6S83
Crystal structure of methionine adenosyltransferase from Pyrococcus furiosus in complex with AMPPCP, SAM, and PCP
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0000287 | molecular_function | magnesium ion binding |
A | 0004478 | molecular_function | methionine adenosyltransferase activity |
A | 0005524 | molecular_function | ATP binding |
A | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
A | 0006730 | biological_process | one-carbon metabolic process |
A | 0016740 | molecular_function | transferase activity |
B | 0000287 | molecular_function | magnesium ion binding |
B | 0004478 | molecular_function | methionine adenosyltransferase activity |
B | 0005524 | molecular_function | ATP binding |
B | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
B | 0006730 | biological_process | one-carbon metabolic process |
B | 0016740 | molecular_function | transferase activity |
C | 0000287 | molecular_function | magnesium ion binding |
C | 0004478 | molecular_function | methionine adenosyltransferase activity |
C | 0005524 | molecular_function | ATP binding |
C | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
C | 0006730 | biological_process | one-carbon metabolic process |
C | 0016740 | molecular_function | transferase activity |
D | 0000287 | molecular_function | magnesium ion binding |
D | 0004478 | molecular_function | methionine adenosyltransferase activity |
D | 0005524 | molecular_function | ATP binding |
D | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
D | 0006730 | biological_process | one-carbon metabolic process |
D | 0016740 | molecular_function | transferase activity |
E | 0000287 | molecular_function | magnesium ion binding |
E | 0004478 | molecular_function | methionine adenosyltransferase activity |
E | 0005524 | molecular_function | ATP binding |
E | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
E | 0006730 | biological_process | one-carbon metabolic process |
E | 0016740 | molecular_function | transferase activity |
F | 0000287 | molecular_function | magnesium ion binding |
F | 0004478 | molecular_function | methionine adenosyltransferase activity |
F | 0005524 | molecular_function | ATP binding |
F | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
F | 0006730 | biological_process | one-carbon metabolic process |
F | 0016740 | molecular_function | transferase activity |
G | 0000287 | molecular_function | magnesium ion binding |
G | 0004478 | molecular_function | methionine adenosyltransferase activity |
G | 0005524 | molecular_function | ATP binding |
G | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
G | 0006730 | biological_process | one-carbon metabolic process |
G | 0016740 | molecular_function | transferase activity |
H | 0000287 | molecular_function | magnesium ion binding |
H | 0004478 | molecular_function | methionine adenosyltransferase activity |
H | 0005524 | molecular_function | ATP binding |
H | 0006556 | biological_process | S-adenosylmethionine biosynthetic process |
H | 0006730 | biological_process | one-carbon metabolic process |
H | 0016740 | molecular_function | transferase activity |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 20 |
Details | binding site for residue MDN A 501 |
