6SSP
Structure of the pentameric ligand-gated ion channel ELIC in complex with a NAM nanobody
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004888 | molecular_function | transmembrane signaling receptor activity |
| A | 0005216 | molecular_function | monoatomic ion channel activity |
| A | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| A | 0006811 | biological_process | monoatomic ion transport |
| A | 0016020 | cellular_component | membrane |
| A | 0034220 | biological_process | monoatomic ion transmembrane transport |
| B | 0004888 | molecular_function | transmembrane signaling receptor activity |
| B | 0005216 | molecular_function | monoatomic ion channel activity |
| B | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| B | 0006811 | biological_process | monoatomic ion transport |
| B | 0016020 | cellular_component | membrane |
| B | 0034220 | biological_process | monoatomic ion transmembrane transport |
| C | 0004888 | molecular_function | transmembrane signaling receptor activity |
| C | 0005216 | molecular_function | monoatomic ion channel activity |
| C | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| C | 0006811 | biological_process | monoatomic ion transport |
| C | 0016020 | cellular_component | membrane |
| C | 0034220 | biological_process | monoatomic ion transmembrane transport |
| D | 0004888 | molecular_function | transmembrane signaling receptor activity |
| D | 0005216 | molecular_function | monoatomic ion channel activity |
| D | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| D | 0006811 | biological_process | monoatomic ion transport |
| D | 0016020 | cellular_component | membrane |
| D | 0034220 | biological_process | monoatomic ion transmembrane transport |
| E | 0004888 | molecular_function | transmembrane signaling receptor activity |
| E | 0005216 | molecular_function | monoatomic ion channel activity |
| E | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| E | 0006811 | biological_process | monoatomic ion transport |
| E | 0016020 | cellular_component | membrane |
| E | 0034220 | biological_process | monoatomic ion transmembrane transport |
| F | 0004888 | molecular_function | transmembrane signaling receptor activity |
| F | 0005216 | molecular_function | monoatomic ion channel activity |
| F | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| F | 0006811 | biological_process | monoatomic ion transport |
| F | 0016020 | cellular_component | membrane |
| F | 0034220 | biological_process | monoatomic ion transmembrane transport |
| G | 0004888 | molecular_function | transmembrane signaling receptor activity |
| G | 0005216 | molecular_function | monoatomic ion channel activity |
| G | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| G | 0006811 | biological_process | monoatomic ion transport |
| G | 0016020 | cellular_component | membrane |
| G | 0034220 | biological_process | monoatomic ion transmembrane transport |
| H | 0004888 | molecular_function | transmembrane signaling receptor activity |
| H | 0005216 | molecular_function | monoatomic ion channel activity |
| H | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| H | 0006811 | biological_process | monoatomic ion transport |
| H | 0016020 | cellular_component | membrane |
| H | 0034220 | biological_process | monoatomic ion transmembrane transport |
| I | 0004888 | molecular_function | transmembrane signaling receptor activity |
| I | 0005216 | molecular_function | monoatomic ion channel activity |
| I | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| I | 0006811 | biological_process | monoatomic ion transport |
| I | 0016020 | cellular_component | membrane |
| I | 0034220 | biological_process | monoatomic ion transmembrane transport |
| J | 0004888 | molecular_function | transmembrane signaling receptor activity |
| J | 0005216 | molecular_function | monoatomic ion channel activity |
| J | 0005230 | molecular_function | extracellular ligand-gated monoatomic ion channel activity |
| J | 0006811 | biological_process | monoatomic ion transport |
| J | 0016020 | cellular_component | membrane |
| J | 0034220 | biological_process | monoatomic ion transmembrane transport |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 401 |
| Chain | Residue |
| A | ASP113 |
| E | ASP158 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue UMQ A 402 |
