Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6SDZ

transthyritin derived amyloid fibril from patient with hereditary V30M ATTR amyloidosis

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005179	molecular_function	hormone activity
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005615	cellular_component	extracellular space
A	0005737	cellular_component	cytoplasm
A	0006144	biological_process	purine nucleobase metabolic process
A	0007165	biological_process	signal transduction
A	0035578	cellular_component	azurophil granule lumen
A	0042802	molecular_function	identical protein binding
A	0070062	cellular_component	extracellular exosome
A	0070324	molecular_function	thyroid hormone binding
B	0005179	molecular_function	hormone activity
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005615	cellular_component	extracellular space
B	0005737	cellular_component	cytoplasm
B	0006144	biological_process	purine nucleobase metabolic process
B	0007165	biological_process	signal transduction
B	0035578	cellular_component	azurophil granule lumen
B	0042802	molecular_function	identical protein binding
B	0070062	cellular_component	extracellular exosome
B	0070324	molecular_function	thyroid hormone binding
C	0005179	molecular_function	hormone activity
C	0005515	molecular_function	protein binding
C	0005576	cellular_component	extracellular region
C	0005615	cellular_component	extracellular space
C	0005737	cellular_component	cytoplasm
C	0006144	biological_process	purine nucleobase metabolic process
C	0007165	biological_process	signal transduction
C	0035578	cellular_component	azurophil granule lumen
C	0042802	molecular_function	identical protein binding
C	0070062	cellular_component	extracellular exosome
C	0070324	molecular_function	thyroid hormone binding
D	0005179	molecular_function	hormone activity
D	0005515	molecular_function	protein binding
D	0005576	cellular_component	extracellular region
D	0005615	cellular_component	extracellular space
D	0005737	cellular_component	cytoplasm
D	0006144	biological_process	purine nucleobase metabolic process
D	0007165	biological_process	signal transduction
D	0035578	cellular_component	azurophil granule lumen
D	0042802	molecular_function	identical protein binding
D	0070062	cellular_component	extracellular exosome
D	0070324	molecular_function	thyroid hormone binding
E	0005179	molecular_function	hormone activity
E	0005515	molecular_function	protein binding
E	0005576	cellular_component	extracellular region
E	0005615	cellular_component	extracellular space
E	0005737	cellular_component	cytoplasm
E	0006144	biological_process	purine nucleobase metabolic process
E	0007165	biological_process	signal transduction
E	0035578	cellular_component	azurophil granule lumen
E	0042802	molecular_function	identical protein binding
E	0070062	cellular_component	extracellular exosome
E	0070324	molecular_function	thyroid hormone binding
F	0005179	molecular_function	hormone activity
F	0005515	molecular_function	protein binding
F	0005576	cellular_component	extracellular region
F	0005615	cellular_component	extracellular space
F	0005737	cellular_component	cytoplasm
F	0006144	biological_process	purine nucleobase metabolic process
F	0007165	biological_process	signal transduction
F	0035578	cellular_component	azurophil granule lumen
F	0042802	molecular_function	identical protein binding
F	0070062	cellular_component	extracellular exosome
F	0070324	molecular_function	thyroid hormone binding
G	0005179	molecular_function	hormone activity
G	0005515	molecular_function	protein binding
G	0005576	cellular_component	extracellular region
G	0005615	cellular_component	extracellular space
G	0005737	cellular_component	cytoplasm
G	0006144	biological_process	purine nucleobase metabolic process
G	0007165	biological_process	signal transduction
G	0035578	cellular_component	azurophil granule lumen
G	0042802	molecular_function	identical protein binding
G	0070062	cellular_component	extracellular exosome
G	0070324	molecular_function	thyroid hormone binding
H	0005179	molecular_function	hormone activity
H	0005515	molecular_function	protein binding
H	0005576	cellular_component	extracellular region
H	0005615	cellular_component	extracellular space
H	0005737	cellular_component	cytoplasm
H	0006144	biological_process	purine nucleobase metabolic process
H	0007165	biological_process	signal transduction
H	0035578	cellular_component	azurophil granule lumen
H	0042802	molecular_function	identical protein binding
H	0070062	cellular_component	extracellular exosome
H	0070324	molecular_function	thyroid hormone binding
I	0005179	molecular_function	hormone activity
I	0005515	molecular_function	protein binding
I	0005576	cellular_component	extracellular region
I	0005615	cellular_component	extracellular space
I	0005737	cellular_component	cytoplasm
I	0006144	biological_process	purine nucleobase metabolic process
I	0007165	biological_process	signal transduction
I	0035578	cellular_component	azurophil granule lumen
I	0042802	molecular_function	identical protein binding
I	0070062	cellular_component	extracellular exosome
I	0070324	molecular_function	thyroid hormone binding
J	0005179	molecular_function	hormone activity
J	0005515	molecular_function	protein binding
J	0005576	cellular_component	extracellular region
J	0005615	cellular_component	extracellular space
J	0005737	cellular_component	cytoplasm
J	0006144	biological_process	purine nucleobase metabolic process
J	0007165	biological_process	signal transduction
J	0035578	cellular_component	azurophil granule lumen
J	0042802	molecular_function	identical protein binding
J	0070062	cellular_component	extracellular exosome
J	0070324	molecular_function	thyroid hormone binding
K	0005179	molecular_function	hormone activity
K	0005515	molecular_function	protein binding
K	0005576	cellular_component	extracellular region
K	0005615	cellular_component	extracellular space
K	0005737	cellular_component	cytoplasm
K	0006144	biological_process	purine nucleobase metabolic process
K	0007165	biological_process	signal transduction
K	0035578	cellular_component	azurophil granule lumen
K	0042802	molecular_function	identical protein binding
K	0070062	cellular_component	extracellular exosome
K	0070324	molecular_function	thyroid hormone binding

