6SAK

Structure of the OTULINcat C129A - SNX27 PDZ domain complex.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004843	molecular_function	cysteine-type deubiquitinase activity
A	1990108	biological_process	protein linear deubiquitination
B	0004843	molecular_function	cysteine-type deubiquitinase activity
B	1990108	biological_process	protein linear deubiquitination

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue GOL A 401

Chain	Residue
A	LEU154
A	ALA297
A	ARG299
A	HOH523
A	HOH534

---

site_id	AC2
Number of Residues	5
Details	binding site for residue GOL A 402

Chain	Residue
A	SO4408
A	TRP167
A	ASP268
A	GLY270
A	ARG274

---

site_id	AC3
Number of Residues	5
Details	binding site for residue GOL A 403

Chain	Residue
A	HIS276
A	GLY284
A	GLY285
A	GLU287
A	GLU290

---

site_id	AC4
Number of Residues	4
Details	binding site for residue GOL A 404

Chain	Residue
A	LEU80
A	ARG122
A	HOH527
A	HOH544

---

site_id	AC5
Number of Residues	9
Details	binding site for residue GOL A 405

Chain	Residue
A	THR193
A	ARG196
A	HOH510
D	GLU63
D	GLY64
D	ALA76
D	GLU110
D	GLY111
D	HOH201

---

site_id	AC6
Number of Residues	6
Details	binding site for residue SO4 A 406

Chain	Residue
A	PRO147
A	TRP148
A	ARG299
A	ASP326
A	TRP327
A	HOH536

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 407

Chain	Residue
A	ARG239
A	ARG299
A	HOH501

---

site_id	AC8
Number of Residues	6
Details	binding site for residue SO4 A 408

Chain	Residue
A	TYR165
A	TRP167
A	TYR244
A	ASN245
A	PRO269
A	GOL402

---

site_id	AC9
Number of Residues	6
Details	binding site for residue GOL B 501

Chain	Residue
B	TRP167
B	ASP268
B	PRO269
B	GLY270
B	ARG274
B	SO4507

---

site_id	AD1
Number of Residues	6
Details	binding site for residue GOL B 502

Chain	Residue
B	HIS276
B	VAL280
B	GLY285
B	GLU287
B	GLU290
B	HOH664

---

site_id	AD2
Number of Residues	3
Details	binding site for residue GOL B 503

Chain	Residue
B	TYR310
B	ASN311
B	PHE315

---

site_id	AD3
Number of Residues	7
Details	binding site for residue GOL B 504

Chain	Residue
B	ARG306
B	LYS309
B	ASP336
B	ASP337
B	HOH603
B	HOH608
B	HOH630

---

site_id	AD4
Number of Residues	6
Details	binding site for residue SO4 B 505

Chain	Residue
B	TRP148
B	ASN238
B	TYR296
B	ALA297
B	HOH609
B	HOH613

---

site_id	AD5
Number of Residues	6
Details	binding site for residue SO4 B 506

Chain	Residue
B	PRO147
B	ARG299
B	ASP326
B	TRP327
B	HOH661
B	HOH674

---

site_id	AD6
Number of Residues	6
Details	binding site for residue SO4 B 507

Chain	Residue
B	TYR165
B	TRP167
B	TYR244
B	ASN245
B	PRO269
B	GOL501

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	228
Details	Domain: {"description":"OTU","evidences":[{"source":"PROSITE-ProRule","id":"PRU00139","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	10
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	20
Details	Region: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	4
Details	Active site: {"evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"24726327","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	Site: {"description":"Linear diubiquitin binding","evidences":[{"source":"PubMed","id":"23708998","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23746843","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3ZNZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4KSL","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"23186163","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"PubMed","id":"20068231","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---