Chain | Residue |
A | LYS26 |
A | HOH625 |
B | ASP63 |
B | ASP159 |
B | GLU303 |
B | LYS308 |
B | HIS313 |
B | PO4501 |
B | MG502 |
B | MG503 |
B | HOH602 |
A | HIS30 |
B | HOH626 |
A | ASP32 |
A | LYS200 |
A | ARG286 |
A | MG502 |
A | SAM503 |
A | HOH603 |
A | HOH612 |
site_id | AC2 |
Number of Residues | 5 |
Details | binding site for residue MG A 502 |
Chain | Residue |
A | ASP32 |
A | MDN501 |
A | HOH607 |
A | HOH625 |
B | PO4501 |
site_id | AC3 |
Number of Residues | 19 |
Details | binding site for residue SAM A 503 |
Chain | Residue |
A | HIS30 |
A | PRO31 |
A | ASP198 |
A | LYS200 |
A | ALA215 |
A | ALA259 |
A | TYR268 |
A | SER275 |
A | GLY279 |
A | ASP280 |
A | MDN501 |
A | HOH614 |
B | HIS59 |
B | ASN61 |
B | ASP141 |
B | LEU142 |
B | ASN158 |
B | ASP159 |
B | HOH637 |
site_id | AC4 |
Number of Residues | 5 |
Details | binding site for residue MG A 504 |
Chain | Residue |
A | ASP159 |
B | ACP504 |
B | HOH621 |
B | HOH634 |
B | HOH657 |
site_id | AC5 |
Number of Residues | 11 |
Details | binding site for residue PO4 B 501 |
Chain | Residue |
A | LYS26 |
A | ASP32 |
A | ARG286 |
A | MDN501 |
A | MG502 |
A | HOH607 |
B | MET302 |
B | GLU303 |
B | ALA304 |
B | LYS308 |
B | MG502 |
site_id | AC6 |
Number of Residues | 4 |
Details | binding site for residue MG B 502 |
Chain | Residue |
A | MDN501 |
B | GLU303 |
B | PO4501 |
B | HOH626 |
site_id | AC7 |
Number of Residues | 7 |
Details | binding site for residue MG B 503 |
Chain | Residue |
A | ARG286 |
A | MDN501 |
A | HOH603 |
A | HOH612 |
B | ASP63 |
B | GLN64 |
B | HOH636 |
site_id | AC8 |
Number of Residues | 25 |
Details | binding site for residue ACP B 504 |
Chain | Residue |
A | HIS313 |
A | MG504 |
B | LYS26 |
B | HIS30 |
B | PRO31 |
B | ASP32 |
B | ASP198 |
B | LYS200 |
B | ALA215 |
B | TYR268 |
B | SER275 |
B | ASP280 |
B | PO4505 |
B | MG506 |
B | MG507 |
B | HOH605 |
B | HOH611 |
B | HOH619 |
B | HOH621 |
B | HOH632 |
B | HOH634 |
B | HOH642 |
B | HOH651 |
B | HOH655 |
B | HOH657 |
site_id | AC9 |
Number of Residues | 13 |
Details | binding site for residue PO4 B 505 |
Chain | Residue |
A | LYS308 |
B | LYS26 |
B | ASP32 |
B | ARG286 |
B | ACP504 |
B | MG506 |
B | HOH609 |
B | HOH611 |
B | HOH614 |
B | HOH619 |
A | MET302 |
A | GLU303 |
A | ALA304 |
site_id | AD1 |
Number of Residues | 6 |
Details | binding site for residue MG B 506 |
Chain | Residue |
B | ASP32 |
B | ACP504 |
B | PO4505 |
B | HOH611 |
B | HOH614 |
B | HOH642 |
site_id | AD2 |
Number of Residues | 6 |
Details | binding site for residue MG B 507 |
Chain | Residue |
B | GLU24 |
B | ACP504 |
B | HOH603 |
B | HOH619 |
B | HOH632 |
B | HOH647 |
site_id | AD3 |
Number of Residues | 19 |
Details | binding site for residue MDN C 501 |
Chain | Residue |
C | LYS26 |
C | HIS30 |
C | ASP32 |
C | LYS200 |
C | PO4502 |
C | MG503 |
C | HOH601 |
C | HOH603 |
C | HOH606 |
C | HOH618 |
C | HOH634 |
D | ASP63 |
D | ASP159 |
D | GLU303 |
D | LYS308 |
D | HIS313 |
D | MG501 |
D | MG502 |
D | HOH632 |
site_id | AD4 |
Number of Residues | 11 |
Details | binding site for residue PO4 C 502 |
Chain | Residue |
C | LYS26 |
C | ASP32 |
C | ARG286 |
C | MDN501 |
C | MG503 |
C | HOH606 |
D | MET302 |
D | GLU303 |
D | ALA304 |
D | LYS308 |
D | MG501 |
site_id | AD5 |