Functional Information from PROSITE/UniProt

site_id	PS00769
Number of Residues	13
Details	TRANSTHYRETIN_2 Transthyretin signature 2. YTIAalLSPYSYS

Chain	Residue	Details
A	TYR105-SER117

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	33
Details	BINDING: BINDING => ECO:0000269\|PubMed:11418763, ECO:0007744\|PDB:1ICT

Chain	Residue	Details
A	LYS15
D	LYS15
D	GLU54
D	SER117
E	LYS15
E	GLU54
E	SER117
F	LYS15
F	GLU54
F	SER117
G	LYS15
A	GLU54
G	GLU54
G	SER117
H	LYS15
H	GLU54
H	SER117
I	LYS15
I	GLU54
I	SER117
J	LYS15
J	GLU54
A	SER117
J	SER117
K	LYS15
K	GLU54
K	SER117
B	LYS15
B	GLU54
B	SER117
C	LYS15
C	GLU54
C	SER117

site_id	SWS_FT_FI2
Number of Residues	11
Details	MOD_RES: Sulfocysteine => ECO:0000269\|PubMed:17175208, ECO:0007744\|PDB:2H4E

Chain	Residue	Details
A	CYS10
J	CYS10
K	CYS10
B	CYS10
C	CYS10
D	CYS10
E	CYS10
F	CYS10
G	CYS10
H	CYS10
I	CYS10

site_id	SWS_FT_FI3
Number of Residues	11
Details	MOD_RES: 4-carboxyglutamate; in a patient with Moyamoya disease => ECO:0000269\|PubMed:18221012

Chain	Residue	Details
A	GLU42
J	GLU42
K	GLU42
B	GLU42
C	GLU42
D	GLU42
E	GLU42
F	GLU42
G	GLU42
H	GLU42
I	GLU42

site_id	SWS_FT_FI4
Number of Residues	11
Details	MOD_RES: Phosphoserine => ECO:0000250\|UniProtKB:P02767

Chain	Residue	Details
A	SER52
J	SER52
K	SER52
B	SER52
C	SER52
D	SER52
E	SER52
F	SER52
G	SER52
H	SER52
I	SER52

site_id	SWS_FT_FI5
Number of Residues	11
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269\|PubMed:16335952, ECO:0000269\|PubMed:19167329

Chain	Residue	Details
A	ASN98
J	ASN98
K	ASN98
B	ASN98
C	ASN98
D	ASN98
E	ASN98
F	ASN98
G	ASN98
H	ASN98
I	ASN98

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)