathione binding
A0046466biological_processmembrane lipid catabolic process
A0050729biological_processpositive regulation of inflammatory response
A0098869biological_processcellular oxidant detoxification
B0004364molecular_functionglutathione transferase activity
B0004464molecular_functionleukotriene-C4 synthase activity
B0004602molecular_functionglutathione peroxidase activity
B0005515molecular_functionprotein binding
B0005635cellular_componentnuclear envelope
B0005783cellular_componentendoplasmic reticulum
B0005789cellular_componentendoplasmic reticulum membrane
B0005886cellular_componentplasma membrane
B0006629biological_processlipid metabolic process
B0006691biological_processleukotriene metabolic process
B0006750biological_processglutathione biosynthetic process
B0008047molecular_functionenzyme activator activity
B0010243biological_processresponse to organonitrogen compound
B0016020cellular_componentmembrane
B0016491molecular_functionoxidoreductase activity
B0016740molecular_functiontransferase activity
B0016829molecular_functionlyase activity
B0019370biological_processleukotriene biosynthetic process
B0032496biological_processresponse to lipopolysaccharide
B0042802molecular_functionidentical protein binding
B0043231cellular_componentintracellular membrane-bounded organelle
B0043295molecular_functionglutathione binding
B0046466biological_processmembrane lipid catabolic process
B0050729biological_processpositive regulation of inflammatory response
B0098869biological_processcellular oxidant detoxification
C0004364molecular_functionglutathione transferase activity
C0004464molecular_functionleukotriene-C4 synthase activity
C0004602molecular_functionglutathione peroxidase activity
C0005515molecular_functionprotein binding
C0005635cellular_componentnuclear envelope
C0005783cellular_componentendoplasmic reticulum
C0005789cellular_componentendoplasmic reticulum membrane
C0005886cellular_componentplasma membrane
C0006629biological_processlipid metabolic process
C0006691biological_processleukotriene metabolic process
C0006750biological_processglutathione biosynthetic process
C0008047molecular_functionenzyme activator activity
C0010243biological_processresponse to organonitrogen compound
C0016020cellular_componentmembrane
C0016491molecular_functionoxidoreductase activity
C0016740molecular_functiontransferase activity
C0016829molecular_functionlyase activity
C0019370biological_processleukotriene biosynthetic process
C0032496biological_processresponse to lipopolysaccharide
C0042802molecular_functionidentical protein binding
C0043231cellular_componentintracellular membrane-bounded organelle
C0043295molecular_functionglutathione binding
C0046466biological_processmembrane lipid catabolic process
C0050729biological_processpositive regulation of inflammatory response
C0098869biological_processcellular oxidant detoxification
Functional Information from PDB Data
site_idAC1
Number of Residues4
Detailsbinding site for residue OLC A 201
ChainResidue
ATYR73
APHE74
ALEU124
AASN128

site_idAC2
Number of Residues5
Detailsbinding site for residue OLC A 202
ChainResidue
AGLN18
ATYR21
AHIS91
ATRP95
CARG109

site_idAC3
Number of Residues12
Detailsbinding site for residue GSH A 203
ChainResidue
AARG51
AASN55
AGLU58
ATYR93
ATYR97
AARG104
APHE108
BALA23
BVAL26
BGLY27
BARG30
BGLN53

site_idAC4
Number of Residues3
Detailsbinding site for residue NO3 B 201
ChainResidue
BARG51
BGLN54
BHOH302

site_idAC5
Number of Residues11
Detailsbinding site for residue GSH C 201
ChainResidue
AALA23
AVAL26
AARG30
AGLN53
AGLN54
CARG51
CASN55
CGLU58
CTYR93
CTYR97
CARG104

Functional Information from PROSITE/UniProt
site_idPS01297
Number of Residues15
DetailsFLAP_GST2_LTC4S FLAP/GST2/LTC4S family signature. GspeFERVFrAQqNC
ChainResidueDetails
AGLY42-CYS56

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues180
DetailsTRANSMEM: Helical => ECO:0000255
ChainResidueDetails
BILE6-VAL26
BPHE59-ALA79
BSER111-LEU131
CILE6-VAL26
CPHE59-ALA79
CSER111-LEU131
AILE6-VAL26
APHE59-ALA79
ASER111-LEU131

219869

PDB entries from 2024-05-15

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