Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SLH

Conformational flexibility within the small domain of human serine racemase.

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
AAA	0000166	molecular_function	nucleotide binding
AAA	0000287	molecular_function	magnesium ion binding
AAA	0003824	molecular_function	catalytic activity
AAA	0003941	molecular_function	L-serine ammonia-lyase activity
AAA	0005509	molecular_function	calcium ion binding
AAA	0005515	molecular_function	protein binding
AAA	0005524	molecular_function	ATP binding
AAA	0005737	cellular_component	cytoplasm
AAA	0005829	cellular_component	cytosol
AAA	0006520	biological_process	amino acid metabolic process
AAA	0006563	biological_process	L-serine metabolic process
AAA	0008152	biological_process	metabolic process
AAA	0008721	molecular_function	D-serine ammonia-lyase activity
AAA	0009069	biological_process	serine family amino acid metabolic process
AAA	0009410	biological_process	response to xenobiotic stimulus
AAA	0014070	biological_process	response to organic cyclic compound
AAA	0016594	molecular_function	glycine binding
AAA	0016829	molecular_function	lyase activity
AAA	0016853	molecular_function	isomerase activity
AAA	0018114	molecular_function	threonine racemase activity
AAA	0030165	molecular_function	PDZ domain binding
AAA	0030170	molecular_function	pyridoxal phosphate binding
AAA	0030378	molecular_function	serine racemase activity
AAA	0032496	biological_process	response to lipopolysaccharide
AAA	0042802	molecular_function	identical protein binding
AAA	0042803	molecular_function	protein homodimerization activity
AAA	0042866	biological_process	pyruvate biosynthetic process
AAA	0043025	cellular_component	neuronal cell body
AAA	0045177	cellular_component	apical part of cell
AAA	0046872	molecular_function	metal ion binding
AAA	0070178	biological_process	D-serine metabolic process
AAA	0070179	biological_process	D-serine biosynthetic process
BBB	0000166	molecular_function	nucleotide binding
BBB	0000287	molecular_function	magnesium ion binding
BBB	0003824	molecular_function	catalytic activity
BBB	0003941	molecular_function	L-serine ammonia-lyase activity
BBB	0005509	molecular_function	calcium ion binding
BBB	0005515	molecular_function	protein binding
BBB	0005524	molecular_function	ATP binding
BBB	0005737	cellular_component	cytoplasm
BBB	0005829	cellular_component	cytosol
BBB	0006520	biological_process	amino acid metabolic process
BBB	0006563	biological_process	L-serine metabolic process
BBB	0008152	biological_process	metabolic process
BBB	0008721	molecular_function	D-serine ammonia-lyase activity
BBB	0009069	biological_process	serine family amino acid metabolic process
BBB	0009410	biological_process	response to xenobiotic stimulus
BBB	0014070	biological_process	response to organic cyclic compound
BBB	0016594	molecular_function	glycine binding
BBB	0016829	molecular_function	lyase activity
BBB	0016853	molecular_function	isomerase activity
BBB	0018114	molecular_function	threonine racemase activity
BBB	0030165	molecular_function	PDZ domain binding
BBB	0030170	molecular_function	pyridoxal phosphate binding
BBB	0030378	molecular_function	serine racemase activity
BBB	0032496	biological_process	response to lipopolysaccharide
BBB	0042802	molecular_function	identical protein binding
BBB	0042803	molecular_function	protein homodimerization activity
BBB	0042866	biological_process	pyruvate biosynthetic process
BBB	0043025	cellular_component	neuronal cell body
BBB	0045177	cellular_component	apical part of cell
BBB	0046872	molecular_function	metal ion binding
BBB	0070178	biological_process	D-serine metabolic process
BBB	0070179	biological_process	D-serine biosynthetic process
CCC	0000166	molecular_function	nucleotide binding
CCC	0000287	molecular_function	magnesium ion binding
CCC	0003824	molecular_function	catalytic activity
CCC	0003941	molecular_function	L-serine ammonia-lyase activity
CCC	0005509	molecular_function	calcium ion binding
CCC	0005515	molecular_function	protein binding
CCC	0005524	molecular_function	ATP binding
CCC	0005737	cellular_component	cytoplasm
CCC	0005829	cellular_component	cytosol
CCC	0006520	biological_process	amino acid metabolic process
CCC	0006563	biological_process	L-serine metabolic process
CCC	0008152	biological_process	metabolic process
CCC	0008721	molecular_function	D-serine ammonia-lyase activity
CCC	0009069	biological_process	serine family amino acid metabolic process
CCC	0009410	biological_process	response to xenobiotic stimulus
CCC	0014070	biological_process	response to organic cyclic compound
CCC	0016594	molecular_function	glycine binding
CCC	0016829	molecular_function	lyase activity
CCC	0016853	molecular_function	isomerase activity
CCC	0018114	molecular_function	threonine racemase activity
CCC	0030165	molecular_function	PDZ domain binding
CCC	0030170	molecular_function	pyridoxal phosphate binding
CCC	0030378	molecular_function	serine racemase activity
CCC	0032496	biological_process	response to lipopolysaccharide
CCC	0042802	molecular_function	identical protein binding
CCC	0042803	molecular_function	protein homodimerization activity
CCC	0042866	biological_process	pyruvate biosynthetic process
CCC	0043025	cellular_component	neuronal cell body
CCC	0045177	cellular_component	apical part of cell
CCC	0046872	molecular_function	metal ion binding
CCC	0070178	biological_process	D-serine metabolic process
CCC	0070179	biological_process	D-serine biosynthetic process
DDD	0000166	molecular_function	nucleotide binding
DDD	0000287	molecular_function	magnesium ion binding
DDD	0003824	molecular_function	catalytic activity
DDD	0003941	molecular_function	L-serine ammonia-lyase activity
DDD	0005509	molecular_function	calcium ion binding
DDD	0005515	molecular_function	protein binding
DDD	0005524	molecular_function	ATP binding
DDD	0005737	cellular_component	cytoplasm
DDD	0005829	cellular_component	cytosol
DDD	0006520	biological_process	amino acid metabolic process
DDD	0006563	biological_process	L-serine metabolic process
DDD	0008152	biological_process	metabolic process
DDD	0008721	molecular_function	D-serine ammonia-lyase activity
DDD	0009069	biological_process	serine family amino acid metabolic process
DDD	0009410	biological_process	response to xenobiotic stimulus
DDD	0014070	biological_process	response to organic cyclic compound
DDD	0016594	molecular_function	glycine binding
DDD	0016829	molecular_function	lyase activity
DDD	0016853	molecular_function	isomerase activity
DDD	0018114	molecular_function	threonine racemase activity
DDD	0030165	molecular_function	PDZ domain binding
DDD	0030170	molecular_function	pyridoxal phosphate binding
DDD	0030378	molecular_function	serine racemase activity
DDD	0032496	biological_process	response to lipopolysaccharide
DDD	0042802	molecular_function	identical protein binding
DDD	0042803	molecular_function	protein homodimerization activity
DDD	0042866	biological_process	pyruvate biosynthetic process
DDD	0043025	cellular_component	neuronal cell body
DDD	0045177	cellular_component	apical part of cell
DDD	0046872	molecular_function	metal ion binding
DDD	0070178	biological_process	D-serine metabolic process
DDD	0070179	biological_process	D-serine biosynthetic process

