6RXM
Crystal structure of CobB Ac2 (A76G, I131C, V162G) in complex with H4K16-Acetyl peptide
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| A | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| A | 0070403 | molecular_function | NAD+ binding |
| B | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| B | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| B | 0070403 | molecular_function | NAD+ binding |
| C | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| C | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| C | 0070403 | molecular_function | NAD+ binding |
| D | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| D | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| D | 0070403 | molecular_function | NAD+ binding |
| E | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| E | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| E | 0070403 | molecular_function | NAD+ binding |
| F | 0036054 | molecular_function | protein-malonyllysine demalonylase activity |
| F | 0036055 | molecular_function | protein-succinyllysine desuccinylase activity |
| F | 0070403 | molecular_function | NAD+ binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | binding site for residue ZN A 300 |
| Chain | Residue |
| A | CYS155 |
| A | SER158 |
| A | CYS174 |
| A | CYS176 |
| A | CYS177 |
| site_id | AC2 |
| Number of Residues | 5 |
| Details | binding site for residue ZN B 301 |
| Chain | Residue |
| B | CYS177 |
| B | CYS155 |
| B | GLN157 |
| B | CYS174 |
| B | CYS176 |
| site_id | AC3 |
| Number of Residues | 5 |
| Details | binding site for residue ZN C 300 |
| Chain | Residue |
| C | CYS155 |
| C | SER158 |
| C | CYS174 |
| C | CYS176 |
| C | CYS177 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue ZN D 301 |
| Chain | Residue |
| D | CYS155 |
| D | CYS174 |
| D | CYS176 |
| D | CYS177 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue ZN E 301 |
| Chain | Residue |
| E | CYS155 |
| E | SER158 |
| E | CYS174 |
| E | CYS176 |
| E | CYS177 |
| site_id | AC6 |
| Number of Residues | 5 |
| Details | binding site for residue ZN F 301 |
| Chain | Residue |
| F | CYS155 |
| F | SER158 |
| F | CYS174 |
| F | CYS176 |
| F | CYS177 |
Functional Information from PROSITE/UniProt
| site_id | PS00047 |
| Number of Residues | 5 |
| Details | HISTONE_H4 Histone H4 signature. GAKRH |
| Chain | Residue | Details |
| G | GLY14-HIS18 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | Active site: {"description":"Proton acceptor","evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 143 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"24176774","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 12 |
| Details | Binding site: {"evidences":[{"source":"HAMAP-Rule","id":"MF_01121","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"15019790","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 6 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"11080160","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"15150415","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"17289592","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19113941","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-methyllysine; alternate","evidences":[{"source":"PubMed","id":"22343720","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
