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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6S6D

Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex

Functional Information from GO Data
ChainGOidnamespacecontents
A0000166molecular_functionnucleotide binding
A0003924molecular_functionGTPase activity
A0005515molecular_functionprotein binding
A0005525molecular_functionGTP binding
A0005634cellular_componentnucleus
A0005654cellular_componentnucleoplasm
A0005737cellular_componentcytoplasm
A0005764cellular_componentlysosome
A0005765cellular_componentlysosomal membrane
A0005829cellular_componentcytosol
A0006915biological_processapoptotic process
A0008104biological_processintracellular protein localization
A0009267biological_processcellular response to starvation
A0010507biological_processnegative regulation of autophagy
A0016787molecular_functionhydrolase activity
A0031625molecular_functionubiquitin protein ligase binding
A0031669biological_processcellular response to nutrient levels
A0032008biological_processpositive regulation of TOR signaling
A0033209biological_processtumor necrosis factor-mediated signaling pathway
A0034198biological_processcellular response to amino acid starvation
A0035556biological_processintracellular signal transduction
A0042593biological_processglucose homeostasis
A0042803molecular_functionprotein homodimerization activity
A0043495molecular_functionprotein-membrane adaptor activity
A0046982molecular_functionprotein heterodimerization activity
A0051219molecular_functionphosphoprotein binding
A0061462biological_processprotein localization to lysosome
A0071230biological_processcellular response to amino acid stimulus
A0072657biological_processprotein localization to membrane
A1904263biological_processpositive regulation of TORC1 signaling
A1990130cellular_componentGATOR1 complex
A1990131cellular_componentGtr1-Gtr2 GTPase complex
A1990877cellular_componentFNIP-folliculin RagC/D GAP
B0000166molecular_functionnucleotide binding
B0003924molecular_functionGTPase activity
B0005515molecular_functionprotein binding
B0005525molecular_functionGTP binding
B0005634cellular_componentnucleus
B0005654cellular_componentnucleoplasm
B0005737cellular_componentcytoplasm
B0005764cellular_componentlysosome
B0005765cellular_componentlysosomal membrane
B0005829cellular_componentcytosol
B0006915biological_processapoptotic process
B0008104biological_processintracellular protein localization
B0009267biological_processcellular response to starvation
B0010507biological_processnegative regulation of autophagy
B0016787molecular_functionhydrolase activity
B0031625molecular_functionubiquitin protein ligase binding
B0031669biological_processcellular response to nutrient levels
B0032008biological_processpositive regulation of TOR signaling
B0033209biological_processtumor necrosis factor-mediated signaling pathway
B0034198biological_processcellular response to amino acid starvation
B0035556biological_processintracellular signal transduction
B0042593biological_processglucose homeostasis
B0042803molecular_functionprotein homodimerization activity
B0043495molecular_functionprotein-membrane adaptor activity
B0046982molecular_functionprotein heterodimerization activity
B0051219molecular_functionphosphoprotein binding
B0061462biological_processprotein localization to lysosome
B0071230biological_processcellular response to amino acid stimulus
B0072657biological_processprotein localization to membrane
B1904263biological_processpositive regulation of TORC1 signaling
B1990130cellular_componentGATOR1 complex
B1990131cellular_componentGtr1-Gtr2 GTPase complex
B1990877cellular_componentFNIP-folliculin RagC/D GAP
C0000166molecular_functionnucleotide binding
C0000287molecular_functionmagnesium ion binding
C0003924molecular_functionGTPase activity
C0005515molecular_functionprotein binding
C0005525molecular_functionGTP binding
C0005634cellular_componentnucleus
C0005654cellular_componentnucleoplasm
C0005737cellular_componentcytoplasm
C0005764cellular_componentlysosome
C0005765cellular_componentlysosomal membrane
C0005829cellular_componentcytosol
C0006351biological_processDNA-templated transcription
C0006915biological_processapoptotic process
C0007264biological_processsmall GTPase-mediated signal transduction
C0008104biological_processintracellular protein localization
C0008380biological_processRNA splicing
C0009267biological_processcellular response to starvation
C0010507biological_processnegative regulation of autophagy
C0016787molecular_functionhydrolase activity
C0019003molecular_functionGDP binding
C0031669biological_processcellular response to nutrient levels
C0032006biological_processregulation of TOR signaling
C0034198biological_processcellular response to amino acid starvation
C0043200biological_processresponse to amino acid
C0043495molecular_functionprotein-membrane adaptor activity
C0046982molecular_functionprotein heterodimerization activity
C0051020molecular_functionGTPase binding
C0060090molecular_functionmolecular adaptor activity
C0061462biological_processprotein localization to lysosome
C0071230biological_processcellular response to amino acid stimulus
C0072657biological_processprotein localization to membrane
C0140767molecular_functionenzyme-substrate adaptor activity
C1903432biological_processregulation of TORC1 signaling
C1904263biological_processpositive regulation of TORC1 signaling
C1990131cellular_componentGtr1-Gtr2 GTPase complex
C1990877cellular_componentFNIP-folliculin RagC/D GAP
