6RXM
Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16-Acetyl peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| B | 0070403 | molecular_function | NAD+ binding |
| C | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| C | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| C | 0070403 | molecular_function | NAD+ binding |
| D | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| D | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| D | 0070403 | molecular_function | NAD+ binding |
| E | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| E | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| E | 0070403 | molecular_function | NAD+ binding |
| F | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| F | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| F | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 300 |
| Chain | Residue |
| A | CYS155 |
| A | SER158 |
| A | CYS174 |
| A | CYS176 |
| A | CYS177 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS177 |
| B | CYS155 |
| B | GLN157 |
| B | CYS174 |
| B | CYS176 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 300 |
| Chain | Residue |
| C | CYS155 |
| C | SER158 |
| C | CYS174 |
| C | CYS176 |
| C | CYS177 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | CYS155 |
| D | CYS174 |
| D | CYS176 |
| D | CYS177 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN E 301 |
| Chain | Residue |
| E | CYS155 |
| E | SER158 |
| E | CYS174 |
| E | CYS176 |
| E | CYS177 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN F 301 |
| Chain | Residue |
| F | CYS155 |
| F | SER158 |
| F | CYS174 |
| F | CYS176 |
| F | CYS177 |
Functional Information from PROSITE/UniProt
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| G | GLY14-HIS18 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 24 |
| Details | DNA_BIND: |
| Chain | Residue | Details |
| G | ALY16-LYS20 | |
| H | ALY16-LYS20 | |
| I | ALY16-LYS20 | |
| J | ALY16-LYS20 | |
| K | ALY16-LYS20 | |
| L | ALY16-LYS20 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0000269|PubMed:22343720 |
| Chain | Residue | Details |
| G | LYS12 | |
| B | ALA258 | |
| C | GLY48 | |
| C | GLN129 | |
| C | GLY214 | |
| C | ASN240 | |
| C | ALA258 | |
| D | GLY48 | |
| D | GLN129 | |
| D | GLY214 | |
| D | ASN240 | |
| H | LYS12 | |
| D | ALA258 | |
| E | GLY48 | |
| E | GLN129 | |
| E | GLY214 | |
| E | ASN240 | |
| E | ALA258 | |
| F | GLY48 | |
| F | GLN129 | |
| F | GLY214 | |
| F | ASN240 | |
| I | LYS12 | |
| F | ALA258 | |
| J | LYS12 | |
| K | LYS12 | |
| L | LYS12 | |
| B | GLN129 | |
| B | GLY214 | |
| B | ASN240 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | MOD_RES: N6-acetyllysine => ECO:0000269|PubMed:11080160, ECO:0000269|PubMed:15150415, ECO:0000269|PubMed:17289592, ECO:0000269|PubMed:19113941 |
| Chain | Residue | Details |
| G | ALY16 | |
| E | ARG95 | |
| F | TYR92 | |
| F | ARG95 | |
| H | ALY16 | |
| I | ALY16 | |
| J | ALY16 | |
| K | ALY16 | |
| L | ALY16 | |
| D | TYR92 | |
| D | ARG95 | |
| E | TYR92 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | BINDING: BINDING => ECO:0000255|HAMAP-Rule:MF_01121, ECO:0000269|PubMed:15019790 |
| Chain | Residue | Details |
| A | CYS155 | |
| E | CYS174 | |
| F | CYS155 | |
| F | CYS174 | |
| A | CYS174 | |
| B | CYS155 | |
| B | CYS174 | |
| C | CYS155 | |
| C | CYS174 | |
| D | CYS155 | |
| D | CYS174 | |
| E | CYS155 |
