6S6Y
X-ray crystal structure of the formyltransferase/hydrolase complex (FhcABCD) from Methylorubrum extorquens in complex with methylofuran
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| C | 0015948 | biological_process | methanogenesis |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0018493 | molecular_function | formylmethanofuran dehydrogenase activity |
| C | 0046914 | molecular_function | transition metal ion binding |
| D | 0006730 | biological_process | one-carbon metabolic process |
| D | 0016740 | molecular_function | transferase activity |
| D | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
| E | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| G | 0015948 | biological_process | methanogenesis |
| G | 0016491 | molecular_function | oxidoreductase activity |
| G | 0018493 | molecular_function | formylmethanofuran dehydrogenase activity |
| G | 0046914 | molecular_function | transition metal ion binding |
| H | 0006730 | biological_process | one-carbon metabolic process |
| H | 0016740 | molecular_function | transferase activity |
| H | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
| I | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| K | 0015948 | biological_process | methanogenesis |
| K | 0016491 | molecular_function | oxidoreductase activity |
| K | 0018493 | molecular_function | formylmethanofuran dehydrogenase activity |
| K | 0046914 | molecular_function | transition metal ion binding |
| L | 0006730 | biological_process | one-carbon metabolic process |
| L | 0016740 | molecular_function | transferase activity |
| L | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
| M | 0016810 | molecular_function | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds |
| O | 0015948 | biological_process | methanogenesis |
| O | 0016491 | molecular_function | oxidoreductase activity |
| O | 0018493 | molecular_function | formylmethanofuran dehydrogenase activity |
| O | 0046914 | molecular_function | transition metal ion binding |
| P | 0006730 | biological_process | one-carbon metabolic process |
| P | 0016740 | molecular_function | transferase activity |
| P | 0030270 | molecular_function | formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 2 |
| Details | binding site for residue FMT A 601 |
| Chain | Residue |
| A | ASN64 |
| A | SER331 |
| site_id | AC2 |
| Number of Residues | 11 |
| Details | binding site for residue MFN A 602 |
| Chain | Residue |
| A | GLN355 |
| A | ASP377 |
| A | ASN380 |
| A | ZN605 |
| A | HIS229 |
| A | LEU233 |
| A | HIS258 |
| A | PHE261 |
| A | THR308 |
| A | SER310 |
| A | TYR345 |
| site_id | AC3 |
| Number of Residues | 3 |
| Details | binding site for residue GOL A 603 |
| Chain | Residue |
| A | PRO130 |
| A | TRP492 |
| B | ARG42 |
| site_id | AC4 |
| Number of Residues | 3 |
| Details | binding site for residue ZN A 604 |
| Chain | Residue |
| A | HIS59 |
| A | KCX176 |
| A | ZN605 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 605 |
| Chain | Residue |
| A | KCX176 |
| A | HIS229 |
| A | HIS258 |
| A | MFN602 |
| A | ZN604 |
| site_id | AC6 |
| Number of Residues | 3 |
| Details | binding site for residue CA A 606 |
| Chain | Residue |
| A | GLU218 |
