6SCJ
The structure of human thyroglobulin
Functional Information from PROSITE/UniProt
| site_id | PS00941 |
| Number of Residues | 11 |
| Details | CARBOXYLESTERASE_B_2 Carboxylesterases type-B signature 2. EDCLYLNVFiP |
| Chain | Residue | Details |
| A | GLU2279-PRO2289 |
| site_id | PS00484 |
| Number of Residues | 31 |
| Details | THYROGLOBULIN_1_1 Thyroglobulin type-1 repeat signature. YvpqCaed.GsFqtvQcqndgrsc....WCVgangS |
| Chain | Residue | Details |
| A | TYR48-SER78 | |
| A | TYR116-GLY145 | |
| A | TYR315-GLY343 | |
| A | PHE616-GLY643 | |
| A | PHE683-GLY710 | |
| A | TYR1027-GLY1057 | |
| A | PHE1104-GLY1132 | |
| A | TYR1165-GLY1195 | |
| A | ALA1519-GLY1548 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | SITE: Not glycosylated => ECO:0000269|PubMed:8615697 |
| Chain | Residue | Details |
| A | ASN110 | |
| A | ASN496 | |
| A | ASN1869 | |
| A | ASN2122 | |
| B | ASN110 | |
| B | ASN496 | |
| B | ASN1869 | |
| B | ASN2122 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 8 |
| Details | MOD_RES: Triiodothyronine; alternate => ECO:0000269|PubMed:2760035 |
| Chain | Residue | Details |
| A | TYR24 | |
| A | TYR704 | |
| A | TYR2573 | |
| A | TYR2766 | |
| B | TYR24 | |
| B | TYR704 | |
| B | TYR2573 | |
| B | TYR2766 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: Iodotyrosine => ECO:0000305|PubMed:32025030 |
| Chain | Residue | Details |
| A | TYR108 | |
| A | TYR234 | |
| A | TYR2540 | |
| B | TYR108 | |
| B | TYR234 | |
| B | TYR2540 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Iodotyrosine; alternate => ECO:0000269|PubMed:2760035, ECO:0000305|PubMed:32025030 |
| Chain | Residue | Details |
| A | TYR149 | |
| B | TYR149 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 10 |
| Details | MOD_RES: Iodotyrosine => ECO:0000269|PubMed:2760035 |
| Chain | Residue | Details |
| A | TYR258 | |
| B | TYR2617 | |
| A | TYR785 | |
| A | TYR2184 | |
| A | TYR2587 | |
| A | TYR2617 | |
| B | TYR258 | |
| B | TYR785 | |
| B | TYR2184 | |
| B | TYR2587 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 6 |
| Details | MOD_RES: Iodotyrosine; alternate => ECO:0000269|PubMed:2760035 |
| Chain | Residue | Details |
| A | TYR869 | |
| A | TYR992 | |
| A | TYR1467 | |
| B | TYR869 | |
| B | TYR992 | |
| B | TYR1467 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 4 |
| Details | MOD_RES: Diiodotyrosine => ECO:0000269|PubMed:2760035 |
| Chain | Residue | Details |
| A | TYR883 | |
| A | TYR2697 | |
| B | TYR883 | |
| B | TYR2697 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Thyroxine => ECO:0000269|PubMed:2760035, ECO:0000305|PubMed:32025030 |
| Chain | Residue | Details |
| A | TYR1310 | |
| B | TYR1310 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 26 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32025030, ECO:0000269|PubMed:8615697, ECO:0000312|PDB:6SCJ |
| Chain | Residue | Details |
| A | ASN76 | |
| A | ASN2013 | |
| A | ASN2250 | |
| A | ASN2295 | |
| A | ASN2582 | |
| B | ASN76 | |
| B | ASN198 | |
| B | ASN484 | |
| B | ASN947 | |
| B | ASN1220 | |
| B | ASN1349 | |
| A | ASN198 | |
| B | ASN1365 | |
| B | ASN1716 | |
| B | ASN1774 | |
| B | ASN2013 | |
| B | ASN2250 | |
| B | ASN2295 | |
| B | ASN2582 | |
| A | ASN484 | |
| A | ASN947 | |
| A | ASN1220 | |
| A | ASN1349 | |
| A | ASN1365 | |
| A | ASN1716 | |
| A | ASN1774 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:32025030, ECO:0000312|PDB:6SCJ |
| Chain | Residue | Details |
| A | ASN110 | |
| A | ASN1869 | |
| A | ASN2122 | |
| B | ASN110 | |
| B | ASN1869 | |
| B | ASN2122 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:8615697 |
| Chain | Residue | Details |
| A | ASN529 | |
| A | ASN748 | |
| A | ASN816 | |
| B | ASN529 | |
| B | ASN748 | |
| B | ASN816 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000305|PubMed:8615697 |
| Chain | Residue | Details |
| A | ASN1348 | |
| B | ASN1348 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 2 |
| Details | CARBOHYD: O-linked (Xyl...) (chondroitin sulfate) serine => ECO:0000269|PubMed:16679516 |
| Chain | Residue | Details |
| A | SER2749 | |
| B | SER2749 |
