Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6S1K

E. coli Core Signaling Unit, carrying QQQQ receptor mutation

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000155	molecular_function	phosphorelay sensor kinase activity
A	0000160	biological_process	phosphorelay signal transduction system
A	0004673	molecular_function	protein histidine kinase activity
A	0005515	molecular_function	protein binding
A	0005524	molecular_function	ATP binding
A	0005737	cellular_component	cytoplasm
A	0005886	cellular_component	plasma membrane
A	0006935	biological_process	chemotaxis
A	0007165	biological_process	signal transduction
A	0016301	molecular_function	kinase activity
A	0016310	biological_process	phosphorylation
A	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
A	0018106	biological_process	peptidyl-histidine phosphorylation
A	0031400	biological_process	negative regulation of protein modification process
A	0050920	biological_process	regulation of chemotaxis
A	0071977	biological_process	bacterial-type flagellum-dependent swimming motility
A	0098561	cellular_component	methyl accepting chemotaxis protein complex
A	1901875	biological_process	positive regulation of post-translational protein modification
A	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
B	0000155	molecular_function	phosphorelay sensor kinase activity
B	0000160	biological_process	phosphorelay signal transduction system
B	0004673	molecular_function	protein histidine kinase activity
B	0005515	molecular_function	protein binding
B	0005524	molecular_function	ATP binding
B	0005737	cellular_component	cytoplasm
B	0005886	cellular_component	plasma membrane
B	0006935	biological_process	chemotaxis
B	0007165	biological_process	signal transduction
B	0016301	molecular_function	kinase activity
B	0016310	biological_process	phosphorylation
B	0016772	molecular_function	transferase activity, transferring phosphorus-containing groups
B	0018106	biological_process	peptidyl-histidine phosphorylation
B	0031400	biological_process	negative regulation of protein modification process
B	0050920	biological_process	regulation of chemotaxis
B	0071977	biological_process	bacterial-type flagellum-dependent swimming motility
B	0098561	cellular_component	methyl accepting chemotaxis protein complex
B	1901875	biological_process	positive regulation of post-translational protein modification
B	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
C	0005515	molecular_function	protein binding
C	0005737	cellular_component	cytoplasm
C	0005829	cellular_component	cytosol
C	0005886	cellular_component	plasma membrane
C	0006935	biological_process	chemotaxis
C	0007165	biological_process	signal transduction
C	0009454	biological_process	aerotaxis
C	0019904	molecular_function	protein domain specific binding
C	0051286	cellular_component	cell tip
C	0051649	biological_process	establishment of localization in cell
C	0098561	cellular_component	methyl accepting chemotaxis protein complex
C	1901875	biological_process	positive regulation of post-translational protein modification
D	0005515	molecular_function	protein binding
D	0005737	cellular_component	cytoplasm
D	0005829	cellular_component	cytosol
D	0005886	cellular_component	plasma membrane
D	0006935	biological_process	chemotaxis
D	0007165	biological_process	signal transduction
D	0009454	biological_process	aerotaxis
D	0019904	molecular_function	protein domain specific binding
D	0051286	cellular_component	cell tip
D	0051649	biological_process	establishment of localization in cell
D	0098561	cellular_component	methyl accepting chemotaxis protein complex
D	1901875	biological_process	positive regulation of post-translational protein modification
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005515	molecular_function	protein binding
E	0005886	cellular_component	plasma membrane
E	0006935	biological_process	chemotaxis
E	0007165	biological_process	signal transduction
E	0007172	biological_process	signal complex assembly
E	0009593	biological_process	detection of chemical stimulus
E	0016020	cellular_component	membrane
E	0032110	biological_process	regulation of protein histidine kinase activity
E	0042802	molecular_function	identical protein binding
E	0043113	biological_process	receptor clustering
E	0048870	biological_process	cell motility
E	0050920	biological_process	regulation of chemotaxis
E	0071230	biological_process	cellular response to amino acid stimulus
E	0098561	cellular_component	methyl accepting chemotaxis protein complex
E	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
F	0004888	molecular_function	transmembrane signaling receptor activity
F	0005515	molecular_function	protein binding
F	0005886	cellular_component	plasma membrane
F	0006935	biological_process	chemotaxis