| I | LYS419 |
| I | GLU421 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 607 |
| Chain | Residue |
| A | GLU398 |
| A | GLU423 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | binding site for residue CA A 608 |
| Chain | Residue |
| A | SER117 |
| A | ASP334 |
| site_id | AC9 |
| Number of Residues | 1 |
| Details | binding site for residue K A 609 |
| Chain | Residue |
| A | ASP463 |
| site_id | AD1 |
| Number of Residues | 1 |
| Details | binding site for residue K A 610 |
| Chain | Residue |
| A | GLU399 |
| site_id | AD2 |
| Number of Residues | 2 |
| Details | binding site for residue CL A 611 |
| Chain | Residue |
| A | GLU289 |
| A | ARG371 |
| site_id | AD3 |
| Number of Residues | 1 |
| Details | binding site for residue CL A 612 |
| Chain | Residue |
| A | LYS208 |
| site_id | AD4 |
| Number of Residues | 3 |
| Details | binding site for residue CA B 401 |
| Chain | Residue |
| B | GLU66 |
| B | ASP217 |
| B | ARG222 |
| site_id | AD5 |
| Number of Residues | 3 |
| Details | binding site for residue CL C 301 |
| Chain | Residue |
| B | ARG251 |
| C | ASP70 |
| C | ARG71 |
| site_id | AD6 |
| Number of Residues | 2 |
| Details | binding site for residue K D 401 |
| Chain | Residue |
| D | ASP60 |
| D | LYS196 |
| site_id | AD7 |
| Number of Residues | 4 |
| Details | binding site for residue ZN E 601 |
| Chain | Residue |
| E | KCX176 |
| E | HIS229 |
| E | HIS258 |
| E | ZN602 |
| site_id | AD8 |
| Number of Residues | 3 |
| Details | binding site for residue ZN E 602 |
| Chain | Residue |
| E | HIS59 |
| E | KCX176 |
| E | ZN601 |
| site_id | AD9 |
| Number of Residues | 6 |
| Details | binding site for residue GOL H 401 |
| Chain | Residue |
| H | VAL50 |
| H | GLU56 |
| H | PHE82 |
| H | GLY170 |
| H | GLY171 |
| H | ASP256 |
| site_id | AE1 |
| Number of Residues | 2 |
| Details | binding site for residue K H 402 |
| Chain | Residue |
| H | ASP60 |
| H | LYS196 |
| site_id | AE2 |
| Number of Residues | 2 |
| Details | binding site for residue FMT I 601 |
| Chain | Residue |
| I | ASN64 |
| I | GLY337 |
| site_id | AE3 |
| Number of Residues | 12 |
| Details | binding site for residue L6K I 602 |
| Chain | Residue |
| I | HIS229 |
| I | LEU233 |
| I | GLY234 |
| I | HIS258 |
| I | PHE261 |
| I | THR308 |
| I | VAL351 |
| I | GLN355 |
| I | ASP377 |
| I | ASN380 |
| I | EDO603 |
| I | ZN604 |
| site_id | AE4 |
| Number of Residues | 3 |
| Details | binding site for residue EDO I 603 |
| Chain | Residue |
| I | ARG315 |
| I | GLN316 |
| I | L6K602 |
| site_id | AE5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN I 604 |
| Chain | Residue |
| I | KCX176 |
| I | HIS229 |
| I | HIS258 |
| I | L6K602 |
| I | ZN605 |
| site_id | AE6 |
| Number of Residues | 3 |
| Details | binding site for residue ZN I 605 |
| Chain | Residue |
| I | HIS59 |
| I | KCX176 |
| I | ZN604 |
| site_id | AE7 |
| Number of Residues | 3 |
| Details | binding site for residue K I 606 |
| Chain | Residue |
| A | ASP505 |
| I | ASP396 |
| I | GLU423 |
| site_id | AE8 |
| Number of Residues | 4 |
| Details | binding site for residue CL I 607 |
| Chain | Residue |
| I | GLY349 |
| I | PRO350 |
| I | VAL351 |
| I | SER352 |
| site_id | AE9 |