Number of Residues | 5 |
Details | binding site for residue MG C 503 |
Chain | Residue |
C | ASP32 |
C | MDN501 |
C | PO4502 |
C | HOH606 |
C | HOH618 |
site_id | AD6 |
Number of Residues | 4 |
Details | binding site for residue MG D 501 |
Chain | Residue |
C | MDN501 |
C | PO4502 |
D | GLU303 |
D | HOH632 |
site_id | AD7 |
Number of Residues | 7 |
Details | binding site for residue MG D 502 |
Chain | Residue |
C | ARG286 |
C | MDN501 |
C | HOH601 |
C | HOH634 |
D | ASP63 |
D | GLN64 |
D | HOH647 |
site_id | AD8 |
Number of Residues | 23 |
Details | binding site for residue ACP D 503 |
Chain | Residue |
C | HIS313 |
D | LYS26 |
D | HIS30 |
D | PRO31 |
D | ASP32 |
D | ASP198 |
D | LYS200 |
D | ALA215 |
D | TYR268 |
D | SER275 |
D | ASP280 |
D | PO4504 |
D | MG505 |
D | MG506 |
D | HOH604 |
D | HOH613 |
D | HOH621 |
D | HOH625 |
D | HOH629 |
D | HOH631 |
D | HOH636 |
D | HOH652 |
D | HOH657 |
site_id | AD9 |
Number of Residues | 13 |
Details | binding site for residue PO4 D 504 |
Chain | Residue |
C | GLU303 |
C | ALA304 |
C | LYS308 |
D | LYS26 |
D | ASP32 |
D | ARG286 |
D | ACP503 |
D | MG505 |
D | MG506 |
D | HOH608 |
D | HOH619 |
D | HOH621 |
D | HOH657 |
site_id | AE1 |
Number of Residues | 6 |
Details | binding site for residue MG D 505 |
Chain | Residue |
D | ASP32 |
D | ACP503 |
D | PO4504 |
D | HOH619 |
D | HOH629 |
D | HOH657 |
site_id | AE2 |
Number of Residues | 7 |
Details | binding site for residue MG D 506 |
Chain | Residue |
D | GLU24 |
D | ACP503 |
D | PO4504 |
D | HOH604 |
D | HOH621 |
D | HOH633 |
D | HOH667 |
site_id | AE3 |
Number of Residues | 19 |
Details | binding site for residue MDN E 501 |
Chain | Residue |
E | LYS26 |
E | HIS30 |
E | ASP32 |
E | LYS200 |
E | MG502 |
E | SAM503 |
E | HOH604 |
E | HOH605 |
E | HOH621 |
F | ASP63 |
F | ASP159 |
F | GLU303 |
F | LYS308 |
F | HIS313 |
F | PO4501 |
F | MG502 |
F | MG503 |
F | HOH605 |
F | HOH612 |
site_id | AE4 |
Number of Residues | 6 |
Details | binding site for residue MG E 502 |
Chain | Residue |
E | ASP32 |
E | MDN501 |
E | HOH605 |
E | HOH621 |
F | PO4501 |
F | MG503 |
site_id | AE5 |
Number of Residues | 21 |
Details | binding site for residue SAM E 503 |
Chain | Residue |
E | HIS30 |
E | PRO31 |
E | ASP198 |
E | LYS200 |
E | ALA215 |
E | ALA259 |
E | TYR268 |
E | SER275 |
E | GLY279 |
E | ASP280 |
E | MDN501 |
E | HOH604 |
E | HOH613 |
E | HOH614 |
F | HIS59 |
F | ASN61 |
F | ASP141 |
F | LEU142 |
F | ASN158 |
F | ASP159 |
F | ILE346 |
site_id | AE6 |
Number of Residues | 11 |
Details | binding site for residue PO4 F 501 |
Chain | Residue |
E | LYS26 |
E | ASP32 |
E | ARG286 |
E | MDN501 |
E | MG502 |
F | ASP63 |
F | MET302 |
F | GLU303 |
F | ALA304 |
F | LYS308 |
F | MG502 |
site_id | AE7 |
Number of Residues | 4 |
Details | binding site for residue MG F 502 |
Chain | Residue |
E | MDN501 |
F | GLU303 |
F | PO4501 |
F | HOH605 |
site_id | AE8 |
Number of Residues | 8 |
Details | binding site for residue MG F 503 |
Chain | Residue |
E | ASP281 |
E | MDN501 |
E | MG502 |
E | HOH604 |
E | HOH621 |
F | ASP63 |
F | GLN64 |
F | HOH647 |
site_id | AE9 |
Number of Residues | 22 |
Details | binding site for residue ACP F 504 |
Chain | Residue |
E | HIS313 |
E | HOH615 |
F | LYS26 |