D0000166molecular_functionnucleotide binding
D0000287molecular_functionmagnesium ion binding
D0003924molecular_functionGTPase activity
D0005515molecular_functionprotein binding
D0005525molecular_functionGTP binding
D0005634cellular_componentnucleus
D0005654cellular_componentnucleoplasm
D0005737cellular_componentcytoplasm
D0005764cellular_componentlysosome
D0005765cellular_componentlysosomal membrane
D0005829cellular_componentcytosol
D0006351biological_processDNA-templated transcription
D0006915biological_processapoptotic process
D0007264biological_processsmall GTPase-mediated signal transduction
D0008104biological_processintracellular protein localization
D0008380biological_processRNA splicing
D0009267biological_processcellular response to starvation
D0010507biological_processnegative regulation of autophagy
D0016787molecular_functionhydrolase activity
D0019003molecular_functionGDP binding
D0031669biological_processcellular response to nutrient levels
D0032006biological_processregulation of TOR signaling
D0034198biological_processcellular response to amino acid starvation
D0043200biological_processresponse to amino acid
D0043495molecular_functionprotein-membrane adaptor activity
D0046982molecular_functionprotein heterodimerization activity
D0051020molecular_functionGTPase binding
D0060090molecular_functionmolecular adaptor activity
D0061462biological_processprotein localization to lysosome
D0071230biological_processcellular response to amino acid stimulus
D0072657biological_processprotein localization to membrane
D0140767molecular_functionenzyme-substrate adaptor activity
D1903432biological_processregulation of TORC1 signaling
D1904263biological_processpositive regulation of TORC1 signaling
D1990131cellular_componentGtr1-Gtr2 GTPase complex
D1990877cellular_componentFNIP-folliculin RagC/D GAP
Functional Information from PDB Data
site_idAC1
Number of Residues22
Detailsbinding site for residue GTP A 401
ChainResidue
ASER16
ATHR42
AGLY64
AGLY65
AHIS127
ALYS128
AASP130
ASER163
AILE164
AMG402
AHOH503
AGLY17
AHOH504
AHOH505
AHOH507
ASER18
AGLY19
ALYS20
ATHR21
ASER22
ATHR36
AARG37
site_idAC2
Number of Residues5
Detailsbinding site for residue MG A 402
ChainResidue
ATHR21
ATHR42
AGTP401
AHOH503
AHOH507
site_idAC3
Number of Residues14
Detailsbinding site for residue GDP C 401
ChainResidue
CARG71
CGLY73
CLYS74
CASN75
CSER76
CTHR90
CLEU91
CGLN147
CHIS178
CLYS179
CASP181
CILE220
CTYR221
CHOH503
site_idAC4
Number of Residues21
Detailsbinding site for residue GTP B 401
ChainResidue
BSER16
BGLY17
BSER18
BGLY19
BLYS20
BTHR21
BSER22
BTHR36
BARG37
BTHR42
BGLY64
BGLY65
BHIS127
BLYS128
BASP130
BSER163
BILE164
BMG402
BHOH501
BHOH502
BHOH504
site_idAC5
Number of Residues5
Detailsbinding site for residue MG B 402
ChainResidue
BTHR21
BTHR42
BGTP401
BHOH501
BHOH502
site_idAC6
Number of Residues8
Detailsbinding site for residue 9JE B 403
ChainResidue
AARG38
AGLY40
AALA41
BGLN107
BLEU151
BSER152
BARG153
BPRO154
site_idAC7
Number of Residues6
Detailsbinding site for residue 9JE B 404
ChainResidue
BSER174
BTYR178
BGLU188
BSER215
BHIS216
CGLY350
site_idAC8
Number of Residues12
Detailsbinding site for residue GDP D 401
ChainResidue
DLEU69
DARG71
DSER72
DGLY73
DLYS74
DASN75
DSER76
DHIS178
DLYS179
DASP181
DSER219
DILE220
Functional Information from PROSITE/UniProt
site_idPS00214
Number of Residues18
DetailsFABP Cytosolic fatty-acid binding proteins signature. KAYkVnpDmNFEvFIHKV
ChainResidueDetails
CLYS163-VAL180
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues6
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36103527","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"8DHB","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31672913","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6NZD","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31704029","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6ULG","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues10
DetailsCross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)","evidences":[{"source":"PubMed","id":"25936802","evidenceCode":"ECO:0000269"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI11
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI12
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI13
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI14
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601764","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6SB0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6SB2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI15
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI16
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"32868926","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6WJ3","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI17
Number of Residues4
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31601708","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6U62","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI18
Number of Residues2
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"35338845","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"36697823","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"7T3B","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UX2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXC","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"7UXH","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

246704

PDB entries from 2025-12-24

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