F	0007165	biological_process	signal transduction
F	0007172	biological_process	signal complex assembly
F	0009593	biological_process	detection of chemical stimulus
F	0016020	cellular_component	membrane
F	0032110	biological_process	regulation of protein histidine kinase activity
F	0042802	molecular_function	identical protein binding
F	0043113	biological_process	receptor clustering
F	0048870	biological_process	cell motility
F	0050920	biological_process	regulation of chemotaxis
F	0071230	biological_process	cellular response to amino acid stimulus
F	0098561	cellular_component	methyl accepting chemotaxis protein complex
F	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
G	0004888	molecular_function	transmembrane signaling receptor activity
G	0005515	molecular_function	protein binding
G	0005886	cellular_component	plasma membrane
G	0006935	biological_process	chemotaxis
G	0007165	biological_process	signal transduction
G	0007172	biological_process	signal complex assembly
G	0009593	biological_process	detection of chemical stimulus
G	0016020	cellular_component	membrane
G	0032110	biological_process	regulation of protein histidine kinase activity
G	0042802	molecular_function	identical protein binding
G	0043113	biological_process	receptor clustering
G	0048870	biological_process	cell motility
G	0050920	biological_process	regulation of chemotaxis
G	0071230	biological_process	cellular response to amino acid stimulus
G	0098561	cellular_component	methyl accepting chemotaxis protein complex
G	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
H	0004888	molecular_function	transmembrane signaling receptor activity
H	0005515	molecular_function	protein binding
H	0005886	cellular_component	plasma membrane
H	0006935	biological_process	chemotaxis
H	0007165	biological_process	signal transduction
H	0007172	biological_process	signal complex assembly
H	0009593	biological_process	detection of chemical stimulus
H	0016020	cellular_component	membrane
H	0032110	biological_process	regulation of protein histidine kinase activity
H	0042802	molecular_function	identical protein binding
H	0043113	biological_process	receptor clustering
H	0048870	biological_process	cell motility
H	0050920	biological_process	regulation of chemotaxis
H	0071230	biological_process	cellular response to amino acid stimulus
H	0098561	cellular_component	methyl accepting chemotaxis protein complex
H	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
I	0004888	molecular_function	transmembrane signaling receptor activity
I	0005515	molecular_function	protein binding
I	0005886	cellular_component	plasma membrane
I	0006935	biological_process	chemotaxis
I	0007165	biological_process	signal transduction
I	0007172	biological_process	signal complex assembly
I	0009593	biological_process	detection of chemical stimulus
I	0016020	cellular_component	membrane
I	0032110	biological_process	regulation of protein histidine kinase activity
I	0042802	molecular_function	identical protein binding
I	0043113	biological_process	receptor clustering
I	0048870	biological_process	cell motility
I	0050920	biological_process	regulation of chemotaxis
I	0071230	biological_process	cellular response to amino acid stimulus
I	0098561	cellular_component	methyl accepting chemotaxis protein complex
I	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
J	0004888	molecular_function	transmembrane signaling receptor activity
J	0005515	molecular_function	protein binding
J	0005886	cellular_component	plasma membrane
J	0006935	biological_process	chemotaxis
J	0007165	biological_process	signal transduction
J	0007172	biological_process	signal complex assembly
J	0009593	biological_process	detection of chemical stimulus
J	0016020	cellular_component	membrane
J	0032110	biological_process	regulation of protein histidine kinase activity
J	0042802	molecular_function	identical protein binding
J	0043113	biological_process	receptor clustering
J	0048870	biological_process	cell motility
J	0050920	biological_process	regulation of chemotaxis
J	0071230	biological_process	cellular response to amino acid stimulus
J	0098561	cellular_component	methyl accepting chemotaxis protein complex
J	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
K	0004888	molecular_function	transmembrane signaling receptor activity
K	0005515	molecular_function	protein binding
K	0005886	cellular_component	plasma membrane
K	0006935	biological_process	chemotaxis
K	0007165	biological_process	signal transduction
K	0007172	biological_process	signal complex assembly
K	0009593	biological_process	detection of chemical stimulus
K	0016020	cellular_component	membrane
K	0032110	biological_process	regulation of protein histidine kinase activity
K	0042802	molecular_function	identical protein binding
K	0043113	biological_process	receptor clustering