| Chain | Residue |
| A | THR259 |
| A | GLN264 |
| A | GLY271 |
| A | SER272 |
| E | TRP206 |
| site_id | AC3 |
| Number of Residues | 2 |
| Details | binding site for residue CA B 401 |
| Chain | Residue |
| A | ASP158 |
| B | ASP113 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue UMQ B 402 |
| Chain | Residue |
| A | TRP206 |
| B | THR259 |
| B | GLN264 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue UMQ B 403 |
| Chain | Residue |
| B | TRP206 |
| C | THR259 |
| C | GLN264 |
| C | ILE311 |
| C | LEU315 |
| site_id | AC6 |
| Number of Residues | 1 |
| Details | binding site for residue CA C 401 |
| Chain | Residue |
| C | ASP113 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue UMQ C 402 |
| Chain | Residue |
| C | TRP206 |
| D | THR259 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue CA D 401 |
| Chain | Residue |
| D | ASN154 |
| D | ASP158 |
| E | ASP113 |
| site_id | AC9 |
| Number of Residues | 3 |
| Details | binding site for residue UMQ E 401 |
| Chain | Residue |
| D | TRP206 |
| E | THR259 |
| E | SER272 |
| site_id | AD1 |
| Number of Residues | 2 |
| Details | binding site for residue CA F 401 |
| Chain | Residue |
| F | ASP113 |
| J | ASP158 |
| site_id | AD2 |
| Number of Residues | 3 |
| Details | binding site for residue CA F 402 |
| Chain | Residue |
| F | ASN154 |
| F | ASP158 |
| G | ASP113 |
| site_id | AD3 |
| Number of Residues | 3 |
| Details | binding site for residue UMQ F 403 |
| Chain | Residue |
| F | THR259 |
| F | GLN264 |
| J | TRP206 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CA G 401 |
| Chain | Residue |
| G | ASN154 |
| G | ASP158 |
| H | ASP113 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue UMQ G 402 |
| Chain | Residue |
| F | TRP206 |
| G | THR259 |
| G | GLN264 |
| site_id | AD6 |
| Number of Residues | 4 |
| Details | binding site for residue UMQ G 403 |
| Chain | Residue |
| G | SER202 |
| G | TRP206 |
| H | THR259 |
| H | GLN264 |
| site_id | AD7 |
| Number of Residues | 3 |
| Details | binding site for residue CA H 401 |
| Chain | Residue |
| H | ASN154 |
| H | ASP158 |
| I | ASP113 |
| site_id | AD8 |
| Number of Residues | 4 |
| Details | binding site for residue UMQ I 401 |
| Chain | Residue |
| H | TRP206 |
| I | THR259 |
| I | GLN264 |
| I | ILE267 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue UMQ J 401 |
| Chain | Residue |
| I | GLU156 |
| I | TRP206 |
| J | ARG117 |
| J | THR259 |
| J | GLN264 |
| J | LEU315 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 600 |
| Details | TRANSMEM: Helical => ECO:0000255 |
| Chain | Residue | Details |
| A | LEU205-LEU225 | |
| A | THR234-PRO254 | |
| A | MET265-HIS285 | |
| B | LEU205-LEU225 | |
| B | THR234-PRO254 | |
| B | MET265-HIS285 | |
| C | LEU205-LEU225 | |
| C | THR234-PRO254 | |
| C | MET265-HIS285 | |
| D | LEU205-LEU225 | |
| D | THR234-PRO254 | |
| D | MET265-HIS285 | |
| E | LEU205-LEU225 | |
| E | THR234-PRO254 | |
| E | MET265-HIS285 | |
| F | LEU205-LEU225 | |
| F | THR234-PRO254 | |
| F | MET265-HIS285 | |
| G | LEU205-LEU225 | |
| G | THR234-PRO254 | |
| G | MET265-HIS285 | |
| H | LEU205-LEU225 | |
| H | THR234-PRO254 | |
| H | MET265-HIS285 | |
| I | LEU205-LEU225 | |
| I | THR234-PRO254 | |
| I | MET265-HIS285 | |
| J | LEU205-LEU225 | |
| J | THR234-PRO254 | |
| J | MET265-HIS285 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 220 |
| Details | TOPO_DOM: Cytoplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU226-GLN233 | |
| A | ARG286-ARG301 | |
| B | GLU226-GLN233 | |
| B | ARG286-ARG301 | |
| C | GLU226-GLN233 | |
| C | ARG286-ARG301 | |
| D | GLU226-GLN233 | |
| D | ARG286-ARG301 | |
| E | GLU226-GLN233 | |
| E | ARG286-ARG301 | |
| F | GLU226-GLN233 | |
| F | ARG286-ARG301 | |
| G | GLU226-GLN233 | |
| G | ARG286-ARG301 | |
| H | GLU226-GLN233 | |
| H | ARG286-ARG301 | |
| I | GLU226-GLN233 | |
| I | ARG286-ARG301 | |
| J | GLU226-GLN233 | |
| J | ARG286-ARG301 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 90 |
| Details | TOPO_DOM: Periplasmic => ECO:0000255 |
| Chain | Residue | Details |
| A | ARG255-GLN264 | |
| B | ARG255-GLN264 | |
| C | ARG255-GLN264 | |
| D | ARG255-GLN264 | |
| E | ARG255-GLN264 | |
| F | ARG255-GLN264 | |
| G | ARG255-GLN264 | |
| H | ARG255-GLN264 | |
| I | ARG255-GLN264 | |
| J | ARG255-GLN264 |