Functional Information from PROSITE/UniProt

site_id	PS00165
Number of Residues	14
Details	DEHYDRATASE_SER_THR Serine/threonine dehydratases pyridoxal-phosphate attachment site. Elfqk.TGSFKIRGA

Chain	Residue	Details
AAA	GLU47-ALA60

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	ACT_SITE: Proton acceptor => ECO:0000250

Chain	Residue	Details
AAA	LLP56
AAA	SER84
BBB	LLP56
BBB	SER84
CCC	LLP56
CCC	SER84
DDD	LLP56
DDD	SER84

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000250

Chain	Residue	Details
AAA	LYS51
DDD	LYS51
DDD	TYR121
DDD	ASP238
AAA	TYR121
AAA	ASP238
BBB	LYS51
BBB	TYR121
BBB	ASP238
CCC	LYS51
CCC	TYR121
CCC	ASP238

site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000305

Chain	Residue	Details
AAA	ARG135
BBB	ARG135
CCC	ARG135
DDD	ARG135

site_id	SWS_FT_FI4
Number of Residues	12
Details	BINDING:

Chain	Residue	Details
AAA	GLU210
DDD	GLU210
DDD	ALA214
DDD	ASP216
AAA	ALA214
AAA	ASP216
BBB	GLU210
BBB	ALA214
BBB	ASP216
CCC	GLU210
CCC	ALA214
CCC	ASP216

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-(pyridoxal phosphate)lysine

Chain	Residue	Details
AAA	LLP56
BBB	LLP56
CCC	LLP56
DDD	LLP56

site_id	SWS_FT_FI6
Number of Residues	4
Details	MOD_RES: S-nitrosocysteine => ECO:0000250\|UniProtKB:Q9QZX7

Chain	Residue	Details
AAA	CYS113
BBB	CYS113
CCC	CYS113
DDD	CYS113

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		Validation report (PDF)
		EDMap 2fo-fc (MTZ)