K	0048870	biological_process	cell motility
K	0050920	biological_process	regulation of chemotaxis
K	0071230	biological_process	cellular response to amino acid stimulus
K	0098561	cellular_component	methyl accepting chemotaxis protein complex
K	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
L	0004888	molecular_function	transmembrane signaling receptor activity
L	0005515	molecular_function	protein binding
L	0005886	cellular_component	plasma membrane
L	0006935	biological_process	chemotaxis
L	0007165	biological_process	signal transduction
L	0007172	biological_process	signal complex assembly
L	0009593	biological_process	detection of chemical stimulus
L	0016020	cellular_component	membrane
L	0032110	biological_process	regulation of protein histidine kinase activity
L	0042802	molecular_function	identical protein binding
L	0043113	biological_process	receptor clustering
L	0048870	biological_process	cell motility
L	0050920	biological_process	regulation of chemotaxis
L	0071230	biological_process	cellular response to amino acid stimulus
L	0098561	cellular_component	methyl accepting chemotaxis protein complex
L	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
M	0004888	molecular_function	transmembrane signaling receptor activity
M	0005515	molecular_function	protein binding
M	0005886	cellular_component	plasma membrane
M	0006935	biological_process	chemotaxis
M	0007165	biological_process	signal transduction
M	0007172	biological_process	signal complex assembly
M	0009593	biological_process	detection of chemical stimulus
M	0016020	cellular_component	membrane
M	0032110	biological_process	regulation of protein histidine kinase activity
M	0042802	molecular_function	identical protein binding
M	0043113	biological_process	receptor clustering
M	0048870	biological_process	cell motility
M	0050920	biological_process	regulation of chemotaxis
M	0071230	biological_process	cellular response to amino acid stimulus
M	0098561	cellular_component	methyl accepting chemotaxis protein complex
M	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
N	0004888	molecular_function	transmembrane signaling receptor activity
N	0005515	molecular_function	protein binding
N	0005886	cellular_component	plasma membrane
N	0006935	biological_process	chemotaxis
N	0007165	biological_process	signal transduction
N	0007172	biological_process	signal complex assembly
N	0009593	biological_process	detection of chemical stimulus
N	0016020	cellular_component	membrane
N	0032110	biological_process	regulation of protein histidine kinase activity
N	0042802	molecular_function	identical protein binding
N	0043113	biological_process	receptor clustering
N	0048870	biological_process	cell motility
N	0050920	biological_process	regulation of chemotaxis
N	0071230	biological_process	cellular response to amino acid stimulus
N	0098561	cellular_component	methyl accepting chemotaxis protein complex
N	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
O	0004888	molecular_function	transmembrane signaling receptor activity
O	0005515	molecular_function	protein binding
O	0005886	cellular_component	plasma membrane
O	0006935	biological_process	chemotaxis
O	0007165	biological_process	signal transduction
O	0007172	biological_process	signal complex assembly
O	0009593	biological_process	detection of chemical stimulus
O	0016020	cellular_component	membrane
O	0032110	biological_process	regulation of protein histidine kinase activity
O	0042802	molecular_function	identical protein binding
O	0043113	biological_process	receptor clustering
O	0048870	biological_process	cell motility
O	0050920	biological_process	regulation of chemotaxis
O	0071230	biological_process	cellular response to amino acid stimulus
O	0098561	cellular_component	methyl accepting chemotaxis protein complex
O	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility
P	0004888	molecular_function	transmembrane signaling receptor activity
P	0005515	molecular_function	protein binding
P	0005886	cellular_component	plasma membrane
P	0006935	biological_process	chemotaxis
P	0007165	biological_process	signal transduction
P	0007172	biological_process	signal complex assembly
P	0009593	biological_process	detection of chemical stimulus
P	0016020	cellular_component	membrane
P	0032110	biological_process	regulation of protein histidine kinase activity
P	0042802	molecular_function	identical protein binding
P	0043113	biological_process	receptor clustering
P	0048870	biological_process	cell motility
P	0050920	biological_process	regulation of chemotaxis
P	0071230	biological_process	cellular response to amino acid stimulus
P	0098561	cellular_component	methyl accepting chemotaxis protein complex
P	1902021	biological_process	regulation of bacterial-type flagellum-dependent cell motility