| Number of Residues | 1 |
| Details | binding site for residue FMT J 401 |
| Chain | Residue |
| J | ARG222 |
| site_id | AF1 |
| Number of Residues | 4 |
| Details | binding site for residue NA J 402 |
| Chain | Residue |
| J | GLU37 |
| J | SER39 |
| J | GLY316 |
| J | ALA317 |
| site_id | AF2 |
| Number of Residues | 1 |
| Details | binding site for residue K J 403 |
| Chain | Residue |
| J | GLU191 |
| site_id | AF3 |
| Number of Residues | 2 |
| Details | binding site for residue CL J 404 |
| Chain | Residue |
| J | ARG251 |
| K | ARG71 |
| site_id | AF4 |
| Number of Residues | 2 |
| Details | binding site for residue CA L 401 |
| Chain | Residue |
| L | ASP60 |
| L | LYS196 |
| site_id | AF5 |
| Number of Residues | 1 |
| Details | binding site for residue CA L 402 |
| Chain | Residue |
| L | GLU189 |
| site_id | AF6 |
| Number of Residues | 1 |
| Details | binding site for residue K L 403 |
| Chain | Residue |
| L | GLU155 |
| site_id | AF7 |
| Number of Residues | 5 |
| Details | binding site for residue ZN M 601 |
| Chain | Residue |
| M | HIS59 |
| M | KCX176 |
| M | SER310 |
| M | LEU311 |
| M | ZN602 |
| site_id | AF8 |
| Number of Residues | 4 |
| Details | binding site for residue ZN M 602 |
| Chain | Residue |
| M | KCX176 |
| M | HIS229 |
| M | HIS258 |
| M | ZN601 |
| site_id | AF9 |
| Number of Residues | 4 |
| Details | binding site for residue GLU O 303 |
| Chain | Residue |
| O | ILE178 |
| O | ARG197 |
| O | ARG198 |
| O | GLU302 |
| site_id | AG1 |
| Number of Residues | 2 |
| Details | binding site for residue K P 401 |
| Chain | Residue |
| P | ASP60 |
| P | LYS196 |
| site_id | AG2 |
| Number of Residues | 1 |
| Details | binding site for residue K P 402 |
| Chain | Residue |
| P | GLU189 |
| site_id | AG3 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide DGL B 402 and GLU C 304 |
| Chain | Residue |
| A | LYS326 |
| B | ALA3 |
| B | TRP4 |
| B | ARG154 |
| B | ARG202 |
| B | ALA287 |
| B | ALA296 |
| B | THR300 |
| B | ALA301 |
| B | VAL303 |
| B | ILE305 |
| B | NH2403 |
| C | ILE178 |
| C | ARG197 |
| C | ARG198 |
| C | GLU303 |
| site_id | AG4 |
| Number of Residues | 5 |
| Details | binding site for Di-peptide DGL B 402 and NH2 B 403 |
| Chain | Residue |
| A | LYS326 |
| B | ARG154 |
| B | ARG202 |
| C | ARG197 |
| C | GLU304 |
| site_id | AG5 |
| Number of Residues | 12 |
| Details | binding site for Di-peptide DGL C 302 and DGL D 402 |
| Chain | Residue |
| C | GLU303 |
| D | GLU12 |
| D | THR14 |
| D | ARG124 |
| D | ALA133 |
| D | TRP147 |
| D | TYR300 |
| D | HIS301 |
| D | ARG303 |
| D | ASP304 |
| D | LEU305 |
| D | IAS403 |
| site_id | AG6 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide DGL C 302 and IAS D 403 |
| Chain | Residue |
| C | ARG160 |
| C | ALA179 |
| C | GLU303 |
| D | GLU12 |
| D | THR14 |
| D | ARG135 |
| D | ARG145 |
| D | TYR300 |
| D | HIS301 |
| D | ARG303 |
| D | ASP304 |
| D | LEU305 |
| D | DGL402 |
| site_id | AG7 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide DGL C 302 and GLU C 303 |
| Chain | Residue |
| C | GLU304 |
| D | DGL402 |
| D | IAS403 |
| site_id | AG8 |
| Number of Residues | 10 |
| Details | binding site for Di-peptide DGL I 608 and GLU L 404 |
