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6SI5

T. cruzi FPPS in complex with 1-methyl-5-(4,5,6,7-tetrahydrothieno[3,2-c]pyridine-5-carbonyl)pyridin-2(1H)-one

Functional Information from GO Data
ChainGOidnamespacecontents
A0004659molecular_functionprenyltransferase activity
A0008299biological_processisoprenoid biosynthetic process
A0016765molecular_functiontransferase activity, transferring alkyl or aryl (other than methyl) groups
Functional Information from PDB Data
site_idAC1
Number of Residues9
Detailsbinding site for residue LEQ A 401
ChainResidue
ALYS48
APHE50
AARG51
ATHR54
ATHR212
ATYR213
APHE246
ATHR357
ASO4402

site_idAC2
Number of Residues6
Detailsbinding site for residue SO4 A 402
ChainResidue
ALYS48
ATYR49
AARG51
AGLN91
ALEQ401
AHOH544

site_idAC3
Number of Residues3
Detailsbinding site for residue SO4 A 403
ChainResidue
AGLN21
ALYS25
AHIS141

Functional Information from PROSITE/UniProt
site_idPS00444
Number of Residues13
DetailsPOLYPRENYL_SYNTHASE_2 Polyprenyl synthases signature 2. IGeyFQVqDDVmD
ChainResidueDetails
AILE242-ASP254

site_idPS00723
Number of Residues15
DetailsPOLYPRENYL_SYNTHASE_1 Polyprenyl synthases signature 1. LVeDDim..DgsvmRRG
ChainResidueDetails
ALEU95-GLY109

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PDB entries from 2024-11-06

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