6RUU

Pseudokinase domain of human IRAK3

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004672	molecular_function	protein kinase activity
A	0005524	molecular_function	ATP binding
A	0006468	biological_process	protein phosphorylation
B	0004672	molecular_function	protein kinase activity
B	0005524	molecular_function	ATP binding
B	0006468	biological_process	protein phosphorylation
C	0004672	molecular_function	protein kinase activity
C	0005524	molecular_function	ATP binding
C	0006468	biological_process	protein phosphorylation

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	binding site for residue HG A 501

Chain	Residue
A	ALA416
A	CYS420

---

site_id	AC2
Number of Residues	3
Details	binding site for residue HG A 502

Chain	Residue
A	MET391
A	CYS399
A	PHE419

---

site_id	AC3
Number of Residues	1
Details	binding site for residue GOL A 503

Chain	Residue
A	TYR230

---

site_id	AC4
Number of Residues	2
Details	binding site for residue GOL A 504

Chain	Residue
A	ARG429
A	LYS431

---

site_id	AC5
Number of Residues	3
Details	binding site for residue SO4 A 505

Chain	Residue
C	PRO263
C	HIS265
A	ARG429

---

site_id	AC6
Number of Residues	7
Details	binding site for residue SO4 A 506

Chain	Residue
A	HIS279
A	HIS282
A	ASN283
A	ILE353
A	SER435
A	MET436
A	ASP437

---

site_id	AC7
Number of Residues	3
Details	binding site for residue SO4 A 507

Chain	Residue
A	PRO263
A	TRP264
A	HIS265

---

site_id	AC8
Number of Residues	3
Details	binding site for residue SO4 A 508

Chain	Residue
A	HIS316
A	PHE317
B	LYS207

---

site_id	AC9
Number of Residues	4
Details	binding site for residue HG B 501

Chain	Residue
B	LEU387
B	MET391
B	CYS399
B	PHE419

---

site_id	AD1
Number of Residues	6
Details	binding site for residue SO4 B 502

Chain	Residue
B	HIS279
B	HIS282
B	ASN283
B	SER435
B	MET436
B	ASP437

---

site_id	AD2
Number of Residues	3
Details	binding site for residue SO4 B 503

Chain	Residue
B	ARG388
B	THR428
B	ARG429

---

site_id	AD3
Number of Residues	3
Details	binding site for residue HG C 501

Chain	Residue
C	CYS420
C	LEU421
C	ARG424

---

site_id	AD4
Number of Residues	4
Details	binding site for residue HG C 502

Chain	Residue
C	LEU387
C	MET391
C	CYS399
C	PHE419

---

site_id	AD5
Number of Residues	2
Details	binding site for residue HG C 503

Chain	Residue
C	CYS291
C	ASP311

---

site_id	AD6
Number of Residues	1
Details	binding site for residue HG C 504

Chain	Residue
A	ARG394

---

site_id	AD7
Number of Residues	1
Details	binding site for residue HG C 505

Chain	Residue
C	ARG394

---

site_id	AD8
Number of Residues	4
Details	binding site for residue GOL C 506

Chain	Residue
A	LEU396
A	ASP397
C	LYS417
C	SER445

---

site_id	AD9
Number of Residues	6
Details	binding site for residue SO4 C 507

Chain	Residue
C	HIS279
C	HIS282
C	ASN283
C	SER435
C	MET436
C	ASP437

---

site_id	AE1
Number of Residues	4
Details	binding site for residue SO4 C 508

Chain	Residue
C	ARG388
C	ALA427
C	THR428
C	ARG429

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	19
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"},{"source":"Reference","evidenceCode":"ECO:0000269","citation":{"citationType":"submission","publicationDate":"JUN-2020","submissionDatabase":"PDB data bank","title":"The IRAK3 Pseudokinase Domain Bound To ATPgammaS.","authors":["Mathea S.","Chatterjee D.","Preuss F.","Kraemer A.","Knapp S."]}},{"source":"PDB","id":"6ZIW","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

---

site_id	SWS_FT_FI2
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00159","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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