| Chain | Residue |
| I | LYS326 |
| I | ARG400 |
| I | ALA401 |
| I | LYS402 |
| I | GLU403 |
| I | ALA405 |
| I | THR406 |
| I | LEU407 |
| I | LEU417 |
| K | DGL301 |
| site_id | AG9 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide GLU I 609 and DGL K 301 |
| Chain | Residue |
| I | GLN260 |
| I | GLN300 |
| I | VAL302 |
| I | LYS326 |
| I | GLN355 |
| I | TRP356 |
| I | GLY381 |
| I | DGL610 |
| J | GLU405 |
| K | ILE178 |
| K | ARG197 |
| K | ARG198 |
| K | GLU302 |
| L | GLU404 |
| site_id | AH1 |
| Number of Residues | 13 |
| Details | binding site for Di-peptide DGL I 610 and GLU J 405 |
| Chain | Residue |
| I | LYS326 |
| I | TRP328 |
| I | ALA401 |
| I | LYS402 |
| I | GLU403 |
| I | ILE404 |
| I | THR406 |
| I | LEU407 |
| I | GLU609 |
| J | GLY73 |
| J | ARG154 |
| J | ARG202 |
| K | ARG197 |
| site_id | AH2 |
| Number of Residues | 7 |
| Details | binding site for Di-peptide DGL K 301 and GLU K 302 |
| Chain | Residue |
| I | GLU609 |
| K | ARG160 |
| K | ARG161 |
| K | ALA179 |
| L | GLU404 |
| L | DGL405 |
| L | DGL406 |
| site_id | AH3 |
| Number of Residues | 11 |
| Details | binding site for Di-peptide DGL K 301 and GLU L 404 |
| Chain | Residue |
| I | DGL608 |
| I | GLU609 |
| K | GLU302 |
| L | THR14 |
| L | PHE15 |
| L | HIS299 |
| L | TYR300 |
| L | LEU302 |
| L | ARG303 |
| L | ASP304 |
| L | LEU305 |
| site_id | AH4 |
| Number of Residues | 17 |
| Details | binding site for Di-peptide GLU K 302 and DGL L 406 |
| Chain | Residue |
| K | ARG160 |
| K | ARG161 |
| K | ALA179 |
| K | GLY180 |
| K | DGL301 |
| L | GLU12 |
| L | THR14 |
| L | ALA133 |
| L | LYS134 |
| L | ARG135 |
| L | ARG145 |
| L | TYR300 |
| L | HIS301 |
| L | ARG303 |
| L | ASP304 |
| L | LEU305 |
| L | DGL405 |
| site_id | AH5 |
| Number of Residues | 16 |
| Details | binding site for Di-peptide GLU K 302 and DGL L 405 |
| Chain | Residue |
| K | ARG160 |
| K | ARG161 |
| K | ALA179 |
| K | ARG198 |
| K | DGL301 |
| L | GLU12 |
| L | THR14 |
| L | ARG124 |
| L | ALA133 |
| L | TRP147 |
| L | TYR300 |
| L | HIS301 |
| L | ARG303 |
| L | ASP304 |
| L | LEU305 |
| L | DGL406 |
| site_id | AH6 |
| Number of Residues | 14 |
| Details | binding site for Di-peptide DGL O 301 and IAS P 404 |
| Chain | Residue |
| B | GLU164 |
| O | GLU302 |
| P | THR14 |
| P | PHE15 |
| P | ALA133 |
| P | ARG135 |
| P | ARG145 |
| P | HIS299 |
| P | TYR300 |
| P | LEU302 |
| P | ARG303 |
| P | ASP304 |
| P | LEU305 |
| P | DGL403 |
| site_id | AH7 |
| Number of Residues | 3 |
| Details | binding site for Di-peptide DGL O 301 and GLU O 302 |
| Chain | Residue |
| O | GLU303 |
| P | DGL403 |
| P | IAS404 |
| site_id | AH8 |
| Number of Residues | 15 |
| Details | binding site for Di-peptide DGL O 301 and DGL P 403 |
| Chain | Residue |
| B | GLU164 |
| O | ARG198 |
| O | LYS258 |
| O | GLU302 |
| P | THR14 |
| P | PHE15 |
| P | ARG124 |
| P | TRP147 |
| P | HIS299 |
| P | TYR300 |
| P | LEU302 |
| P | ARG303 |
| P | ASP304 |
| P | LEU305 |
| P | IAS404 |
Functional Information from PROSITE/UniProt
| site_id | PS01070 |
| Number of Residues | 9 |
| Details | NUCLEASE_NON_SPEC DNA/RNA non-specific endonucleases active site. DRGHLregA |
| Chain | Residue | Details |
| A | ASP445-ALA453 |