Functional Information from PROSITE/UniProt

site_id	PS00039
Number of Residues	9
Details	DEAD_ATP_HELICASE DEAD-box subfamily ATP-dependent helicases signature. FFDEADElL

Chain	Residue	Details
A	PHE12-LEU20

site_id	PS00538
Number of Residues	23
Details	CHEMOTAXIS_TRANSDUC_1 Bacterial chemotaxis sensory transducers signature. RTEQQaaSLeETAASMEQLTATV

Chain	Residue	Details
E	ARG294-VAL316

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4140
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
E	MET1-LYS6
I	TRP211-PHE551
J	MET1-LYS6
J	TRP211-PHE551
K	MET1-LYS6
K	TRP211-PHE551
L	MET1-LYS6
L	TRP211-PHE551
M	MET1-LYS6
M	TRP211-PHE551
N	MET1-LYS6
E	TRP211-PHE551
N	TRP211-PHE551
O	MET1-LYS6
O	TRP211-PHE551
P	MET1-LYS6
P	TRP211-PHE551
F	MET1-LYS6
F	TRP211-PHE551
G	MET1-LYS6
G	TRP211-PHE551
H	MET1-LYS6
H	TRP211-PHE551
I	MET1-LYS6

site_id	SWS_FT_FI2
Number of Residues	504
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
E	ILE7-PHE30
I	GLN191-VAL210
J	ILE7-PHE30
J	GLN191-VAL210
K	ILE7-PHE30
K	GLN191-VAL210
L	ILE7-PHE30
L	GLN191-VAL210
M	ILE7-PHE30
M	GLN191-VAL210
N	ILE7-PHE30
E	GLN191-VAL210
N	GLN191-VAL210
O	ILE7-PHE30
O	GLN191-VAL210
P	ILE7-PHE30
P	GLN191-VAL210
F	ILE7-PHE30
F	GLN191-VAL210
G	ILE7-PHE30
G	GLN191-VAL210
H	ILE7-PHE30
H	GLN191-VAL210
I	ILE7-PHE30

site_id	SWS_FT_FI3
Number of Residues	1908
Details	TOPO_DOM: Periplasmic => ECO:0000255

Chain	Residue	Details
E	ASN31-SER190
N	ASN31-SER190
O	ASN31-SER190
P	ASN31-SER190
F	ASN31-SER190
G	ASN31-SER190
H	ASN31-SER190
I	ASN31-SER190
J	ASN31-SER190
K	ASN31-SER190
L	ASN31-SER190
M	ASN31-SER190

site_id	SWS_FT_FI4
Number of Residues	24
Details	MOD_RES: Glutamate methyl ester (Gln) => ECO:0000269\|PubMed:2033064, ECO:0000269\|PubMed:6402709

Chain	Residue	Details
E	GLN297
I	GLN311
J	GLN297
J	GLN311
K	GLN297
K	GLN311
L	GLN297
L	GLN311
M	GLN297
M	GLN311
N	GLN297
E	GLN311
N	GLN311
O	GLN297
O	GLN311
P	GLN297
P	GLN311
F	GLN297
F	GLN311
G	GLN297
G	GLN311
H	GLN297
H	GLN311
I	GLN297

site_id	SWS_FT_FI5
Number of Residues	24
Details	MOD_RES: Glutamate methyl ester (Glu) => ECO:0000269\|PubMed:2033064, ECO:0000269\|PubMed:6402709

Chain	Residue	Details
E	GLU304
I	GLU493
J	GLU304
J	GLU493
K	GLU304
K	GLU493
L	GLU304
L	GLU493
M	GLU304
M	GLU493
N	GLU304
E	GLU493
N	GLU493
O	GLU304
O	GLU493
P	GLU304
P	GLU493
F	GLU304
F	GLU493
G	GLU304
G	GLU493
H	GLU304
H	GLU493
I	GLU304

site_id	SWS_FT_FI6
Number of Residues	12
Details	MOD_RES: Glutamate methyl ester (Glu) => ECO:0000269\|PubMed:2033064

Chain	Residue	Details
E	GLU502
N	GLU502
O	GLU502
P	GLU502
F	GLU502
G	GLU502
H	GLU502
I	GLU502
J	GLU502
K	GLU502
L	GLU502
M	GLU502

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)