6SBI

X-ray structure of murine Fumarylacetoacetate hydrolase domain containing protein 1 (FAHD1) in complex with inhibitor oxalate

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
B	0003824	molecular_function	catalytic activity
C	0003824	molecular_function	catalytic activity
D	0003824	molecular_function	catalytic activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	binding site for residue MG A 301

Chain	Residue
A	GLU74
A	GLU76
A	ASP105
A	LYS126
A	OXL306
A	HOH404

---

site_id	AC2
Number of Residues	6
Details	binding site for residue K A 302

Chain	Residue
B	LYS21
B	ASN22
B	HOH412
A	LYS21
A	ASN22
A	HOH402

---

site_id	AC3
Number of Residues	3
Details	binding site for residue CL A 303

Chain	Residue
A	PRO121
A	TRP122
B	TRP122

---

site_id	AC4
Number of Residues	6
Details	binding site for residue CL A 304

Chain	Residue
A	ARG69
A	ASN70
A	ALA108
A	ARG109
A	ASP110
A	VAL111

---

site_id	AC5
Number of Residues	1
Details	binding site for residue CL A 305

Chain	Residue
A	GLU207

---

site_id	AC6
Number of Residues	13
Details	binding site for residue OXL A 306

Chain	Residue
A	GLY27
A	ARG28
A	HIS33
A	PHE48
A	GLU74
A	GLU76
A	ASP105
A	LYS126
A	GLY194
A	THR195
A	MG301
A	HOH404
A	HOH405

---

site_id	AC7
Number of Residues	6
Details	binding site for residue MG B 301

Chain	Residue
B	GLU74
B	GLU76
B	ASP105
B	LYS126
B	OXL304
B	HOH405

---

site_id	AC8
Number of Residues	4
Details	binding site for residue CL B 302

Chain	Residue
B	CYS68
B	ARG69
B	ASN70
B	ALA108

---

site_id	AC9
Number of Residues	6
Details	binding site for residue CL B 303

Chain	Residue
B	HIS147
B	ALA148
B	LEU149
B	LYS164
B	THR165
B	SER166

---

site_id	AD1
Number of Residues	12
Details	binding site for residue OXL B 304

Chain	Residue
B	VAL26
B	GLY27
B	ARG28
B	HIS33
B	GLU74
B	GLU76
B	ASP105
B	LYS126
B	GLY194
B	THR195
B	MG301
B	HOH405

---

site_id	AD2
Number of Residues	6
Details	binding site for residue MG C 301

Chain	Residue
C	GLU74
C	GLU76
C	ASP105
C	LYS126
C	OXL306
C	HOH401

---

site_id	AD3
Number of Residues	6
Details	binding site for residue K C 302

Chain	Residue
C	LYS21
C	ASN22
C	HOH405
D	LYS21
D	ASN22
D	HOH404

---

site_id	AD4
Number of Residues	6
Details	binding site for residue CL C 303

Chain	Residue
C	ARG69
C	ASN70
C	ALA108
C	ARG109
C	ASP110
C	VAL111

---

site_id	AD5
Number of Residues	1
Details	binding site for residue CL C 304

Chain	Residue
C	GLU58

---

site_id	AD6
Number of Residues	3
Details	binding site for residue CL C 305

Chain	Residue
C	PRO121
C	TRP122
D	TRP122

---

site_id	AD7
Number of Residues	11
Details	binding site for residue OXL C 306

Chain	Residue
C	GLY27
C	ARG28
C	HIS33
C	GLU74
C	GLU76
C	ASP105
C	LYS126
C	GLY194
C	THR195
C	MG301
C	HOH401

---

site_id	AD8
Number of Residues	6
Details	binding site for residue MG D 301

Chain	Residue
D	LYS126
D	OXL303
D	HOH403
D	GLU74
D	GLU76
D	ASP105

---

site_id	AD9
Number of Residues	5
Details	binding site for residue CL D 302

Chain	Residue
D	ARG69
D	ASN70
D	ALA108
D	ASP110
D	VAL111

---

site_id	AE1
Number of Residues	11
Details	binding site for residue OXL D 303

Chain	Residue
D	GLY27
D	ARG28
D	HIS33
D	GLU74
D	GLU76
D	ASP105
D	LYS126
D	GLY194
D	THR195
D	MG301
D	HOH403

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000269|PubMed:32068790, ECO:0007744|PDB:6SBI

Chain	Residue	Details
A	ARG28
A	LYS126
B	ARG28
B	LYS126
C	ARG28
C	LYS126
D	ARG28
D	LYS126

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	BINDING: BINDING => ECO:0000269|PubMed:32068790, ECO:0007744|PDB:6SBI, ECO:0007744|PDB:6SBJ

Chain	Residue	Details
A	GLU74
D	GLU74
D	GLU76
D	ASP105
A	GLU76
A	ASP105
B	GLU74
B	GLU76
B	ASP105
C	GLU74
C	GLU76
C	ASP105

---

site_id	SWS_FT_FI3
Number of Residues	4
Details	MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:Q6AYQ8

Chain	Residue	Details
A	SER43
B	SER43
C	SER43
D	SER43

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:23576753

Chain	Residue	Details
A	LYS116
B	LYS116
C	LYS116
D	LYS116

---

site_id	SWS_FT_FI5
Number of Residues	4
Details	MOD_RES: N6-succinyllysine => ECO:0007744|PubMed:23806337

Chain	Residue	Details
A	LYS118
B	LYS118
C	LYS118
D	LYS118

---