F | HIS30 |
F | PRO31 |
F | ASP32 |
F | ASP198 |
F | LYS200 |
F | ALA215 |
F | TYR268 |
F | SER275 |
F | ASP280 |
F | PO4505 |
F | MG506 |
F | MG507 |
F | HOH625 |
F | HOH627 |
F | HOH634 |
F | HOH636 |
F | HOH640 |
F | HOH641 |
F | HOH642 |
site_id | AF1 |
Number of Residues | 12 |
Details | binding site for residue PO4 F 505 |
Chain | Residue |
E | GLU303 |
E | ALA304 |
E | LYS308 |
E | HOH615 |
F | LYS26 |
F | ASP32 |
F | ARG286 |
F | ACP504 |
F | MG506 |
F | HOH609 |
F | HOH642 |
F | HOH643 |
site_id | AF2 |
Number of Residues | 6 |
Details | binding site for residue MG F 506 |
Chain | Residue |
F | ASP32 |
F | ACP504 |
F | PO4505 |
F | HOH615 |
F | HOH625 |
F | HOH642 |
site_id | AF3 |
Number of Residues | 7 |
Details | binding site for residue MG F 507 |
Chain | Residue |
E | HOH615 |
F | GLU24 |
F | LYS200 |
F | ACP504 |
F | HOH601 |
F | HOH610 |
F | HOH636 |
site_id | AF4 |
Number of Residues | 11 |
Details | binding site for residue PO4 G 501 |
Chain | Residue |
G | LYS26 |
G | ASP32 |
G | ARG286 |
G | MG502 |
G | HOH604 |
H | MET302 |
H | GLU303 |
H | ALA304 |
H | LYS308 |
H | MDN501 |
H | MG502 |
site_id | AF5 |
Number of Residues | 5 |
Details | binding site for residue MG G 502 |
Chain | Residue |
G | ASP32 |
G | PO4501 |
G | HOH604 |
G | HOH620 |
H | MDN501 |
site_id | AF6 |
Number of Residues | 18 |
Details | binding site for residue MDN H 501 |
Chain | Residue |
G | LYS26 |
G | HIS30 |
G | ASP32 |
G | LYS200 |
G | PO4501 |
G | MG502 |
G | HOH620 |
H | ASP63 |
H | ASP159 |
H | GLU303 |
H | LYS308 |
H | HIS313 |
H | MG502 |
H | MG503 |
H | HOH608 |
H | HOH611 |
H | HOH617 |
H | HOH630 |
site_id | AF7 |
Number of Residues | 5 |
Details | binding site for residue MG H 502 |
Chain | Residue |
G | PO4501 |
H | SER161 |
H | GLU303 |
H | MDN501 |
H | HOH611 |
site_id | AF8 |
Number of Residues | 7 |
Details | binding site for residue MG H 503 |
Chain | Residue |
G | ARG286 |
H | ASP63 |
H | GLN64 |
H | MDN501 |
H | HOH608 |
H | HOH630 |
H | HOH635 |
site_id | AF9 |
Number of Residues | 19 |
Details | binding site for residue ACP H 504 |
Chain | Residue |
G | GLU303 |
G | HIS313 |
G | HOH601 |
H | LYS26 |
H | HIS30 |
H | PRO31 |
H | ASP32 |
H | ASP198 |
H | LYS200 |
H | ALA215 |
H | TYR268 |
H | SER275 |
H | ASP280 |
H | PO4505 |
H | MG506 |
H | MG507 |
H | HOH602 |
H | HOH605 |
H | HOH610 |
site_id | AG1 |
Number of Residues | 13 |
Details | binding site for residue PO4 H 505 |
Chain | Residue |
G | MET302 |
G | GLU303 |
G | ALA304 |
G | LYS308 |
H | LYS26 |
H | ASP32 |
H | ARG286 |
H | ACP504 |
H | MG506 |
H | MG507 |
H | HOH605 |
H | HOH619 |
H | HOH632 |
site_id | AG2 |
Number of Residues | 6 |
Details | binding site for residue MG H 506 |
Chain | Residue |
H | ASP32 |
H | ACP504 |
H | PO4505 |
H | HOH610 |
H | HOH619 |
H | HOH632 |
site_id | AG3 |
Number of Residues | 5 |
Details | binding site for residue MG H 507 |
Chain | Residue |
H | GLU24 |
H | ACP504 |
H | PO4505 |
H | HOH602 |
H | HOH605 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 8 |
Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_00136 |
Chain | Residue | Details |
A | GLY136 | |
B | GLY136 | |
C | GLY136 | |
D | GLY136 | |
E | GLY136 | |
F | GLY136 | |
G | GLY136 | |
H | GLY136 |