6S8H

Cryo-EM structure of LptB2FG in complex with LPS

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000166	molecular_function	nucleotide binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0016887	molecular_function	ATP hydrolysis activity
A	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
A	0055085	biological_process	transmembrane transport
B	0000166	molecular_function	nucleotide binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0016887	molecular_function	ATP hydrolysis activity
B	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
B	0055085	biological_process	transmembrane transport
F	0005886	cellular_component	plasma membrane
F	0015920	biological_process	lipopolysaccharide transport
F	0016020	cellular_component	membrane
F	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
F	0055085	biological_process	transmembrane transport
G	0005886	cellular_component	plasma membrane
G	0015920	biological_process	lipopolysaccharide transport
G	0016020	cellular_component	membrane
G	0043190	cellular_component	ATP-binding cassette (ABC) transporter complex
G	0055085	biological_process	transmembrane transport

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	binding site for residue LMN F 401

Chain	Residue
F	ARG292
F	GLN293
G	ARG86
G	LMN401

---

site_id	AC2
Number of Residues	18
Details	binding site for residue JSG F 402

Chain	Residue
F	ARG263
F	THR314
G	SER30
G	ILE33
G	LYS34
G	ASP37
G	LYS41
G	MET70
G	ARG133
G	ILE313
G	GLY316
G	GLN324
G	LMN401
F	ILE25
F	PHE26
F	GLN29
F	LEU62
F	GLN248

---

site_id	AC3
Number of Residues	21
Details	binding site for Poly-Saccharide residues MET F 74 through LMT F 404

Chain	Residue
F	ILE21
F	LEU70
F	GLY71
F	LEU72
F	LEU73
F	THR75
F	LEU76
F	LYS78
F	ARG295
G	THR22
G	MET70
G	ALA72
G	LEU73
G	GLY75
G	ALA76
G	LEU77
G	LEU78
G	GLY306
G	VAL307
G	PHE317
G	LMN401

---

site_id	AC4
Number of Residues	3
Details	binding site for Poly-Saccharide residues ARG G 301 through LMT G 402

Chain	Residue
G	LEU300
G	SER302
G	VAL303

---

site_id	AC5
Number of Residues	17
Details	binding site for Di-peptide LMN G 401 and LEU G 74

Chain	Residue
F	LEU297
F	LMN401
F	JSG402
G	THR18
G	MET21
G	THR22
G	MET70
G	ALA72
G	LEU73
G	GLY75
G	ALA76
G	LEU77
G	LEU78
G	MET82
G	VAL309
G	GLY312
G	ILE313

---

Functional Information from PROSITE/UniProt

site_id	PS00211
Number of Residues	15
Details	ABC_TRANSPORTER_1 ABC transporters family signature. LSGGERRRVEIARAL

Chain	Residue	Details
A	LEU138-LEU152

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	466
Details	Domain: {"description":"ABC transporter","evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	14
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00434","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI3
Number of Residues	120
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI4
Number of Residues	26
Details	Topological domain: {"description":"Periplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI5
Number of Residues	29
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

---